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BRAF in Medical News

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

EGFR Pathway Test analyzes in sequential reflex fashion more mutations potentially inhibiting anti-EGFR therapy response in metastatic colorectal cancer patients MADISON, N.J., June 1 /PRNewswire-FirstCall/ -- Quest Diagnostics Incorporated (NYSE: DGX ), the world's leading cancer diagnost...

MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009

... a change from current practice High level of excitement around the braf inhibitor PLX4032, leading to strong interest in clinical trial participati...s entering the "age of targeted therapies" through the use of screening for braf and KIT mutations, driving the selection of appropriate therapies. ...

Hormone therapy offers potential protective effect against colon cancer in older women

...ally looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the CpG island methylator phenotype, or braf gene mutations. No associations were detected between hormone use and these molecular markers. Of note, the investigative team previously reported tha...

Some Hiroshima Survivors at Thyroid Cancer Risk

...thyroid cancer, new research indicates. Papillary thyroid cancer (PTC) is typically linked to a particular genetic mutation involving the so-called braf gene. But Japanese researchers say that among Japanese atom bomb survivors, a different and relatively rare disease trigger -- involving the chromosom...

Blood vessel inhibitor shows promise against metastatic thyroid cancer

...dian progression-free survival was estimated to be 40 weeks. Genetic analyses of 25 patients indicated that those with a specific mutation known as braf V600E in their tumors had a better response to motesanib diphosphate than did those without the mutation. Additional research is needed on this geneti...

New Drug Slows Thyroid Cancer

...gression-free survival was about 40 weeks. Genetic analysis of 25 patients revealed that drug response was better in those with a mutation known as braf V600E in their tumors than in those without the mutation. Further research into this genetic connection is needed, the researchers said. "Finding t...

Too many gene copies stimulate tumor cell growth

... the duplication of a region of DNA containing the braf gene. Tumors with this genetic mutation showed signs of increased braf protein activity. Consistent with the idea that increased braf activity had a role in the development of the tumo...

JCI online early table of contents: April 8, 2008

... the duplication of a region of DNA containing the braf gene. Tumors with this genetic mutation showed signs of increased braf protein activity. Consistent with the idea that increased braf activity had a role in the development of the tumo...

Natural secretion marks difference between mole and melanoma

...verted to a therapeutic." Mutations that leave braf permanently activated are found at high frequency ... proliferation and tumor growth. Yet activating braf mutations are also present in up to 82 percent of ... very rarely, and studies have shown that the same braf mutations tied to cancer also cause pigment-produc...

Genome-wide survey nets key melanoma gene

...single amino acid change in a protein called BRAF. braf is part of a signaling system that is important for cell growth and proliferation. The braf mutation found in nevi and melanoma increases the activity of the braf protein, prompting cells to multiply abnormally. I...
BRAF in Medical Technology

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

...s with advanced melanoma whose cancer harbours the braf mutation (known as mutation-positive ). Patients t...e way by selectively inhibiting the cancer-causing braf mutation, and is being developed in parallel with ...otential use in a number of cancers harbouring the braf mutation. They are also co-developing the diagnost...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

...and BRAF-mutated human colorectal cancer cell lines. Recent clinical studies have shown that patients with tumor cells harboring mutations in KRAS and braf oncogenes do not respond to treatment with Erbitux or Vectibix. These patients make up more than 40% of colorectal cancer patients. ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

...colorectal cancer patients with tumor cells harboring mutations in KRAS and braf oncogenes. These two populations make up more than 40% of colorectal cancer...imab/panitumumab-resistant human colorectal cancer cells harboring KRAS and braf mutations, resulting in the destruction of these cancer cells. In mice, dai...

Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement

...tner in this endeavor." About B-Raf Inhibitors braf kinase is one of the most frequently mutated membe...lon, and thyroid cancers. The V600E mutant form of braf kinase in particular has been associated with incr...ra is pursuing two distinct strategies centered on braf inhibition. The first strategy seeks potent and hi...

Kosan Presents Preliminary Phase 2 Data Showing Antitumor Activity of Hsp90 Inhibitor Tanespimycin in Metastatic Melanoma at ASCO

... metastatic melanoma, including one patient with a braf mutation (V600E) who had failed prior chemotherapy... antitumor approach in melanoma, as members of the braf signaling pathway are client proteins and are impl...e patients. One of the 6 evaluable patients with a braf mutation (V600E) showed evidence of anti-melanoma ...
BRAF in Biological News

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

A team of researchers led by scientists at Memorial Sloan-Kettering Cancer Center have discovered that a new class of drugs -- now in early stage clinical trials -- work best in patients with mutations in the BRAF gene. BRAF is a protein that plays a central role in the growth and survival of cance...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

...A 182 also belongs to a cluster located in a genomic region, chromosome 7q, that is frequently amplified in melanoma and contains two other oncogenes; braf and C-MET. The study found a correlation between genomic amplification and miRNA over expression, though it is unclear whether other molecular mechani...

Researchers discover atomic bomb effect results in adult-onset thyroid cancer

...nset papillary thyroid cancers with RET/PTC rearrangements and those with a braf mutation. More than 70 percent of adult onset papillary thyroid cancer in non-exposed patients is associated with mutations in the braf gene. The researchers looked at the genetic profile of cancer patients ...

Presence of gene mutation helps guide thyroid cancer treatment

...ng to new study findings. The mutation, called braf V600E, is a genetic alteration in the braf oncogene, a modified gene believed to cause cancer...cular variant of PTC) to determine the presence of braf V600E and its association with factors such as tum...

Sun exposure early in life linked to specific skin cancer gene mutation

...birth to 20 years old, may specifically increase the risk of melanomas with braf gene mutations. A different mutation, on the NRAS gene, was found in patien...hen analyzed for mutations. Patients with melanomas that contained the braf mutation, found in about half of all melanomas, were more likely to report ...

Important discovery about second most fatal cancer

...ttle evidence of tumour immunity # Frequent mutation of an oncogene called braf (also mutated in cancer of thyroid, ovary, and melanoma) # Frequent DNA me...ore been ignored up to now. These polyps also show mutation of the oncogene braf and DNA methylation. It is likely that the same polyps may sometimes become...

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BRAF in Biological Technology

Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer

...l be responsible for driving diagnostic development, commercial relations, and product introduction including Exosome's new blood based EGFR, KRAS and braf assays. "Greg brings considerable industry expertise to our operating team," said James McCullough, Chief Executive Officer of Exosome Diagn...

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

..."DxS") today announced that they will collaborate on the development of blood-based companion diagnostics for key cancer gene mutations, such as KRAS, braf and EGFR. The collaboration will use DxS' industry leading Scorpions(R) real-time PCR Mutation Test Kits in conjunction with ExosomeDX's x OS(TM) te...
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