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Asparagine in Medical News

New Insights into Prion Propogation

...t prion protein in another fungus. A key difference between the two is that the yeast prion proteins are rich in the amino acids glutamine and asparagine in the regions of the protein used to transform them into a prion. In contrast, the fungal prion lacks a rich supply of these amino acids -- a charact...

A new recovery for heart attacks

...the molecular switch for that has to date been unknown.Dr Whitelaw and colleagues found under low-oxygen levels, HIF loses a hydroxyl molecule from an asparagine amino acid on this other domain. This changes the shape of the protein and allows it to activate the genes. "The finding has implications for tre...
Asparagine in Medical Technology

Leukemic Cells Find Safe Haven in Bone Marrow

...ells must have to survive but do not make efficiently. This extra supply of asparagine helps leukemic cells survive treatment with asparaginase, a drug that norma... also suggest that drugs now being developed to block the enzyme that makes asparagine should be tested to see if they also prevent mesenchymal cells from making ...
Asparagine in Biological News

UC Davis researchers discover Achilles' heel in pancreatic cancer

...e are also being studied for their potential in treating cancers of the blood, such as leukemia and lymphoma. In those cases, depleting the amino acid asparagine may be used in slowing cancer-cell growth. Bold and his colleagues are continuing their laboratory work on the effects of arginine deprivation on p...

Leukemic cells find safe haven in bone marrow

... but do not make efficiently. This extra supply of asparagine helps leukemic cells survive treatment with aspara... The "ASNS" gene controls production of the enzyme asparagine synthetase (ASNS), which leukemic cells use to mak...addition, the ability of mesenchymal cells to make asparagine might be decreased by cancer drugs that are alread...

Scientists crack 40-year-old DNA puzzle and point to 'hot soup' at the origin of life

...an be excluded from the doublet system and are likely to be relatively recent 'acquisitions' by the genetic code. As these amino acids - glutamine and asparagine - are unable to hold their shape in high temperatures, this suggests that heat prevented them from being acquired by the code at some point in the pas...
Asparagine in Biological Products

Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam

Description:... Rabbit monoclonal [EP282Y] to asparagine synthetase ( Abpromise for all tested applications). Antigen: Synthetic peptide corresponding to residues in the C-terminus of Human asparagine synthetase. Entrez GeneID: 440 SWISS Protein ID: P08243...
Company:Abcam

Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam

Description:... Rabbit monoclonal [EP282Y] to asparagine synthetase ( Abpromise for all tested applications). Antigen: Synthetic peptide corresponding to residues in the C-terminus of Human asparagine synthetase. Entrez GeneID: 440 SWISS Protein ID: P08243...
Company:Abcam

ISOQUANT Isoaspartate Detection Kit from Promega

Description:...ended for quantitative detection of isoaspartic acid residues in proteins and peptides, which can result from the gradual, nonenzymatic deamidation of asparagine or rearrangement of aspartic acid residues during storage or handling. Because the kit does not depend on the monitoring of charge differences for det...
Company:Promega
Asparagine in Biological Definition

Amino acid

... acid is X . The three letter symbol asx means the amino acid is either asparagine or aspartic acid . Abbrev. Full Name Side chain type Ma...ed into a protein; sometimes removed after translation. N Asn asparagine hydrophilic 132.12 5.41 2.14 8.72 P Pro ...

Genetic code

... example, the codon AAU represents the amino acid asparagine (Asp), and cysteine (Cys) is represented by UGU...ine ACG (Thr/T) Threonine AAU (Asn/N) asparagine AAC (Asn/N) asparagine AAA (Lys/K) Lysine AAG (Lys/K) Lysine ...

Genetic code

... example, the codon AAU represents the amino acid asparagine (Asp), and cysteine (Cys) is represented by UGU...ine ACG (Thr/T) Threonine AAU (Asn/N) asparagine AAC (Asn/N) asparagine AAA (Lys/K) Lysine AAG (Lys/K) Lysine ...

Glycoprotein

...of a protein and a carbohydrate (a sugar ). The carbohydrate is usually attached to the protein in a posttranslational modification , at either asparagine , hydroxylysine , hydroxyproline , serine , or threonine . Possible carbohydrates include glucose , glucosamine , galactose , galactosamine , ...

Prion

...t prion proteins. A typical yeast prion proteins contain a region ( protein domain ) with many repeats of the amino acids glutamine (Q) and asparagine (N); these Q/N-rich domains form the core of the prion's structure. Ordinarily, prion domains are flexible and lack a defined structure. When they co...
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