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BRCA in Medical News

New Cancer Drug Fights Tumors in Those With BRCA Mutations

Olaparib prevents malignant cells from repairing themselves, researchers say ,, WEDNESDAY, June 24 (HealthDay News) -- A new cancer drug called olaparib worked well in an early clinical trial against breast, ovarian and prostate cancers in individuals who were genetically vulnerable t...

Mutation of BRCA gene influences women's views of preventive mastectomy

Women whose cells harbor harmful mutations in the BRCA genes are likely to view preventive mastectomy as the best way to reduce their risk and fears of developing breast cancer, despite other, less drastic options available. That is the conclusion of a new study published in the April 1, 2009 issu...

Women with BRCA mutation, or worry, most likely to undergo prophylactic mastectomy

HOUSTON ― Women at increased risk for breast cancer because of the genetic BRCA mutations are more likely to think a prophylactic mastectomy is the best way to reduce their risk for the disease, compared to other women who are at high risk, according to researchers at The University of Texas...

Men With BRCA Gene Mutations Unaware of Cancer Risks

They need to be more aware of the threats to themselves and relatives, study says FRIDAY, Feb. 27 (HealthDay News) -- Men who are part of families in which some members have BRCA1 or 2 gene mutations -- which boost the risk for breast and ovarian cancer -- typically avoid genetic couns...

Family History Ups Breast Cancer Risk Even Without BRCA Gene

Unknown mutations may account for increased odds, researchers say MONDAY, Nov. 17 (HealthDay News) -- The risk of breast cancer for a woman with a strong family history is four times higher than that of the general population -- even if she does not carry one of the breast cancer-linke...

Second breast cancer may be greater than thought for high-risk women without BRCA mutations

New York, NY A preliminary analysis of ongoing research suggests that high-risk women with breast cancer who do not have a BRCA1/2 mutation may face a greater chance for developing a second breast cancer than previously thought. With the increased risk of cancer in these women, should sentinel no...

Breast cancer risk amplified by additional genes in combo with BRCA mutation

PHILADELPHIA - Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published this month in the American Journal of Human Genetics. Researchers at the University of Pennsylvania School of Medicine join an i...

Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment

Tampa, Fla. - Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer were presented at this week's Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers, by researchers from The University of Texas M. D. Anderson Cancer Center. ...

Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene

Alexandria, VAIsraeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carr...

Many Opt for Surgery to Lower Breast, Ovarian Cancer Risk

... Women with brca gene mutations often choose preventive measures, study finds FRIDAY, Aug. 7 (HealthDay News) -- Many women with a high risk of breast or o...
BRCA in Medical Technology

Presbyterian Hospital Dallas Starts Advanced Breast-Cancer Risk-Assessment Program

...s identified Elizabeth at "high risk" because she carries a mutation of the brca gene, which predisposes her to the disease. "So many doctors' appointment...breast cancer, history of ovarian cancer, an abnormal breast biopsy, or the brca gene mutation. "Learning about their risk factors for breast cancer shoul...

New Computer-Based Tools Will Help Make Best Use of Genetic Breast Cancer Tests

...tory is associated with an increased risk for BRCA1 or BRCA2 gene mutations are referred for genetic counseling and evaluation to measure the need for brca testing. AHRQ has also published an Evidence-based Practice Center report on the impact of GEP tests on breast cancer outcomes. The new project to c...

BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer

...A-negative patients are at higher risk of breast and ovarian cancer because brca plays a key role in repairing DNA errors that lead to tumor formation." O...ccount for about 15 percent of the patient population. Women with defective brca genes are also at considerably higher risk of breast cancer. "We have ide...
BRCA in Medical Definition

Personalized medicine

...e rise to cancer. Recent medical research indicates that medications, lifestyle changes and increased screening can mitigate some risk. An example is brca mutations where the carrier can have an increased lifetime risk of 85% for developing a breast cancer or up to 40% increased risk of getting ovarian ...
BRCA in Biological News

Should children be permitted to get genetic testing for BRCA 1/2 mutations?

PHILADELPHIA -- Its an ethical dilemma with serious implications. Should children be tested for gene mutations that predispose them to developing breast cancer and/or ovarian cancer later in life" New research suggests the next generation of parents may support testing minors even when any step...

Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk. That is the conclusion of a study at Fox Chase Cancer Center exploring how families communicate genetic test results. Like...

Association for Molecular Pathology joins ACLU to challenge gene patents

...d the University of Utah Research Foundation, which hold the patents on the brca genes. The plaintiffs include organizations representing over 150,000 resea...d or even shut down due to concerns about gene patents. In the case of the brca genes, Myriad's lab is the only place in the country that performs full seq...

Easton honored with inaugural AACR Outstanding Investigator Award in Breast Cancer Research

...ations in these loci are associated with increased risk of breast cancer in brca mutation carriers. These observations may become important in counseling women who carry the brca mutation, and will be important for risk stratification in the general popu...

Genetic risk factors may tailor prostate cancer screening approaches

... prostate cancer or two second-degree relatives with prostate cancer on the same side of the family. The group also includes African-American men with brca 1/2 mutations. Giri and colleagues compared the Caucasian high-risk men in PRAP with a control group, an all-Caucasian set of men who have no fami...

Study looks at psychological impact of gene test for breast cancer

...w insights into how women cope with the results of brca testing for hereditary breast canceran increasingl...ustment in 215 women who underwent DNA testing for brca gene mutations associated with hereditary breast c...stment to Uncertainty An inconclusive result on brca testing means the woman carries no genetic mutatio...

Gene variant increases breast cancer risk

...women from breast cancer families, respectively. This shows that the AKAP9 variants have much less effect on breast cancer risk than, for example, brca mutations. On the other hand, these variants are much more common in the population. We also do not know yet which control cycles of the cell metaboli...

Many parents at-risk for cancer disclose genetic test results to children

...e at which interventions are believed to be helpful. Yet, many children of brca mutation carriers learn of their parents genetic test results many years be...logy, describes the prevalence and experiences of parental communication of brca results to children under the age of 25 years old. More than half of the...

First confirmed common genetic risk factors for breast cancer

...east cancer genes. The five genetic variants identified by Dr. Liu and collaborators occur more frequently among women with breast cancer than do brca and the other previously identified breast cancer susceptibility genes. The five genes are the FGFR2, TNRC9/ LOC643714, MAP3K1, and LSP1. "T...
BRCA in Biological Technology

Enhanced siRNA Delivery and Long-term Gene Silencing

.... Long-term Reduction in Target Gene Expression Results in Morphological Changes. Retroviral DNA, expressing cyclophilin A, brca 1, or a negative control siRNA from the H1 promoter, was transfected into a packaging cell line in a 6 well dish in triplicate. ...
BRCA in Biological Dictionary

Complementary sequence

...complementary periodic sequence pairs. that minimize the merit factor. ... have suggested choosing one sequence from a complementary ... ... brca 2, Celiac disease, complementary sequences , CYP2C19, CYP2C9, CYP2D6, Cystic ... Most Emailed. complementary sequences . Name. Address. City. St...

Complementary sequences

.... Each strand is complementary to the other in that the base pairs between them are non-covalently connected via two or three hydrogen... ... brca 2, Celiac disease, complementary sequences , CYP2C19, CYP2C9, CYP2D6, Cystic ... Most Emailed. complementary sequences . Name. Address. City. St...
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