Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
The surgical removal of the ovaries has been widely adopted as a cancer-risk-reducing strategy for women with either BRCA1
or BRCA2 mutations. A new multicenter study led by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) is the first prospective examination of the impact of this pro...
Biological Link Between BRCA1 and Breast Cancer Detailed
Finding suggests the gene, when not mutated, helps repair damaged DNA
THURSDAY, Jan. 17 (HealthDay News) -- A newly discovered role played by the breast cancer gene BRCA1
in repairing damaged DNA may help explain why women who inherit a mutated version of the gene are more likely to develop brea...
New pathway provides more clues about BRCA1 role in breast cancer
DURHAM, N.C. -- A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer.
The discovery also could lead to more effective therapies for women with ...
Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers
There is a broad variation in the risk of developing breast cancer among people who carry the BRCA1
and BRCA2 gene mutation, according to a study in the January 9/16 issue of JAMA.
and BRCA2 are gene mutations that predispose carriers to breast cancer. The magnitude of the risk of breast...
Coffee Reduces Risk of Breast Cancer in BRCA1 Mutation Carriers
An article appearing in the January 2006 issue of the International Journal of Cancer says that women with a BRCA1
gene mutation, which puts // them at high risk for breast cancer, could actually benefit by drinking large amounts of coffee.
Dr. Steven A. Narod, of the University of Toronto, On...
Scientists Unravel Link Between HRT And Breast Cancer Gene, BRCA1
It is a well established fact that any genetic alterations in either the BRCA1
or BRCA2 gene can predispose to breast cancer. The BRCA1
gene, has been known to play a significant role// in the utilization of estrogen in cells present in the breast. Researchers from Georgetown University Medical Ce...
Many Opt for Surgery to Lower Breast, Ovarian Cancer Risk
...heir study included 211 women, aged 35 to 45, with brca1
or BRCA2 gene mutations, which are known to increa...reduction surgery.
Forty percent of women with brca1
and BRCA2 gene mutations had both breasts removed ...moved.
When looked at separately, 52 percent of brca1
gene mutation carriers had both ovaries removed, c...
June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments
...alities in women with dense breast tissue and for those who have other risk factors, including:
Known carriers of the gene mutation brca1
A lifetime risk of 20 percent or higher, based on family history of breast cancer and other health factors. Doctors work with women t...
New Cancer Drug Fights Tumors in Those With BRCA Mutations
... developing these malignancies.
Women who carry brca1
and BRCA2 gene mutations are susceptible to develo... treated 60 men and women who were carriers of the brca1
or BRCA2 mutations, or had a family history of BRC...tients, all of whom were confirmed carriers of the brca1
or BRCA2 mutation. Those patients received 200 mi...
New Insights, Inroads Against Breast, Ovarian Cancers
...breast cancer patients who have this type of aggressive tumor have only the option of surgery and chemotherapy.
Breast cancers associated with the brca1
and BRCA 2 gene mutations (which heighten risk) are almost always triple negative, explained Dr. Joyce O'Shaughnessy, lead author of one of the studi...
BRCA1 in Medical Technology
Gene Findings Unlocking Reasons for Neuroblastoma Risk
...the Children's Oncology Group.
The BARD1 gene had already attracted attention from oncology researchers because it is associated with the gene brca1
, which was the first discovered familial breast cancer gene. "Researchers have suspected that variants in BARD1 also increased the risk of breast c...
New Computer-Based Tools Will Help Make Best Use of Genetic Breast Cancer Tests
... tests to evaluate and treat breast cancer.
The first pair of tools will assess whether a woman with a family
history of cancer should be tested for brca1
and BRCA2 gene mutations.
Knowing whether a woman has inherited these gene mutations may help
determine her chances of developing certain kinds of can...
BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer
...ancer is linked to a hereditary genetic defect. Clinicians
at Memorial Sloan-Kettering Cancer Center will enroll patients who have a
mutation in their brca1
or BRCA2 genes.
"We believe BSI-201 holds great promise as a targeted therapy in this
difficult-to-treat type of ovarian cancer," said Carol Aghajan...
Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women
...tu breast cancer, and
Caucasian women are far more prone to develop breast cancer than Asian
women, for reasons unknown.
Although the mutations in brca1
and BRCA2 were identified as genetic
risk factors for breast cancer more than a decade ago, they only account
for five percent of the breast cancer ca...
New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit
...ese and related studies, a clinical trial will soon be
initiated specifically targeting patients with genetic defects in mismatch
repair genes such as brca1
and 2, which are associated with susceptibility
for breast and ovarian cancer.
To review the poster and see more detailed information about the stud...
Use of Sequenom's MassARRAY System Leads to Significant Scientific
Advances in Understanding Cancer, Diabetes and Drug-Resistant
...hool, University of Cambridge and National Cancer
Institute, found evidence of an association between breast cancer
and CASP8 D302H. Mutations such as brca1
and 2 account for less
than 25% of the familial risk of breast cancer. In this study, the
researchers demonstrate that common breast cancer susceptibi...
BRCA1 in Biological News
New study reveals for first time how BRCA1 mutations cause breast cancer
NEW YORK An international team of researchers led by Columbia University Medical Centers Herbert Irving Comprehensive Cancer Center and Swedens Lund University has, for the first time, revealed how mutations in the BRCA1
gene lead to breast cancer. Findings show that one way BRCA1
Women often opt to surgically remove their breasts, ovaries to reduce cancer risk
...was measured among 211 women with known unaffected brca1
or BRCA2 mutation carriers. brca1
and BRCA2 are hereditary gene mutations that indic...s). These surgeries are widely used by carriers of brca1
and BRCA2 gene mutations to reduce the risk for br...
Stem cell 'daughters' lead to breast cancer
...p in women carrying mutations in the gene BRCA1.
gene mutations are found in 10-20 per cent of women with hereditary breast cancer. Women with brca1
mutations often develop 'basal-like' breast cancer...n recent years that breast stem cells gave rise to brca1
tumours. "However, research carried out at the ins...
Genetic testing for breast or ovarian cancer risk may be greatly underutilized
...ing genetic information into real-world clinical practice.
"Testing for brca1
and 2 mutations has been around a long time and should be a good indicator ...for ovarian cancer is less than 2 percent. But women with mutations in the brca1
or BRCA2 genes may be 3 to 7 times more likely to develop breast cancer and...
Association for Molecular Pathology joins ACLU to challenge gene patents
...ated with breast and ovarian cancer are unconstitutional and should be invalidated. Individuals with certain mutations along these two genes, known as brca1
and BRCA2, are at a significantly higher risk for developing hereditary breast and ovarian cancers.
The lawsuit, Association for Molecular Patholo...
CRG buys Genomatix' Next Generation Sequencing analysis solution
...esearch in two major areas. The first is the molecular mechanism of cancer. We are working to address the mechanism by which tumor suppressors such as brca1
and BRCA2 exerted their biological effects. Our second avenue of research entails the delineation of the mechanisms by which the genome is silenced th...
Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
...am and Women's Hospital, Boston, Massachusetts, is studying the role of the brca1
gene, which has been linked to familial breast cancer. His goal is to iden... that act in concert with BRCA1, which could explain the specific effect of brca1
mutations on breast tissue carcinogenesis.
Jesse Zalatan, PhD, with his...
Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research
...l studies in breast cancer explained the genetic patterns and causes of the brca1
and BRCA2 gene mutations which indicate a person's risk for breast cancer, ...um, which provided the first estimates of breast and ovarian cancer risk in brca1
mutation carriers and developed a risk model that is used daily in clinics ...
Study looks at psychological impact of gene test for breast cancer
...0 women will be diagnosed in the U.S. this year with breast cancer and a significant minority of them will have developed cancer because they harbor a brca1
or BRCA2 mutation," comments Dr. James P. Evans, Editor-in-Chief of Genetics in Medicine . "Sequencing of these genes has been a boon to patient man...
Should embryos with a hereditary disorder be transferred if no unaffected embryos are available?
...d. Debate about this is urgent, as centres are already confronted with parental requests to transfer embryos found to have the targeted mutation (e.g. brca1
or BRCA2 genes for hereditary breast cancer) in cases where no non-affected ones turned out to be available. How should they respond? That there seems...
BRCA1 in Biological Technology
ASCP Joins ACLU Lawsuit Opposing Gene Patents
... human genes -- specifically, patents covering the brca1
and BRCA2 genes, which are associated with breast ...human genes -- specifically, patents covering the brca1
and BRCA2 genes, which are associated with breast ...ndependently looking at or interpreting a person's brca1
and BRCA2 genes to determine if the person is at a...
deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
...arly familial, it has taken painstaking research to find
genetic variants predisposing to its common forms. The strongly
predisposing mutations in the brca1
and BRCA2 genes have a less than 0.5%
frequency in the general population in the US and Europe. These mutations
are estimated to account for only 1-3%...
Susan G. Komen for the Cure(R) Announces Largest Grants Slate Ever: $100 Million to Speed Delivery of Breast Cancer Discoveries, Cures
...Komen for the Cure grant was awarded to Insoo Bae, Ph.D., of Georgetown University to identify environmental agents that cause DNA damage to brca1
defective breast cells, triggering the development of cancerous tumors. -- A Komen for the Cure grant is supporting the work of Amy Trenth...
LineaGen Inc. Launches With Close of $5.8 Million Series A Funding Round
...Utah's unique and proven population-based
genetic resources and information, which facilitated the identification of
several cancer genes -- including brca1
and BRCA2 (breast cancer) and the
APC (colon cancer).
LineaGen's strategic partnerships with prominent scientists and
researchers will draw upon and...
Lance Armstrong and the future of cancer care
...ected more effectively toward cancer cells but are also targeted by virtue of patient-specific genetic factors.
Women with certain mutations in the brca1
gene, for example, have an 80 percent lifetime risk of breast cancer. For these women, radical mastectomy is not such an extreme therapeutic (preventa...
A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity
... these shRNAs, lead to increased sensitivity of cells to paclitaxel (Figure 3). Again, there is evidence in the literature to support this finding. brca1
has been found to be mutated in breast and ovarian tumors, and patients with these mutations can be more responsive to chemotherapies than patients ...
SNPs Powerful Tools for Association Studies
...n used successfully ever since. The discoveries of brca1
and Crohns disease gene locus represent the triump...es in general.
4.1.1. Discovery of the brca1
Researchers attempting to ... when Mark Skolnicks group identified the specific brca1
gene (Miki et al., 1994).
Oragene and DNA sequencing with ABI PRISM
...or GJB2 mutations. Auris, Nasus, Larynx. 29: 231-239.
3. Elit, L., Jack, E., Kwan, E., Baigal, G., and S. Narod. (2001). A
mutation identified in Mongolia. International Journal
of Gynecological Cancer. 11: 241-243.
4. DNA Genotek. (2004). DNA Yield wi...
TTGE on the DCode System
...ouble-stranded and a partially melted state. For example,
the theoretical melting curve of a GC-clamped exon 2 sequence from the
gene is very flat, containing only one melting domain (Figure 1A).
The steep S-shaped curve in the perpendicular DGGE makes it difficult
Enhanced siRNA Delivery and Long-term Gene Silencing
...ed for cells expressing cyclophilin
siRNAs after 8 months of culture post selection. ...
expression of cyclophilin and brca1
had been reduced long-term
be...l siRNA (Figure
3C). Although brca1
mRNA levels were 60% of that observed in
BRCA1 in Biological Definition
Mutations can also be inherited. Inheriting certain mutations in the brca1
gene renders a woman much more likely to develop breast cancer and ovar...mples are:
breast cancer and ovarian cancer in female carriers of brca1
tumors of various endocrine organs in multiple endocrine neoplasia (M...
BRCA1 in Biological Dictionary
... ... NDT80 is required for exit from pachytene (Xu et al., 1995) ... Staging of pachytene nuclei based on the morphology of the XY pair with brca1
... We suggest that the pachytene phenotype develops secondarily to a primary defect ... Figure 1: During early pachytene , SUMO-1 is observed...
...ase levels of transcription. ... The intragenic deletions were detected in almost 6% of all high-risk families ... The proportion of intragenic brca1
rearrangements could be overestimated because ... ...
...the two motifs are conserved in mouse orthologous genes that undergo exon skipping. ... For example, mutations in exon 18 of the breast cancer brca1
gene cause ... PTB: A REPRESSOR OF EXON DEFINITION. MECHANISMS OF PTB REPRESSION ... The recognition of intron- exon boundaries, the splice si...
...ntrolled by checkpoints. ... following page shows the three main checkpoints that control the cell cycle . ... The subcellular localization of brca1
changes with respect to the cell cycle . ... Blockage of cell cycle progression also resulted in phosphorylation, either at ... Includes ima...
... Library :: Alleles :: [Polymorphism -930A > G of the cytochrome b ... Mesh-terms: Alleles ; Alternative Splicing; Amino Acid Sequence; Animals; brca1
... Multiple Alleles | Macmillan Genetics. Multiple Alleles summary with 2 pages of encyclopedia entries, research information, and more. Fo...