Jefferson scientists see breast cancer gene activity from outside the body
...e hyperactivity of CCND1, a common breast cancer gene. The gene is copied thousands of times in most breast cancer cells. The high concentration makes ccnd1
copies easier to image with the genetic PET probe. The research team found a much higher concentration of the cancer gene activity in estrogen recepto...
JCI table of contents: April 22, 2008
...tin riboside was shown to inhibit expression of both the CCND2 gene and the ccnd1
gene. Further analysis revealed that the chemical inhibited the expression ...ple myeloma.
TITLE: Identification of kinetin riboside as a repressor of ccnd1
and CCND2 with preclinical antimyeloma activity