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CLL in Medical News

Lenalidomide safe as single therapy for elderly CLL patients

SAN FRANCISCO ― The oral medication lenalidomide is safe and well-tolerated for elderly patients with chronic lymphocytic leukemia, a group without a well-defined frontline therapy for their disease, researchers from The University of Texas M. D. Anderson Cancer Center reported today at the ...

Dismissed leukemia drug helps cll patients, studies show

COLUMBUS, Ohio A drug once dismissed as ineffective in patients with chronic lymphocytic leukemia (CLL) has shown promising results in two phase I and II clinical trials, according to researchers at The Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research I...

GlaxoSmithKline's Drug Will Become New Clinical Gold Standard by 2012 for the Treatment of Relapsed/Refractory CLL

An Agent Showing Improvement in Overall Response Rate Would Earn Higher Patient Share in U.S. Than Europe, According to a New Report from Decision Resources WALTHAM, Mass., Jan. 20 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceu...

Phase 2 Results of Rigel's R788 Show Clinical Benefit in Diffuse Large B-Cell Lymphoma and CLL

SAN FRANCISCO, Dec. 7 /PRNewswire-FirstCall/ -- Results of the Phase 2 clinical trial of R788 (fostamatinib disodium) in patients with relapsed or refractory B-Cell non-Hodgkin's lymphoma (NHL) will be presented today at a plenary session during the 50th Annual American Society of Hematology (ASH)...

Sagent Pharmaceuticals Announces Launch of First Two Oncolytic Products: Fludarabine Phosphate for Injection, USP and Epirubicin Hydrochloride Injection

... one standard alkylating-agent containing regimen. The safety and effectiveness of the product in previously untreated or non-refractory patients with cll have not been established. The package insert, which is available at www.SagentPharma.com, contains detailed information about the indication, ...

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

...ciety, there will be more than 15,000 new cases of cll diagnosed in 2009 alone. The study results were p...atment with TREANDA, some patients had no signs of cll in their blood. "CLL is the most common f...rapy, was approved by the FDA for the treatment of cll in March 2008. Efficacy relative to other first li...

Agent Orange Linked to Parkinson's, Heart Disease

...l leukemias, Hodgkin's disease and chloracne, a skin condition. The committee also clarified that hairy cell leukemia belonged in the same category as cll and lymphomas. In addition to Parkinson's and heart disease, there was "limited or suggestive evidence" of an association between the herbicides an...

Limited data suggest possible association between Agent Orange exposure

...mas. Previous reviews in the series found sufficient evidence to state that there is an association between herbicide exposure and increased risk for cll and lymphomas. The report presents scientific data only and does not suggest or intend to imply policy decisions that the U.S. Department of Vetera...

Prospect Therapeutics Inc.'s GCS-100 Has Focused on Developing Treatment for Three Blood-Borne Cancers

...L"), multiple myeloma ("MM") and diffuse large B cell lymphoma ("DLBCL"). In clinical studies, GCS-100 has demonstrated activity as a single agent in cll and in combination with existing therapy in MM. The intellectual property, regulatory dossier, fixed assets and clinical inventory of Prospect wi...

Gene Studies Reveal Cancer's Secrets

... to lead researcher Susan Slager, associate professor of biostatistics at the Mayo Clinic in Rochester, Minn. About 15,000 Americans will develop cll each year, and 4,000 will die, so it is one of the rarer cancers, Slager said during the teleconference. However, "if you have a family member with ch...
CLL in Medical Technology

Genmab A/S - Company Announcement: Recruitment Completed In Ofatumumab CLL Front Line Study

COPENHAGEN, Denmark, July 9 /PRNewswire-FirstCall/ -- Summary: Genmab has completed recruitment of patients in the Phase II study of ofatumumab in combination with fludarabine and cyclophosphamide to treat front line CLL. Genmab A/S (OMX: GEN) announced today it has completed recruitment of ...

The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial

WHITE PLAINS, N.Y., June 18 /PRNewswire/ -- The Leukemia & Lymphoma Society (LLS) and Memgen jointly announced an agreement today to collaborate on a new Phase I clinical trial. The trial will use Memgen's ISF35, an active immunotherapy approach for treating chronic lymphocytic leukemia (CLL)....

Long-Term Followup in Phase 3 CLL Trial Shows Genasense(R) is Associated with Significantly Increased Survival in All Responders

New Data to be Presented at ASCO Shows Survival Benefit in Complete and Partial Responders Compared with Chemotherapy Alone BERKELEY HEIGHTS, N.J., May 29 /PRNewswire-FirstCall/ -- Genta Incorporated (OTC Bulletin Board: GNTA) announced the results of long-term followup from a Phase 3...

Genasense Plus Chemotherapy Is Associated With Prolonged Survival in Patients With Relapsed/Refractory CLL Who Achieve Complete Remission

Updated Phase 3 Results Released at American Society of Hematology Meeting BERKELEY HEIGHTS, N.J., Dec. 10 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA ) announced the release of new survival analyses based upon extended follow-up of patients in the Company's randomized Phase 3 t...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

Data Showed Campath May Lead to Overall Survival in Patients with Poor Prognostic Factors SAN FRANCISCO, Dec. 9 /PRNewswire/ -- Bayer HealthCare Pharmaceuticals Inc. today announced results from three studies showing that treatment with Campath(R) (alemtuzumab) showed activity in high-ris...

Polyphenon Pharma Receives Orphan Drug Designation for Its Botanical Drug, Polyphenon E, for the Treatment of CLL

NEW YORK, July 28 /PRNewswire/ -- Polyphenon Pharma, an emerging research-based pharmaceutical company, today announced that the Food and Drug Administration (FDA) has granted Orphan Drug Designation to its botanical drug, Polyphenon E(R), for the treatment of chronic lymphocytic leukemia (CLL...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...rmaceutical (SMIP(TM)), in Relapsed and Refractory cll -- Early Promising Clinical Activity The clini...cal trial (#16007) of TRU-016 for the treatment of cll and small lymphocytic leukemia (SLL). The objectives of the Phase 1 TRU-016 cll study were to define safety and tolerability, iden...

FDA Advisory Panel Makes Favorable Recommendation for GlaxoSmithKline and Genmab's ARZERRA(TM) (ofatumumab)

...nts with CLL. While current initial treatments for cll can provide prolonged remissions, some patients wi... the FDA towards an approval for ofatumumab." cll is the most common form of adult leukemia in the W...h as infections and death. Less than 25 percent of cll patients who are resistant to current treatments r...

Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis

...d Chief Executive Officer, Quest Diagnostics. cll is a blood cancer that usually progresses slowly o...n, and other organs may also be affected. Although cll is the most common form of leukemia in adults in W...team and others showed that some family members of cll patients can have B-cells in their blood that have...

New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia

...r. Reynolds. "New therapies such as these offer hope for our patients." The research found that both PCR and FCR have significant activity in cll and can be given safely in the community setting. Both regimens possess significant toxicity and response rates in this multi-institution, community-b...
CLL in Medical Definition

Hematopathology

...gy : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , cll , HCL ) • Lymphoma ( Hodgkin's disease , NHL ) • LPD • Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : Myeloid leuk...

Pathology

...gy : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , cll , HCL ) • Lymphoma ( Hodgkin's disease , NHL ) • LPD • Myeloma ( Multiple myeloma , Extramedullary plasmacytoma ) Myeloid : Myeloid leuk...
CLL in Medical Dictionary

Lymph

... news resource. ... Exercising After Mastectomy and Lymph Node Removal. Additional Resources and References ... Leukemia - Chronic Lymphocytic - cll | Cancer.Net - The American Society of Clinical ... Swelling of lymph nodes in the neck, under the arms, or in the groin. ... When you get certa...
CLL in Biological News

Study validates means to measure possible leukemia marker

...ove the diagnosis and gauge response to therapy in cll patients. The findings are published online in a...used LC-MS to analyze variations in histones in 40 cll patients and four healthy patients. It showed sign... the relative abundance of histone H2A variants in cll cells compared with healthy B cells and suggested ...

Two suppressor molecules affect 70 genes in leukemia

...s. First, they measured differences in gene activity in laboratory-grown cll cells that had either high or low levels of the two molecules. Next, the...owth, cell death and cancer development. Last, the researchers used human cll cells from 16 patients to verify the gene targets. Together, these exten...

Researchers discover inherited mutation for leukemia

...John C. Byrd, professor of internal medicine and a cll specialist. "They also show the importance o...ns when identifying problem genes," he says. cll is the most common form of adult leukemia, with 15... their 50s, 60s and 70s. About 90 percent of cll cases are sporadic; that is, they have no genetic ...

Massey researchers induce cell death in leukemia

...ration and TopoTarget A/S), were examined in human cll cells isolated from five patients. Bortezomib dram... Parallel studies conducted on two established cll cell lines provided additional preclinical evidenc...lly with both agents to induce cell death in human cll cells. Romidepsin and belinostat are histone deace...

Knocking out survival protein could aid leukemia treatment

... be an effective target for drugs directed against cll and ALL," says principal investigator John C. Byrd...tionale for lowering the amount of this protein in cll cells and suggest that this should enhance the act... Rituximab is an antibody-based drug that targets cll and ALL cells and causes the cells to self-destruc...

Mouse mimics chronic leukemia, will aid drug development

...tly hampered the development of new treatments for cll as well as research into its causes and the change...renders treatment ineffective, as often happens in cll patients," says principal investigator John C. Byr...of internal medicine. Byrd is a specialist in cll at the Ohio State University Comprehensive Cancer ...

The very unexpected life and death of a leukemic cell

...of information regarding the rate of production of cll cells, and the time-course of their death. For years, doctors and scientists believed that cll was a static disease of long-lived lymphocytes -- ...oblems with the programmed cell death machinery in cll cells. This was a hint that perhaps the leukemia c...

Enzyme allows B cells to resist death, leading to leukemia

...ed leukemia cells from 40 patients with B-CLL and compared them with lymphocytes from normal donors. They found that Lyn was markedly overexpressed in cll cells and an unusual amount of the enzyme was found in the cell cytosol. In addition, the enzyme was constantly active compared with levels of activit...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...rmation in the scientific community's knowledge of cll that has occurred over the past decade. The review...oned in many cases," said Dr. Rai, who treats many cll patients. "New and upcoming discoveries made colle...ly incurable leukemia," he added. A decade ago, cll was considered a uniform disease of immature white...
CLL in Biological Technology

Genmab A/S: Ofatumumab Pivotal CLL Data to be Presented at ASH

Responses Significantly Correlated to Overall Survival Summary: Three ofatumumab Abstracts Have Been Accepted for Presentation at the ASH Meeting December 6-9, 2008 COPENHAGEN, November 10 /PRNewswire-FirstCall/ -- Genmab A/S (OMX: GEN) announced today that three of...

National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment

Genzyme Genetics to Provide Testing for Important Cancer and Leukemia Group B Study WESTBOROUGH, Mass., Dec. 4 /PRNewswire-FirstCall/ -- Genzyme Genetics, a business unit of Genzyme Corporation (Nasdaq: GENZ ), announced today its participation in a Cancer and Leu...

Genmab Announces Update on Recruitment of Patients in ofatumumab CLL Pivotal Study

Summary: Genmab and GlaxoSmithKline Have Completed Recruitment of 66 CLL Patients Respectively to Both Study Groups in a Pivotal Study of ofatumumab COPENHAGEN, Denmark, November 28 /PRNewswire-FirstCall/ -- Genmab A/S (OMX: GEN) announced today recruitment of 132 patients has been completed i...

Genta Completes Appeal of FDA Decision for Genasense(R) in CLL

Submission Seeks Approval of Genasense in Relapsed/Refractory Patients BERKELEY HEIGHTS, N.J., Oct. 25 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA ) announced that the Company has completed the filing of the Company's formal appeal to Dr. Janet Woodcock, Acting Director of the...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

... Phase 1: Encouraging Results Observed in cll Patients Treated With Low Doses of TRU-016 P...erapeutics Preclinical Mechanism Apoptosis in cll Cells Occurs Via Distinct Mechanism Compared With ...ating the effect of TRU-016 on direct apoptosis in cll cells. (Logo: http://www.newscom.com/cgi-bin...

Sanofi-aventis U.S. to Acquire Oral Chronic Lymphocytic Leukemia Treatment

... December 2008 to treat adult patients with B-cell cll whose disease has not responded to, or has progres...nt for the treatment of adult patients with B-cell cll whose disease has not responded to, or has progres...tunistic infections have occurred in patients with cll treated with fludarabine phosphate. About...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... 2 single-arm, open-label program in patients with cll who failed previous treatment. No partial or comp...rodesine HCl 200 mg once-daily. Based on both the cll interim analysis and the PK and PD study results, the dosing regimen in the ongoing Phase 2 cll study was amended to evaluate 200 mg Forodesine HC...

Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells

...These reports now broaden ONCONASE's activity into cll and AML, and include a related endoribonuclease, R...ells were isolated from 36 untreated patients with cll and were cultured for 24-72 hours with either ONCO...ph in CLL, and synergism with the most widely used cll therapies. For the study in AML, leukemic...

Genmab Announces Results for the First Nine Months of 2008

... studies with ofatumumab this year: 1) Phase III cll front line chlorambucil combination study. 2) Phase II cll ofatumumab retreatment and maintenance treatment s...nts who have participated in the ongoing Phase III cll study. 3) Phase II NHL ofatumumab retreatment an...

Genmab Reaches Fifth Milestone in Ofatumumab Collaboration

...32.7 Million From GSK for Achievement of Positive Results in the Phase III cll Study COPENHAGEN, August 21 /PRNewswire-F...n, Ph.D., Chief Executive Officer of Genmab, "it is even more important for cll patients who are waiting for new treatments to combat their difficult to tr...
CLL in Biological Definition

Full blood count

...indicate bacterial infection. Lymphocytes - Higher with some viral infections such as glandular fever . Also raised in lymphocytic leukaemia cll . Monocytes - May be raised in bacterial infection Eosinophil granulocytes - Increased in parasitic infections. Basophil granulocytes ...
CLL in Biological Dictionary

Monoclonal Antibody

...it. ... The production of monoclonal antibodies was pioneered by ... cll Topics - Patients dedicated to the fight against chronic lymphocytic leukem...Related Articles: Review of Monoclonal Antibodies in Development ... cll Topics - Patients dedicated to the fight against chronic lymphocytic leukem...

Monoclonal antibodies

... Antibody Therapy in Lymphoid Malignancies ... cll Topics - Patients dedicated to the fight against c...Rituxan and Campath have changed the landscape for cll ... cll Topics - Patients dedicated to the fight against c...

Gene therapy

...is to modify the genetic material of ... Exploring this new method of gene therapy has been the work of many labs in ... gene therapy ... cll Topics - Patients dedicated to the fight against chronic lymphocytic leukemia ... Gene Therapy is the title that was chosen to describe a ... ...
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