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Benzodiazepine in Medical News

Hip Fractures Not Caused By Benzodiazepine

According to a new study from the Department of Ambulatory Care and Prevention (of Harvard Medical School and Harvard Pilgrim Health Care), Benzodiazepine use - not shown to be associated with hip fractures after all. // Previous epidemiological studies suggesting an association have been used...

Almost 1 quarter of Spanish women take antidepressants

...al records in 64.5% of cases, with the primary causes being depression (11.6%), anxiety (9.9%) and insomnia (3.3%). The scientists also found that benzodiazepine use increases with age. However, they did not find the same with antidepressant use. "We think that greater training is needed in identifying SLE and ...

Organ Failure, Sedative Use in ICU May Lead to Depression

...rity of organ failure and to have received 75 milligrams or more a day of a benzodiazepine sedative. More severe organ failure can lead to a longer period of physi...ain the association they found between increased risk of depression and the benzodiazepine dose given to people in the ICU. The study was published online in the j...

In the ICU, use of benzodiazepines, other factors may predict severity of post-stay depression

...failure and being given relatively high doses of a benzodiazepine sedative. "The hope is that as we learn more ab...an failure and to have received 75 mg or more of a benzodiazepine sedative daily. Bienvenu says that because more...explain the association between depression and ICU benzodiazepine dose. One possibility could be that the amount...

Cognitive Behavior Therapy Eases Anxiety for Older People

...cing anxiety in older adults, and even helped reduce blood pressure, too. In the new study, about 42 percent of the volunteers were taking either a benzodiazepine or an antidepressant at the start of the trial. Stanley said the researchers didn't ask anyone to stop the use of their medications, because they want...

Primary Insomnia Tied to Brain Neurochemical Imbalance

... people with mood and anxiety disorders may be tied to sleep disturbances. Many of the hypnotic medications most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons, the study also reported. More information The American Academy of ...

Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults

...y be based on disturbances in sleep. The study also reports that many of the hypnotic medications that are most effective in treating insomnia are benzodiazepine receptor antagonists (BzRAs), which increase activity at the GABA neurons. According to a new clinical guideline for the evaluation and management of ...

Anti-inflammatory medications may become a treatment for schizophrenia

... the development of schizophrenia. The authors reported increased binding levels of [11C]PK11195, a radiotracer with high affinity for the peripheral benzodiazepine receptor (PBR) in patients who had carried the diagnosis of schizophrenia for five years or less. PBR is a molecular target that is present at higher...

Fall Risk Higher in Older Women Who Sleep Less

...otic medicines used to treat insomnia). Use of any benzodiazepine (short and long combined) was associated with a 1....ased risk of falls, whereas short- and long-acting benzodiazepine use was associated with an increased odds of 1.43 ...r pharmaceutical interventions for insomnia (e.g., benzodiazepine receptor agonists) or cognitive behavioral therapy...

Jazz Pharmaceuticals, Inc. Announces LUVOX CR Launch Plans and Reports Development Pipeline Progress at Investor Day Presentation

... Jazz Pharmaceuticals has received orphan drug designation from the FDA for JZP-8. This novel formulation incorporates clonazepam, a widely prescribed benzodiazepine indicated for the chronic treatment of epilepsy. In December 2007, Jazz Pharmaceuticals dosed the first patient in an ongoing Phase II clinical trial ...
Benzodiazepine in Medical Technology

Evotec Reports Positive Proof-of-Concept Top-Line Results with Insomnia Drug Candidate EVT 201

...al symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed that EVT 201 did not impair slow wave sleep unlike many benzodiazepine full agonists. The study therefore demonstrated EVT 201 has robust effects on both sleep onset and sleep maintenance and is without meaningful next da...

Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line Results with ...

...al symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed that EVT 201 did not impair slow wave sleep unlike many benzodiazepine full agonists. The study therefore demonstrated EVT 201 has robust effects on both sleep onset and sleep maintenance and is without meaningful next da...

Indevus Announces Presentation of Pagoclone Data at 47th Annual New Clinical Drug Evaluation Unit Meeting

...goclone is a novel, non-benzodiazepine, GABA-A selective receptor modulator. It is part of a new chemical class of agents and lacks many of the common benzodiazepine side effects such as sedation and withdrawal. The precise mechanism of action is unknown, however, GABA is believed to be an important neurotransmitte...
Benzodiazepine in Biological Technology

Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201

...ange tested the next day 9 h after dosing. The PSG analysis also showed that EVT 201 did not have a negative impact on sleep architecture unlike many benzodiazepine full agonists. As in all previous clinical studies, EVT 201 was demonstrated to be safe and well-tolerated at both doses. No serious or unexpected ad...
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