Biomarker

Biomarkers isolated from saliva successfully predict oral and breast cancer

Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers. In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva...

UCLA cancer researchers shake loose hidden biomarker

Using a common chemotherapy agent, researchers at UCLA's Jonsson Cancer Center and the Department of Pathology and Laboratory Medicine found a way to move an important biomarker expressed in prostate cancer, shaking it loose from one location in a cell ?where it could not be accessed by blood ?to another, easier to target area. The discovery, outlined in the cover article of May 11 editio...

Measurement Challenges In Detecting Cancer Biomarkers

Effective control of sexually transmitted diseases (STDs) requires treatment of the sexual partners of infected patients. A new study shows that providing infected men with antibiotics to give their partners is more effective than traditional means of contacting and treating the partners, according to an article in the Sept. 1 issue of Clinical Infectious Diseases, now available online. Men with...

Biomarkers may hone anti-aging therapies

Lotions and potions that promise to remove wrinkles and other effects of aging crowd cosmetics aisle shelves, but do these treatments really work? Vanderbilt University Medical Center investigators have identified new molecular indicators -- or "biomarkers" -- of aging in the skin that could be used to evaluate anti-aging therapies. Their findings are reported in the February issue of the...

Abnormal overexpression of p53 is a predictive molecular biomarker

A common laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy - making it potentially the first predictive biomarker test for a gene-based drug. Researchers at Introgen Therapeutics, Inc., in Austin, Texas, found that pati...

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Biomarker at Biology Products

Serum Biomarker Chip from Whatman, Inc

Description:The first high-density serum biomarker chip to profile the relative abundance of cancer serum proteins. An antibody chip containing 120 human cancer serum biomarker-specific antibodies. A research tool that enables biomarker discovery scientists to study panels of biomarkers related to early detection, benefits of therapy and the likelihood of recurrence of cancer. Familiar gene expression chip f...
Company:Whatman, Inc

Biomarker at Biology Technology

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

Jaclyn Shingara, Kerri Keiger, Ila Wolf, Jeffrey Shelton, Emmanuel Labourier, and David Brown R&D Division, Ambion, Inc. MicroRNAs (miRNAs) are small, siRNA-like molecules, encoded in the genomes of plants and animals,...

Multiplexed Quantitative Peptide Assays for Protein Biomarkers of Cardiovascular Disease in Human Plasma

As the study of protein biomarkers increases in importance, extensive lists of candidate markers are being developed based on protein pathway information and discovery-based proteomics experiments. Even larger numbers of candidate genomic markers exist from DNA transcriptional profiling based on microarray-based gene expressio...

Biomarker at Medicine News

Biomarker for prostate cancer may be separated for treatment

Scientists at UCLA had been able to isolate a biomarker for prostate cancer cells do// that it will become easier to treat the disease. The biomarker protein, which was hidden inside the cells, can now be moved to a different location from where it can go into the blood. This will make it possible for the medical professionals to treat the prostate cancer disease with both chemotherapy...

Osteopontin: a useful biomarker in asbestos-related cancer

Pleural mesothelioma is an asbestos-related cancer that invades the chest cavity and the lining of the lungs. Workers at risk for high levels of exposure are miners, factory workers, carpenters, electricians//, ship fitters, ships' electricians, boilermakers, insulation manufacturers, railroad workers, gas-mask manufacturers, and pipe insulators. Recently, a study, published in the Octo...

Biomarkers May Indicate Alzheimer's Disease

The early signs of Alzheimer's disease can be identified by using the compounds, or biomarkers in the cerebrospinal fluid, according to scientific research conducted by Sweden’s Lund University.// Loss of memory and confusion can also be interpreted as early signs of the onset of the disease, and it is not always easy to differentiate the symptoms of Alzheimer's, and that of growing old....

Biomarkers Could Prove Significant In Understanding Aging Process

Researchers at the Vanderbilt University Medical Center have zoned in on new molecular indicators, called "biomarkers", // for aging of the skin that could be an interesting pointer when evaluating anti-aging therapies. The findings of this particular study are reported in the latest issue of the Journal of Investigative Dermatology. “There's a lot of interest in the pharmaceutical and...

Biomarker Reduces Length of Antibiotic Treatment

For hospitalized patients with community-acquired pneumonia (CAP), lower measurements of procalcitonin, a biomarker of infection, can reduce the length of antibiotic //treatment by an average of seven days. The study, which is the first research trial of its kind, appears in the first issue for July 2006 of the American Journal of Respiratory and Critical Care Medicine, published by th...

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Introgen Reports Updated Phase 2 Advexin Data Correlating Improved Survival, Tumor Responses and Predictive p53 Biomarker

CHICAGO--(BUSINESS WIRE)--Jun 4, 2007 - Introgen Therapeutics, Inc.(NASDAQ: INGN) and the Company's clinical collaborators todayreported updated Phase 2 data demonstrating a significantcorrelation between abnormal p53, tumor responses and increasedsurvival following ADVEXIN(R) therapy in patients with recurrentsquamous cell carcinoma of the head and neck. The data (Abstract#6057) were prese...

Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Bruton's Tyrosine Kinase Inhibitors

SUNNYVALE, Calif. and LOS ANGELES, April 18, 2007/PRNewswire-FirstCall/ -- Pharmacyclics, Inc. today announced datafrom two preclinical studies, one identifying a functionalbiomarker for its novel histone deacetylase (HDAC) inhibitor andanother demonstrating preclinical anti-tumor activity with itsBruton's tyrosine kinase (BTK) inhibitor compounds. The data werepresented at the American...

Millennium Discovers Biomarkers Potentially Predictive of Response to Velcade (Bortezomib) for Injection

- Findings Published in Blood Highlight Millennium Leadership inPersonalized Medicine and Could Strengthen the Role of VELCADE asFoundation of Therapy in Broad Range of Multiple Myeloma Patients - CAMBRIDGE, Mass., April 17, 2007 /PRNewswire-FirstCall/ --Findings published in the April 15th issue of Blood show that ateam of researchers led by Millennium Pharmaceuticals, Inc. hasdiscovered...

Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference

LOS ANGELES--(BUSINESS WIRE)--Apr 16, 2007 - Introgen Therapeutics,Inc. (NASDAQ:INGN) reported updated ADVEXIN(R) biomarker data overthe weekend in Los Angeles, California at the Annual Meeting of theAmerican Association for Cancer Research. Abnormality of the p53 tumor suppressor is one of the mostcommon and fundamental molecular defects in cancer. ADVEXIN'smechanism of action is targete...

DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy

EVRY, France, April 12, 2007 /PRNewswire/ -- DNA TherapeuticsS.A. an emerging pharmaceutical company specialized in innovativecancer therapy announces today the elucidation of a new mechanismof action and the identification of a biomarker of itsfirst-in-class antitumoral lead molecule Dbait. It will bepresented at the forecoming American Association for CancerResearch annual meeting 2007...