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Butyrylcholinesterase in Medical Technology

PharmAthene's Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimer's Disease

ANNAPOLIS, Md., April 9, 2008 /PRNewswire-FirstCall/ -- PharmAthene, Inc. (Amex: PIP ) a biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological threats, announced today that scientists from the Hebrew University of J...

PharmAthene's Recombinant Butyrylcholinesterase (rBChE) Program the Subject of Promising New Alzheimer's Research

In Vitro Assays Show rBChE Suppresses Amyloid Plaque Formation ANNAPOLIS, Md., April 03, 2007 /PRNewswire/ -- PharmAthene, Inc., a leading biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological terrorism, announced today ...

Pharmathene's Recombinant Butyrylcholinesterase (rBChE) Program the Subject of Promising New Alzheimer's Research

In Vitro Assays Show rBChE Suppresses Amyloid Plaque Formation ANNAPOLIS, Md., April 3, 2007 - PharmAthene, Inc., a leading biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological terrorism, announced today that new data...

PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)

...produced in the milk of transgenic goats, is a recombinant version of human butyrylcholinesterase (BChE), which has been shown to be effective in animal models in preventing...produced in the milk of transgenic goats, is a recombinant version of human butyrylcholinesterase (BChE), a naturally occurring protein found in minute quantities in blood (...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

...sure prophylaxis for inhalational anthrax. Summary of Data Presented: Non-pegylated rBChE Findings Reported In a poster entitled, "Recombinant butyrylcholinesterase (rBChE) Therapy Following VX Poisoning by the Percutaneous Route: Preliminary Results from Guinea Pig Studies," investigators studied the effects of n...
Butyrylcholinesterase in Biological News

American Chemical Society's Weekly PressPac -- Sept. 10, 2008

...int out no effective anti-cocaine medication currently exists for cocaine abuse. One of the most promising approaches focuses on substances that mimic butyrylcholinesterase (BChE), a natural blood protein that helps break down and inactivate the drug, researchers say. However, natural BChE is too weak and ineffective for ...
Butyrylcholinesterase in Biological Technology

PharmAthene Reports Year-End 2007 Financial Results

...velop into bacteria and preventing toxin production and propagation of the infection. -- Demonstrating new research showing that recombinant butyrylcholinesterase (rBChE) may effectively block the formation of amyloid fibrils, which are believed to be important precursors to Alzheimer's disease. -- Sho...

Department of Defense Awards $5.8 Million Contract Modification Providing Additional Funding for PharmAthene's Protexia(R) Program

...gram," continued Dr. Troyer. Preclinical studies suggest that recombinant butyrylcholinesterase used as a prophylactic against nerve agents would add a valuable capability...in vivo challenge studies with nerve agents. As a prophylactic, recombinant butyrylcholinesterase may reduce or eliminate the need for post-exposure therapeutics. In additio...
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