Aromatase

Genomic Health Announces Study Establishing the Utility of Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated with Aromatase Inhibitors

SAN ANTONIO, Dec. 13 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX ) today announced findings from a European study demonstrating that the Oncotype DX Recurrence Score(R) result is a significant independent predictor of distant recurrence in both node-negative and node-positive, h...

Late Use of Aromatase Inhibitor Still Effective Against Breast Cancer

Letrozole cut women's risk of recurrent or new tumors by more than half, study found TUESDAY, March 11 (HealthDay News) -- There's good news for the 60 percent of women with breast cancer whose malignancies are estrogen-driven: Researchers say taking the aromatase inhibitor (AI) drug...

Early Switch to an Aromatase Inhibitor Increases Survival

For breast cancer patients taking tamoxifen, switching to an aromatase inhibitor within three years significantly improves survival rates//, according to a new study. The study reveals that the clear survival benefit was also achieved without an increased risk of death from other causes – a signifi...

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

... been a recent shift toward treating ER-positive breast tumor patients with aromatase inhibitors such as tamoxifen that block estrogen biosynthesis. The thought ...r with biological significance for breast cancer furthers the argument that aromatase inhibitors would effectively block estrogen action at both types of estroge...

Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer

... to do is to choose other medications while trying to sort this out." Marcom agreed. He also noted that breast cancer-inhibiting medications called aromatase inhibitors, which include letrozole (Femara) and exemestane (Aromasin), "are one possible alternative to tamoxifen. There are also genotyping issues -...

PET scan can non invasively measure early assessment of treatment for common type of breast cancer

...rm of breast cancer - estrogen receptor positive type - respond to standard aromatase inhibitor therapy after only two weeks and shows similar findings that more...University of Washington, scanned 21 patients before and after two weeks of aromatase inhibitor therapy. Many of the patients also underwent a needle biopsy as a...

Mayo Clinic Researchers Say Agent Provides Treatment Option for Women with Hot Flashes

...taking their study drug -- the content of which was unknown to them. In the study group, 34 percent were using anti-estrogen therapy -- either an aromatase inhibitor, raloxifene, or tamoxifen -- to help prevent the recurrence of estrogen-sensitive breast cancer. The researchers found that for the 163...

Mayo Clinic researchers say agent provides treatment option for women with hot flashes

... while taking their study drug the content of which was unknown to them. In the study group, 34 percent were using anti-estrogen therapy either an aromatase inhibitor, raloxifene, or tamoxifen to help prevent the recurrence of estrogen-sensitive breast cancer. The researchers found that for the 163 pati...

UAB wins $6.4 million nonprofit grant to fight aggressive breast cancer

...egative) and progesterone (PR-negative), and for the protein HER2. This makes them resistant to several powerful cancer-fighting drugs like tamoxifen, aromatase inhibitors and Herceptin. The triple-negative research project started after the Birmingham-based Breast Cancer Research Foundation of Alabama prov...

GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US

...respectively to the European Medicines Agency (EMEA) and to the U.S. Food and Drug Administration (FDA) for the combination of TYVERB/TYKERB plus an aromatase inhibitor based on the recent study, EGF30008. This study evaluated TYVERB/TYKERB in combination with letrozole in women whose breast cancer expressed...

Aromatase in Medical Technology

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

- Femara showed reduced risk of death by 13% (P=0.08), despite inclusion of patients crossing over from tamoxifen to Femara therapy - In a separate censored analysis excluding patients after they crossed over to Femara, reduction in risk of death was 19% - Long-term follow-up fro...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... cognition is a concern among breast cancer patients taking hormonal therapies. Estrogen is believed to have a direct influence on cognitive function. aromatase inhibitors reduce the level of circulating estrogen in the body. It has been suggested that reduced estrogen in the body is linked to a decline in cog...

Meditrina Pharmaceuticals, Inc. Opens Investigational New Drug (IND) Application for Phase IIb Clinical Trial With MPI-676 in Endometriosis

...nced the approval of its second investigational new drug (IND) application for a Phase IIb dose ranging clinical trial to study MPI-676, the Company's aromatase inhibitor (AI), in combination with estrogen and progestin for the treatment of endometriosis. MPI-676 is the newest addition to Meditrina's clinical ...

VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy

... finishing tamoxifen - Femara only member of aromatase inhibitor class with data demonstrating this potential benefit, as publish...ars after completing tamoxifen treatment(1). Femara is the only drug in the aromatase inhibitor class with data showing its potential to reduce the risk of breas...

Anastrozole Confirmed Superior in Breast Cancer Prevention

...n Combination) trial that compared 5 years of tamoxifen with 5 years of the aromatase inhibitor anastrozole for the treatment of postmenopausal women with invasi...for increased bone loss and risk of fracture that can occur with the use of aromatase inhibitors. It was not known whether these effects would persist after the ...

Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women

... in the risk of recurrence to the same breast (local recurrence), the other breast and to the lymph nodes (regional recurrence). "Femara is the only aromatase inhibitor shown to significantly reduce the risk of distant metastases versus tamoxifen as initial adjuvant therapy in postmenopausal women with hormo...

Antidepressant Use May Boost Fracture Risk, From Harvard Women's Health Watch

...e: -- Update on treating IBS -- Driving safety and aging -- Simpler CPR for cardiac arrest -- By the way doctor: Tamoxifen versus aromatase inhibitors for breast cancer Harvard Women's Health Watch is available from Harvard Health Publications, the publishing division of Harva...

Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen

...n for two years would benefit from switching to an aromatase inhibitor (AI). The study demonstrated that women ...0065) "This new study is the first individual aromatase inhibitor trial showing a benefit in overall survi...vantage of starting their adjuvant therapy with an aromatase inhibitor and are currently taking tamoxifen shoul...

First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex

...rmone-receptor positive early breast cancer who had been receiving endocrine treatment with tamoxifen for two years would benefit from switching to an aromatase inhibitor (AI). The study demonstrated that women switching to anastrozole (n=489) rather than remaining on tamoxifen (n= 490) experienced1: &mid...

Peer Reviewed Journal Article Indicates Repros' Proellex Exhibits Potential for New Approach to the Treatment and Prevention of Breast Cancer

... with breast cancer in 2005. Women whose primary lesions contain both estrogen and progesterone receptors are typically treated with anti-estrogens or aromatase inhibitors which inhibit the synthesis of estrogen. Progestins (progesterone like compounds) have been shown to increase the incidence of spontaneous ...

Aromatase in Medical Dictionary

Sertoli

... estradiol - aromatase from Sertoli cells convert testosterone to 17 beta ... The tight junctions of Sertoli cells form the blood-testis barrier, a structure ......

Aromatase in Biological News

New research shows no link between aromatase inhibitors and cardiovascular problems

Berlin, Germany: New evidence has emerged that, contrary to some current fears, aromatase inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring. In a study presented today (Thursday) at the 6th European Breas...

National Lung Cancer Partnership and LUNGevity Foundation announce 2009 grant recipients

... estrogen, which many lung cancers either make or are responsive to, similarly to breast cancer. Aromatase-inhibitors, drugs which turn off the enzyme aromatase which can cause some cancers to grow and have long been used in breast cancer treatment, will be studied in a pre-clinical trial to determine their ef...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

...h's solution of the three-dimensional structure of aromatase is the first time that scientists have been able t...urnal Nature will be publishing the structure of aromatase at 2.90 angstrom resolution in an upcoming issue. ...to customized, comprehensive medical treatment. aromatase is the only enzyme in the vertebrate world that ma...

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

...roup was randomized to five years of tamoxifen therapy, and the other randomized to tamoxifen for two years followed by three years of anastrozole, an aromatase inhibitor. The initial results of ABCSG-8, reported in 2005, concluded that women who switched to anastrozole had a 40 percent reduced risk of breast ...

The dietary supplement genistein can undermine breast cancer treatment

... CHAMPAIGN, Ill. Women taking aromatase inhibitors to treat breast cancer or prevent its r...rogen in the body, can negate the effectiveness of aromatase inhibitors, which are designed to reduce the level...earch, appears in the journal Carcinogenesis . aromatase inhibitors are a mainstay of breast cancer treatme...

Growth factor predicts poor outcome in breast cancer

...er option." Currently, the Breast Center is studying the effects of an IGF receptor antibody combined with a drug called exemestane (Aromasin or an aromatase inhibitor that blocks estrogen production) in postmenopausal women. One group of women take the combination and the other takes exemestane. Bioi...

AACR, BCRF award inaugural grants in translational breast cancer research

...on in ER+/HER2+ Breast Cancers, will address resistance to endocrine therapies. Through a Phase II study, she seeks to learn if the combination of an aromatase inhibitor with an EGFR/HER2 inhibitor will work better in preventing failure of tumors to respond to anti-hormonal treatment. Mayer hopes that her r...

Linchpin gene may be useful target for new breast cancer therapies

...strogen's interaction with a primary estrogen receptor called ER-alpha, and aromatase inhibitors that reduce the amount of estrogen the body makes and therefore ...plain why tamoxifen, which targets a single pathway, is less effective that aromatase inhibitors, which likely affect many estrogen pathways. Weigel noted tha...

Women well informed about breast cancer, yet lacking knowledge about current treatments

...the survey, nearly all respondents were aware of chemotherapy and radiation. However, fewer than one out of four had heard of newer therapies such as aromatase inhibitors or monoclonal antibodies, nor were they informed about their benefits. Doctor-patient dialogue is vital If diagnosed, the major...

Scientists discover way to block growth of prostate cancer cells

... Dr Basu said: "After surgery and radiotherapy for the primary tumour, breast cancer patients can be treated with several drugs such as tamoxifen and aromatase inhibitors that prevent or delay breast cancer recurrence. No such treatment exists for prostate cancer patients. After treatment of their primary t...

Aromatase in Biological Technology

Genomic Health Announces Third Quarter 2008 Financial Results and Business Progress

...re added earlier this year. -- Completed European study using Oncotype DX in node-negative and node-positive, breast cancer patients treated with aromatase inhibitors, which was accepted for oral presentation at the San Antonio Breast Cancer Symposium in December 2008. -- Continued to make progre...

Genomic Health Announces Second Quarter 2008 Financial Results and Business Progress

...ive HER2 scores in all Oncotype DX reports by the end of 2008. -- Conducting a study using Oncotype DX in breast cancer patients treated with aromatase inhibitors with the goal of reporting results this year. Colon Cancer -- Received first trial specimens for our clinical validation study, which ...

Meditrina Pharmaceuticals, Inc. Announces Exclusive Global License Agreement With AstraZeneca

... it is has completed a global licensing agreement to make, develop and commercialize products under AstraZeneca's IP and know-how regarding the use of aromatase inhibitors (AI) in combination with estrogen and progestin to treat endometriosis. This agreement expands Meditrina's clinical stage product portfolio...

New Drug to Prevent Bone Loss Caused by Breast Cancer Treatment

...e laboratory monitoring. A group of drugs called aromatase inhibitors is used to prevent the recurrence of br...ess of denosumab in preventing bone loss caused by aromatase inhibitors, a clinical trial recruited 252 patient...cancer and for whom treatment with anastrozole, an aromatase inhibitor, was planned. Half of the patients were ...

Aromatase in Biological Dictionary

Pachytene

...cal term. What does pachytene mean? ... pachytene /pachy·tene/ (pak'ĭ-tēn) in the prophase of meiosis, ... pachytene ... ... (ERß) and P450 aromatase in pachytene spermatocytes suggests a role for estrogens ... a well-known model of pachytene spermatocyte apoptosis in adult rats ... After e...