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Conserved amino acids play both structural and mechanistic roles in sandwich-like protein

The question of whether amino acids in sandwich-like proteins are there to stabilize the structure or to speed up the protein-folding process is best answered by "all of the above," according to researchers at Rice University in Houston. This discovery, reported in today's issue of the Proceedings of the National Academy of Sciences, could benefit future research on treatments for disease...

Pair of cancer genes found to drive both cell migration and division

Johns Hopkins researchers have found that two genes already known to control cell movement are also needed for proper cell division. They report their findings in the April issue of Developmental Cell. The researchers discovered that the two genes are required for a dividing cell's halves to separate, raising the possibility that interfering with them could be helpful in stopping the uncon...

Both alcoholism and chronic smoking can damage the brain's prefrontal cortex

University of Utah researchers will receive up to $10.3 million to help develop a new prosthetic arm that would work, feel and look like a real arm. The Utah work is a key part of a U.S. Department of Defense contract worth up to $55 million to develop the new device for soldiers and potentially others whose arms were amputated. "Imagine an artificial arm that moves naturally in response t...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Pennsylvania School of Veterinary Medicine. The researchers discovered how IL-25, a signaling protein kn...

Queensland scientists identify molecule that links both sides of the brain

A Queensland Brain Institute-led team has identified a molecule that plays a key role in establishing the major nerve connections between each side of the adult brain. QBI neural migration laboratory head Associate Professor Helen Cooper said her group's research provided new clues regarding development of the corpus callosum, the main connecting nerve tract that shuttles information betw...

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The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR

CypHer5 is a red-excited, pH-sensitive cyanine dye that is non-fluorescent at pH 7.4 and maximally fluorescent at pH 5.5. It is therefore ideally suited for monitoring internalization of cell surface receptors via acidic endosomal vesicles upon agonist stimulation (1, 2). <P >In the assay, the receptor can be epitop...

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Alcoholism Influenced By Both Genetics & Family Environment

In a study involving identical and non-identical twins, researchers conducted telephone interviews with 1,213 sets of male-male twins, average age 50.// The researchers’ goal was to better understand the hereditary and environmental effects on developing alcoholism -- not by studying the twins themselves, but by interviewing the twins’ children (ages 12 to 26) and the mothers of those chi...

Diabetics Can Now Be Able To Control Both Blood Sugar And Their Weight

Type 2 diabetics can now control their blood sugar without gaining weight or increasing their insulin doses, say researchers according to a new study.// In an effort to achieve near normal control of blood sugar research has resulted in a variety of drugs that lower blood sugar levels while improving blood pressure and lipid levels in the blood. Despite these advances, diabetics have had...

Vaginal Birth After C-section Dangerous For Both Mother And Baby

Women who opt for a vaginal birth after first delivering a child via cesarean section may be putting themselves and their newborns at risk,// say researchers based on findings of a recent study. Though the overall chance anything will go wrong is extremely small, uterine rupture is possible, as is injury to the newborn due to lack of oxygen (hypoxic-ischemic encephalopathy). Women may als...

Revolutionary Simple Pregnancy Blood Test Can Save Both Mother And Child

Pre-eclampsia is a disease that causes high blood pressure in 20th week// of Pregnancy and is a major cause of death of mother and infant in the world. Now a simple test that measures HLA-G levels in blood can predict women who are likely to develop the problem. Researchers in Canada may have discovered this simple blood test. "We're really excited about this finding," said Clifford L...

Being together matters, both in marriage and smoking

The risk of stroke is high among couples who smoke according to a new study// which has reported a six times higher relative risk of total stroke than cigarette-smoking women with non-smoking spouses. The study recorded the smoking and marital status and the incidence of total stroke and ischemic stroke (a stroke caused by a blood clot blocking blood flow to the brain) among various gr...

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Daytrana (methylphenidate transdermal system) Provides Significant Effectiveness in ADHD Symptom Relief in Both Boys and Girls

SAN DIEGO, May 23, 2007 /PRNewswire-FirstCall/ -- Shire plcannounced today that DAYTRANA(TM) (methylphenidate transdermalsystem), its Attention Deficit Hyperactivity Disorder (ADHD) patch,had significant efficacy in reducing the symptoms of ADHD in bothmale and female children aged 6 to 12 years, according to clinicaltrial results reported at the American Psychiatric Association(APA) ann...

Trexima (Sumatriptan/Naproxen Sodium) Provided Relief of Both Traditional and Non-traditional Migraine Symptoms

New data show efficacy across the range of migraine symptoms BOSTON, May 02, 2007 /PRNewswire/ -- While many migrainesufferers experience traditional symptoms such as nausea orsensitivity to light and sound, migraine attacks can also involvesymptoms like neck pain or sinus pain that are not traditionallyassociated with migraine headaches. New data show thatsignificantly more patients usin...

Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies

- Combination Therapy Significantly Decreased Tumor Blood VesselDensity and Serum PSA Levels in Prostate Tumors - LOS ANGELES and TUSTIN, Calif., April 17, 2007/PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. , aclinical stage biopharmaceutical company developing targetedmonoclonal antibodies for the treatment of cancer and hepatitis Cvirus (HCV) infection, today announced that p...