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BACE in Medical News

Mardil Inc. Appoints Medical Device Veteran Daniel A. Pelak to Its Board of Directors

...ound to our board." The Mardil device, called bace (basal annuloplasty of the cardia externally), beg... internationally in the third quarter of 2009. The bace device serves as a tension band that encircles the...valve repair and replacement techniques. "The bace device is truly a breakthrough technology that has...

Common anesthetic induces Alzheimer's-associated changes in mouse brains

...nced levels of the Alzheimer's-associated proteins bace and A-beta," says Zhongcong Xie, MD, PhD, of the M...he cell-death protein caspase and raised levels of bace and gamma-secretase as part of a pathway leading t...hours showed that caspase levels were elevated and bace had modestly increased in mice that received isofl...

Alzheimers Disease Enzyme may Interfere With Brain Function

...precursor protein (APP) is clipped by two enzymes bace and gamma-secretase which releases the amyloid-be...tudies from Kovacs team and others showed that the bace and gamma-secretase enzymes that release amyloid-b... beta2 subunit, similar to APP, can be acted on by bace and gamma-secretase, releasing a portion of the be...

Alzheimer's-associated Enzyme Linked to Seizures

...precursor protein (APP) is clipped by two enzymes, bace and gamma-secretase, which release the amyloid-bet...s (MGH-MIND). Earliers studies have shown that the bace and gamma-secretase enzymes also work on the beta2... beta2 subunit, similar to APP, can be acted on by bace and gamma-secretase, releasing a portion of the be...
BACE in Medical Technology

Mardil Inc. Advances Its Novel Cardiac Device to First-In-Human Trials for Mitral Valve Regurgitation

...o treating mitral regurgitation. "We designed bace to reduce the significant costs, side effects and ...r stopping the heart to implant the device." bace represents a departure from current devices becaus...ly normal." In addition, the novel feature of bace is that it can be remotely adjusted through ports ...
BACE in Biological News

Alzheimer's disease drug treats traumatic brain injury, report GUMC researchers

...ered and untreated "normal" mice, brain injury resulted in a rapid accumulation of beta amyloid, along with cognitive and motor deficits. But DAPT and bace knock-out mice had brain lesions that were as much as 70 percent smaller than control animals and they experienced minimal impairment. The findings...

How neuronal activity leads to Alzheimer's protein cleavage

... is why neuronal activity should cause APP to jump from syntaxin domains to bace domains. What is clear, however, is that the process is an active one, requ...is currently in trials for cancer treatment, reduced APP's association with bace microdomains and reduced APP cleavage. ...
BACE in Biological Technology

New Pharmaceutical Company to Target Alzheimer's Disease

...sease sufferers. In addition, Archer Pharmaceuticals, Inc. has several other agents in the preclinical stage, including Gamma Secretase Inhibitors and bace Inhibitors. These approaches are designed to attack the Alzheimer's disease soluble amyloid in different ways, providing complementary approaches to t...
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