COMT

ADHD Gene Doesn't Predict Response to Drugs

...gene encoding catechol-O-methyltransferase (COMT). comt regulates levels of the brain chemical dopamine in...tend to be disrupted in children with ADHD. The comt gene is marked by a particular genetic variant tha...ally, the researchers determined the status of the comt gene variant in each child. The team detected a...

NARSAD researchers identify specific genes and family traits linked to mental illnesses

.... Roffman's team is looking at the combination of MTHFR and another gene -- comt (catechol-O-methyltransferase) -- that affects dopamine levels in the brain...offman and his colleagues also found that the same combination of MTHFR and comt variants were associated with abnormally low activity in the prefrontal cor...

Gene May Be Key to Pregnancy Complication

...current experiments, the researchers worked with mice that did not have the comt gene, and therefore do not produce 2-ME. After 14 weeks of gestation -- equ...s of preeclampsia disappeared, Kalluri said. Kalluri's team found that comt levels were deficient, and 2-ME levels were also lower, in women diagnosed ...

Genetic Mechanism Helps Explain Chronic Pain Disorders

...hers have discovered that specific variants of the comt gene can dramatically affect the secondary structu...The researchers found that three major variants of comt show significant differences in how they code for ...portant because pain conditions resulting from low comt activity or elevated catecholamine levels are like...

The Pain from Fibromyalgia Is Real, Researchers Say

...hy volunteers. Researchers also have found that individual mutations in the comt gene are related to the future development of temporomandibular joint disor...J, a condition related to fibromyalgia. Together, these studies about comt and numerous studies with animals suggest that pain sensitivity is determin...

COMT in Medical Technology

Merck Serono's Safinamide Significantly Improved Motor Function in Patients With Advanced Parkinson's Disease in a Phase III Pivotal Trial

...r morning dose in patients with mid- to late-stage Parkinson's disease receiving optimized treatment with drugs including levodopa, dopamine agonists, comt inhibitors, anti-cholinergics and amantidine, the results indicate a statistically significant improvement of motor function. Previously reported resu...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

... intake was associated with symptoms that were especially severe. Now, Dr. Roffman's team is looking at the combination of MTHFR and another gene -- comt (catechol-O-methyltransferase) -- that affects dopamine levels in the brain. Although the two genes have separately been associated with schizophrenia...

Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme

...as an ongoing discovery programme to develop novel comt inhibitors. The paper reviews the preclinical an...recent developments in the analysis of the role of comt genotypes and their involvement in cognitive defic...r supports the view that there is potential to use comt inhibitors in ameliorating their cognitive deficit...

COMT in Biological News

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

...is also associated with higher neuroticism scores and anxious behavior. The comt enzyme is involved in breaking down dopamine, a brain chemical important fo...on of the gene did not. In addition, a variation in the gene coding for the comt enzyme was associated with fear extinction - volunteers with this particula...

Interaction between gene variants may alter brain function in schizophrenia

...n only in the schizophrenia patients, not in controls. While variations in comt did not influence cortical activation patterns on their own, the combined e...ssociated MTHFR variant was even more pronounced in patients who also had a comt variant previously associated with less efficient working-memory-related br...

Genes may make some people more prone to anxiety

...rst determined which participants carried which variations (alleles) of the comt gene, which encodes an enzyme that breaks down dopamine, weakening its sign...ter for analysis. People carrying two copies of the Met158 allele of the comt gene showed a significantly stronger startle reflex in the unpleasant-pictu...

At Boston symposium, NARSAD researchers report on genes and family traits

.... Roffman's team is looking at the combination of MTHFR and another gene -- comt (catechol-O-methyltransferase) -- that affects dopamine levels in the brain...offman and his colleagues also found that the same combination of MTHFR and comt variants were associated with abnormally low activity in the prefrontal cor...

A new gene trigger for pregnancy disorder identified

... BOSTON The comt gene known already for its role in schizophrenia ...the Kalluri laboratory revealed an enzyme known as comt (catechol-O-methyltransferase) in preeclampsia, a ...Kalluri. We wondered if, in cases of preeclampsia, comt was not functioning properly. In support of this h...

Cognitive, genetic clues identified in imaging study of alcohol addiction

...nformation less efficiently." The study also found that a variant of the comt gene, which controls the level of the neurotransmitter dopamine in the cort...er said, that the area is working less efficiently in those people. The comt gene has two common variants with a single amino acid difference at positio...

Alcoholism, smoking and genetics among Plains American Indians

...'s reward pathway." Enoch added that the enzyme comt plays an important role in the breakdown of dopami... brain, its activity varying according to a common comt polymorphism, Val158Met. "The Met allele results ...rinking and smoking histories. Additionally, five comt loci ?including Val158Met ?were genotyped. "T...

Brain Scans Reveal How Gene May Boost Schizophrenia Risk

...d in those who had inherited two copies of the met comt gene. This "trait-like characteristic" of comt gene type fits a model in which the prefrontal cor...site directions, depending on which version of the comt gene one inherits: up with val, down with met. In ...

COMT in Biological Technology

New Report Provides Expert Analysis of Recent Advances and Setbacks in Parkinson's Disease Drug Development

...astin, GAD/glutamic acid decarboxylase), alpha-synuclein; -- Dopamine agonists, monoamine oxidase inhibitors; -- Levodopa formulations, comt inhibitors; and -- Adenosine A2A receptor antagonists, cholinesterase inhibitors, AMPA, 5-HT, anticonvulsants, antihypertensives, farnesyl ...