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Bisphosphonates in Medical News

Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined

BOSTON, Feb. 16, 2008 According to the National Osteoporosis Foundation, osteoporosis affects some 25 million Americans annually, 80 percent of them women. Because the disease causes a thinning of the bone, it can lead to hip fractures, spinal fractures and a whole host of debilitating and someti...

X-Rays Help Predict Permanent Bone Damage From Bisphosphonates

CHICAGO, May 7 /PRNewswire-USNewswire/ -- Breast cancer patients, individuals at risk for osteoporosis and those undergoing certain types of bone cancer therapies often take drugs containing bisphosphonates. These drugs have been found to place people at risk for developing osteonecrosis of the ja...

Drugs With Bisphosphonates Packs Osteonecrosis Risk

A report on the Journal of General Dentistry reveals breast cancer patients, people with osteoporosis, and individuals undergoing bone cancer therapies are supposed //to take drugs that contain bisphosphonates, which puts patients at risk of developing osteonecrosis of the jaws (a rotting of the ja...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...cines II-35 Donor Lymphocyte Infusion II-35 Hematological Cancer Drug Classes II-35 Hypomethylating Agents & Antimetabolites II-35 bisphosphonates II-36 Alkylating Agents and DNA-Damaging Agents II-36 DNA-Repair Enzyme Inhibitors II-36 Histone Deacetylase Inhibitor II-36 Immunomod...

Amgen's Denosumab and Eli Lilly's Forteo/Forsteo Will Drive Robust Annual Growth in the Osteoporosis Drug Market From 2013 to 2018

...y, Italy, Spain, the United Kingdom and Japan. The new Pharmacor report entitled Osteoporosis finds that concerns about the long-term safety of bisphosphonates -- which currently dominate the market -- will help convince primary care physicians and specialists to switch patients to PTH analogues and novel age...

Procter & Gamble Wins Patent Infringement Lawsuit for Osteoporosis Therapy Actonel

... Finn, P&G President, Global Health Care. "P&G pioneered the use of bisphosphonates in humans almost 30 years ago. We specifically selected Actonel for development versus a stable of many other bisphosphonates because our extensive R&D efforts suggested Actonel had many important,...

Osteoporosis Drugs Might Not Raise Cancer Risk

... Two studies suggest bisphosphonates don't increase chances of esophageal tumors ...find that the class of osteoporosis drugs known as bisphosphonates may not, in fact, raise the risk of esophageal can...ad been diagnosed with cancer of the esophagus. bisphosphonates have come under scrutiny in recent years for a var...

Once-a-Year Drug Helps Counter Steroid-Linked Bone Loss

...phonate drugs can strengthen bone, they are not without their problems. For example, recent studies have suggested links between long-term use of oral bisphosphonates such as Fosamax (alendronate) to a heightened risk for irregular heartbeat and a particular type of fracture. For the current investigation, Reid a...

Link between widely used osteoporosis drugs and heart problems probed

...there could be a potential link between the use of bisphosphonates and the development of serious heart rhythm proble...-1990s. Early studies indicated that the use of bisphosphonates might cause problems with heart rhythm, or atrial ...s who had osteoporosis or fractures and were given bisphosphonates were compared to the records of more than 13,000 p...

ADA Informs Patients About Osteoporosis Medications and Oral Health

...ing osteonecrosis of the jaw for patients who take bisphosphonates is unknown; however researchers agree that the cha...ts who are or have received repeated high doses of bisphosphonates intravenously. The remaining 6 percent diagnosed w...ook oral bisphosphonates. "Patients who take bisphosphonates for osteoporosis are encouraged to talk to their d...
Bisphosphonates in Medical Technology

Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference

- Data Support Intravenous to Subcutaneous Conversion - SAN DIEGO, April 16 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO ), a biopharmaceutical company developing and commercializing products targeting the extracellular matrix, today announced new pre-clinical f...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

...19%), dizziness (excluding vertigo) (18%), insomnia (16%), decreased weight (16%), back pain (15%) and paresthesia (15%). Caution is advised when bisphosphonates are administered with aminoglycosides, loop diuretics and potentially nephrotoxic drugs. Zometa contains the same active ingredient as found in R...

AAOMS Updates BRONJ Position Paper

...y or more rarely, patients treated with oral or IV bisphosphonates for osteoporosis. (Logo: http://www.newscom.... stresses that the relationship between oral or IV bisphosphonates for treating osteoporosis and BRONJ is more diffic... Given the long-term biologic activity of IV bisphosphonates noted in the literature, the 2009 Position Paper s...

Halozyme Therapeutics Begins Phase 1 Clinical Trial of Bisphosphonate Administered With rHuPH20 Enzyme

.... This study will explore the safety, tolerability and pharmacokinetics of SC administration of a bisphosphonate plus rHuPH20. Currently, injectable bisphosphonates must be administered intravenously (IV). "We are pleased that the first clinical trial is underway for our bisphosphonate program, our third ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...ch as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, oral bisphosphonates or anticoagulants. The most frequently occurring adverse reactions...%), back pain (15%) and paresthesia (15%). Caution is advised when bisphosphonates are administered with aminoglycosides, loop diuretics and potentially nephr...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

... (19%), dizziness (excluding vertigo) (18%), insomnia (16%), decreased weight (16%), back pain (15%), and paresthesia (15%). Caution is advised when bisphosphonates are administered with aminoglycosides, loop diuretics, and potentially nephrotoxic drugs. Zometa contains the same active ingredient as found in Rec...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

...in reliever to make you more comfortable. In some cases, ZOMETA and other bisphosphonates have been known to cause kidney damage. Prior to each infusion, your doctor...NJ in patients requiring dental procedures. A connection between the use of bisphosphonates and ONJ has not been established. Based on your condition, your doctor will...

Genta Clinical Programs Featured at American Society of Hematology Meeting

...ed hypercalcemia who were resistant to hydration, randomized double-blind trials have been conducted with Ganite compared with calcitonin and with two bisphosphonates (etidronate [Didronel(R); Proctor and Gamble] and pamidronate [Aredia(R); Novartis, Inc.]). G4544 was developed to enable extended administration of...

Genta Completes Initial Clinical Dosing of G4544, a New Oral Drug for Bone Diseases

...ed hypercalcemia who were resistant to hydration, randomized double-blind trials have been conducted with Ganite compared with calcitonin and with two bisphosphonates (etidronate [Didronel(R); Proctor and Gamble] and pamidronate [Aredia(R); Novartis, Inc.]). G4544 was developed to enable extended administration of ...

Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models

...ministration (FDA) as a significant unmet medical need. Targanta has developed a novel drug discovery platform through which it tethers bone-targeting bisphosphonates to approved antibiotics to generate molecules that deliver the antibiotics directly to the bone, targeting the site of infection. In the first study,...
Bisphosphonates in Biological News

Meet-the-expert sessions on 20 key topics to enhance scientific programme of IOFWCO-ECCEO10

...s (USA) Bone mass/structure measurements during growth, R. Rizzoli (Switzerland) Bone disease in primary hyperparathyroidism, J.P. Bilezikian (USA) bisphosphonates in chronic renal failure, S. Papapoulos (NL) Pharmaco-genomics, M.L. Brandi (Italy) Vertebro/kyphoplasty, S. Boonen (Belgium) Issues in designing a...

New drug agent knocks out multiple enzymes in cancer pathway

... cell signaling to go awry. These efforts have met with limited success. bisphosphonates act on other enzymes, called FPPS and GGPPS, which are upstream of Ras in t...o bone, reducing its efficacy in other tissues. "We're trying to develop bisphosphonates that will be very active but won't bind to the bone, because if they bind t...

USC School of Dentistry researchers uncover link between osteoporosis drugs and jaw infection

...adeh, lead researcher and assistant clinical professor at the USC School of Dentistry. Sold under brand names such as Fosamax, Boniva and Actonel, bisphosphonates are prescribed to millions of patients to combat osteoporosis, a bone-wasting disease that increases the risk of fractures. Sedghizadeh said there ...

Researchers urge monitoring of bone health during chemotherapy

...anti-osteoporosis agent that inhibits osteoclasts, were resistant to the effects of G-CSF on bone tumor growth. Weilbaecher is currently investigating bisphosphonates as a means to prevent tumor metastasis to bone in breast cancer patients. "We used G-CSF as a tool to understand the implications for tumor growt...

New study reveals promising osteoporosis treatment

...based osteoporosis treatments, such as bisphosphonate drugs and hormone therapies, do not effectively repair bone that has already been lost. In fact, bisphosphonates have been shown to actually inhibit bone redevelopment. Many of these treatments also have serious side effects, including increasing the risk of hea...
Bisphosphonates in Biological Technology

Osteoporosis Drugs Increase Risk for Heart Problems

...iami evaluated the relationship between the use of bisphosphonates and AF, a condition that can produce a wide range ...ncluding hospitalization or death. Patients taking bisphosphonates were more likely to experience AF than patients re...ege of Chest Physicians. "A potential link between bisphosphonates and atrial fibrillation warrants additional resear...

Halozyme Therapeutics to Host Research Day for Investors and Analysts

...entific Officer -- Insulins -- Faster Acting, Regular and Analog, Douglas B. Muchmore, M.D., Vice President, Endocrinology Clinical Development -- bisphosphonates -- Advantages of Subcutaneous Injection with rHuPH20, Douglas B. Muchmore, M.D., Vice President, Endocrinology Clinical Development -- PEGPH20 -- A ...

Halozyme Therapeutics Reports 2008 First Quarter Financial Results

...he local tolerability and pharmacokinetics of bisphosphonates combined with PH20 at the American Association for...r increasing the dispersion and absorption of bisphosphonates in the skin and subcutaneous tissues with PH2...cid and ibandronate. The pharmacokinetics of bisphosphonates in blood were also examined and compared to i...

Halozyme Therapeutics Reports Fourth Quarter and Year End 2007 Financial Results

...echnology Phase I/IIa data -- American Association of Cancer Research (AACR) Annual Meeting 2008 -- April 12-16th -- presentation of subcutaneous bisphosphonates / rHuPH20 pre-clinical data -- American Association of Cancer Research (AACR) Annual Meeting 2008 -- April 12-16th -- presentation of systemi...

Stonegate Report About Unigene Laboratories Inc.

...rnal articles have suggested that long-term use of bisphosphonates could lead to osteonecrosis of the jaw (ONJ). More...tor modulators (SERMs). The results indicated that bisphosphonates are not more effective than alternative osteoporos...s reports of negative side effects associated with bisphosphonates continue to garner media coverage. Unigene's bro...

NEWSWEEK: Media Lead Sheet/December 10, 2007 Issue (on newsstands Monday, December 3).

...ost well known of these are part of a group called bisphosphonates. But a new generation of drugs aims to build bone. These could work in concert with bisphosphonates or other medications that slow bone loss to re-create the balance necessary for the growth of healthy bone. Other researchers are looking at ways of u...
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