Resistance to Malaria Drug Reported in Cambodia
... Millions at risk if artemisinin
treatment becomes ineffective, study says
...people a year, mainly children and pregnant women. artemisinin
causes fewer side effects than other anti-malaria ...Program, based in Bangkok, compared the effects of artemisinin
drugs in 40 malaria patients in western Cambodia a...
New global subsidy for malaria medicines must ensure quality of care
... is designed to address concerns of poor access to artemisinin
combination therapies (ACTs) for malaria, and fear...p the AMFm to meet the long unfulfilled promise of artemisinin
for the millions who continue to suffer from malar...ng ACTs more affordable and to delay resistance to artemisinin
derivatives by driving...
Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication
... used only in combination with another effective antimalarial -- as artemisinin-combination therapies (ACTs) -- for the treatment of malaria. However, artemisinin
monotherapies continue to be used widely around the world. In their paper, Ramanan Laxminarayan and Hellen Gelband of Resources for the Future discuss...
Tools for more accurate dosage of drugs against HIV/AIDS and malaria
...cribe how the catabolism of the anti-malarial drug artemisinin
increases and the concentration of the drug decreases when patients take this drug. When artemisinin
was given to 97 patients in Vietnam without other ...l drug, piperaquine, may be a suitable partner for artemisinin
in the treatment of malaria. An investigation of 1...
Rx for Africa Ethiopia to Launch a Minimum of 36 New Products in 2009
...s formulated nine generic pharmaceuticals, and is on track to launch a minimum of 36 new products in calendar 2009. The state of the art malaria drug artemisinin
is scheduled for a third-quarter launch, and HIV/AIDS pharmaceuticals are in process. "Globally, malaria is responsible for more than one million dea...
Broccoli compound targets key enzyme in late-stage cancer
...m is the anti-malarial drug artemisinin. Last month, the Journal of Biological Chemistry accepted a paper by Firestone and his colleagues showing that artemisinin
blocks prostate cancer cell growth by interfering with the same intracellular pathway as does I3C. This pathway involves the transcription factor SP1,...
Applying 'supply and demand' business principles to treat infectious diseases worldwide
...py (ACT) is it can take up to two years for the plants to grow, extract the artemisinin
and then for pharmaceutical companies to develop the drugs. If demand isn'...upport the signing of agreements with suppliers to reduce the volatility in artemisinin
supply, reduce drug prices, and help ensure access to high-quality, low-cos...
Study: Delaying evolution of drug resistance in malaria parasite possible
"We don't have anything in the pipeline after ACTs, and it's basically just a matter of time until drug resistance evolves and artemisinin
also fails," Smith said. "So the question becomes how do we keep ACTs in our arsenal for as long as effectively possible?"
The researchers' models ...
Discovery of key malaria proteins could mean sticky end for parasite
...treatments such as chloroquine and mefloquine, and there is some evidence of increasing resistance against even the most effect and newest treatments, artemisinin
derivatives such as artesunate.
"Malaria parasites are evolving, making our current treatments increasingly less effective," says Professor Alister...
Maternal malaria researcher wins prestigious international prize
...commend treating women in the second and third trimesters of pregnancy with artemisinin
combination therapies. They have also provided almost all the available clinical evidence on the safety of treating pregnant women with artemisinin
therapies, including the largest series on exposure during the first trimes...
Synthetic biology can help extend anti-malaria drug effectiveness
... extend the effectiveness of this drug. Fermenting artemisinin
via engineered microbes, such as yeast, can be don... , the sweet wormwood tree, making microbial-based artemisinin
a much cheaper but equally effective treatment. Re...ology to responsible manufacturers who will bundle artemisinin
as part of an anti-malarial drug "cocktail" rather...
Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
...ncept that commercially relevant concentrations of artemisinin
precursors can be produced by microbes for convers...nt for malaria. However, supplies of plant-derived artemisinin
are subject to the seasonality and volatility comm...nin. Commercial scale production of semi-synthetic artemisinin
would have the potential to stabilize supply and s...
Largest synthetic gene ever built offers insights into anti-malarial drug resistance
...s or anemia that are consequences of red cell infection.
Natural products such as quinine, extracted from the cinchona tree, and leaves from the artemisinin
shrub were the only options available to treat the infection until World War II, when both Germany and the United States started massive drug discover...
Twenty Years of Malaria Research: Outcomes and Perspectives
...ntly recommended malaria therapies (based on drug combinations including an artemisinin
derivative) are the result of research carried out at SMRU, which is part o...eatments for pregnant women, the unit has carried out crucial research into artemisinin
combination therapies (ACTs) aimed at combating the rapid rise in drug-resi...
...f malaria, as well as the discomfort of insect bites.
Extracts from the plant Artemisia (specifically Artemisia annua ), containing the compound artemisinin
, a substance unrelated to the quinine derivatives, offer some future promise.
Prospects of disease control
Vaccines for malaria are under deve...
..., present in Erythroxylon coca the Coca plant
Class Terpenoids :
Azadirachtin A, present in Azadirachta indica , Neem tree
, present in Artemisia annua Chinese wormwood
Class Aliphatic , Aromatic and Heteroaromatic organic acids:
Class Polyketides :