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Bosentan in Medical News

Cialis May Help Ease Pulmonary Hypertension

...n Philadelphia. For the study, Barst's team randomly assigned 405 pulmonary hypertension patients to Cialis or placebo once a day, or to Cialis and bosentan (Tracleer) a common treatment for pulmonary hypertension. The researchers found that over 16 weeks, Cialis increased patients' six-minute walk dist...

New research about chronic lung disease presented at CHEST 2008

...tadalafil vs. 16 percent for placebo). Researchers conclude that tadalafil may provide an effective oral, once-daily therapy that can be combined with bosentan therapy for patients with PAH. #6783 IN-HOSPITAL STATIN USE MAY IMPROVE SEVERE SEPSIS MORTALITY (Tuesday, October 28, 10:30 AM EST) New rese...

CHEST 2008: Featured abstracts

...tadalafil vs. 16 percent for placebo). Researchers conclude that tadalafil may provide an effective oral, once-daily therapy that can be combined with bosentan therapy for patients with PAH. #7310 OMEGA-3 FATTY ACID LEVELS MAY AFFECT SLEEP APNEA SEVERITY (Tuesday, October 28, 1:00 PM EST) The level of...

Drug Effective Against Heart-Lung Disorder

... bosentan slowed decline linked to pulmonary arterial hypert... THURSDAY, June 19 (HealthDay News) -- The drug bosentan reduced clinical decline in patients with early-st...ure and death. Previous studies have shown that bosentan improves exercise capacity and pulmonary vascular ...

A combination therapy of 3 vasodilators may treat portopulmonary hypertension

... Combination therapy of Prostacyclin, Sildenafil, and bosentan helped a young male patient with severe portopulmonary hypertension improve enough to receive a liver transplant. It was also used post-transplant to ...

New Drug Shows Significant Improvement In HIV-related Heart Condition

... Latest research has shown that treatment with the oral drug bosentan (Tracleer) has led to significant improvements in an often fatal disease, p... leads to PAH, a condition that in most cases is the direct cause of death. bosentan mediates the effects of excess endothelin production. For the study 16 H...
Bosentan in Medical Technology

Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease

SOUTH SAN FRANCISCO, Calif. and ALLSCHWIL, Switzerland, June 20 /PRNewswire/ -- Actelion Ltd (SWX: ATLN) announced today that data published in The Lancet(1) show that, in mildly symptomatic pulmonary arterial hypertension (PAH) patients (WHO functional class II - WHO FC II), bosentan (Traclee...

Actelion Announces Positive Study with Bosentan (Tracleer) in CTEPH

First-Ever Placebo-controlled Study in Inoperable Chronic Thromboembolic Pulmonary Hypertension - Primary Endpoint of Reduction in Pulmonary Vascular Resistance Met - Six-Minute-walk Test Unchanged - Significant Effect on Dyspnoea Score and Biological Disease Marker ALLSCHWIL, Switzerland, M...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

...effect was 44m (95 percent confidence-interval, 20m to 69m), as compared to 23m (95 percent confidence-interval, -2m to 48m) in patients on background bosentan therapy. Among secondary objectives, patients administered tadalafil 40 mg showed improvement in time to clinical worsening, as compared to plac...

New Drug Application for Inhaled Treprostinil Submitted to the U.S. Food and Drug Administration

...eceiving an approved background therapy. The study population consisted of 235 patients who were optimized on an approved oral therapy for PAH, either bosentan (Tracleer(R)), an endothelin receptor antagonist, or sildenafil (Revatio(R)), a phosphodiesterase-5 inhibitor. The majority of patients were New York ...

Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration

...olled trial of patients with severe PAH. The study population consisted of 235 patients who were optimized on an approved oral therapy for PAH, either bosentan (Tracleer(R)), an endothelin receptor antagonist, or sildenafil (Revatio(R)), a phosphodiesterase-5 inhibitor. In addition to one of these oral therap...

Results of TRIUMPH-1 Trial of Viveta in Pulmonary Arterial Hypertension to Be Announced Before Market Open on Thursday, November 1, 2007

...AH, a chronic, life-threatening illness. The study population consisted of 235 patients who were optimized on an approved oral therapy for PAH, either bosentan (Tracleer), an endothelin receptor antagonist, or sildenafil (Revatio), a phosphodiesterase-5 inhibitor. The primary efficacy endpoint of the trial wa...

Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension

... Physicians, taking place in Chicago. COMPASS-1 (Effects of Combination Of bosentan and sildenafil versus sildenafil Monotherapy on morbidity and mortality in ...ortant focus for research, and these results support our belief that adding bosentan to sildenafil could potentially slow disease progression." "The results of...

Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension

...on, MD, Professor of Medicine, Mayo Clinic, Rochester, Minnesota. This open-label study evaluated 36 patients who had previously discontinued the ERAs bosentan (86 percent), sitaxsentan (6 percent), or both (8 percent) due to the development of liver function abnormalities. In this study, patients with idiopa...
Bosentan in Biological News

New cardiology research presented at CHEST 2008

...tadalafil vs. 16 percent for placebo). Researchers conclude that tadalafil may provide an effective oral, once-daily therapy that can be combined with bosentan therapy for patients with PAH. #6480 INSOMNIA DOES NOT PREDICT HIGH BLOOD PRESSURE (Tuesday, October 28, 1:00 PM EST) Difficulty falling asle...
Bosentan in Biological Technology

Actelion Announces Multiple Presentations on Tracleer(R) and the REVEAL Registry at CHEST 2007

...n: Pulmonary Vascular Disease: Pulmonary HTN, ID # 900 Oral Presentation: bosentan improves hemodynamics in patients receiving background Sildenafil treatme... Sildenafil in comparison with inhaled nitric oxide in patients receiving bosentan therapy for pulmonary arterial hypertension (COMPASS-1) Location: Conve...
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