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Ascending in Medical News

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

- PSI-7851 was generally safe and well tolerated in Phase 1a single ascending dose trial - Further results from single ascending and multiple ascending dose trials are expected in second half 2009 PRINCETON, N.J., June 9 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) annou...

Arena Pharmaceuticals Announces Second Quarter 2009 Financial Results and Recent Developments

...the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose of APD597 in healthy volunteers. Ortho-McNeil-Janssen has initiated another clinical trial evaluating multiple ascending doses of APD597. Completed a public offering of 12.5 million shares o...

Financing Available for Healthcare Equipment from DRE Medical Equipment

...al generators and vital signs monitors , such as the DRE ASM 6000 Pro, a new multi-parameter monitor available with EtCO2, five-agent monitoring, and ascending and descending tones. DRE also provides veterinary facilities with access to financing. DRE Veterinary has an extensive selection of veterinary...

Is somatic hypersensitivity a predictor of irritable bowel syndrome?

... a 3 cm 3 cm surface area. Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects. The research revealed controls were less ...

A case of cecal volvulus

...ulus is axial twisting that occurs involving the cecum, terminal ileum, and ascending colon. Rarely, it may take the form of upward and anterior folding of the ascending colon ("cecal bascule"). The research team led by Prof. Hiroshi Suzuki ...

QLT announces completion of Phase Ia safety trial of its synthetic retinoid product

...degenerative disease that leads to retinal dysfunction and visual impairment beginning at birth. The Phase Ia trial is an open-label, single center, ascending dose trial conducted by QLT to evaluate the safety and tolerance of multiple administrations of the synthetic retinoid drug in 20 healthy adult volunt...
Ascending in Medical Technology

Pharmacopeia Announces Additional Positive Findings from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)

Results Show Statistically Significant Indications of PS433540's Potential in Treating Hypertension PRINCETON, N.J., Dec. 3 /PRNewswire-FirstCall/ -- Pharmacopeia (Nasdaq: PCOP), an innovator in the discovery and development of novel small molecule therapeutics, announced...

Pharmacopeia Announces Positive Results from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)

Pharmacopeia Elects to Expand Study to Include 1,000 mg Dose PRINCETON, N.J., Sept. 12 /PRNewswire-FirstCall/ -- Pharmacopeia (Nasdaq: PCOP ), an innovator in the discovery and development of novel small molecule therapeutics, today announced that based on initial results from the Compa...

Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers

-R7128 Demonstrates Safety and Tolerability with No Clinically Significant Adverse Events- -Conference Call Scheduled for 8:30AM (ET) Today- PRINCETON, N.J., Sept. 10 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) is presenting safety, tolerabil...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...hibitor of HCV. PSI-7851 Phase 1 Multiple ascending Dose Study Overview In June 2009, Pharmasset initiated a phase 1 multiple ascending dose study with PSI-7851. The trial was conducted ...ere similar between healthy subjects in the single ascending dose study and HCV infected patients in the multip...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

...s with carcinoid syndrome who are symptomatic despite treatment with currently available therapy. Up to four dose levels may be evaluated in a serial ascending fashion. Once an optimal or maximal dose is identified, additional patients will be added to confirm clinical observations. In addition to L...

New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer

...fficacy of Neratinib (HKI-272) in Combination with Paclitaxel in Patients with Solid Tumors In a separate phase 1/2, open-label, 2-part study, ascending multiple daily oral doses of neratinib (160 mg, 240 mg) were administered in combination with IV paclitaxel 80 mg/m2, if tolerable, or 70 mg/m2 on day...
Ascending in Medical Products

Carbo-Seal Valsalva Ascending Aortic Prosthesis

Description: Carbo-Seal Valsalva AAP is the first valved graft to replicate the natural Sinus of Valsalva, encouraging the natural formation of systolic vortices....
Company:CarboMedics, Inc.

Vasopressin (AVP) RIA Test

Description:... include pain, stress, sleep and exercise [1]. The primary function of AVP is the regulation of water permeability of the renal collecting tubules and ascending loop of Henle. Mediated through activation of cAMP, the effect of AVP is to allow the kidney to reabsorb water and concentrate urine [1]. At high plas...
Company:Diagnostic Systems Laboratories, Inc.

SphygmoCor Px Central Blood Pressure Assessment and Management System

Description:...a, and is intended to enhance the treatment and management of patients. Using a validated generalized transfer function, the system derives the ascending aortic blood pressure waveform from the radial arterial pressure waveform. SphygmoCor then analyzes the central aortic waveform to central pressures a...
Company:AtCor Medical Pty Ltd.
Ascending in Medical Definition

Pathology

... - PBC - Budd-Chiari - Hepatocellular carcinoma Accessory digestive Gallbladder / Biliary tree ( Gallstones , Cholecystitis , PSC , ascending cholangitis ) - Pancreas ( Acute pancreatitis , Chronic pancreatitis , Pancreatic pseudocyst , Hereditary pancreatitis , Pancreatic cancer ) ...

Neuropsychiatry

...uality NMDA receptor activation in the human prefrontal cortex Ross et al (2006) Visual hallucination - retinogeniculocalcarine tract, ascending brainstem modulatory structures Mocellin, Walterfang, Velakoulis, 2006 Auditory hallucination - frontotemporal functional connectivity ...
Ascending in Medical Dictionary

Values

.... They are the values that buttress mental and physical courage when we ... Anti- values can be classified into the following six categories by ascending ... Everett's classification does not cover all the values in our life. ... ... congregations take action on their values by providing "how-to...

Tissue

... Tissue from the human ascending aorta was harvested from pediatric patients ... After harvesting, the arterial tissue was rinsed of blood with phosphate ... Find a reliable...

Tick paralysis

...lowed several ... Definition: Tick paralysis results from a tick bite. Causes, incidence, and risk factors: ... The resulting paralysis is ascending (starting in the lower body ... Clinical Picture: Tick paralysis , also known as tick toxicosis, is a relatively ... Tick paralysis in ch...

Systole

...n ... Normally, during systole the left ventricle contracts and ejects approximately ... ... blood flow from the left ventricle to the ascending aorta during systole . ... later in systole (ie, crescendo phase becomes longer and decrescendo phase ... C. aortic valve during systole . D...

Scales

... In music, a scale is a group of musical notes collected in ascending and descending order, that provides material for or is used to conveniently represent part or all of a musical work including melody and/or harmony. ...

Pyelonephritis

... Pyelonephritis is an ascending urinary tract infection that has reached the pyelum (pelvis) of the kidney . If the infection is severe, the term "urosepsis" is use...
Ascending in Biological News

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

...orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine Inhibitors ( BSCIs ). The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated at all doses studied and no serious adverse events or subject withdrawals wer...

Studying volcanoes with balloons

...e of three on Hawaii. After the first balloon was released into strong winds left over from tropical storm Elida, it worked for a couple of hours, ascending to 2,500 meters around Mauna Loa mountain. The flight lasted for just under two hours before the balloon crashed into the mountain north of the launc...

In the race to the top, zigzagging is more efficient than a straight line

...ght angle. Trails evolve, among other reasons, because of physical differences in people and the differences in the biomechanics and energy cost of ascending and descending a slope. You get a different pattern if people are going up or down and this may lead to the emergence of shortcuts. Walking downhi...

Young chimps top adult humans in numerical memory

...or to human memory. In the current study, the researchers tested three pairs of mother and infant chimpanzees (all of which had already learned the ascending order of Arabic numerals from 1 to 9) against university students in a memory task of numerals. One of the mothers, named Ai, was the first chimpanzee...

UF scientists reveal ancient origin of vertebrate skeleton

...body parts. About 40 million years into the process, jawed and jawless vertebrates branched into different paths from the starting point, like the two ascending lines in the letter "V." "The lamprey is like the great-, great-, great-aunt descended from the earliest backboned animal," said Michael Miyamoto, ...

UF scientists reveal ancient origin of vertebrate skeleton

...body parts. About 40 million years into the process, jawed and jawless vertebrates branched into different paths from the starting point, like the two ascending lines in the letter "V." "The lamprey is like the great-, great-, great-aunt descended from the earliest backboned animal," said Michael Miyamoto, ...
Ascending in Biological Technology

Memory Pharmaceuticals Completes Phase 1 Multiple Ascending Dose Study of R4996/MEM 63908

- Results Expected in Fourth Quarter of 2008 - MONTVALE, N.J., Sept. 26 /PRNewswire-FirstCall/ -- Memory Pharmaceuticals Corp. (Nasdaq: MEMY ) today announced that it has completed its Phase 1 multiple ascending dose study of R4996/MEM 63908 in healthy volunteers. The multiple ascending dos...

Neurocrine Biosciences Reports Second Quarter 2009 Results

...ntary hyperkinetic movements such as Tardive Dyskinesia. A Clinical Trial Application has been approved by Health Canada and we will initiate a single ascending dose Phase 1 study in August 2009. Conference Call and Webcast Thursday, July 30, 2009 at 8:30 a.m. EDT Neurocrine will hold a live confere...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... - In Q2 the SPC3649 compound targeting hepatitis C finalized a single dose First/In/Man study with encouraging results and a multiple ascending dose study in healthy volunteers is scheduled to commence in Q3 2009. - Santaris Pharma's new lead candidate SPC4955 targeting apolip...

Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action

...orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine Inhibitors (BSCIs). The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated at all doses studied and no serious adverse events or subject withdrawals wer...

Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome

...s with carcinoid syndrome who are symptomatic despite treatment with currently available therapy. Up to four dose levels may be evaluated in a serial ascending fashion. Once an optimal or maximal dose is identified, additional patients will be added to confirm clinical observations. "The clinical trial ...

Sequella Commences Phase 1B Study for New Tuberculosis Drug SQ109

...rium tubercul o sis , the causative agent of tuberculosis (TB). The Phase 1B study will assess safety, pharmacokinetics and tolerability of multiple ascending doses of SQ109 in three cohorts of healthy volunteers. "We are pleased to begin this Phase 1B safety trial and to continue the clinical developm...
Ascending in Biological Definition

DNA

... helix reveals that nucleotides are heading one way along one strand (the " ascending strand "), and the other way along the other strand (the " descending stran...ion ". In a vertically oriented double helix, the 3' strand is said to be ascending while the 5' strand is said to be descending. Sense and antisense ...

Kidney

...ct system , which consists of: the connecting tubule the cortical collecting duct the medullary collecting duct . The site where the ascending loop of Henle touches the afferent arteriole, is called the juxtaglomerular apparatus . It contains macula densa and juxtaglomerular cells . Juxta...
Ascending in Biological Dictionary

Stem

...hat have vascular tissue and that ... Stem (bicycle part), connects the handlebars to the steer tube of a bicycle fork ... stem n. The main ascending axis of a plant; a stalk or trunk. ... If a stem creeps along the ground, rooting at the nodes, it is said to be repent ... Stem (bicycle par...

Pericardium

...pericardium , is a delicate membrane which lies within ... The pericardium consists of two parts: (1) a strong external layer composed of ... The ascending aorta carries the pericardium superiorly beyond the heart to the ... The pericardium is a tough, fibrous, outer coating with discrete attac...

Loop of Henle

...entration gradient in... Loop diuretics are diuretics that act on the ascending loop of Henle in the kidney. They are primarily used in medicine to treat...II. Collecting Tubule and Duct. VIII. ... The third loop is formed by the ascending limb of Henle and the descending ... The loop of Henle stick...

Interneuron

... Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. interneuron synonyms. interneuron usage examples ... ascend: ascending interneuron seen in spinal cord viewed from left side ... near interneuron ... Psychology research, information, analysis and reviews from Ps...

Hemizygous

... hemizygous vein synonyms, hemizygous vein antonyms. Information about hemizygous vein in the ... hemizygous vein - a continuation of the left ascending ... ...

Cecum

... The cecum or caecum is a pouch, connecting the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve (ICV) or Bauhin's valve, and is considered to be the begin...
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