BAFF

Potential preventative therapy for Type 1 diabetes

...ontaneously develop Type 1 diabetes, Eliana Mario found that if she blocked baff (a hormone that controls survival of B cells) prior to onset, none of the m...h with the compound. The molecule used by Grey and colleagues to inhibit baff is known as BCMA, and is already being used in clinical trials for other au...

How molecules out of balance lead to human multiple myeloma and other cancers

..., an enzyme that acts closely with BAFF, the substance that regulates the number of B cells in our bodies. Work done previously by Professor Mackay on baff showed that levels correlate with B cell hyperplasia (expansion) and cancer. The current study shows that if we have too much NIK in our systems, then...

BAFF in Biological News

Protein amplification in melanoma is possible drug target

...and BAFF, to trigger the signal for B cells to mature. Geha believes that additional cases of immune deficiency result from mutations in the APRIL and baff genes, and plans to verify this in further studies. ...

Gene for immune deficiency syndromes found

...and BAFF, to trigger the signal for B cells to mature. Geha believes that additional cases of immune deficiency result from mutations in the APRIL and baff genes, and plans to verify this in further studies. ...

BAFF in Biological Technology

Lilly Highlights Transformation Strategy for Wall Street, Reviews Robust Pipeline and Sets 2009 Financial Guidance

...inical trials in the near future, while IL-23 entered Phase I in 2008. The company also anticipates initiating larger Phase II clinical trials for its baff antagonist antibody and IL-1beta in the near future. Dr. Eric Rowinsky, M.D., executive vice president and chief medical officer of Lilly's wh...

MedImmune Presents Data Highlighting its Progressive Inflammatory Disease Portfolio at the 72nd Annual Meeting of the American College of Rheumatology

... 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1346 -- Neutralizing IFN-alpha in SLE affects GMCSF, TNF-alpha, IL-10, IL1-beta and baff signaling pathways - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1340 -- Memory T lymphocytes ...

Anthera Pharmaceuticals Forms Scientific Advisory Board

...ting Phase 2 studies in 2008. BAFF, a tumor necrosis factor family member, is critical for the survival and maturation of B cells. AMG 623 is a potent baff antagonist that is being developed as a treatment for B-cell dependent autoimmune diseases and is initially targeted for SLE. About Anthera Pharmace...