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BioSynthetic in Medical News

ACS PressPac -- Dec. 10, 2008

... ability of B. cinerea to make botrydial, the researchers suggest. MTS ARTICLE #2 FOR IMMEDIATE RELEASE "Sesquiterpene Synthase from the Botrydial biosynthetic Gene Cluster of the Phytopathogen Botrytis cinerea" DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/cb800225v...

Burnham and HeadNorth Foundation join forces to advance spinal cord research

... to bringing that hope to fruition." Stem cells can be programmed to become many types of cells, including spinal cord neural cells. When used with biosynthetic scaffoldsbio-engineered materials that provide a foothold for genesstem cells have promoted the formation of neural cells in adult rats with acute spi...

Decoding Muscle Stem Cell Development

... protein kinase (AMPK). These results define a pathway in which activation of AMPK in response to low glucose levels stimulates expression of the NAD+ biosynthetic enzyme Nampt. NAD+ is a known co-factor of SIRT1, which plays an important role in numerous physiological processes, including differentiation of skel...

Researchers sharpen search for new marine medicines with novel techniques

...ship. In the PNAS paper, published in February, researchers T. Luke Simmons, Gerwick, Dorrestein and their colleagues probe such production issues, or biosynthetic origins, and review a variety of traditional and emerging techniques being used to localize the molecular machinery responsible for potential new drug...

Constant High Blood Sugar Disables Insulin 'Off' Switch

...with mice, the Salk team focused on the hexosamine biosynthetic pathway. Activation of this pathway promotes the a...ion of circulating glucose activate the hexosamine biosynthetic pathway. But we had no idea that the resulting O-g...in's team decreased the activity of the hexosamine biosynthetic pathway in insulin-resistant diabetic mice and in ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

...HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol. Pharmacokinetics Lovastatin is a lactone which is readily hydrolyzed in vivo to the corresponding beta-hydroxyacid, a pot...

Researchers genetically engineer micro-organisms into tiny factories

... off of the shelf and drop into it the enzymes that constitute a particular biosynthetic pathway in order to make exactly the product we want, said Mattheos A. G. K...ultures, and artemisinin, the anti-malaria drug, have P450 enzymes in their biosynthetic pathways. The Koffas lab has introduced ways to modify both the P450 monoo...

MIT Biologists Solve Vitamin Puzzle

...factors are not consumed in the reaction. Cannibalization of a cofactor has very rarely been observed before in vitamin synthesis or any type of biosynthetic pathway, says Michiko Taga, an MIT postdoctoral fellow in Walker's lab and lead co-author of the Nature paper. 'There are almost no other exampl...

Unique Tomatoes Tops In Disease-Fighting Antioxidants

...r of health benefits, such as reducing the risk of developing cancer, cardiovascular disease and macular degeneration. “The tomato is a wonderful biosynthetic factory for carotenoids, and scientists are working on ways to enhance the fruit's antioxidant content and composition,” Schwartz continued. The ...

Anti Cancer Drug from Blue Green Algae

...e unable to devise efficient synthetic strategies that favored that configuration. Sherman's team accomplished this by isolating the entire set of biosynthetic genes and key enzymes and developing a new, efficient method to manufacture the broad class of cryptophycin natural products, including important anal...
BioSynthetic in Medical Products

Avaulta™ Posterior BioSynthetic Support System

Description: Avaulta™ BioSynthetic Mesh is a monofilament, polypropylene mesh coated in the central section with an absorbable, hydrophilic film of porcine collagen. The lateral segments of the Avaulta™ BioSynthetic Mesh are not coated to maximize mesh fixation immediately post-implantation....
Company:C. R. Bard, Inc.

Avaulta™ Anterior BioSynthetic Support System

Description: Avaulta™ BioSynthetic Mesh is a monofilament, polypropylene mesh coated in the central section with an absorbable, hydrophilic film of porcine collagen. The lateral segments of the Avaulta™ BioSynthetic Mesh are not coated to maximize mesh fixation immediately post-implantation....
Company:C. R. Bard, Inc.

17a-OH Progesterone RIA Test

Description:...oxylase in CAH, 17alpha-OH-P cannot be efficiently converted to cortisol and instead, accumulates in large amounts which are shunted into the androgen biosynthetic pathway. The resulting elevations in androgen levels cause progressively severe virilization beginning during fetal life and infancy. In addition, 21-...
Company:Diagnostic Systems Laboratories, Inc.

17a-OH Progesterone EIA Test

Description:...oxylase in CAH, 17alpha-OH-P cannot be efficiently converted to cortisol and instead, accumulates in large amounts which are shunted into the androgen biosynthetic pathway. The resulting elevations in androgen levels cause progressively severe virilization beginning during fetal life and infancy. In addition, 21-...
Company:Diagnostic Systems Laboratories, Inc.
BioSynthetic in Medical Dictionary

Porphyrias

... Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme biosynthetic pathway . They are broadly classified as acute (hepatic) porphyrias and cutaneous porphyrias , based on the site of the... " Porphyri...
BioSynthetic in Biological News

Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii

...s organism as a host for the expression and purification of oxygen-sensitive enzymes." The work will also provide more information about the unique biosynthetic pathways involved in the bacteria's ability to adapt its metabolism to diverse sources of nutrients. For example, if no carbon source is present, A. ...

The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen

...ances in, for instance, plants. In particular, her research has focused on biosynthetic pathways, regulation and transport of glucosinolates in cruciferous plants....h group have identified and characterized a number of genes involved in the biosynthetic pathway of glucosinolates. In recent years, they have had increased their f...

New way to make malaria medicine also first step in finding new antibiotics

...ause malaria were discovered by others to have a pathway that FR900098 could disrupt, researchers saw a way to put the compound to good use. That same biosynthetic pathway does not exist in animals, which have a different way of making isoprenoids. Understanding these pathways "opens the door to finding other ...

How plants fine tune their natural chemical defenses

...reat disease. "Understanding the chemistry and evolutionary principles that underlie this extraordinary biological diversity will show us how to alter biosynthetic pathways to equip crops with natural and environmentally friendly defenses against pests and diseases, to produce new pharmaceuticals, to enhance leve...

Biochemists manipulate fruit flavor enzymes

...gle amino acid substitution converts one enzyme into another, thereby showing how a single point mutation can contribute to the evolution of different biosynthetic pathways. This begins to answer the long-standing question as to how the same starting molecule can be converted into different products by enzymes th...

Drought tolerance in potatoes

...cid and wax synthase genes suggested the reinforcement of cell membranes and cuticles. Genes for cell wall components were also upregulated, as were biosynthetic genes for antioxidants such as flavonoids and anthocyanins, which function in cell protection and detoxification under oxidative stress Many of the a...

A place in the sun

...nsported to sites in the stem where it can participate in the growth response, explains Chory. Although we showed earlier that at least two additional biosynthetic routes to auxin exist in Arabidopsis, these other pathways are unable to compensate for the loss of the TAA1-dependent pathway. ...

UC San Diego researchers eliminate drug discovery bottleneck

...lecule and its pharmacological activities. In addition to screening for new drugs and studying natural compounds, the authors say this work may aid biosynthetic engineering efforts to reprogram E. coli strains in order to turn them into NRP assembly lines, now that researchers have a rapid method for character...

Unique fungal collection could hold key to future antibiotics

...ill be applied to state-of-the-art screening techniques for the discovery of new compounds and the manipulation, recombination and expression of their biosynthetic pathways to bioengineer new, related compounds. Dr Nicholls experience in the biotechnology industry and Dr Kelleys expertise and knowledge of mycolog...

Disrupting common parasites' ability to 'talk' to each other reduces infection

...es. "Signals are sometimes even better targets for drug development than biosynthetic pathways," says Sibley. "Taking out a biosynthetic pathway means you take away one thing from the parasite. But if you can suc...
BioSynthetic in Biological Technology

eMetagens infectious disease technology licensed by WARF

...as many other therapeutics for indications ranging from cancers to hypertension to psychiatric disorders. eMetagens technologies provide access to the biosynthetic machinery of the vast diversity of organisms in the environment that cannot readily be cultivated in the laboratory and the tools to screen for new na...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... B-Peru allele of the B regulatory gene in the maize anthocyanin biosynthetic pathway. When expressed together, these genes activate this path... Radicella, J. P. and Chandler, V. L., Transactivation of anthocyanin biosynthetic genes following transfer of B regulatory genes into maize tissue...

The Bio-Rad Silver Stain, Rev E

... the twodimensional gel electrophoresis pattern of cellular proteins, Hum Genet 66, 248251 (1984) 37. Kostyo JL et al., biosynthetic 20-kilodalton methionyl-human growth hormone has diabetogenic and insulin-like activities, Proc Natl Acad Sci USA 82, 42504253 (...

Sample Preparation for Microinjection

... [2] Pepperkok, R., Scheel, J., Horstmann, H.,Hauri, H.P., Griffiths, G., and Kreis,T. E. (1993b). -COP is essential for biosynthetic membrane transport from the endplasmic reticulium to the Golgi complex in vivo. Cell 74, 71-82. [3] Peppe...

New Mammalian Two-Hybrid System Detects Protein-Protein Interactions

...ins results in restoration of the activation of the transcriptional activator. Genetic selection for this interaction is provided by an amino acid biosynthetic enzyme that is absent in the yeast host and whose expression becomes induced only when the transcription activator is reconstituted. This two-hybr...
BioSynthetic in Biological Definition

Primary nutritional groups

...g reducing equivalents (electrons) from environmental sources to be used in biosynthetic pathways (e. g. in the form of NADH or NADPH). An organism is defined as o...motrophs must be diverted into both energy-yielding oxidative pathways and biosynthetic reductive pathways. The range of possible pairs of electron donors and acce...
BioSynthetic in Biological Dictionary

Secondary metabolite

...ndary metabolite productivity may be used to identify ... To Stretch the Boundary of Secondary Metabolite Production in Plant Cell-Based ... biosynthetic genes, enzymes, and pathways for a specific secondary metabolite . ... ... an overview of the secondary metabolite content of a ... seconda...

Pyrimidine

... cytoplasm and starts ... While pyrimidine rings can be degraded completely to CO2 and NH3 (urea excretion) ... GO:0019856 : pyrimidine base biosynthetic process [44 gene products] ... GO:0006206 : pyrimidine base metabolic process [145 gene products] ... ,biological,biology definition,biolog...

Gene cluster

... placed in its optimal cluster , a greedy approach is ... 2. The C-1027 biosynthetic gene cluster from Streptomyces globisporus (Antimicrob. ... The leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus ... Researchers at The ...

Deoxyribonucleotide

...acteriophage T4 DNA replication. Intrinsic control of synthesis of thymine and 5-hydroxymethylcytosine ... GO:0009265 : 2'- deoxyribonucleotide biosynthetic process [95 gene products] ... GO:0009219 : pyrimidine deoxyribonucleotide metabolic process [37 gene products] ... DNA is made up of many ...
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