Aptamer

Kinovate Life Sciences, Inc. and Nitto Denko Corporation Announce Successful Development of NittoPhase™ HL High Loading Solid Support for Oligonucleotide Synthesis

...e base structure used in the synthesis of oligonucleotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. The market leading loading capacity of NittoPhase&trade...

Positive Results for Ophthotech's Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome

...rincipal investigator in over 50 macular clinical trials. E10030 is an aptamer targeting PDGF, a key molecule involved in the recruitment and maturation o...to treat wet and dry AMD. Additional molecular entities include an anti-C5 aptamer and volociximab, an anti-angiogenic monoclonal antibody targeting the a5B1 ...

Regado Biosciences to Present at the 2009 Wharton Healthcare Business Conference

...Biosciences is pioneering a new therapeutic technology with the creation and development of two-component drug systems. Each system is comprised of an aptamer therapeutic that can be controlled directly by its specific and matched active control agent. This technology is being applied to acute care injectabl...

What are protective effects of anti-ricin A-chain aptamer?

...TA), the protective effects of a 31-nucleotide RNA aptamer (31RA), which formed a high affinity complex with ...s were evaluated. They have shown that 31RA RNA aptamer can protect against ricin ribotoxicity in cell-bas...ciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a ...

Researcher refining synthetic molecules to prevent HIV resistance

... a cell," Burke-Aguero said. "The structure of the aptamer is very important. Broad-spectrum aptamers must ha...id sequence making it difficult to create a single aptamer that will work on every substype. Synthetic molecu... goal is to develop broad-spectrum aptamers. If an aptamer has broad-spectrum function, viruses will be less ...

ALS Patients and Researchers Unite in Boston for 4th Annual Leadership Summit

...evelopment of an immunotherapy for ALS," Jean-Pierre Julien, Ph.D., Professor, Laval University, Quebec, Quebec City, Canada; -- "Developing an aptamer Library for ALS," G. Thomas Caltagirone, Ph.D., President & CEO, Aptagen, LLC, Jacobus, Penn.; -- "A Comprehensive Approach to Communication Sy...

Scientists: New technique identifies molecular 'biomarkers' for disease

... aptamers recognize, Tan said. These targets will form a molecular foundation in understanding diseases, he said. In 2006, we did not know what the aptamer recognized on the cancer cell surface, he said. In this current work, we report discovering these biomarkers, which then form the molecular foundation...

Isis Reports Financial Results and Highlights for Fiscal year 2007

...artner, Archemix, for discovery and development of aptamer drugs. We are also using our technology to expand ...che. * Isis licensed technology to Archemix for aptamer drug applications in exchange for milestones and royalties on aptamer drugs developed by Archemix that incorporate ...

New Technique To Diagnose Cancer At Molecular Level

...re prior knowledge of cancer indicators, Tan said. "Using the cell-based aptamer selection strategy, we can generate aptamers which can specifically recogni...shed leukemia T-cells from lymphoma B-cells. Both results indicate that the aptamer method could be used to identify many different types of cancer, researcher...

Aptamer in Medical Technology

Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172

...o antibodies. Characteristics of aptamers include high specificity and affinity, and the ability to target protein-protein interactions. NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to...

Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System

... - Phase 1b Study is First to Show RNA aptamer Drug:Antidote Pair Offers Rapid Reversal of Anticoagulant Effect in Patients with Coronary Artery Disease - DURHAM, ...

Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172

...o antibodies. Characteristics of aptamers include high specificity and affinity, and the ability to target protein-protein interactions. NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to...

Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172

...o antibodies. Characteristics of aptamers include high specificity and affinity, and the ability to target protein-protein interactions. NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to...

Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172

... president of research and development for Nuvelo. "We look forward to sharing top-line data from this trial in the first half of 2008." NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to...

Data supporting three Antisoma programmes presented at AACR

... Broad potential of AS1411 alone and in combination New data show that the aptamer drug AS1411 kills cells from a wide variety of cancer cell lines. These inc...capable of interacting with particular target proteins. AS1411 is the first aptamer to be tested as a treatment for cancer. It binds to the protein nucleolin, ...

Archemix Announces Completion of Phase 1 Trial of ARC1779

...tamers, announced the successful completion of a Phase 1 study of its novel aptamer therapeutic, ARC1779. ARC1779 is designed to selectively block the activati... the primary site of arterial blockage." "We are developing a pipeline of aptamer therapeutics with a proprietary focus in acute cardiovascular and hematolog...

Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis

...Session (P-S-067): Discovery of a Potent, Direct Thrombin Inhibiting aptamer Date/Time: Sunday, July 8, 2007, 5:30 p.m. CEST Poster Session (P-S-072): Pharmacokinetic/Pharmacodynamic Profile of a Novel aptamer Direct Thrombin Inhibitor in Cynomolgus Monkeys and Yorkshire Pigs Fo...

Aptamer in Biological News

New cancer drug delivery system is effective and reversible

...verting them into effective sensors and diagnostic agents. His team used an aptamer that binds to nucleolin receptors, which are found in abundance on certain ...cells. The researchers then developed an effective method for attaching the aptamer to a liposome loaded with cisplatin, a drug that effectively kills cancer c...

New DNA and RNA aptamers offer unique therapeutic advantages

...d stability and residence time in the bloodstream. aptamer therapeutics presently in clinical development tar...uss the challenges that must still be overcome for aptamer technology to achieve its full potential. "This is a comprehensive and timely review of aptamer development and therapeutic applications that our ...

Reveal the enemy

...trands that can be designed and made to bind a specific target molecule. An aptamer that specifically binds to salmonella has recently been developed. The Spanish researchers chose to use this aptamer for their biosensor. By means of additional functional groups, they securel...

Genetic switch potential key to new class of antibiotics

...eighboring expression platform. The binding of the aptamer to the signaling molecule changes the platform's s...c information. The order of bases in a typical aptamer domain of the riboswitch causes the chain to fold ...ghts into how the loop end of the preQ1 riboswitch aptamer domain binds to preQ0, and about how that binding ...

Developing kryptonite for Superbug

...ally, he has been searching through a vast molecular library looking for an aptamer molecule, a piece of RNA that binds to a target, Dobler explained. His ...lps bind the staph to human tissue. The research has not yet yielded an aptamer that would most effectively and most specifically recognize staph. In his y...

Scientists design simple dipstick test for cocaine, other drugs

...are single-stranded nucleic acids that can bind to specific molecules in three-dimensions. For each molecular target, such as cocaine, a corresponding aptamer can be selected from a large DNA library. By using lateral flow devices as platforms to separate aptamer-linked nanoparticle aggregates, Lu, postd...

Researchers use 'trickery' to create immune response against melanoma

...gnificant promise for future cancer treatment," remarked Dr Farokhzad. "Through modification of the controlled-release polymer system or tweaks to the aptamer targeting group it may be possible to produce a diverse range of specific and selective bioconjugates. In this way, drug delivery 'vehicles' can be ma...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...gnificant promise for future cancer treatment," remarked Dr Farokhzad. "Through modification of the controlled-release polymer system or tweaks to the aptamer targeting group it may be possible to produce a diverse range of specific and selective bioconjugates. In this way, drug delivery 'vehicles' can be ma...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...e base structure used in the synthesis of oligonucleotides, including diagnostic probes and primers, antisense including RNAi, microRNA, DNA-based and aptamer drugs and represents a substantial portion of the cost to manufacture these oligonucleotides. NittoPhase?has been rigorously tested at both small a...

Aptamer in Biological Technology

Regado Biosciences Expands Medical Advisory Board

...neering a new therapeutic technology with the creation and development of two-component drug systems. Each system comprises a nuclease-stabilized RNA aptamer that can be controlled directly by its specific and complementary oligonucleotide active control agent. This technology is being applied to injectabl...

Regado Biosciences Establishes Medical Advisory Board

...g a new therapeutic technology with the creation and development of two-component drug systems. Each system is comprised of a nuclease-stabilized RNA aptamer therapeutic that can be controlled directly by its specific and complementary oligonucleotide active control agent. This technology is being applied i...

Fitting pieces for biosensors

... measure harmful substances in water. The term aptamer means something like "fitting pieces" (from the La...however, the scientists have to identify the right aptamer for a particular target molecule. Such target mole...s, another advantage of this is the possibility of aptamer selection even for toxic substances. Once suitable...

Dr. Steven L. Zelenkofske Joins Regado Biosciences as Senior Vice President, Clinical and Medical Affairs and Chief Medical Officer

...Biosciences Regado Biosciences is pioneering a new therapeutic field with the creation and development of two-component drug systems, comprising an aptamer therapeutic that can be controlled directly by its specific and matched reversal agent. Regado's technology is designed to give physicians the abilit...

Regado Biosciences To Present at the 27th Annual J.P. Morgan Healthcare Conference

...iosciences is pioneering a new therapeutic technology with the creation and development of two-component drug systems. Each system is comprised of an aptamer therapeutic that can be controlled directly by its specific and matched reversal agent. This technology is being applied to acute care injectable ant...

Ellen McDonald Joins Regado Biosciences as Senior Vice President of Business Operations and Chief Business Officer

...osciences Regado Biosciences is pioneering a new therapeutic field with the creation and development of two-component drug systems, comprising an aptamer therapeutic that can be controlled directly by its specific and matched reversal agent. Regado's technology is designed to give physicians the abilit...

David J. Mazzo, Ph.D., Joins Regado Biosciences as President and CEO

...hed success and further harness the great potential in Regado's lead programs and discovery platform. The Company is unique in its focus on developing aptamer therapeutics paired with agents that can directly modulate their activity. This has the potential to provide unprecedented control to the physician an...

SomaLogic and Otsuka Enter Into Research Collaboration

...aboration agreement to use SomaLogic's proprietary aptamer technology to discover and develop novel diagnosti... healthcare will help us achieve our goal of using aptamer technology to transform medicine. Otsuka believes ...o. The company's mission is to use its proprietary aptamer technology to develop aptamers with remarkable aff...

Aptamer in Biological Products

Standard 2'-OMe RNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for RNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive DNA/RNA Aptamer Microarray Service. Probe Content Our Standard 2-OMe RNA Ap...
Company:LC Sciences

Standard 2'-F RNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for RNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive DNA/RNA Aptamer Microarray Service. Probe Content Our Standard 2-F RNA Apta...
Company:LC Sciences

Standard DNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for DNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive DNA/RNA Aptamer Microarray Service. Probe Content Our Standard DNA Aptamer ...
Company:LC Sciences

Custom 2'-F RNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for RNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. Thousands of customer specified RNA sequences can be synthesized on-chip and LC Sciences can provide assistance with custom sequence design...
Company:LC Sciences

Custom DNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for DNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. Thousands of customer specified sequences can be synthesized on-chip and LC Sciences can provide assistance with custom sequence design. Th...
Company:LC Sciences

Custom 2'-OMe RNA Aptamer Microarray from LC Sciences

Description: Microarrays designed for RNA aptamer screening and binding optimization and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. Thousands of customer specified RNA sequences can be synthesized on-chip and LC Sciences can provide assistance with custom sequence design...
Company:LC Sciences

DNA/RNA Aptamer Microarray - Comprehensive Service from LC Sciences

Description: LC Sciences provides unique aptamer microarray services using a novel Paraflo technology, aptamer sequence databases, and sequence design software to suit your needs for basic research and screening of aptamers as drug candidates. This comprehensive service includes assistance with sequence design,...
Company:LC Sciences

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Aptamer in Biological Definition

Genetic code

...transcription tables would have done just as well? Already a cursory look at the table shows patterns that suggest that this is not the case. Recent aptamer experiments have shown that amino acids have indeed a selective chemical affinity for the base triplets that code for them. This suggests that the cu...

Genetic code

...transcription tables would have done just as well? Already a cursory look at the table shows patterns that suggest that this is not the case. Recent aptamer experiments have shown that amino acids have indeed a selective chemical affinity for the base triplets that code for them. This suggests that the cu...