Research points to a new way to protect kidneys threatened by insufficient blood or toxins
...a rapid death march that only begins with the breakup. Next, two proteins, bak
and Bax, typically found at divergent places in the cell, work together to ...SA), Dr. Dong's laboratory showed that mitochondrial fragmentation involves bak
but not Bax.
Glaucoma Survey: Half Unaware of Preservative-Free Beta-Blocker, Ophthalmologists Cite Benefits of Preservative-Free Medications on Ocular Comfort and Quality of Life
...h no preservatives at all for their glaucoma patients with ocular surface disease or dry eye syndrome, compared to glaucoma medications preserved with bak
(3%) or non-BAK preservatives (36%).
Nearly half (47%) do not know a preservative-free beta-blockers is ava...
Key step in the 'puncture' mechanism of cell death revealed
...lls self-destruction is driven by a protein called bak
that acts by puncturing the membrane of the mitoch...nt is wrecked, the cell is doomed.
But how does bak
do this? The crux seems to be the way bak
can bind to itself and form complexes that damage ...
Penn study finds pro-death proteins required to regulate healthy immune function
...lls that lack Bax (Bcl-2-associated X protein) and bak
(Bcl-2-antagonist/killer) continue living under co...lar basis of both findings is based on how Bax and bak
work on intracellular membranes.
Specifically, ...ompsons group investigated the function of Bax and bak
in T cells, the team thinks their findings will li...
Bak Protein Sets Stressed Cells on Suicide Path
...a heart attack, stroke or cancer, a protein called bak
just may set it up for suicide, researchers have found.
In a deadly double whammy, bak
helps chop the finger-like filament shape of the ...eath contents into the cell.
"We found out bak
has a distinct function in regulation of the mito...
New Method For Fighting Leukemia
...otic actions of Bcl-2 and Bcl-xL by ABT-737 resulted in the marked activation of an important pro-apoptotic protein known as Bak. Grant said that when bak
is freed from its constraints by these actions, it cooperates with other pro-death proteins to induce mitochondrial damage, culminating in the dramati...
... mitochondrion. This homodimers (of molecules like bak
and BAX) are required in order to make the mitchon...he release of caspase activators. Just how BAX and bak
are controlled under the normal conditions of cell...rial outer-membrane protein, VDAC2, interacts with bak
to keep this potentially lethal apoptotic effector...