U.S. Department of Defense Exercises $2.0 Million Option to Fund Cethromycin Development

...te cethromycin's efficacy in combating Category A and B bioterror agents such as Fransicella tularensis (tularemia), Yersinia pestis (plague) and burkholderia pseudomallei (melioidosis). Under the terms of the contract, $1.8 million of DoD funds were initially available to initiate the studies. The $2.0 mi...

Snoring or soaring? Strength of fruit-fly immune system varies

...ircadian proteins whose activity, in turn, is disrupted by these mutations. Strangely, though, infecting the flies with a third bacterial pathogen, burkholderia cepacia, produced the opposite result. Circadian-mutant flies coped better with the infection than did normal flies, suggesting that in this case, a d...

Lung transplants in cystic fibrosis patients with life-threatening bacteria sparks debate at ISHLT

...ighlight of the session was the concluding debate: burkholderia Cenocepacia is an Absolute Contradiction to Transp...ges Pompidou Hospital, Paris. Cystic Fibrosis, burkholderia Cenocepacia and Lung Transplantation Patients wi... in 5 percent of patients with CF, bacteria called burkholderia cenocepacia infects the lungs before transplant. T...

Scientists Find New Way to Kill Antibiotic-resistant Bacteria

... bisphosphonates also attack similar species like Acinetobacter baumannii (hospital-acquired pneumonia), Staphylococcus aureus (staph infections), and burkholderia (lung infections). "We hope this discovery will help existing antibiotics or offer a new treatment for antibiotic-resistant bacteria," he said...

Key Found to Kill Cystic Fibrosis Superbug

...& Dentistry at The University of Western Ontario , working with a group from Edinburgh//, have discovered a way to kill the cystic fibrosis superbug , burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research publi...

Burkholderia in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

...s patients has received a second orphan drug designation in the US only weeks after a first designation was granted. The recent designation relates to burkholderia cepacia pathogens that can cause lethal infections in cystic fibrosis patients. For Axentis Pharma AG of Zurich, Switzerland, both designations affirm...

Nanoemulsion Kills Highly Resistant Bacteria Found in Patients With Cystic Fibrosis

...ract infections are the primary cause of death in persons with cystic fibrosis, and there are simply no effective therapies for patients infected with burkholderia and other bacterial species that are resistant to all known antibiotics," said John LiPuma, M.D., professor and associate chair for research in the de...

Lung Transplants in Cystic Fibrosis Patients With Life-Threatening Bacteria Sparks Debate at ISHLT Meeting

...orges Pompidou Hospital, Paris. Cystic Fibrosis, burkholderia Cenocepacia and Lung Transplantation Patients wi...er or not to allocate donor lungs to patients with burkholderia cenocepacia knowing that the success rate is much ...plants should not be performed on CF patients with burkholderia cenocepacia until new research indicates a way to ...

Burkholderia in Biological News

Scientists identify bacteria that increase plant growth

... on plant growth, others had no effect, and some resulted in decreased growth. In particular, poplar cuttings inoculated with Enterobacter sp. 638 and burkholderia cepacia BU72 repeatedly showed the highest increase in biomass production up to 50 percent as compared with non-inoculated control plants. Though no...

Key found to kill cystic fibrosis superbug

...amp; Dentistry at The University of Western Ontario , working with a group from Edinburgh, have discovered a way to kill the cystic fibrosis superbug, burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research publi...

Scientists determine structure of enzyme that disrupts bacterial virulence

...loped for use in treating human and animal pathogens that also rely on quorum-sensing for their virulence. For example, bacterial pathogens such as burkholderia mallei, which is responsible for the biowarfare threat glanders, and Pseudomonas aeruginosa, which often forms opportunistic infections on the lung su...

Burkholderia in Biological Technology

Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study

...is also being developed to combat other high priority bioterror agents such as Fransicella tularensis (tularemia) , Yersinia pestis (plague) and burkholderia pseudomallei (melioidosis) under a two year, $3.8 million contract with the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defens...

Trius Awarded $28 Million Contract to Develop Novel Antibiotics

...ase IV, with the aim of optimizing these drugs for activity against relevant biodefense pathogens such as Yersinia pestis, Francisella tularensis, and burkholderia pseudomallei. Trius will collaborate with investigators at Lawrence Livermore National Laboratories to identify and optimize lead molecules and to tes...

Advanced Life Sciences Awarded U.S. Department of Defense Biodefense Contract Valued at up to $3.8 Million

... Excellence for Biodefense and Emerging Infectious Diseases Research, Colorado State University stated, "Our initial evaluation of cethromycin against burkholderia pseudomallei shows that it is very active and may have a more favorable resistance profile than other approved antibiotics in treating melioidosis." D...

Advanced Life Sciences Announces First Quarter 2008 Financial Results

...f Health and Human Services to fund the advanced development of cethromycin in combating bioterror agents such as anthrax, tularemia, plague and burkholderia pseudomallei; * Initiate enrollment by the end of the summer in Phase I/II dose-escalating study to assess the safety, tolerability, and prelim...

SGI Breakthrough Technology Empowers Genome Center Research Around the World

...ently underway at MGI. For example, the Microbial Genomics Research for Gene and Natural Product Discovery project is focusing on two model organisms, burkholderia pseudomallei, a locally important soil pathogen and Eimeria tenella, a local avian protozoan. The project will harness the SGI solution to dissect the...

Burkholderia in Biological Products

Rabbit Anti-Burkholderia pseudomallei Flagellin Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to Flagellin ( Abpromise for all tested applications). Antigen: Synthetic peptide from the flagellin C terminal domain of burkholderia pseudomallei....
Company:Abcam