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Aprotinin in Medical News

Frost & Sullivan Commends Nycomed for Excellence in Product Differentiation Innovation

...brin sealants or hemostats available in the market today are bovine-based. These products have attendant safety concerns related to the bovine protein aprotinin or bovine thrombin which carries the risk of allergic reactions, autoimmune syndromes and transfer of diseases. "With TachoSil, Nycomed has elimi...

Another Study Warns of Risk From Cardiac Surgery Drug

... blood loss during surgery. "Lysine analogues are almost as effective as aprotinin in controlling blood loss, are cheaper, and appear not to increase mortalit...of Medicine earlier this year. That study found that patients treated with aprotinin were 53 percent more likely to die than those treated with two similar drug...

Risk of death may be higher with drug commonly used during cardiac surgery

...anada expert advisory panel will meet to decide on aprotinin use. The study is being early released in advance ...ystematic review of 49 randomized trials, compared aprotinin with lysine analogues. It includes new information...s taking aprotinin. In the CMAJ review, while aprotinin was slightly more effective at controlling blood l...

Danger From Heart Surgery Drug Confirmed

...sked were serious complications, such as death and organ failure, lower for aprotinin compared to the two other drugs," Fergusson said. The report was publish...less there is surprising new data, the BART findings preclude future use of aprotinin in cardiac surgery, even though we don't fully understand why the increased...

A new finding in liver transplantation and antifibrinolytics?

...e performed a meta-analysis to study the effect of aprotinin used in OLT on the intraoperative requirement of b...operative outcomes. This study clearly showed that aprotinin can reduce the intraoperative requirement of blood...here are still some conflicting results on whether aprotinin can reduce blood loss or requirement of transfusio...

More Evidence of Danger From Heart Surgery Drug

...blems with the medication. "There continues to be an association between aprotinin and higher death rates and kidney damage," said Dr. Andrew Shaw, an associa...Shaw said. "There does appear to be an association between continued use of aprotinin and reduced kidney function," he said. The second study, led by physicia...

Drug Combo Tied to Kidney Risk With Some Cardiac Surgeries

... aprotinin plus ACE inhibitor associated with renal woes duri...(HealthDay News) -- While use of the clotting drug aprotinin (Trasylol) appears safe during on-pump cardiac sur... research that noted an association between use of aprotinin -- which reduces the risk of bleeding during compl...

Trasylol Pulled From Worldwide Market

...sed nonprofit group, said that "the death rate for aprotinin patients far outstrips that for the other two drug...r complications linked to the drug might be due to aprotinin being prescribed for "higher-risk patients who cou...s have shown that "in carefully selected patients, aprotinin is a good drug," he said. The information used...

Bayer Temporarily Suspends Global Trasylol(R) Marketing

...ficance for 30- day mortality) for patients in the aprotinin treatment arm compared to patients who received ei...d reactions is increased among patients with prior aprotinin exposure and a history of any prior aprotinin exposure must be sought prior to Trasylol(R) admin...

FDA to Review Clotting Drug After Trial Suggests Death Risk

...aid it will review the safety of the clotting drug aprotinin (Trasylol), after a major Canadian trial was stopp...c surgery. While less bleeding was noted in the aprotinin group versus patients assigned one of two other drugs, "a trend toward increased mortality in the aprotinin group had been observed throughout the study," the...
Aprotinin in Medical Technology

Bayer Issues Additional Guidance to Physicians on Trasylol(R)

...increase in all-cause mortality in patients in the aprotinin treatment arm compared to patients who received ei...d reactions is increased among patients with prior aprotinin exposure and a history of any prior aprotinin exposure must be sought prior to Trasylol(R) admin...

FDA Advisory Committees Recommend Continued U.S. Marketing Authorization for Trasylol(R)

...d reactions is increased among patients with prior aprotinin exposure and a history of any prior aprotinin exposure must be sought prior to Trasylol(R) admin...exposure within 12 months of the most recent prior aprotinin exposure. Trasylol(R) should be administered only ...
Aprotinin in Medical Dictionary

Kinins

...peptides liberated from the protein precursor, kininogen, ... Under physiological conditions, endogenous kinins are degraded into inactive ... aprotinin or the kinin antagonist produced no consistent change in renal ... These studies provide evidence that kinins generated in the kidney particip...
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