Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

..., Massachusetts, aims to understand how autophagy, the process of cellular "self-cannibalism," is involved in a large number of cancers. Learning how autophagy is coordinated with other cellular processes will better elucidate its multiple roles in cancer. Taiowa A. Montgomery, PhD, with his sponsor Gary R...

Scientists advance safety of nanotechnology

...ophagic cell death. They also showed that using an autophagy inhibitor prevented the cell death and counteract...eath through the Akt-TSC2-mTOR signalling pathway. autophagy is a process that degrades damaged materials in a...archers also found that treating the cells with an autophagy inhibitor known as 3MA significantly inhibited th...

Enhancing the effects of the drug used to treat chronic myeloid leukemia

...tent with studies indicating that the induction of autophagy can provide a mechanism of cellular survival, suppression of autophagy using either drugs or RNA interference enhanced im.... The authors therefore suggest that inhibitors of autophagy might be used with imatinib mesylate or other drug...

JCI online early table of contents: April 13, 2009

...tent with studies indicating that the induction of autophagy can provide a mechanism of cellular survival, suppression of autophagy using either drugs or RNA interference enhanced im.... The authors therefore suggest that inhibitors of autophagy might be used with imatinib mesylate or other drug...

Experimental Biology 2009 meets April 18-22

...the biology of aging, cancer stem cells, the epigenetic pathogenesis of cancer, advances in the pathobiology of angiogenesis, circulating tumor cells, autophagy (digestion of cells by enzymes originating within those same cells) in cardiac disease and atherosclerosis, interdisciplinary approaches to liver dise...

Helicobacter pylori can multiply in autophagic vesicles

...e patients, but not standard strains, can multiply in the double-layered vesicles of macrophages. The senior author, Dr. Huan-Yao Lei stated that "The autophagy induction by H. pylori is not only found in macrophages, but also in dendritic cells and gastric epithelial cells". This new finding has several imp...

Dormant cancer cells rely on cellular self-cannibalization to survive

...mechanism for dormant cancer cells. "Prolonged autophagy is lethal to cancer cells, but a little autophagy can help dormant cancer cells survive, possibly by...estored to ovarian cancer cells in the laboratory, autophagy was induced and cancer cells died within a few day...

Toxicity mechanism identified for Parkinson's disease

...agues began examining how alpha-synuclein influenced MEF2D after a report from another laboratory on disposal of alpha-synuclein by chaperone-mediated autophagy (CMA). During CMA, certain selected proteins are funneled into lysosomes, compartments of the cell devoted to chewing up discarded proteins. Mao an...

Protein compels ovarian cancer cells to cannibalize themselves

...fective cells die from self-induced damage to their nuclei and DNA complex. autophagy kills when a cell entraps parts of its cytoplasm in membranes and digests t...s growth effects. Now they've found that PEA-15 in the cytoplasm induces autophagy in cancer cells, a second method of inhibiting cancer growth. "These two v...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

... MONDAY, DECEMBER 8th Abstract 3663 TITLE: Combination of Nab-Rapamycin and Perifosine Induces Synergistic Cytotoxicity and Antitumor Activity Via autophagy and Apoptosis in Multiple Myeloma (MM) Session Name: Myeloma - Pathophysiology / Preclinical Studies excluding Therapy Poster III Presentation Ti...

Autophagy in Medical Technology

Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction

...rastic reduction of TG2 expression (up to 94 percent) and telltale signs of autophagy in the cancer cells, which became riddled with cavities called vacuoles. When autophagy occurs, a double membrane forms around a cell organ, or organelle. This aut...

Innovive Pharmaceuticals Announces Additional Data Presentations at American Association for Cancer Research Annual Meeting

...pril 16, 2007, 8:00 a.m. - 12:00 p.m. Location: Exhibit Hall, Los Angeles Convention Center Presentation Title: "Cell death and autophagy induced by INNO-406, a novel Bcr-Abl inhibitor, in Philadelphia leukemias" Abstract Number: 27...

Autophagy in Biological News

Muscle atrophy through thick but not thin

...hers fall victim to other ubiquitin ligases and autophagy. Inhibitors that work upstream to block signals that activate ubiquitin ligases and initiate autophagy are a better bet. ...

Self-digestion as a means of survival

...oteins and cellular organs. The process - known as autophagy - takes place in special organelles called autopha...s and organelles they should degrade. "Although autophagy has been known for more than 30 years, it is aston...irkin immediately began their search for potential autophagy receptors that might bind to the family of ATG8 pr...

Einstein scientists receive $10 million NIH grant

...l cell process that may hold the key to aging. autophagy (which literally means "self-eating") refers to se...be used as fuel. Many studies have documented that autophagy becomes less efficient with age, allowing protein ...olleagues will test their hypothesis that impaired autophagy may explain the decline in organ function, weakene...

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

...ome, its level was increased upon the induction of autophagy in macrophages, and reduced when autophagy was suppressed. This indicates cross-talking between autophagy and phagocytosis that may play an important role i...

Form of Crohn's disease traced to disabled gut cells

...ts conducted a follow-up experiment where a related gene, Atg5, was knocked out in mice. Like Atg16L1, Atg5 contributes to an important process called autophagy that lets cells consume and reuse their own resources and may have other functions as well. Paneth cells in this line of mice had impairments similar ...

Breast cancer cells recycle to escape death by hormonal therapy

...(Ehrlich II) Oct. 3-5 in Nrenberg, Germany. It's called macroautophagy autophagy means "self eating" and within a week, breast cancer cells can reorganize ...with an antiestrogen and measure cell death. "Most cancers probably use autophagy as a survival mechanism. You can either block the autophagosome with your t...

Cellular self-eating promotes pancreatitis

... called autophagy. But as Hashimoto et al. reveal, autophagy can have a down side, destroying the pancreas by p...overed that in mice with pancreatitis the level of autophagy in pancreatic cells surges. Pancreatitis occurs wh...a pancreatic cell. Hashimoto et al. tested whether autophagy promotes this early activation by delivering tryps...

International team identifies 21 new genetic risk factors for Crohn's disease

... Several of these are involved with the immune system's inital response to pathogens, supporting earlier evidence that disruptions in a process called autophagy may lead to the disorder's characteristic immune system overactivity. The report will appear in the journal Nature Genetics and is receiving early o...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

...re Lab. "We knew- said Michael Sherman- that polyQ aggregates are destroyed in cells by a special degradation system, called autophagy. Interestingly, autophagy plays a key role in the processing of certain antigens, which is critical for the immune response. So, attachment of a polyQ tail should specifically...

Researchers discover architecture for fundamental processes of life

... that controls recycling of the molecular building blocks of life called autophagy. These processes are implicated in diseases such as cancers and autophagy has recently been shown to be involved in degenerative neurological disorders such as Alzheimer's and Huntington's diseases. The discovery will fill g...

Autophagy in Biological Technology

Prous Institute Presents Innovative Approach to Drug Discovery

...y programs are being developed at the Institute. One is focused on the design, synthesis and biological evaluation of new small-molecule modulators of autophagy as therapeutic agents for cancer and neurodegeneration (Alzheimer's disease and Huntington's disease). Another program looks at target-driven drug dis...

Autophagy in Biological Products

Rabbit Anti-APG5L Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... APG5 autophagy 5-like (S. cerevisiae)...
Company:Proteintech Group, Inc.

Autophagy in Biological Dictionary

Cell vacuole

...ze of the cell . ... The vacuole typically is 50% of the volume of the cell , yet it can take up to 95 ... Vacuoles also play a major role in autophagy (degradation of a cell's own ... The vacuole is a major part in the plant and animal cell . ... The vacuole is an organelle that occup...