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Artemisinin in Medical News

Resistance to Malaria Drug Reported in Cambodia

... Millions at risk if artemisinin treatment becomes ineffective, study says ...people a year, mainly children and pregnant women. artemisinin causes fewer side effects than other anti-malaria ...Program, based in Bangkok, compared the effects of artemisinin drugs in 40 malaria patients in western Cambodia a...

New global subsidy for malaria medicines must ensure quality of care

... is designed to address concerns of poor access to artemisinin combination therapies (ACTs) for malaria, and fear...p the AMFm to meet the long unfulfilled promise of artemisinin for the millions who continue to suffer from malar...ng ACTs more affordable and to delay resistance to artemisinin derivatives by driving...

Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication

... used only in combination with another effective antimalarial -- as artemisinin-combination therapies (ACTs) -- for the treatment of malaria. However, artemisinin monotherapies continue to be used widely around the world. In their paper, Ramanan Laxminarayan and Hellen Gelband of Resources for the Future discuss...

Tools for more accurate dosage of drugs against HIV/AIDS and malaria

...cribe how the catabolism of the anti-malarial drug artemisinin increases and the concentration of the drug decreases when patients take this drug. When artemisinin was given to 97 patients in Vietnam without other ...l drug, piperaquine, may be a suitable partner for artemisinin in the treatment of malaria. An investigation of 1...

Rx for Africa Ethiopia to Launch a Minimum of 36 New Products in 2009

...s formulated nine generic pharmaceuticals, and is on track to launch a minimum of 36 new products in calendar 2009. The state of the art malaria drug artemisinin is scheduled for a third-quarter launch, and HIV/AIDS pharmaceuticals are in process. "Globally, malaria is responsible for more than one million dea...

Broccoli compound targets key enzyme in late-stage cancer

...m is the anti-malarial drug artemisinin. Last month, the Journal of Biological Chemistry accepted a paper by Firestone and his colleagues showing that artemisinin blocks prostate cancer cell growth by interfering with the same intracellular pathway as does I3C. This pathway involves the transcription factor SP1,...

Applying 'supply and demand' business principles to treat infectious diseases worldwide

...py (ACT) is it can take up to two years for the plants to grow, extract the artemisinin and then for pharmaceutical companies to develop the drugs. If demand isn'...upport the signing of agreements with suppliers to reduce the volatility in artemisinin supply, reduce drug prices, and help ensure access to high-quality, low-cos...

Study: Delaying evolution of drug resistance in malaria parasite possible

...lasmodium parasite. "We don't have anything in the pipeline after ACTs, and it's basically just a matter of time until drug resistance evolves and artemisinin also fails," Smith said. "So the question becomes how do we keep ACTs in our arsenal for as long as effectively possible?" The researchers' models ...

Discovery of key malaria proteins could mean sticky end for parasite

...treatments such as chloroquine and mefloquine, and there is some evidence of increasing resistance against even the most effect and newest treatments, artemisinin derivatives such as artesunate. "Malaria parasites are evolving, making our current treatments increasingly less effective," says Professor Alister...

Maternal malaria researcher wins prestigious international prize

...commend treating women in the second and third trimesters of pregnancy with artemisinin combination therapies. They have also provided almost all the available clinical evidence on the safety of treating pregnant women with artemisinin therapies, including the largest series on exposure during the first trimes...
Artemisinin in Biological News

Synthetic biology can help extend anti-malaria drug effectiveness

... extend the effectiveness of this drug. Fermenting artemisinin via engineered microbes, such as yeast, can be don... , the sweet wormwood tree, making microbial-based artemisinin a much cheaper but equally effective treatment. Re...ology to responsible manufacturers who will bundle artemisinin as part of an anti-malarial drug "cocktail" rather...

Milestone achieved toward production of malaria treatment using synthetic biology and fermentation

...ncept that commercially relevant concentrations of artemisinin precursors can be produced by microbes for convers...nt for malaria. However, supplies of plant-derived artemisinin are subject to the seasonality and volatility comm...nin. Commercial scale production of semi-synthetic artemisinin would have the potential to stabilize supply and s...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...s or anemia that are consequences of red cell infection. Natural products such as quinine, extracted from the cinchona tree, and leaves from the artemisinin shrub were the only options available to treat the infection until World War II, when both Germany and the United States started massive drug discover...

Twenty Years of Malaria Research: Outcomes and Perspectives

...ntly recommended malaria therapies (based on drug combinations including an artemisinin derivative) are the result of research carried out at SMRU, which is part o...eatments for pregnant women, the unit has carried out crucial research into artemisinin combination therapies (ACTs) aimed at combating the rapid rise in drug-resi...
Artemisinin in Biological Technology

Amyris Biotechnologies Co-Founder Neil Renninger Named to Technology Review's Prestigious TR35 List of Top Young Innovators

...ninger applied Amyris' technology platform to develop a microbially-derived artemisinin precursor which is expected to reduce the cost of artemisinin to a fraction of its current cost. In the next application of this technolo...
Artemisinin in Biological Definition

Malaria

...f malaria, as well as the discomfort of insect bites. Extracts from the plant Artemisia (specifically Artemisia annua ), containing the compound artemisinin , a substance unrelated to the quinine derivatives, offer some future promise. Prospects of disease control Vaccines for malaria are under deve...

Secondary metabolite

..., present in Erythroxylon coca the Coca plant Class Terpenoids : Azadirachtin A, present in Azadirachta indica , Neem tree artemisinin , present in Artemisia annua Chinese wormwood Class Aliphatic , Aromatic and Heteroaromatic organic acids: Class Polyketides : ...
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(Date:7/10/2014)... Interdisciplinary Research (MIIR) and the Marshall University Joan ... will be partnering with an international biosciences company ... agreement with Shanghai-based HD Biosciences Co. Ltd., the ... of discovery and development of these new drugs. ... and commercialization rights to products developed through the ...
(Date:7/10/2014)... around a family of enzymes known as heme enzymes, ... their active site. At the centre of the heme ... (ferryl) when a reacting heme is in an intermediate ... unanswered for decades is whether this oxidation involves just ... Resolving this fundamental question has implications for understanding oxidative ...
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