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Bioluminescence in Medical News

Midbrook Tackles Medical Decontamination

...ng the ATP that is present to ‘fire’ a synthetic version of the bioluminescence chemistry found in fireflies,” said Midbrook Technology Center Direct...gent is used to force ATP out of the cells where it then interacts with the bioluminescence chemistry, allowing us to get a quick reading of how much ATP is present on...

TV crime drama compound highlights immune cells' misdeeds

...or Shimon Gross, Ph.D., a postdoctoral fellow, proposed that luminol might be used to image inflammation when he found earlier studies linking luminol bioluminescence with myloperoxidase (MPO), a protein some types of immune cells use to make bleach during the inflammatory process. When activated, cells known as pha...

Drug-Eluting Stents Show Promise for Leg Arteries

...'s bone marrow and injected into the legs of someone with peripheral arterial disease to grow new blood vessels. Recent success using luciferase, a bioluminescence imaging agent produced by fireflies, enabled researchers to locate and track stem cells in the body and move this treatment one step closer to reality...

Seaweed and fireflies brew may guide stem cell treatment for peripheral artery disease

...neered the stem cells within the capsules to produce luciferase, the same bioluminescent chemical produced by fireflies, which is highly visible under bioluminescence imaging. "Once we were able to trick the immune system into not attacking the cells, we had to know they arrived at their destination and were liv...

'Seeing' Stem Cells Helps in Fight Against Peripheral Arterial Disease

...r in Regenerating Blood Vessels to Open Clogged Arteries, Uses Firefly-like bioluminescence Imaging Agent SAN DIEGO, March 10 /PRNewswire-USNewswire/ -- Intervent...hers then induced the stem cells within the bubble to produce luciferase, a bioluminescence imaging agent produced by fireflies -- to "see" living stem cells. "We coul...

Society of Interventional Radiology Hosts 34th Annual Scientific Meeting

...s to treat peripheral arterial disease (PAD). A major research center presents its findings on advancing this research with the help of a firefly-like bioluminescence imaging agent and seaweed "bubble." (Embargoed for release until Tuesday, March 10, 2009, 9 a.m. Eastern) B-roll and illustrations are available. ...

MBL scientist Osamu Shimomura wins Nobel Prize for discovery of green fluorescent protein

...autiful protein," Dr. Shimomura says, until 1979, he devoted his research to characterizing GFP, its companion protein in the jellyfish, aequorin, and bioluminescence in general. "Most of my knowledge came from self-study," says Dr. Shimomura. "If you find an interesting subject, study it through to the finish. ...

Tracking Cancer Drug's Effectiveness

... bioluminescence imaging a lower cost tool than MRI for evaluating new drugs, study says ...ne that gives fireflies their distinctive glow. Using a technique called bioluminescence imaging (BLI), the University of Teexas Southwestern Medical Center team ad...

Fireflies' glow helps UT Southwestern researchers track cancer drug's effectiveness

...ck the effectiveness of anti-cancer drugs over time. UT Southwestern Medical Center researchers are among the first to show that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that choke off a tumors blood supply. The technique requires a substrate...

Mouse model for mesothelioma reproduces human disease

...k4a/Arf and Nf2;p53 mutations developed MM after a short latency period. The mouse MM tumors, which could be followed noninvasively through the use of bioluminescence imaging, closely resembled human MM. Interestingly, Nf2;Ink4a/Arf knockout mice had a more invasive cancer when compared with Nf2;p53 knockout mice. T...
Bioluminescence in Medical Products

ULTRA Evolution Multi-Detection Microplate Reader

Description:...sation Fluorescence Energy Resonance Transfer (FRET) assays Green-fluorescent-protein (GFP)-based assays Luminescent-based reporter assays and bioluminescence energy transfer-based assays Cell-based assays including migration, proliferation and toxicity assays All general fluorometric and colorimetric as...
Company:Tecan
Bioluminescence in Biological News

Scripps scientists help decode mysterious green glow of the sea

...nd their light production. Marine fireworms use bioluminescence to attract suitors in an undersea mating ritual. R... , provides insights into the function of fireworm bioluminescence and moves scientists closer to identifying the mol...other step toward understanding the biology of the bioluminescence in fireworms, and it also brings us closer to isol...

Stopping autoimmunity before it strikes

...fore provide a new tool in the evaluation of early autoimmune therapies. The article from Zangani et al "indicate[s] that NF-κB mediated bioluminescence is a very sensitive and early indicator of inflammation and disease", allowing precise identification of incipient disease sites for biomedical and pa...

'Seeing' stem cells helps in fight against peripheral arterial disease

...d not determine if the stem cells within the bubble remained alive. Researchers then induced the stem cells within the bubble to produce luciferase, a bioluminescence imaging agent produced by firefliesto "see" living stem cells. "We could 'see' the bubble via X-ray and tell if the stem cells remained alive as they ...

Society of Interventional Radiology hosts 34th annual scientific meeting

...s to treat peripheral arterial disease (PAD). A major research center presents its findings on advancing this research with the help of a firefly-like bioluminescence imaging agent and seaweed "bubble." (Embargoed for release until Tuesday, March 10, 2009, 9 a.m. Eastern) B-roll and illustrations are available. ...

Vanderbilt scientists invent world's smallest periscopes

...tual light sources in two or three dimensions allows the researchers to reject spurious signals. This should be useful in quantitative fluorescence or bioluminescence studies: Cells can be genetically modified to glow in the dark to provide a measure of cellular metabolic activity or the expression of a specific gen...

New light shed on marine luminescence

...elaxation. Nitric oxide is also thought to play an important role in the bioluminescence of krill. It is produced in the small capillary vessels that keep the krill...because of the increased flow of oxygenated blood to the photocytes. As bioluminescence has developed independently at several different points in evolution, diffe...

New research lights up chronic bacterial infection inside bone

.... Their report published in the journal Disease Models & Mechanisms ( DMM ), dmm.biologists.org describes how they use a technique called in vivo bioluminescence to light up bacteria and allow them to see extremely tiny amounts of bacterial cells in living animals. Using this method, they found that small pers...

Single adult stem cell can self renew, repair tissue damage in live mammal

...s. As a result, every transplanted cell glowed under ultraviolet light and was easy to trace. "To be able to detect the presence of the cells by bioluminescence was really a breakthrough," says Blau. "It taught us so much more. We could see how the cells were responding, and really monitor their dynamics." ...

Keeping the body in sync -- The stability of cellular clocks

...rhythms in such a noisy environment? Using mouse fibroblast circadian bioluminescence recordings from the Schibler Lab at the University of Geneva, the researche...e the first to discuss how the stability of the oscillator directly affects bioluminescence recordings,?explains Felix Naef, a systems biology professor at EPFL and th...

NRL scientists detect 'milky sea' phenomena

...s" are hypothesized to be manifestations of strong bioluminescence produced by colonies of bacteria associated with a...chers have generally thought that the detection of bioluminescence emission from space was unlikely if not impossible...gs of Harvard University, a leader in the field of bioluminescence and communicator of this paper to PNAS, called thi...
Bioluminescence in Biological Technology

HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services

...stem). The HALO(R) Platform and other proprietary assays (LUMENESC(TM) and LumiSTEM(TM)) for different cell systems share the same ATP-based, in vitro bioluminescence technology. This allows biological responses to virtually any agent to be directly compared with each other across cell systems from different species...

Celsis Launches RapiScreen(TM) Beverage Microbial Screening System

...orm now can be used to test for contamination across their entire spectrum of products, quickly and efficiently." Adenosine Triphosphate (ATP) bioluminescence is the industry standard for the rapid microbial screening of UHT and ESL beverage products. Using proprietary innovations in enzyme technology, RapiS...

Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy

...ons from in vitro to in vivo imaging." Biospace Lab offers a wide range of in vitro and in vivo imaging products. The Photon Imager(TM), a real time bioluminescence and fluorescence system, dynamically detects and quantifies the optical signal. With the In Actio(TM) add-on, anesthesia is no longer required. The Ph...

HemoGenix(R), Inc. Receives Issued Patent for its HALO(R) Technology Platform From the United States Patent and Trademark Office (USPTO).

...m for drug development and environmental agent testing. All HALO(R) platforms rely on highly sensitive and fully standardized, instrument-based, ATP bioluminescence technology. This innovative technology has allowed HemoGenix(R) to become "The Leader in Hemotoxicity Testing." Instrumental in the issuance of the ...

VisEn Medical Files Action to Invalidate New Caliper Life Sciences Patent

...expansion of the very best in fluorescence in vivo imaging technology. While we generally respect the contributions of Caliper/Xenogen to the field of bioluminescence imaging, we believe it is clear, and also fundamentally understood in the industry, that that the basic methods of fluorescence in vivo imaging were w...

Near Infrared Technology and Optical Agents For Molecular Imaging

...geted NIR-labeled ligands can be used to visualize virtually any pathology without the need for engineered cell lines as required for imaging by bioluminescence or fluorescent proteins. In addition, NIR optical imaging has a further advantage in that it has the potential to translate into the clinic. Sev...

ATP Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #40)

...Lmax provides a powerful and convenient instrument control and data calculation package. REFERENCES 1. Jones, D. 1998. bioluminescence assays using ATP. Luminescence Forum , 4: 1-9. 2. DeLuca, M.A. and W.D. McElroy, (1978) in Meth. Enzymol. vol 53:, p.3 3. Promega...

A highly sensitive ATP-luminescence assay using VICTOR2 with the dispenser option

... The assay of an ATP dilution series in a plate with a constant luciferase concentration was performed according to the kit instructions (ATP bioluminescence Assay kit HS II, Boehringer Mannheim, Germany). 50 μL of Luciferase reagent was dispensed into white microplates (Combiplate, Labsystems, Finland...

Translate High Yields of Biologically Active Proteins

... decrease of absorbance of NADPH at 340 nm at 30C [1]. Adenylate kinase 1 (AK1): Activity was measured by a luciferase-based ATP bioluminescence assay (Sigma) in the presence of 1 mM ADP [2]. Carbonic anhydrase 2 (CA2): Esterase activity of CA2 was monitored by the net inc...

Genetic Reporter Systems

...able for this purpose. Firefly Luciferase The enzyme from the North American firefly (Photinus pyralis) catalyzes a bioluminescence reaction. In the luciferase assay, the lysates of transfected cells are incubated with luciferin, molecular oxygen, ATP and Mg 2+ . In ...
Bioluminescence in Biological Products

AChE Bioluminescence Assay Kit, aCella from BACHEM

Description: Bioluminescence assay for monitoring acetylcholinesterase (AChE) activity. This is a highly sensitive, very rapid (less than 5 min), non-radioactive and easy to use assay for AChE activity that uses the natural substrate, acetylcholine. A series of coupled enzyme reactions translates the presence o...
Company:BACHEM

BD Monolight 3096 Microplate Luminometer from BD Biosciences Pharmingen

Description:... The MONOLIGHT 3096 Microplate Luminometer has been designed for the detection of chemi- and bioluminescence and for all measurements of glow and flash luminescence on microplates, i.e. for reactions where the light remain nearly constant over a longer ...
Company:BD Biosciences Pharmingen

Luciferase Reporter Assay Kit from MBL International

Description:...tyltransferase (CAT) assay. Firefly luciferase catalyzes the oxidative carboxylation of luciferin, a reaction with the highest efficiency of any known bioluminescence reaction. The light emission from the reaction can be recorded using a luminometer. MBLs Luciferase Reporter Assay Kit provides a simple means for det...
Company:MBL International

Adenosine 5'-triphosphate (ATP) Luminescence Assay Kit from Thermo Scientific

Description:... The ATP Monitoring Kit measures adenosine triphosphate (ATP) concentrations with high sensitivity and a dynamic range. Based on the bioluminescence technique, the assay measures ATP in bacterial, plant or animal cells over a concentration range of 10-11 to 10-6 M....
Company:Thermo Scientific
Bioluminescence in Biological Dictionary

Reporter Gene

..... Detect reporter gene activity with assays appropriate for any application, from ... Introduction to Reporter Gene Assays Introduction to bioluminescence Assays The ... Hi. I know how the reporter gene works in a transfected cell. ... of one of the most famous reporter genes , GFP, was awarded...
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