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Atrophy in Medical News

Study Evaluating Efficacy and Safety of Two Low-dose Regimens of PREMARIN Vaginal Cream for the Treatment of Moderate to Severe Vaginal Atrophy Now Published

COLLEGEVILLE, Pa., July 13 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), announced the publication of data that supported daily and twice-weekly use of PREMARIN((R)) (conjugated estrogens) Vaginal Cream 0.5 g to relieve some of the bothersome s...

Measuring brain atrophy in patients with mild cognitive impairment

Scientists at the University of California, San Diego School of Medicine have shown that a fully automated procedure called Volumetric MRI which measures the "memory centers" of the brain and compares them to expected size is effective in predicting the progression from mild cognitive impairment...

Families of Spinal Muscular Atrophy Announces its New Medical Advisory Council

LIBERTYVILLE, Ill., May 19 /PRNewswire-USNewswire/ -- Families of Spinal Muscular Atrophy has just launched a new Medical Advisory Council (MAC). The Families of SMA MAC is one of the most highly respected bodies of SMA medical and clinical experts in the U.S., setting the agenda for proactive, c...

MRI shows brain atrophy pattern that predicts Alzheimer's

OAK BROOK, Ill. Using special MRI methods, researchers have identified a pattern of regional brain atrophy in patients with mild cognitive impairment (MCI) that indicates a greater likelihood of progression to Alzheimer's disease. The findings are published in the online edition of Radiology . ...

Researchers discover target that could ease spinal muscular atrophy symptoms

COLUMBIA, Mo. There is no cure for spinal muscular atrophy (SMA), a genetic disorder that causes the weakening of muscles and is the leading genetic cause of infant death, but University of Missouri researchers have discovered a new therapeutic target that improves deteriorating skeletal muscle t...

Molecular therapy for spinal muscular atrophy closer to clinical use

COLUMBIA, Mo. Spinal muscular atrophy, a neurodegenerative disorder that causes the weakening of muscles, is the leading cause of infant death and occurs in 1 in 6,000 live births. While trans-splicing (a form of molecular therapy) has had impressive results as a treatment for spinal muscular a...

Most Fit Have Less Brain Atrophy From Alzheimer's

Even moderate exercise, done regularly, improves quality of life SUNDAY, July 27 (HealthDay News) -- Physical fitness can help the mind, body and quality of life of people with early Alzheimer's disease and dementia, according to new research. "These studies reinforce the need for...

A rare diagnosis in the operation room: Kidney atrophy due to duplicated colon in an adult

Gastrointestinal congenital anomalies are rare entities in an adult patient. Commonly they are located in the upper gastrointestinal system and present with intestinal symptoms such as bleeding, obstruction and/or perforation of the intestine. One extraordinary case of colon duplication was recent...

PTC Therapeutics Announces Additional $1.6 Million Grant from the Spinal Muscular Atrophy Foundation

Expanded Collaboration Focuses on Discovery of Small-Molecule Drugs for Spinal Muscular Atrophy SOUTH PLAINFIELD, N.J., Dec. 6 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development, and commercialization of small-...

Brain atrophy in elderly leads to unintended racism, depression and problem gambling

As we age, our brains slowly shrink in volume and weight. This includes significant atrophy within the frontal lobes, the seat of executive functioning. Executive functions include planning, controlling, and inhibiting thought and behavior. In the aging population, an inability to inhibit unwanted...
Atrophy in Medical Technology

Families of Spinal Muscular Atrophy Announces Latest Developments on Three SMA Drug Discovery Programs

LIBERTYVILLE, Ill., June 18 /PRNewswire-USNewswire/ -- Families of Spinal Muscular Atrophy has just released details of the latest developments for the Families of SMA funded therapeutic pipeline. Families of SMA is currently funding three distinct drug discovery programs: 1) Quinazolines to ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

ANN ARBOR, Mich., March 31 /PRNewswire/ -- QuatRx Pharmaceuticals, a privately-held biopharmaceutical company, today announced that it has completed enrollment in the Company's second pivotal Phase 3 clinical trial of Ophena(TM) (ospemifene tablets). Together with the previously completed firs...

QuatRx Pharmaceuticals Announces Additional Data From Phase 3 Study for Ophena(TM) (Ospemifene Tablets) Showing Improvements in Clinical Symptoms of Vulvovaginal Atrophy

Separate survey shows high prevalence of "bothersome" vaginal atrophy symptoms among sexually active and non-sexually active postmenopausal women; results presented today at 19th Annual North American Menopause Society Meeting ANN ARBOR, Mich., Sept. 24 /PRNew...

Quatrx Pharmaceuticals Presents Results From Ophena(TM) (Ospemifene Tablets) Phase 3 Study Related to Treatment of Symptoms of Vulvovaginal Atrophy

Results presented at the 90th annual Endocrine Society meeting show significant improvements among women affected by moderate to severe vaginal dryness and painful intercourse ANN ARBOR, Mich, June 16 /PRNewswire/ -- QuatRx Pharmaceuticals today announced detailed primary ...

QuatRx Pharmaceuticals Announces Presentation of Further Data from Ophena(TM) (Ospemifene) Phase 3 Study for Treatment of Symptoms of Vulvovaginal Atrophy

Results presented at 12th World Congress on the Menopause show significant improvement in vaginal dryness and dyspareunia, two of the most frequent symptoms associated with vulvovaginal atrophy ANN ARBOR, Mich., May 21 /PRNewswire/ -- QuatRx Pharmaceuticals today announced further...

Genzyme Genetics Announces Launch of Carrier Testing and Prenatal Diagnosis for Spinal Muscular Atrophy

Motor Neuron Disease is Leading Cause of Death for Infants WESTBOROUGH, Mass., April 14 /PRNewswire-FirstCall/ -- Genzyme Genetics, a business unit of Genzyme Corporation (Nasdaq: GENZ ), announced today that it is the first national laboratory specializing in reproductive testing to p...

New Position Statement from The North American Menopause Society Addresses Use of Local Estrogen for Treatment of Vaginal Atrophy in Postmenopausal Women

CLEVELAND--(BUSINESS WIRE)--May 10, 2007 - An evaluation of the safety and effectiveness of local vaginal estrogen therapy for the treatment of vaginal atrophy, a frequent complaint of postmenopausal women, has just been released by The North American Menopause Society (NAMS). Entitled "The role of...

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... the frequency and severity of hot flushes and improved measures of vaginal atrophy when compared to placebo. In this study, uterine bleeding was not statistic... the frequency and severity of hot flushes and improved measures of vaginal atrophy compared with placebo. In this study, analysis of most clinical laboratory ...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

... associated with nucleosides, which can include neuropathy, myopathy, renal toxicity, hepatic steatosis, lactic acidosis, bone marrow suppression, fat atrophy and, with certain agents, increased risk of myocardial infarction.(5-7) About the Phase II Naive Study This randomized, control...

Sirion Therapeutics Announces Clinical Data Presentations at the 2009 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting

...e II clinical trial in the treatment of geographic atrophy (GA) associated with age-related macular degenerat...cacy of Fenretinide in the Treatment of Geographic atrophy in Subjects with Age-Related Macular Degeneration:...cacy of Fenretinide in the Treatment of Geographic atrophy in Subjects with Age-Related Macular Degeneration:...
Atrophy in Medical Products

Vacurect

Description:... and their physicians because of the very positive associated benefits. In fact, Vacuum Therapy should be used as a daily exercise to prevent atrophy and to promote penile health. Evidence from leading urologists promotes the idea that this treatment improves penile health by restoring adequate bloo...
Company:Bonro Medical, Inc.

VACO®PED

Description:...n not be influenced, the circumstances of treatment can be altered significantly. Excessive stiffness of the ankle joint as well as excessive muscular atrophy can be avoided due to the fact that immediate access to the patient's lower leg can be made available, e.g. for physiotherapy. (Please refer to "Studi...
Company:OPED Inc.

The Carpal Solution

Features:...g sleep with active use during the day. This results in an ideal rhythmic therapy for rapid relief from Carpal Tunnel Syndrome symptoms with no muscle atrophy or down time. The hand rehabilitates through normal use once pain is relieved. The Carpal Solution has been shown to enhance blood circulation t...
Company:First Hand Medical

Bledsoe Adjustable Knee Brace

Features:... Adjustable from 22" to 34" (56 cm to 86 cm) in length and up to 34" (86 cm) in leg circumference; adjusts for atrophy and edema; adapts as the patient progresses. Open design reduces skin breakdown over long-term use; the open cell foam padding provides greater comf...
Company:Bledsoe Brace Systems

SofTec Genu

Features:...rigidity The knit controls A/P laxity, provides full soft tissue control and supports muscle activity- enhancing muscle strengthening and preventing atrophy Viscoelastic insert controls edema, increases proprioception, controls the patella and provides an easy, consistent fit every time "Technically in...
Company:Bauerfeind USA, Inc.
Atrophy in Medical Definition

Muscle atrophy

Muscle atrophy refers to a decrease in the size of skeletal muscle, which occurs in a variety of settings. Atrophy may or may not be distinct from " sarcopenia ", which is the loss of muscle seen in the aged. When a muscle atrophies, it necessarily becomes weaker, since the ability to exert forc...

Cachexia

... Cachexia ( pronounced [kəˈkɛksiə] ) is loss of weight , muscle atrophy , fatigue, weakness and significant loss of appetite in someone who is no...ing, which hits the skeletal muscle especially hard, resulting in muscle atrophy . Mechanism The exact mechanism in which these diseases cause c...
Atrophy in Medical Dictionary

Atrophy

Atrophy is the partial or complete wasting away of a part of the body. Causes of atrophy include poor nourishment, poor circulation, loss of hormonal support, loss of nerve supply to the target organ, disuse or lack of exercise or disease intrinsic to the tissue itself.... Muscle ...

Spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a neuromuscular disease characterized by degeneration of motor neurons, resulting in progressive muscular atrophy (wasting away) and weakness. The clinical spectrum of SMA ranges from early infant death to normal adult life with only... Spinal mus...

Optic nerve atrophy

Optic atrophy is the loss of some or most of the fibers of the optic nerve . In medicine, " atrophy " usually means "shrunken but capable of regrowth", so some argue that " optic atrophy " as a pathological term is somewhat... OPTIC ATROPHY . DESCRIPTION: D...

Muscular atrophy

Muscle atrophy is defined as a decrease in the mass of the muscle; it can be a partial or complete wasting away of muscle. When a muscle atrophies, it becomes weaker, since the ability to exert force is related to mass; muscle atrophy is a co-morbidity of several common... Spinal mus...

Muscle atrophy

Muscle atrophy is defined as a decrease in the mass of the muscle ; it can be a partial or complete wasting away of muscle . When a muscle atrophies, it becomes weaker, since the ability to exert force is related to mass; muscle atrophy is a co-morbidity of several common... Atro...

Multiple system atrophy

Multiple system atrophy (MSA) is a degenerative neurological disorder. MSA is associated with the degeneration of nerve cells in specific areas of the brain. This cell degeneration causes problems with movement, balance and autonomic functions of the body such as... Information sheet on...

Vitamin B-12 level

... High vitamin B12 level in elderly individuals may protect against brain atrophy ... Vitamin B12 levels should be monitored in people taking aminosalicylic acid for ... Your doctor may check your blood to see if yo...

Tennis elbow

...of a slight tear in a ... Tennis Elbow if left untreated can last up to 6 months. ... If Tennis Elbow is not treated properly, muscle atrophy and death can occur. ... Tennis elbow — Comprehensive overview covers symptoms, treatment, prevention of this common overuse in...

Smooth tongue

... Wife's ... Atrophic Glossitis, Smooth Tongue ... Atrophic GlossitisAka: Smooth Tongue . Advertisement. Pathophysiology. Filiform papillae atrophy ... Glossitis is a condition in which the tongue is swollen and changes color. ... of the tongue (called papillae) are lost, causing the ton...

Rigor Mortis

... Rigor mortis (disambiguation) ... Rigor Mortis Similar Artists: Gorefest , Fleshcrawl , Slayer , Metallica , Megadeth , Cannibal Corpse , atrophy , Atheist , Anthrax Genres: Rock Learn what rigor mortis is and why it happens. ... Rigor mortis can be used to help estimate time of deat...

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Atrophy in Biological News

Muscle atrophy through thick but not thin

During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids. In a new study published online June 8 and in the June 15, 2009 print issue of the Journal...

ISU researchers find possible treatment for spinal muscular atrophy

AMES, Iowa - Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world. Ravindra Singh, associate professor in biomedical sciences at Iowa State University's College of Veterinary Medicine, would like to see Spinal Muscular Atrophy lose its high ranking and even slide ...

Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy

Tampa, Fla. (June 16, 2009) To determine if guided fat (adipose) precursor cells (APCs) could improve nerve regeneration and functional recovery, researchers at the University of Pittsburgh (USA) used biodegradable nerve guides to transplant APCs into the injured peripheral nerves of laboratory r...

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

Cold Spring Harbor, NY In the neuromuscular disease called spinal muscular atrophy, or SMA, a protein deficiency caused by a single gene mutation leads to serious damage in growing nerve cells and the muscles they control. Now, in laboratory experiments, researchers at Cold Spring Harbor Labo...

Mice stressed in simulated weightlessness show organ atrophy

New Brunswick, N.J. A ground-based, experimental model used to simulate astronaut weightlessness in space has provided Rutgers scientists an opportunity to study the effects of stress on immune organs. Earlier collaborative research with Japanese scientists employing this model implicated th...

As good as it gets: Octogenarian muscles don't get stronger with exercise

... with a sedentary lifestyle, the fast twitch muscles lose functionality and atrophy more quickly than slow-twitch. From the muscle biopsies, the researcher...eople to build up the muscle before 80," he said. Next steps Muscle atrophy relates not only to aging, but to people whose muscles are immobilized for ...

The Prestige oil spill caused changes in the cell structure of mussels

...the digestive gland of the mussel. Between 2004 and 2005, serious changes were observed in these tissue in the samples from all the locations studied atrophy of certain parts of the digestive gland, for example Measuring health The health of the mussels was studied through the control of certain biom...

Spun-sugar fibers spawn sweet technique for nerve repair

... portion of a nerve cell called the axon, a long fiber attached to the cell body that transmits signals. Fast regeneration is essential to prevent the atrophy of muscles and organs connected to severed nerves. The researchers also discovered that the polymer tubes contain pores that are ideal for supplyin...

Patient-derived induced stem cells retain disease traits

...shes, he couldn't have been more pleased. The dying cells the same type lost in patients with the devastating neurological disease spinal muscular atrophy confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using stem cells...

Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration

...n weight and a significantly reduced mean brain weight/body weight ratio, providing evidence that obesity with T2DM is sufficient to cause mild global atrophy in the brain. De la Monte says, "In essence, the brain shrinks and several biochemical and molecular abnormalities found in patients with AD, incl...
Atrophy in Biological Technology

PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration

Project will advance novel platform for treatment of Spinal Muscular Atrophy SOUTH PLAINFIELD, N.J. and NEW YORK, May 12 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC) and the Spinal Muscular Atrophy (SMA) Foundation today announced the expansion of their research collaboration in which the SM...

Alimera Sciences Begins Pilot Study to Assess Safety and Efficacy of Iluvien(TM) in Patients With Bilateral Geographic Atrophy Due to AMD

ATLANTA, Dec. 11 /PRNewswire/ -- Alimera Sciences Inc., a privately held biopharmaceutical company that specializes in the research, development and commercialization of prescription ophthalmic pharmaceuticals, today reported that enrollment has begun for a pilot study to assess the safety and eff...

Assay Designs(TM), Inc. and the Spinal Muscular Atrophy Foundation Announce Collaboration To Accelerate the Discovery of New Therapeutics for Spinal Muscular Atrophy (SMA)

ANN ARBOR, Mich., Sept. 15 /PRNewswire/ -- Assay Designs and the Spinal Muscular Atrophy Foundation (SMAF) are very pleased to announce a collaborative agreement for development of reagents and assays for SMN (Survival Motor Neuron) protein to expedite drug discovery and development efforts fo...

Families of Spinal Muscular Atrophy; University of California, Irvine Stem Cell Scientist; and California Stem Cell Announce Collaboration for Safety Studies for Stem Cell Therapy in Spinal Muscular Atrophy

Safety Studies Leading to FDA Application for Stem Cell Therapy in SMA will begin in early 2008 LIBERTYVILLE, Ill., Feb. 19 /PRNewswire-USNewswire/ -- Families of Spinal Muscular Atrophy (FSMA); a stem cell scientist at University of California, Irvine (UCI); and California Stem Cell, Inc....

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

...land Capital Partners, MPM Capital and FinTech Global Capital. The initial focus of the company is in neurodegeneration, particularly spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and Parkinson's disease as well as in cardiovascular disease, where iPierian has a collaboration with The G...

iZumi Bio Appoints Dr. Corey Goodman to Board of Directors and Scientific Advisory Board

...ive knowledge and leadership in neurology to help advance our proprietary neurodegenerative programs in amyotrophic lateral sclerosis, spinal muscular atrophy and Parkinson's disease," said John P. Walker, chief executive officer of iZumi. "Over the next few months, we intend to build a world-renowned scient...

EyeIC Receives FDA 510(k) Clearance for MatchedFlicker(TM) Retinal Aid Detection Technology

... Radcliffe added, "Subtle features that might escape detection on side by side review of photographs, such as faint disc hemorrhages or peripapillary atrophy progression, can be spotted easily and in a matter of seconds. The software package is intuitive to use and offers a variety of mark-up tools that fac...

Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors

...ed in a recently completed Phase 2 NT-501 study in patients with geographic atrophy associated with dry age-related macular degeneration (AMD), the results of ...ition to these RP studies, we are actively developing NT-501 for geographic atrophy associated with dry AMD, and plan to initiate a Phase 1 study for our secon...

iZumi Bio Appoints Dr. Berta Strulovici as Chief Technology Officer and Dr. Dushyant Pathak as Vice President of Business Development

...einer Perkins Caufield and Byers and Highland Capital Partners. The initial focus of the company is in neurodegeneration, particularly spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and Parkinson's disease as well as in cardiovascular disease, where iZumi has a collaboration with The Glad...

Sirion Therapeutics Supplemental New Drug Application for Durezol(TM) to Treat Uveitis is Accepted for Review by the FDA

...diverse product portfolio includes products that address ocular diseases and conditions including uveitis, herpetic keratitis, dry eye, and geographic atrophy associated with dry AMD. For more information, please visit http://www.siriontherapeutics.com . ...
Atrophy in Biological Definition

X chromosome

...enne and Becker's muscular dystrophy nonsyndromic deafness and X-linked nonsyndromic deafness Rett syndrome spinal and bulbar muscular atrophy X-linked severe combined immunodeficiency X-linked sideroblastic anemia References Earlier versions of this article contain m...
Atrophy in Biological Dictionary

Sensory neurons

...sory neurons express ASIC3. ... Finally we also exclude an anti-proliferative role of Necdin in developing sensory neurons . ... pronounced atrophy of sensory neurons resulting in a reduction ... Exposing sensory neurons to 1 µM PGE2 produced a twofold increase in the number ... In th...

RNA Splicing

...A Splicing antisense technology studied at Cold Spring Harbor Laboratory effectively corrected an mRNA splicing defect found in spinal muscular atrophy patients. With a high-tech fix for faulty cellular editing, scientists at Cold Spring Harbor Laboratory have moved a step closer to developing trea...
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