Genomic Health Announces Study Establishing the Utility of Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated with Aromatase Inhibitors
SAN ANTONIO, Dec. 13 /PRNewswire-FirstCall/ -- Genomic Health, Inc.
(Nasdaq: GHDX ) today announced findings from a European study demonstrating
that the Oncotype DX Recurrence Score(R) result is a significant independent
predictor of distant recurrence in both node-negative and node-positive,
Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer
Letrozole cut women's risk of recurrent or new tumors by more than half, study found
TUESDAY, March 11 (HealthDay News) -- There's good news for the 60 percent of women with breast cancer whose malignancies are estrogen-driven: Researchers say taking the aromatase
inhibitor (AI) drug...
Early Switch to an Aromatase Inhibitor Increases Survival
For breast cancer patients taking tamoxifen, switching to an aromatase
inhibitor within three years significantly improves survival rates//, according to a new study. The study reveals that the clear survival benefit was also achieved without an increased risk of death from other causes – a signifi...
Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer
... been a recent shift toward treating ER-positive breast tumor patients with aromatase
inhibitors such as tamoxifen that block estrogen biosynthesis. The thought ...r with biological significance for breast cancer furthers the argument that aromatase
inhibitors would effectively block estrogen action at both types of estroge...
Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer
... to do is to choose other medications while trying to sort this out."
Marcom agreed. He also noted that breast cancer-inhibiting medications called aromatase
inhibitors, which include letrozole (Femara) and exemestane (Aromasin), "are one possible alternative to tamoxifen. There are also genotyping issues -...
PET scan can non invasively measure early assessment of treatment for common type of breast cancer
...rm of breast cancer - estrogen receptor positive type - respond to standard aromatase
inhibitor therapy after only two weeks and shows similar findings that more...University of Washington, scanned 21 patients before and after two weeks of aromatase
inhibitor therapy. Many of the patients also underwent a needle biopsy as a...
Mayo Clinic Researchers Say Agent Provides Treatment Option for Women with Hot Flashes
...taking their study drug -- the content of which was unknown to them.
In the study group, 34 percent were using anti-estrogen therapy -- either an aromatase
inhibitor, raloxifene, or tamoxifen -- to help prevent the recurrence of estrogen-sensitive breast cancer.
The researchers found that for the 163...
Mayo Clinic researchers say agent provides treatment option for women with hot flashes
... while taking their study drug the content of which was unknown to them.
In the study group, 34 percent were using anti-estrogen therapy either an aromatase
inhibitor, raloxifene, or tamoxifen to help prevent the recurrence of estrogen-sensitive breast cancer.
The researchers found that for the 163 pati...
UAB wins $6.4 million nonprofit grant to fight aggressive breast cancer
...egative) and progesterone (PR-negative), and for the protein HER2. This makes them resistant to several powerful cancer-fighting drugs like tamoxifen, aromatase
inhibitors and Herceptin.
The triple-negative research project started after the Birmingham-based Breast Cancer Research Foundation of Alabama prov...
GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US
...respectively to the European Medicines Agency (EMEA) and to the U.S. Food and Drug Administration (FDA) for the combination of TYVERB/TYKERB plus an aromatase
inhibitor based on the recent study, EGF30008. This study evaluated TYVERB/TYKERB in combination with letrozole in women whose breast cancer expressed...
Aromatase in Medical Technology
Aromatase in Medical Dictionary
... estradiol - aromatase
from Sertoli cells convert testosterone to 17 beta ... The tight junctions of Sertoli cells form the blood-testis barrier, a structure ......
Aromatase in Biological News
New research shows no link between aromatase inhibitors and cardiovascular problems
Berlin, Germany: New evidence has emerged that, contrary to some current fears, aromatase
inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring.
In a study presented today (Thursday) at the 6th European Breas...
National Lung Cancer Partnership and LUNGevity Foundation announce 2009 grant recipients
... estrogen, which many lung cancers either make or are responsive to, similarly to breast cancer. Aromatase-inhibitors, drugs which turn off the enzyme aromatase
which can cause some cancers to grow and have long been used in breast cancer treatment, will be studied in a pre-clinical trial to determine their ef...
HWI scientist first in world to unravel structure of key breast cancer target enzyme
...h's solution of the three-dimensional structure of aromatase
is the first time that scientists have been able t...urnal Nature will be publishing the structure of aromatase
at 2.90 angstrom resolution in an upcoming issue. ...to customized, comprehensive medical treatment.
is the only enzyme in the vertebrate world that ma...
Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
...roup was randomized to five years of tamoxifen therapy, and the other randomized to tamoxifen for two years followed by three years of anastrozole, an aromatase
inhibitor. The initial results of ABCSG-8, reported in 2005, concluded that women who switched to anastrozole had a 40 percent reduced risk of breast ...
The dietary supplement genistein can undermine breast cancer treatment
... CHAMPAIGN, Ill. Women taking aromatase
inhibitors to treat breast cancer or prevent its r...rogen in the body, can negate the effectiveness of aromatase
inhibitors, which are designed to reduce the level...earch, appears in the journal Carcinogenesis .
inhibitors are a mainstay of breast cancer treatme...
Growth factor predicts poor outcome in breast cancer
Currently, the Breast Center is studying the effects of an IGF receptor antibody combined with a drug called exemestane (Aromasin or an aromatase
inhibitor that blocks estrogen production) in postmenopausal women. One group of women take the combination and the other takes exemestane.
AACR, BCRF award inaugural grants in translational breast cancer research
...on in ER+/HER2+ Breast Cancers, will address resistance to endocrine therapies. Through a Phase II study, she seeks to learn if the combination of an aromatase
inhibitor with an EGFR/HER2 inhibitor will work better in preventing failure of tumors to respond to anti-hormonal treatment. Mayer hopes that her r...
Linchpin gene may be useful target for new breast cancer therapies
...strogen's interaction with a primary estrogen receptor called ER-alpha, and aromatase
inhibitors that reduce the amount of estrogen the body makes and therefore ...plain why tamoxifen, which targets a single pathway, is less effective that aromatase
inhibitors, which likely affect many estrogen pathways.
Weigel noted tha...
Women well informed about breast cancer, yet lacking knowledge about current treatments
...the survey, nearly all respondents were aware of chemotherapy and radiation. However, fewer than one out of four had heard of newer therapies such as aromatase
inhibitors or monoclonal antibodies, nor were they informed about their benefits.
Doctor-patient dialogue is vital
If diagnosed, the major...
Scientists discover way to block growth of prostate cancer cells
Dr Basu said: "After surgery and radiotherapy for the primary tumour, breast cancer patients can be treated with several drugs such as tamoxifen and aromatase
inhibitors that prevent or delay breast cancer recurrence. No such treatment exists for prostate cancer patients. After treatment of their primary t...
Aromatase in Biological Technology
Aromatase in Biological Dictionary
...cal term. What does pachytene mean? ... pachytene /pachy·tene/ (pak'ĭ-tēn) in the prophase of meiosis, ... pachytene ... ... (ERß) and P450 aromatase
in pachytene spermatocytes suggests a role for estrogens ... a well-known model of pachytene spermatocyte apoptosis in adult rats ... After e...