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Autoimmunity in Medical News

Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk

Do You Know Your Family AQ? DETROIT, April 3, 2008 /PRNewswire-USNewswire/ -- What do former President George H.W. Bush, Fox Business News anchor Neil Cavuto, comedian and actor Bernie Mac, Poison lead singer and reality television star Bret Michaels and Seattle Seahawks wide receiver Bobb...

JDRF to establish an autoimmunity center at University of Colorado Denver

AURORA, Colo. (Jan. 28, 2008) Researchers at the Barbara Davis Center for Childhood Diabetes at the University of Colorado Denver have new resources in their fight against type 1 diabetes: The Juvenile Diabetes Research Foundation has approved funding for the establishment of a JDRF Autoimmunity ...

Celiac Disease Provides Clues To Solving Autoimmunity

DEERFIELD BEACH, Fla., Aug. 6 /PRNewswire/ -- According to an article published in Scientific America, a study of potentially fatal food-triggered disease has uncovered a process that may contribute to many autoimmune disorders. The epidemiology of celiac disease that once wa...

Vitamin A signals offer clues to treating autoimmunity

Distributed around the body, dendritic cells act as the security alarms of the immune system. After sensing the presence of intruders, dendritic cells can transmit the alarm to white blood cells or tell them to relax, depending on the signals they send out. Researchers at the Emory Vaccine Cen...

NIH scientists find a novel mechanism that controls the development of autoimmunity

Scientists at the National Institutes of Health (NIH) have found a mechanism in the immune systems of mice that can lead to the development of autoimmune disease when turned off. The findings shed light on the processes that lead to the development of autoimmunity and could also have implications ...

St. Jude study shows how T cell's machinery dials down autoimmunity

A St. Jude Childrens Research Hospital study shows that T cells, the bodys master immune regulators, do not use simple on/off switches to govern the cellular machinery that regulates their development and function. Rather, they possess sophisticated molecular controls that enable them to adjust th...

Chopped up proteins trigger autoimmunity

He has also discovered that PM/Scl-75, one of the components from which the exosome is built, is cut as soon as a cell dies. Finally, Schilders has identified an exosome-associated protein that is also frequently recognised by antibodies. These antibodies possibly form an interesting additional ma...

Sunlight May Cause Rash in Autoimmune Disease

...and causes distinctive rashes, instead of the form called polymyositis that does not have a rash," Dr. Frederick W. Miller, chief of the Environmental autoimmunity Group at the National Institute of Environmental Health Sciences, said in a news release. "Although we have not shown a direct cause-and-effect lin...

Sun exposure may trigger certain autoimmune diseases in women

...tinctive rashes, instead of the form called polymyositis that does not have a rash," said Frederick W. Miller, M.D., Ph.D., chief of the Environmental autoimmunity Group, Program of Clinical Research, at NIEHS. "Although we have not shown a direct cause and effect link between UV exposure and this particular auto...

Study aims to induce recovery from ankylosing spondylitis

...discoveries published by the California non-profit autoimmunity Research Foundation (ARF) with the medical experti...ed and more formalized version of a trial that the autoimmunity Research Foundation has been conducting over the p...in Tom Perez at the 2008 International Congress on autoimmunity in Portugal. "As a physician who has seen hundr...
Autoimmunity in Medical Technology

St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity

Immune cells adjust their function like a radio dial, not an on/off light switch; a discovery that hints at how autoimmune disease may develop late in life MEMPHIS, Tenn., May 12 /PRNewswire-USNewswire/ -- A St. Jude Children's Research Hospital study shows that T cells, the body's master ...

Getting More From Whole-Transcript Microarrays

...pies that have changed the face of disease and human health worldwide. Today they are focused on four big global medical challenges: cancer, immunity, autoimmunity and infectious diseases. The Walter and Eliza Hall Institute is located at Parkville, Victoria where it will soon be housed in a state-of-the-art new ...

Epidemics of Both Type 1 Diabetes (Insulin Dependent) and Type 2 Diabetes (Obesity Related) Are Linked to Immunization

...The picture is becoming clear. Not only are vaccines causing an epidemic of autoimmunity including type 1 diabetes but they are causing an epidemic of metabolic syndrome as the immune system acts to suppress the inflammation and autoimmunity caused by the vaccines. The current practice of vaccinating diabetics as we...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

... blood cell count), thrombocytopenia (low platelet count) and neutropenia (low neutrophil count); thyroiditis (inflammation of the thyroid gland); and autoimmunity (production of antibodies against the body's own tissues). About Peg-IFN Interferon is a protein produced naturally by white blood cells to help t...

Merrimack Pharmaceuticals Completes Enrollment in a Phase 2 Study of MM-093 in Patients with Rheumatoid Arthritis

... Merrimack Pharmaceuticals, Inc., is a biotechnology company focused on the discovery and development of novel treatments for diseases in the areas of autoimmunity and cancer. Its lead compound, MM-093, is currently in clinical development to treat patients with rheumatoid arthritis or with autoimmune uveitis. MM...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

...endritic cells, which are thought to produce proinflammatory cytokines, which further contribute to disease process. Other studies have indicated that autoimmunity in rheumatoid arthritis (RA) and psoriasis also is mediated through one or more of these TLRs. Coley evaluated and selected TLR7, 8 and 9 as importan...

New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments

...mber 6th with an accompanying editorial. In this paper, the scientists identified another risk gene -- TRAF1-C5. "The identification of these two new autoimmunity genes has profound significance for our understanding of these complex diseases and our ability to develop more specific diagnostic tests and therapie...

MedImmune Publishes New Data in Nature Immunology Demonstrating The Role HMGB1 May Play in Systemic Autoimmune Diseases

...thology of lupus and the role of B cells in autoimmunity," said Anthony J. Coyle, vice president, research and development, and head, inflammation and autoimmunity research. "These data, applicable to several programs within our pipeline, demonstrate a novel mechanism by which HMGB1 mediates B cell activation and...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...ly focused on the role of B cells in autoimmunity," said Anthony J. Coyle, Ph.D., vice president, research and development, and head, inflammation and autoimmunity research. "These data provide new insight into the mechanisms by which the pro-inflammatory protein HMGB1, implicated in the activation of B cells, ma...

Mymetics' HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model

...ative HIV proteins may lead to cross-reactions toward human proteins and, consequently, increased risk of developing potential long-term autoimmunity side effects after vaccination with unmodified HIV proteins. Mymetics' concept is to use a small engineered HIV protein sequence (gp41)...
Autoimmunity in Medical Definition

Autoimmune regulator

... is a human gene which is expressed in the thymus . It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self. It is mutated...

Central tolerance

...ylatoxins ) • Cytokines • White blood cells • Antibody ( Monoclonal antibodies , Autoantibody ) • Antigen • APC • MHC Immunity • autoimmunity • Tolerance ( Central ) • Immunodeficiency Phagocyte • Opsonin • Reticuloendothelial system Allotype • Isotype • Idiotype ...

Pathology

...s may be incited or exacerbated by a variety of external and internal influences, including trauma , infection , poisoning , loss of blood flow , autoimmunity , inherited or acquired genetic damage , or errors of development . One common theme in pathology is the way in which the body's responses to injury...

Thymocyte

... regulatory T cells . If these peripheral tolerance mechanisms also fail, autoimmunity may arise. Thymus Settling Thymocytes are ultimately der...uld be capable of activating an immune response against self, resulting in autoimmunity . Negative selection is the process evolved to reduce this risk. During neg...

Unsolved problems in medicine

...ing measurable results with a variety of experimental inputs? Chronic Urticaria . What is the cause of such a disease? Can it be pinpointed as an autoimmunity or is it frankly idiopathic? Can it be cured or can the symptoms merely be controlled? Spinal cord injury . Is it possible to completely repair les...
Autoimmunity in Medical Dictionary

Autoimmune thyroiditis

...le please ... dog health problems, dog health, dog hip displasia, pano, dog shedding, dog itchy ... Autoimmune thyroiditis and polyglandular autoimmunity of purebred dogs. ... ...

Autoimmune disorders

...mmune Disorders : Immune Disorders : Merck Manual Home Edition" ... Celiac disease: a multisystem autoimmune disorder " ... autoimmunity is the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any...

Autoimmune Diseases

...n the body. In other words, the body really attacks its own cells. This may be restricted to certain organs or involve a particular tissue in... autoimmunity is the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any...

Autoimmune disease

...n the body. In other words, the body really attacks its own cells. This may be restricted to certain organs or involve a particular tissue in... autoimmunity is the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any...
Autoimmunity in Biological News

Stopping autoimmunity before it strikes

Oslo, Norway MA Current research describes a new method to track the development of autoimmune diseases before the onset of symptoms. The related report by Zangani et al, "Tracking early autoimmune disease by bioluminescent imaging of NF-κB activation reveals pathology in multiple organ sys...

New insights into autoimmunity and depression

Systemic lupus erythomatosus (SLE), often simply called lupus, is a complex autoimmune disease marked by joint pain, skin rashes, extreme fatigue, and depression, among other symptoms. Some studies have described a possible link between SLE’s most severe psychiatric manifestation, psychosis, and a ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

...that must be destroyed. "Because cyclin B1 is a 'self' protein, there have been concerns that boosting the immune response against it would produce autoimmunity and create new problems," Dr. Finn said. "But now that we know that perhaps 20 to 30 percent of people already recognize it as abnormal when made in e...

Omega fatty acid balance can alter immunity and gene expression

... shift has brought about an increased risk of inflammation (associated with autoimmunity and allergy), and now using a controlled diet study with human volunteers, ...ls of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that pro...

Genetic study confirms the immune system's role in narcolepsy

...the disorder. "The link between narcolepsy and autoimmunity was proposed decades ago, but efforts to verify it...eatedly. Current findings leave little doubt that autoimmunity plays a role," says Merrill Mitler, Ph.D., a progr...lepsy-cataplexy. Until now, the best evidence for autoimmunity as a cause of the disorder was the discovery that ...

Vitamin D may exacerbate autoimmune disease

... regarded as contributing to autoimmune disease, but a review appearing in autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune ...se. Authored by a team of researchers at the California-based non-profit autoimmunity Research Foundation, the paper goes on to point out that molecular biologis...

Fireflies and jellyfish help illuminate quest for cause of infertility

...tified cells producing prolactin throughout the body. This included the pituitary gland, the thymus an organ in the chest which helps protect against autoimmunity the spleen and inflammatory cells in the abdominal cavity. ...

New scientific knowledge on juvenile diabetes

...sis of type 1 diabetes has been the development of autoimmunity to pancreatic beta cells in the measurable form of islet autoantibodies. Although the autoimmunity usually precedes the clinical disease by months to...y lysophosphatidylcholines several months prior to autoimmunity to pancreatic beta cells. The metabolic profile wa...

JDRF announces 2008 Scholar Award recipients

...ne, who has a long-term commitment to the field of autoimmunity and immune intolerance, received the award for his... Dr. Bluestone's project will advance knowledge in autoimmunity and accelerate the pace of research JDRF promotes. Steady progress in autoimmunity research will eventually lead to approaches to kil...

UT pathologists believe they have pinpointed Achilles heel of HIV

...o other virus uses this trick to evade the body's defenses." Paul is the senior author on a paper about this theory in a June issue of the journal autoimmunity Reviews . Additional data supporting the theory are to be presented at the XVII International AIDS Conference Aug. 3-8 in Mexico City in two studies t...
Autoimmunity in Biological Technology

Merrimack Pharmaceuticals Promotes Ulrik B. Nielsen, Ph.D. to Chief Scientific Officer and Edward J. Stewart to Senior Vice President of Business Development

...ck Pharmaceuticals, Inc., is a biotechnology company focused on the discovery, design and development of novel treatments for diseases in the areas of autoimmunity and cancer. Its first oncology product, MM-121 is currently in Phase 1 clinical development. MM-121 is an investigational drug and has not been approv...

More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization

...The picture is becoming clear. Not only are vaccines causing an epidemic of autoimmunity including type 1 diabetes but they are causing an epidemic of metabolic syndrome as the immune system acts to suppress the inflammation and autoimmunity caused by the vaccines. Current data shows that vaccines are much more dang...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist

...ck Pharmaceuticals, Inc., is a biotechnology company focused on the discovery, design and development of novel treatments for diseases in the areas of autoimmunity and cancer. Its autoimmune candidate, MM-093, is currently in Phase 2 clinical development. Its first oncology product, MM-121 is currently in Phase 1...

Merrimack Pharmaceuticals Raises $60 Million in Private Financing

...ck Pharmaceuticals, Inc., is a biotechnology company focused on the discovery, design and development of novel treatments for diseases in the areas of autoimmunity and cancer. Its lead compound, MM-093, is currently in clinical development to treat patients with rheumatoid arthritis or with autoimmune uveitis. MM...

Depth of MedImmune's Respiratory Disease Research Program Highlighted at Annual Meeting of the American Thoracic Society

...committed to finding innovative solutions that may one day help patients struggling with respiratory diseases," said Tony Coyle, vice president, head, autoimmunity inflammation and respiratory disease research. "We are pleased to present a plethora of promising data that could potentially address diseases such as...

FDA Grants Priority Review for Schering-Plough's Peginterferon Alfa-2b for the Adjuvant Treatment of Patients With Stage III Melanoma

... blood cell count), thrombocytopenia (low platelet count) and neutropenia (low neutrophil count); thyroiditis (inflammation of the thyroid gland); and autoimmunity (production of antibodies against the body's own tissues.) Depression and suicidal behavior, including suicidal ideation, suicidal attempts and comp...

Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9

... new approach for the treatment of lupus. The ability of IRS 954 to specifically intervene in the inappropriate immune signaling cascade that leads to autoimmunity may have application for other autoimmune diseases as well." IRS 954 represents a novel class of oligonucleotides, named immunoregulatory sequences ...

World Think Tank on Type 1 Diabetes Meets in Miami

...on the use of adult stem cells in the reversal of type 1 diabetes. He will also talk about the critical immunologic steps that lead to autoimmunity in type 1 diabetes and the use of this information to prevent and possibly cure type 1 diabetes. Umbilical Cord Infusion to R...

ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles

...at can rapidly predict T-cell antigens in any protein sequence. It is widely applicable across many disease areas such as cancer, infectious diseases, autoimmunity and in transplantation, and is ideally suited to therapeutic programmes with time pressures, such as the development of vaccines for emerging diseases...

Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium

...lba Nova University Center, Department of Proteomics (Sweden) - "Multiplexed Approaches within Antibody Proteomics" -- Dr. Corrado M. Cilio, Cellular autoimmunity Unit, Department of Clinical Sciences and Pediatrics, Malmo University Hospital (Sweden) - "MicroRNA" -- Dr. Oliver Poetz, NMI, Natural and Medical S...
Autoimmunity in Biological Definition

Immunology

... adequate response (examples include chronic granulomatous disease ), and autoimmunity , in which the immune system attacks its own antigens (examples include sy...pathogens) by their chitinous shells. See Also Immune system autoimmunity References Goldsby RA, Kindt TK, Osborne BA and Kuby J (2003) I...

Liver

...from the blood and excretes it through bile. Hepatitis , inflammation of the liver, caused mainly by various viruses but also by some poisons, autoimmunity or hereditary conditions. Cirrhosis is the formation of fibrous tissue in the liver, replacing dead liver cells. The death of the liver cells can...
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