Blinded

Champion of blinded soldiers, Congressman Murtha, is Man of Vision

Schepens Eye Research Institute has named Congressman John P. Murtha, Chairman of the House Appropriations Subcommittee on Defense, this year's Man of Vision for his advocacy on behalf of veterans blinded by war and for research to restore their vision. Its highest honor, each year the Institu...

Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find

...ut four days. The facial filler lasted 7 percent longer in African-Americans (median of 117 days, compared with 109 days in the overall population) in blinded assessments, and 20 percent longer in African-Americans (129 compared with 107 ) according to self-assessments by study participants. The study als...

Top-Five Global Pharmaceutical Company Names NewCardio as its Provider of Automated Thorough QT Solution

...valuated several automated cardiac safety solutions before choosing QTinno(TM) as its automated solution moving forward. As part of this evaluation, a blinded TQT dataset was provided for processing by the automated solutions. The automated results were then un-blinded by the pharmaceutical company and compa...

Abbott Introduces Molecular Diagnostic System Intended for Broad Identification of Infectious Agents

...pes virus and human parvovirus B19 were injected into human plasma specimens from healthy volunteers. This was followed by a retrospective study of 54 blinded samples of cerebral spinal fluid, urine and plasma. The Ibis technology detected all viral pathogens that were added to the plasma specimens with a li...

Cell Therapeutics Completes Pixantrone NDA Submission and Requests Priority Review

...therapeutic agents (4.7 months vs. 2.6 months, p=0.007, respectively). PFS, CR/CRu and ORR were determined by an independent assessment panel that was blinded to the treatment assignments. The most common grade 3/4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus ...

Dysport Available! New Wrinkle Treatment in Washington, DC Offers Botox Alternative

... a 3:1 dose relationship. In 2006, Dr. Robert M. Adrian, founder of the Center for Laser Surgery, sponsored and fully funded a 24-patient double blinded comparative study of Dysport and Botox in the treatment of forehead lines in Karlsruhe, Germany. The results of this independent study, both physical ...

Successful Disease Management Programs Can Play Role in Health Care Reform

...th the operation and implementation of the program being done solely by the states and CNS. If the state decides to share data with Lilly, the data is blinded and aggregated and does not contain information about individual patients or providers. In addition, Lilly has sought approval and received support fr...

Two Drugs Better Than One for Crohn's Patients

...econd group received infliximab plus a placebo and the third group received azathioprine plus a placebo for 30 weeks, with the option to continue in a blinded study extension through week 50. After 50 weeks, 72.2 percent of patients who'd received the infliximab/azathioprine drug combination were in stero...

Ceregene Presents Additional Clinical Data from Phase 2 Trial of CERE-120 for Parkinson's Disease

... the results of these protocol-prescribed analyses in patients who remained blinded for up to 18 months, as well as by the insight we gained," stated Dr. Bartu...nd efficacy, with over half the subjects followed for 15 to 18 months under blinded conditions, allowing longer-term analyses of the therapeutic effects of CER...

Becoming Aware of Veterans' Vision Needs

...one. Log on to VisionAWARE.org for detailed information on: Direct links to the sites of the U.S. Department of Veterans' Affairs, blinded Veterans Association, Disabled American Veterans, and National Association of Blind Veterans. Scheduling a low vision examination to determine...

Blinded in Medical Technology

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

First-Ever Trial to Evaluate Whether Olmesartan Medoxomil Prevents Onset of Early Kidney Disease in Type 2 Diabetes Patients SAN FRANCISCO, May 8 /PRNewswire/ -- Blinded one-year blood pressure (BP) reduction data from the ongoing landmark study ROADMAP ( R andomized O lmesartan A nd D ...

Large Blinded Clinical Study Achieves High Accuracy for the Diagnosis of Melanoma Using In Vivo Confocal Microscopy

- Lesions non-invasively imaged in 5 to 10 minutes - - Landmark Study Reported in Journal of Investigative Dermatology - ROCHESTER, N.Y., Sept. 18 /PRNewswire/ -- A landmark publication that appeared in the Journal of Investigative Dermatology reports the results of a large, two sit...

Based on Up to 6 Years of Follow-Up, Biovest Announces Favorable Interim Blinded Data for Fast-Tracked Pivotal Phase 3 Clinical Trial of BiovaxID Anti-Cancer Vaccine for Non-Hodgkin's Lymphoma

WORCESTER, Mass.--(BUSINESS WIRE)--Jun 28, 2007 - Biovest International, Inc. (OTCBB: BVTI), a majority owned subsidiary of Accentia Biopharmaceuticals, Inc. (NASDAQ:ABPI), announced on June 27, 2007 blinded interim data from the start of its fast-tracked pivotal Phase 3 clinical trial of BiovaxID(...

Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing

...f 2.0-3.0 for 12 weeks. The INR was determined weekly for four weeks and every two weeks thereafter. Investigators, sponsors and study subjects were blinded to the edoxaban dose; however, those taking warfarin were aware they were randomized to the warfarin arm. Bleeding events were evaluated us...

New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

... in some countries outside the United States. Patients participating in the SONIC study through 30 weeks were given the option of continuing in a blinded study extension through 54 weeks. The proportion of patients achieving steroid-free remission among the overall randomized population (N=508), includi...

Data From Clinical Study of bioTheranostics Molecular Diagnostic Test Presented at American Society of Clinical Oncology Annual Meeting

...f tumors with a higher success rate than traditional diagnostic tests, thereby helping to reduce the number of cancers that remain "unknown". The blinded study involved 28 patients who had an unknown primary cancer that was subsequently identified during their lives. Researchers assessed tissue from the...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

...over time. Patients from the placebo cohort in the blinded studies entered this study with approximately doub..."We are especially interested in the data from the blinded and open-label studies indicating that XERECEPT(R)...nd has submitted them to an independent center for blinded review. This review is ongoing, and to date the s...

Intercell AG Announces First Subject Enrolled in a Phase II Trial for the Further Development of Its Investigational Vaccine Enhancement Patch to Improve Pandemic Influenza Prevention in Collaboration With U.S. Department of Health and Human Services (HHS

...d its efforts to develop its VE Patch to improve prevention of H5N1 pandemic influenza with the start of a Phase II clinical trial. The randomized and blinded study aims to determine the optimal dosage of both Intercell's VE Patch and the H5N1 influenza vaccine injected concomitantly, when combined with each...

Pelleve Receives FDA Clearance for the Treatment of Mild to Moderate Facial Wrinkles

...nd took an average of 15 to 20 minutes, depending on size of the area. More than 87% of patients showed measurable and immediate positive results in a blinded assessment of skin laxity and wrinkle improvement with continued response at six months after treatment. Patients were typically able to return to wor...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

...ontinued treatment due to adverse events Findings from LUX -Lung 1 In addition, preliminary data on the demographic and blinded safety data from the ongoing Phase III study, the LUX-Lung 1 trial, will be presented at ASCO for the first time.(5) The LUX-Lung 1 study addres...

Blinded in Medical Dictionary

Polyp

... a polyp ? ... Endoscopic removal of large colonic polyps . Epidemiology and risk factors for ... Polyp removal patients ... Ten radiologists, blinded to polyp findings, retrospectively interpreted 730 ... Polyp Histology ... The polyp -matching algorithm required CTC and optical ... ... c...

Blinded in Biological News

Carbon nanoparticles toxic to adult fruit flies but benign to young

...ing holes, or spiracles, which may have suffocated them. In other adults, the nanoparticles covered the surface of their compound eyes, which may have blinded them. The nanoparticles "glom onto the flies," Rand noted while watching a video of flies in the test tubes. "They just can't move. It's like a din...

Gene panel predicts lung cancer survival, study finds

...ey could be predictive of patient outcome. They then looked at the other two additional tumor sets for which all outcome data had remained unknown and blinded to the researchers, called "validation sets," to assess whether the outcome of the training set could be duplicated. ...

MIT-led teams unravel heparin death mystery

...sels, and one that produces anaphylactic toxins. The first leads to a dangerous decrease in blood pressure, the second a serious allergic reaction. In blinded laboratory tests, the contaminated heparin activated the biological pathways, while normal heparin did not. Sasisekharan emphasized the remarkable...

Continuous oral contraceptives better at easing pain, bleeding

...2 healthy women, randomly assigned to receive either cyclical or continuous birth control pills, for six months with both researchers and participants blinded to the study group. "We monitored vaginal bleeding, quality of life, and ovarian and endometrial suppression," said Legro, whose team's findings a...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

..." says principal investigator Charles Lu, M.D., associate professor in M. D. Anderson's Department of Thoracic, Head and Neck Medical Oncology. blinded analysis of pretreatment and post-treatment biopsies of three patients' tumors show that expression of FUS1 was absent from pretreatment samples whi...

Artificial cornea offers better results for infants, some blind patients

...rtificial corneas, and Aquavella doing cornea transplants on thousands of patients. Together the pair has logged more than 100 years treating patients blinded by severe cornea disease or injury and creating new ways to treat them. Among the efforts has been a series of designs for artificial corneas, wh...

Gardenia fruit compound starting point for diabetes therapy

...effects on the UCP2 enzyme. "When I first saw the results, I was in disbelief," Lowell said. "I didn't think we could ever be that lucky." However, blinded repetition of the initial experiments confirmed the results every time, he said. Through a series of chemical analyses, the researchers then zeroed...

Speeding the search for elusive chromosomal errors

...dated the microarray by using it to test samples from two patients with known chromosomal rearrangements and well-characterized genetic diseases. In a blinded analysis, the experiment found the correct location of the abnormal regions. In the second part of the study, the researchers studied samples from ...

Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience

...get other substances-weak or strong-that might change perception or consciousness. Most important, a third "red herring" group of six subjects had two blinded placebo sessions, then were told they'd receive psilocybin at a third. This tactic-questionnaires later verified-kept participants and monitors in th...

Can dogs smell cancer?

...trol samples. Standard, humane methods of dog training employing food rewards and a clicker, as well as assessment of the dog's behavior by observers blinded to the identity of the cancer patient and control samples, were used in the experiment. The results of the study showed that dogs can detect breast...

Blinded in Biological Technology

Ceregene Receives Additional Grant From Michael J. Fox Foundation to Expand Long-Term Testing of CERE-120 Patients

...gion of the brain and were followed for a minimum of 12 months for safety and efficacy, with over half the subjects followed for 15 to 18 months under blinded conditions, allowing longer-term analyses of the therapeutic effects of CERE-120. About CERE-120 and its Application to Treating Parkinson'...

Cardium Provides Update on Phase 2b Excellarate Clinical Study and Plans for Additional Tissue Repair Applications

...leted their initial 12-week evaluation period with respect to key safety and efficacy criteria. While the efficacy data from the MATRIX study remains blinded as final patients advance through the 12-week evaluation period, there continues to be no safety concerns since our announcement of completion of pati...

RadMD First to Offer CME-Certified Education and Training For Medical Imaging in Clinical Trials

...tion and training is offered through the company's blinded Reader and Investigator Training Institute (BRITI)...harmaceutical personnel, on-site investigators and blinded readers. For more information, visit www.ra...w.rad-md.net ) provides consulting, training, and blinded reader services to the pharmaceutical and biotech ...

BioSyntech Reports Positive Results from Pivotal Trial for BST-CarGel(R) Cartilage Repair Device

...re alone. In particular, after applying the International Cartilage Repair Society's (ICRS) histological scoring systems I and II to the biopsies in a blinded manner, several parameters were found to be statistically significant between treatment groups at p(less than)0.05. First, the Overall ICRS II score w...

Lumbar Matrix(TM) Scan From SpineMatrix(R) Revolutionizes the Diagnosis of Low Back Pain

...res. Factor in the savings on unnecessary treatments to relieve the pain, and the positive impact on healthcare costs significantly increases. In blinded clinical studies at the Cleveland Clinic, Texas Back Institute and The Ohio State University College of Medicine, the Lumbar Matrix Scan was shown t...

Resverlogix Provides Quarterly Update

...erlogix would also like to announce that RVX-208 has demonstrated that it is safe, tolerable and has favorable pharmacokinetics. The study is a double blinded placebo trial, thus an interim analysis will not be released until after the completion date of July 2009. As a result of the recently announced finan...

BASF Set To Commercialize pro-t-action(TM) Eliminating Caries Causing Bacteria From the Mouth

...r. Lang. "Application testing together with BASF revealed the potential for improved oral care." Dr. Tanzer will present his work focusing on the blinded testing that was conducted to reveal a significant reduction, as much as 40 percent, in the level of colonization of Streptococcus mutans on the tee...

Dendreon Reports Fourth Quarter and 2008 Year End Financial Results

...the investigational active cellular immunotherapy PROVENGE(R) (sipuleucel-T) in men with androgen-independent prostate cancer. While Dendreon remains blinded to the data, the independent data monitoring committee (IDMC) reported to Dendreon a 20 percent reduction in the risk of death in the PROVENGE arm rel...

Pilot Study Finds Adding Topical Imiquimod To Laser Therapy Improves The Response Of Port Wine Stain Birthmarks

... different test sites at each follow-up visit - one, three, six and 12 months following PDL therapy. The individual performing these measurements was blinded as to the test sites' treatment regimen.     Based on the amount of blood in the lesions at each follow-up visit, test sites which r...

Dendreon Reports Third Quarter 2008 Financial Results

...ive cellular immunotherapy PROVENGE(R) (sipuleucel-T) in men with metastatic androgen-independent prostate cancer. While Dendreon remains blinded to the data, the independent data monitoring committee (IDMC) reported to Dendreon a 20 percent reduction in the risk of death in the PROV...