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Binds in Medical News

Prospect Therapeutics' In Vitro Studies Demonstrate that GCS-100 Drug Binds to and Blocks the Effects of Galectin-3

WELLESLEY HILLS, Mass., June 15 /PRNewswire/ -- Joseph F. Finn, Jr., C.P.A. ("Finn") announced today that in vitro studies have demonstrated that GCS-100 binds to and blocks the effects of galectin-3. Galectin-3 plays an important role in tumor cell survival, new blood vessel growth, cell prolife...

Sunlight May Cause Rash in Autoimmune Disease

...called the anti-Mi-2 autoantibody and we know from our previous research that UV radiation increases levels of the Mi-2 protein that this autoantibody binds to." In addition to finding that women with higher UV exposure levels were more likely to develop dermatomyositis, the researchers also found an as...

Micromet, Inc. Reports Second Quarter 2009 Financial Results

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Gut Hormone Could be Key to Blood Sugar

...tors to regulate glucose levels. It does so via a gut-brain-liver neuronal axis," Tony Lam of the University of Toronto said in a news release. CCK binds to local receptors on nerves of the small intestine, triggering a message to the brain which, in turn, tells the liver to stop producing glucose. L...

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

... approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the GnRH receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH...

Sun exposure may trigger certain autoimmune diseases in women

...called the anti-Mi-2 autoantibody and we know from our previous research that UV radiation increases levels of the Mi-2 protein that this autoantibody binds to," said Miller. In addition to finding an association between the level of UV radiation and the proportion of women who developed dermatomyositi...
Binds in Medical Technology

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...nergism in combination with standard cytotoxic agents as well as with newer targeted therapies, in preclinical experimental tumor models. Brostallicin binds covalently to DNA within the DNA minor groove, interfering with DNA division and leading to tumor cell death. More than 200 patients have been treated...

CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Advanced Breast Cancer

...nsed from Seattle Genetics, Inc. The ADC is designed to be stable in the bloodstream. Following intravenous administration, CR011-vcMMAE targets and binds to GPNMB, a specific protein that is predominantly expressed on the surface of cancer cells, including melanoma, breast cancer and glioma. Upon inter...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

...to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic response that is a key component of t...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Peregrine Pharmaceuticals Highlights Promising Early Data From Its Three Phase II Bavituximab Cancer Trials

...lly not exposed on the surface of normal tissues, they represent a unique target for anti-cancer treatments. Bavituximab is a monoclonal antibody that binds specifically to these phospholipids exposed on the surface of the cells lining tumor blood vessels. Once bound, bavituximab alerts the body's immune ...
Binds in Medical Products

VACUETTE EDTA tubes - Ridged (safety screw cap)

Description:... Are offered as either EDTA K2 or EDTA K3 tubes. EDTA binds the calcium ions and therefore blocks the coagulation cascade. Erythrocytes, leucocyytes and thrombocytes in an EDTA anticoagulated blood sample are s...
Company:Greiner Bio-One

VACUETTE EDTA tubes - Non-ridged (pull cap)

Description:... Are offered as either EDTA K2 or EDTA K3 tubes. EDTA binds the calcium ions and therefore blocks the coagulation cascade. Erythrocytes, leucocyytes and thrombocytes in an EDTA anticoagulated blood sample are s...
Company:Greiner Bio-One

SHBG IRMA Test

Description:... Human sex hormone-binding globulin (SHBG) is a serum glycoprotein which binds several sex steroids with relatively high specificity and low capacity, inc...und to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bioavailability of sex ste...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-1, Total IRMA Test

Description:... Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests ...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-1, Total ELISA Test

Description:... Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a phosphoprotein, produced primarily in the liver, which specifically binds and modulates the bioactivity of IGF-I and IGF-II [1]. The role of IGFBP-1 has not been completely defined, but the nature of its regulation suggests ...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-4 ELISA Test

Description:... Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24 kDa protein which specifically binds and modulates the actions of IGF-I and IGF-II. It is also present in a glycoslyated form with a molecular weight of 28 kDa. IGFBP-4 has been identifie...
Company:Diagnostic Systems Laboratories, Inc.
Binds in Medical Definition

Depolarization-induced suppression of inhibition

...d. This has been demonstrated to be caused by the release of endogenous cannabinoids from the depolarized neuron which diffuses to nearby neurons, and binds and activates CB1 receptors, which act presynaptically to reduce neurotransmitter release. Contents 1 History 2 DSI medi...

Muscle atrophy

...rected to some proteins but not others - specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase ". Each E3 ubiquitin ligase binds to a particular set of substrates, causing their ubiquitination. Potential treatment Muscle atrophy can be opposed by the signaling pathwa...
Binds in Medical Dictionary

Melanin

... the pigment that gives skin its color. While investigating a fungus known to cause an infection in people with AIDS, two ... antibody, that binds to melanin based on scientific evidence suggesting ... ...

Intrinsic factor

...tor is a protein produced by the stomach that binds to vitamin B12. ... Intrinsic factor is ... Intrinsic factor is a gastric substance that binds with vitamin B12 and allows ... Stage II is radi...trinsic factor is produced in the stomach and binds (attaches) to Vitamin B-12. ... Kinetics of th...

Intestine

...etection and diagnosis of Crohn's Disease, Gastrointestinal bleeding, Inflammatory Bowel ... Another name for the intestine . ... The mesocolon binds the large intestine to the posterior abdominal wall. ... From the stomach, chyme passes into the small intestine . ... Small Intestine ... ...

Immunofixation

...ed to study changes in protein structure (for ... Information on Immunofixation Electrophoresis of Serum. ... Immunofixation electrophoresis binds antiserum to human immunoglobulin G, A, and ... Sign-up to receive press releases directly in your e-mail inbox the minute they ... B12, as we...

Haptoglobin

... that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and th...in the free online English ... haptoglobin - a protein in plasma that binds free hemoglobin and removes it (as from wounds) ... The world's firs...

Ferritin

...toxic form. Ferritin that is... Ferritin is found in the liver, spleen, skeletal muscles, and ... Ferritin is a protein in the body that binds to iron; most of the iron stored in ... Describes how the ferritin test is used, when the ferritin test is ordered, and what the results of a ...
Binds in Biological News

New cancer drug delivery system is effective and reversible

... in isolating aptamers that bind to specific molecules and converting them into effective sensors and diagnostic agents. His team used an aptamer that binds to nucleolin receptors, which are found in abundance on certain breast cancer cells. The researchers then developed an effective method for attaching ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... lead investigator, Anton Wellstein, MD, PhD, a professor of oncology and pharmacology at Lombardi. He adds that ALK receptors and the protein that binds to it, the growth factor pleiotrophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors....

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

...ve cancer in mice. In the current paper, the researchers discover that DLX5 binds to and actively promotes the activity of a gene known as MYC, which evidenc...erase enzyme fireflies use to make light to see exactly where DLX5 protein binds to the promoter region of the MYC gene. They found that there were two site...

Sticky protein helps reinforce fragile muscle membranes

... the team identified a protein called alpha dystroglycan as the "glue" that binds muscle membranes to a tough layer of extracellular proteins called the basa...showed that a virus called LCMV (Lymphocytic Choriomeningitis virus), which binds tightly to alpha dystroglycan, also disrupts the basal lamina muscle membra...

Reveal the enemy

...e. Aptamers are synthetic, short DNA or RNA strands that can be designed and made to bind a specific target molecule. An aptamer that specifically binds to salmonella has recently been developed. The Spanish researchers chose to use this aptamer for their biosensor. By means of additional functional gr...

Chasing tiny vehicles

...sed in a membrane vesicle invaded the cells. The vesicles move randomly, often downright erratically inside the cell, until a so-called motor protein binds them and quickly transports them towards the cell nucleus the ultimate target for the gene. The research team is now in a position to characteriz...
Binds in Biological Technology

Micromet Closes $80.5 Million Public Offering of Common Stock

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Eiger BioPharmaceuticals Acquires Exclusive License to Novel Hepatitis C Virus (HCV) Technology From Stanford University

...effrey Glenn, M.D., Ph.D., is focused on a variety of novel targets, including key features of NS4B, a non-structural protein in the HCV genome, which binds to HCV-RNA and is required for viral replication. "We are delighted to have licensed the rights to this exciting new technology from Stanford U...

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Micromet Announces Pricing of Public Offering of Common Stock

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Micromet Announces Public Offering of Common Stock

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...

Micromet, Inc. to Host Conference Call and Webcast to Report Second Quarter 2009 Financial Results on August 6, 2009

...ase 1 clinical trial for the treatment of patients with solid tumors. MT110 binds to the epithelial cell adhesion molecule, or EpCAM, which is overexpressed ...olid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM and is being developed under a collaboration with Merck Serono. Ad...
Binds in Biological Products

Goat Anti-FbxL7 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Goat polyclonal to FbxL7 The F box, named after cyclin F in which it was originally observed, is an approximately 40-amino acid motif that binds SKP1. F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs (SKP1, cullin, F-box proteins), which function in phosphorylat...
Company:GeneTex

Anti-Acetylcholine Receptor-alpha (AChR-alpha) Monoclonal Antibody, Unconjugated from CHEMICON

Description:... Human acetylcholine receptor (AChR)-alpha. Exhibits homogenous, high affinity binding to the receptor. binds weakly to a64-78. Inhibits binding of many myasthenia gravis sera to human AChR....
Company:CHEMICON

GIBCO Streptomycin Sulfate from Invitrogen

Description:... Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Company:Invitrogen

PS20 and RS100 preactivated ProteinChip Arrays from Ciphergen

Description:... PS10 ProteinChip Arrays are preactivated with carbonyl diimidazole chemistry that covalently binds to free primary amine groups. The PS10 array contains the same binding chemistry as the former PS1 array, but with an updated hydrophobic barrier coat...
Company:Ciphergen

ImmunoPure IgM Purification Kit from Pierce Biotechnology, Inc.

Description:... IgM binds poorly to Protein A and, until recently, no readily available affinity chromatography product existed for one- step IgM purification. Standard methods...
Company:Pierce Biotechnology, Inc.

Affi-Prep Protein A Support, 25 ml from Bio-Rad

Description:...bulins (IgG), selectively remove IgG prior to analysis of other immunoglobulin classes, or adsorb immune complexes for antigen purification. Protein A binds to the Fc region of immunoglobulins, especially IgG from mammalian species. This ready-to-use, bottled support is supplied as 25 ml....
Company:Bio-Rad
Binds in Biological Definition

Actin

...ith the association of three G-actin monomers into a trimer. ATP-actin then binds the plus (+) end, and the ATP is subsequently hydrolyzed , which reduces t... rapid turnover is important for the cells movement. The protein cofilin binds to ADP-actin units and promotes their dissociation from the minus end and p...

Active site

...hen a molecule chemically similar to the substrate binds to the active site but cannot be processed by the ...yme. In noncompetitive inhibition , the inhibitor binds to the enzyme at another site, the allosteric sit... and the induced fit model whereby the active site binds and encloses the substrate molecule. Often enzymes...

Affinity chromatography

... method that combines size fractionation capability of gel permeation chromatography with the ability to design a stationary phase that reversibly binds to a known subset of molecules. This method is usually used to: Purify and concentrate a molecule from a mixture into a buffering solution. R...

Albumin

...rly fat soluble ones Transports fatty acids ("free" fatty acids) Transports unconjugated bilirubin Transports many drugs Competitively binds calcium ions (Ca 2+ ) Buffers pH Causes of albumin deficiency: Cirrhosis of the liver (most commonly) Decreased production (as in...

Allostery

... Allosteric inhibition occurs when the binding of one ligand decreases the affinity for substrate at other active sites. For example, when 2,3-BPG binds to a regulatory site on hemoglobin, the affinity for oxygen of all subunits decreases or increases. Related topics cooperative binding ...

Allostery

... Allosteric inhibition occurs when the binding of one ligand decreases the affinity for substrate at other active sites. For example, when 2,3-BPG binds to a regulatory site on hemoglobin, the affinity for oxygen of all subunits decreases or increases. Related topics cooperative binding ...
Binds in Biological Dictionary

Virion

...a.(ANOTHER DIMENSION)(Poem) ... Information about virion in the free online English dictionary and encyclopedia. virions ... After the virion binds to the surface of a specific host cell, its ... Definition of Virion at Dictionary.com with free online dictionary, ... Virion Definition. Fi...

UvrA

... have ATPase/GTPase activity. The UvrA dimer binds with UvrB and forms a trimer which is able to dete...A and UvrB. ... In this process, dimerized UvrA binds UvrB in a search for damage-induced ... The Uv...he end of a ... The UvrA protein on its own binds preferentially to damaged DNA (Seeberg and ... Inc...

Transposase

... Transposase is an enzyme that binds to the ends of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replica...

Transferrin receptor

... Transferrin is a blood plasma protein for iron ion delivery that, in humans, is encoded by the TF gene. Transferrin is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less... Transferrin receptor transferrin receptor (p90, CD71) Ide...

Transcription factor

...logy, a transcription factor is a protein that binds to specific DNA sequences and thereby controls the...Sp1 is a zinc-finger transcription factor that binds to the sequence 5' GGGCGG 3' ... Section T of...... A transcription factor is a protein that binds DNA at specific sites where it ... Transcripti...

Theory

...hesaurus, Word of the Day, and word games. Brief and Straightforward Guide: What is M-Theory? ... In that sense, M-Theory is "the one theory that binds them all," and did so by ... This article looks at theory in general. See Psychological theories for specific theories within the discipline....
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(Date:4/17/2014)... One of the most popular vaccine brands for children ... may be overlooking some cost factors when choosing vaccines, ... expensive option, according to a new study by University ... administer can be driven by numerous factors," says Sheldon ... professor of computer science and of mathematics at the ...
(Date:4/17/2014)... at the University of California, San Diego School of ... who have suffered a recent major loss are more ... adults. , The study is published in this month,s ... . , Because compassionate behaviors are associated with better ... offer insights into ways to improve the outcomes of ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... Il. (April 17, 2014) Doctors who treat ... called lymphangioleiomyomatosis (LAM) can face an agonizing treatment ... of the disease and help relieve shortness of ... transplants, and sirolimus can cause potentially fatal complications ... pulmonologist Dr. Daniel Dilling, medical director of Loyola ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
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(Date:4/17/2014)... German . ... also provide us with a continuous stream of information about ... sit still in a car the world glides by ... Seemingly without effort, our brain calculates self-motion from this "optic ... a steady gaze during our own movements. Together with biologists ...
(Date:4/17/2014)... available in German . ... protection money demanded of him, he can expect his premises ... as fear of the consequences is enough to make restaurant ... birds, which lay their eggs in other birds, nests. If ... parasites take their revenge by destroying the entire nest. Consequently, ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
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