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Bacteriophage in Medical News

New Research Shows MicroPhage Test Accurately and Rapidly Detects Serious Bacterial Infections

... eight different antibiotics could be tested using bacteriophage amplification technology with an accuracy of 95 pe...e bacterial strain. MicroPhage has adapted bacteriophage amplification technology, a natural biologic proce...cteria. In the detection process, reaction of the bacteriophage proteins on the test strip indicates the sample is...

BWF awards $11.2 million to support physician-scientists

...arvard Medical School Genotype-phenotype studies of rheumatoid arthritis susceptibility genes David Tevis Pride, M.D., Ph.D. Stanford University bacteriophage communities in oral health and disease Miguel Nicolas Rivera, M.D. Harvard Medical School Characterization of a novel X-linked tumor suppressor, ...

Bacteria beware: MIT student invents knock-out punch for antibiotic resistance

...engineering at Boston University, Lu developed two bacteriophage platforms to overcome antibiotic resistance. bacteriophage are viruses that only infect bacteria, not human c...s to achieve novel functions. Lu has engineered bacteriophage to boost antibiotic effectiveness. The...

New viruses to treat bacterial diseases -- 'My enemies' enemy is my friend'

...an clinical reports have come from Eastern Europe, particularly the Tbilisi bacteriophage Institute in Georgia where bacteriophages are used for successful treatment...ns becoming not only more prevalent but also more infectious and dangerous. bacteriophage therapy offers an alternative that needs to be taken seriously in Western E...

FDA Extends GRAS Approval Listex to All Food Products

... The FDA and USDA Announced Today They Have Approved LISTEX(TM) P100, the Natural bacteriophage Product Against Listeria, as GRAS (Generally Recognised as Safe), for all Food Products . In the fight against Listeria, one of the most danger...

Key Mechanism to Emergence of Strep Bacteria

...ccurred about 30 years ago when a virus known as a bacteriophage infected the strep bacteria and introduced a new g... In the case of the invasive strep clone, a bacteriophage provided the bacterium a genetic advantage that tu...deadly disease agent. A gene present on the bacteriophage acquired by the M1T1 strep encodes an enzyme that ...

Experts to Develop New Weapons Against Food Poisoning

...l bacteria or gut cells. The term is commonly used in its shortened form, phage. Both GangaGen and The University of Nottingham are leaders in bacteriophage research and view the technology as a vital breakthrough in the control of bacterial contamination and associated health risks. The research agreement...

Bacteriophages may Boost the Effectiveness of Antibiotics

...c gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164). The bacteriophage approach would also be particularly useful for treating cases of food poisoning, because the lower doses of antibiotic needed would not disrupt the fr...

Mutating viruses helps produce antibodies

...tagious and potentially lethal respiratory diseases such as whooping cough. Bordatella is afflicted by a plague of its own, a kind of virus known as a bacteriophage or "bacteria eater." This phage infects Bordatella using its tail-like structures, which latch onto a specific molecule on the bacteria's surface. ...
Bacteriophage in Medical Technology

MicroPhage Successfully Completes Beta Trial for Rapid MRSA Test

...ctions. "Phages" are bacteria-specific viruses that multiply aggressively when exposed to target bacteria. In the detection process, reaction of the bacteriophage proteins on the test strip indicates the sample is positive for staph bacteria. For susceptibility analysis, the organism in the sample is challenged...
Bacteriophage in Biological News

NYU scientists discover dangerous new method for bacterial toxin transfer

... bacterial viruses did the completely unexpected. "We have found that a bacteriophage can transfer genetic elements, or DNA, between unrelated bacterial species ...aph aureus genes. In addition, they plan to follow the fate of an S. aureus bacteriophage once it injects its own DNA into L. monocytogenes, and they would like to t...

Biologists learn structure, mechanism of powerful 'molecular motor' in virus

...urdue's Hanley Distinguished Professor of Biological Sciences. The motor is needed to insert DNA into the capsid of the T4 virus, which is called a bacteriophage because it infects bacteria. The same kind of motor, however, also is likely present in other viruses, including the human herpes virus. "Molecular...

Collegiate Inventors Competition recognizes top student inventors

...hool and Massachusetts Institute of Technology (Advisor: J.J. Collins) Combating Antibiotic-resistant Bacteria and Bacterial Biofilms with Engineered bacteriophage and Synthetic Gene Sensors An engineered bacteriophagea virus that infects bacteriathat works in conjunction with antibiotics, making them much more ...

Scientists discover DNA knot keeps viral genes tightly corked inside shell

...gles, UCSD chemists Jinghua Tang, Norman Olson and Timothy Baker, a professor of chemistry and biological sciences, have determined the structure of a bacteriophage called phi29 with a resolution finer than 8 Angstroms (one Angstrom equals a tenth of a nanometer). Their project was part of a long-term collaborati...

Scientists spy enzyme that makes us unique

...duality. The discovery of the T7 endonuclease 1 enzymes structure was made by using x-ray crystallography techniques. The enzyme is derived from a bacteriophage a naturally occurring virus-like agent that attacks bacteria but the molecular processes are expected to be similar in other organisms, including hu...

Society for General Microbiology 161st Meeting, University of Edinburgh

...st control, tracking Yersinia and microbe-identifying microchips, novel insecticides and drug-producing sponge bacteria, hepatitis C vaccine research, bacteriophage therapy and the control of coastal pollution. Individual press releases for all of the above presentations are available. Please contact SGM if you...

Tips from the Journals of the American Society for Microbiology

... Phage Therapy May Control Staph Infections in Humans Including MRSA Researchers from Italy have identified a bacteriophage active against Staphylococcus aureus, including methicillin-resistant strains, in mice and possibly humans. They report their findings in the August ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...hich peptides ?or protein fragments ?were active in the tissue environment surrounding the tumors. This phage displayed library ?called so after the bacteriophage viruses used to capture protein fragments ?was then isolated and tested. With the library, Dr. Diaz and his colleagues could select peptides that...

The connector rotation hypothesis? Phage do not pack their DNA by rotation

...earchers Thorsten Hugel, Jens Michaelis, Craig Hetherington, and Carlos Bustamante present their detailed investigation into how the Bacillus subtilis bacteriophage รถ29 crams its DNA into the capsid following replication. Using their innovative system, Hugel and colleagues were able to observe capsids as they...

New approach could lower antibiotic requirements by 50 times

...tic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164). The bacteriophage approach would also be particularly useful for treating cases of food poisoning, because the lower doses of antibiotic needed would not disrupt the fr...
Bacteriophage in Biological Technology

SANYO Donates Air Purification Systems Effective Against Flu Viruses to New York Airports and Schools

...ly reducing the level of viable airborne viruses, according to an independent research institution in the US. This research study included tests using bacteriophage MS2, commonly used by the scientific and testing community as a representative virus, which roughly approximates the aerosol-related physical characte...

MIT, BU team combats antibiotic resistance with engineered viruses

...quinolones, beta-lactams and aminoglyclosides) and had good results with all three. In mice infected with bacteria, those treated with both engineered bacteriophage and antibiotics had an 80 percent survival rate, compared with 50 percent for mice treated with natural bacteriophages and antibiotics, 20 percent for...

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

...I's Cynthia Andrews-Pfannkoch) made the first significant strides in the development of a synthetic genome by assembling the 5,386 base pair genome of bacteriophage phi X174 (phi X). They did so using short, single strands of synthetically produced, commercially available DNA (known as oligonucleotides) and using ...

MicroPhage Closes Latest Financing

...them against current methods. We are looking forward to completing our validation work and launching products, which leverage the tremendous power of bacteriophage amplification technology for rapid bacterial identification and susceptibility testing." About MicroPhage Based in Longmont, Colo. and...

Collegiate Inventors Competition(R) Recognizes Top Student Inventors

...ool and Massachusetts Institute of Technology (Advisor: J.J. Collins) Combating Antibiotic-resistant Bacteria and Bacterial Biofilms with Engineered bacteriophage and Synthetic Gene Sensors - An engineered bacteriophage - a virus that infects bacteria-that works in conjunction with antibiotics, making them much ...

Strategic Diagnostics Reports Fourth Quarter and Full-Year Financial Results

...ssociated with the Company's new products and services utilizing the GAT(TM) platform as well as ongoing development of the ethanol application of its bacteriophage technology for the selective control of lactic acid-producing bacteria. Pre-tax income for the fourth quarter of 2007 totaled $409,000, compared to ...

Venter Institute Scientists Create First Synthetic Bacterial Genome

...enter, Smith and Hutchison made the first significant strides in the development of a synthetic genome by their work in assembling the 5,386 base pair bacteriophage FX174 (phi X). They did so using short, single strands of synthetically produced, commercially available DNA (known as oligonucleotides) and using an ...

Tips from the Journals of the American Society for Microbiology

... Phage Therapy May Control Staph Infections in Humans Including MRSA Researchers from Italy have identified a bacteriophage active against Staphylococcus aureus, including methicillin-resistant strains, in mice and possibly humans. They report their findings in the August ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

...al polio, measles, mumps, and rubella vaccines. bacteriophage A virus that infects bacteria, sometimes used as a vector. base ... artificially constructed plasmid vector that contains a specific bacteriophage gene, which allows it to carry up to 45,000 base pairs of desired...

Scalable Automation of the TempliPhi DNA Sequencing Template Amplification and DYEnamic ET Terminator Sequencing Kits on the Sciclone ALH 3000

...ation of source DNA is a basic building block technique in molecular biology research. The TempliPhi DNA Sequencing Template Amplification Kit employs bacteriophage j29 DNA polymerase applied in an isothermal rolling circle amplification (RCA) 1 to produce large amounts of product DNA (1-3 μg) 2 and elimina...
Bacteriophage in Biological Products

Rabbit Anti-M13 Bacteriophage Coat Proteins Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Company:Abcam

PhageMaker System from Novagen

Description:... Novagens PhageMaker System is optimized for maximum packaging efficiencies of cDNA and genomic DNA inserts ligated with any bacteriophage l vector. Using a test insert with Novagen's l vector arms, efficiencies > 10^7 pfu/g arms (> 4 x 10^8 pfu/g ligated l control DNA) are typically obta...
Company:Novagen

Lambda Protein Phosphatase from New England Biolabs

Description:...ase with activity towards phosphorylated serine, threonine and tyrosine residues. It is the 221 amino-acid product of the ORF221 open reading frame on bacteriophage lambda (1,2)....
Company:New England Biolabs

Lambda Protein Phosphatase from New England Biolabs

Description:...ase with activity towards phosphorylated serine, threonine and tyrosine residues. It is the 221 amino-acid product of the ORF221 open reading frame on bacteriophage lambda (1,2)....
Company:New England Biolabs

Ph.D. Peptide Display Cloning System from New England Biolabs

Description:... The Ph.D. Peptide Display Cloning System facilitates the display of custom peptide libraries on the surface of bacteriophage M13 as coat protein fusions, creating a physical linkage between each displayed peptide and its encoding DNA sequence. Peptide ligands for a variety o...
Company:New England Biolabs
Bacteriophage in Biological Definition

Evolutionary biology

...quick generation time of some microbes to answer evolutionary questions. Similar features have led to progress in viral evolution, particularly for bacteriophage . Notable evolutionary biologists Notable contributors to evolutionary biology include: Charles Darwin Erasmus Darwin Richard ...

Genetics

...for the first time by Fred Sanger , Walter Gilbert , and Allan Maxam working independently. Sanger's lab complete the entire genome of sequence of bacteriophage Φ-X174; . 1983 Kary Banks Mullis discovers the polymerase chain reaction enabling the easy amplification of DNA 1989 The first human ...

Genomics

...The related field of genetics is the study of genes and their role in inheritance. The first genome to be sequenced in its entirety was that of bacteriophage FX174 (5,368 kb) in 1980 . The first free-living organism to be sequenced was that of Haemophilus influenzae (1.8Mb) in 1995 , and since then gen...

Immune system

... same sequence. Therefore, the bacterium's DNA will not be damaged by the first enzyme because of the presence of the second enzyme. However, when a bacteriophage attempts to infect this bacterium, the viral DNA has not been protected, and gets degraded by the first enzyme. While study of the bacterial immune sy...

Max Delbr

...he US during World War II , teaching physics at the Vanderbilt University in Nashville . In 1939, he co-authored a paper called The Growth of bacteriophage with E.L. Ellis in which they demonstrated that viruses reproduce in "one step ", rather than exponentially as cellular organisms do. In 194...

Microbiology

...led petri dish to analogous locations on several other petri dishes. After replicating a plate of E. coli , they exposed each of the new plates to a bacteriophage (also called phage). They observed that phage-resistant colonies were present at analogous locations on each of the plates, allowing them to conclude...

Phage

... A phage (also called bacteriophage ) (in Greek phageton = food/consumption) is a small virus that infects only bacteria . Like viruses that infect eukaryotes , phages consist ...

Virus

...e term virus usually refers to those particles which infect eukaryotes (multi-celled organisms and many single-celled organisms), whilst the term bacteriophage or phage is used to describe those infecting prokaryotes ( bacteria and bacteria-like organisms). Typically these particles carry a small amou...
Bacteriophage in Biological Dictionary

Bacteriophage

A bacteriophage is any one of a number of viruses that infect bacteria. Bacteriophages are among the most common organisms on Earth. The term is commonly used in its shortened form,... any of a group of viruses that infect bacteria. Bacteriophages were discovered independently by Frederick W. ...

T7 RNA Polymerase

... extremely promoter-specific and only transcribes bacteriophage T7 DNA or DNA cloned downstream of a T7 pro...gous pol I ... The RNA polymerase (RNAP) from bacteriophage T7 has several advantages for use ... ... St...tions with small synthetic ... Transcription from bacteriophage T7 and SP6 RNA polymerase promoters in the ...

Recombinase

...ecombinase , often abbreviated to Cre, is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DNA between loxP sites. Th...n the Salmonella ... Cre Recombinase is a Type I topoisomerase from bacteriophage P1 that catalyzes ... Is the Cre Recombinase control DNA available as a ...

Prophage

...ge integrated into the host chromosome or existing as an extrachromosomal plasmid. This is a latent... prophage ( ) n. The latent form of a bacteriophage in which the viral genes are incorporated into the bacterial chromosomes without causing disruption Prophage content of four human bacterial...

Primase

...ading strand as well. ... ... has both primase and helicase ... this study, we report the development of a primase -based ... which utilizes bacteriophage T7 gp4 primase to synthesize ... Primase ,biological,biology dictionary,biology terminology,biology terms,biology abbreviations ... of two prot...

Phagemid

...of these clones were amplified by PCR and digested with BstNI, ... encoded in the phagemid vector, a small percentage of tar ... A filamentous bacteriophage containing a phagemid vec ... produce functional phagemid particles, ... 1) Phagemid derived from pUC118/119, pTZ18/19, or Bluescript SK/KS....

Phage

... A bacteriophage is any one of a number of viruses that infect bac...1. 36,524. AF157835. AF157835. 54 FASTA SRS ... bacteriophage ( ) n. A virus that infects and lyses certain ba...chers actively involved in the disparate areas of bacteriophage research this book ... Phage can confer key phe...

Mismatch repair

...; it corrects ... The Escherichia coli mismatch repair system greatly improves DNA replication ... Lieb M. Specific mismatch correction in bacteriophage lambda crosses by very ... Methyl-directed mismatch repair (MMR) is the primary pathway for correcting ... The complete mismatch repair ...

Lytic cycle

...ysogeny, or the lysogenic cycle , is one of two methods of viral reproduction . Lysogeny in prokaryotes is characterized by integration of the bacteriophage nucleic acid into the host bacterium's genome. The newly integrated genetic material, called a prophage can be... MySpace Music profile ...

Ligase

... products fueling innovation in both basic research and emerging technology ... The smallest known ATP-dependent DNA ligase is the one from the bacteriophage T7 ... http://www.biochem.ucl.ac .uk/bsm/xtal/teach/repl/ ligase .html ... ...
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