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Apoptotic in Medical News

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

...amage DNA in rapidly replicating cells, dramatically boosting the amount of apoptotic death happening in tumors. Some experimental models indicate that inducing ...study or to Akrotome. The approach also holds promise for tracking unwanted apoptotic damage to tissues in disorders such as macular degeneration or traumas such...

Quark Pharmaceuticals Announces the Presentation of Data Indicating Potential Utility of QPI-1002 in Chronic Kidney Disease at the RNA Interference Summit

... I/II study for delayed graft function (DGF) in kidney transplantation. QPI-1002 targets p53, a gene that plays a pivotal role in the stress-response apoptotic pathway. Using intravital 2-photon in life microscopy to follow the distribution of fluorescent labeled siRNA in the rat kidney, Prof. Molitoris ...

A new light on the mechanisms of early stage liver reperfusion injury

...mmation and the subsequent cell death by apoptosis are the most important changes in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion was increased. ...

JCI online early table of contents: April 6, 2009

... protein Drp1, which is known to be involved in mitochondrial fission, and blocking its function substantially reduced mitochondrial fragmentation and apoptotic cell death. Consistent with these data, mitochondrial fragmentation was observed in two mouse models of acute kidney injury and treatment with a newly...

Cathepsin B increases apoptosis in fulminant hepatic failure

...athepsin B expression initiates hepatocyte apoptosis in fulminant hepatic failure. Cathepsin B, a lysosomal cysteine protease, is a candidate for an apoptotic mediator originating from acidic vesicles. CA-074me is a selective inhibitor of cathepsin B , and it is highly cell-permeant and can decrease the expr...

MicroRNA undermines tumor suppression

... programmed cell death that can be triggered by p53) both increased, whereas an increase in miRNA125b levels decreased levels of p53 and the number of apoptotic cells. To confirm that miRNA125b played a similar role in developing organisms, Le changed the miRNA125b levels in zebrafish embryos. When she red...

JCI online early table of contents: March 9, 2009

...e data suggest that these two RPTPs normally act redundantly to control key apoptotic events in the distal common nephric duct, allowing correct positioning of t...roper connection of the ureter to the bladder wall. In the absence of these apoptotic events, the ureter fails to contact the bladder, resulting in ureter-bladde...

What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?

...AR- are currently being studied as a novel treatment. The PPAR-gamma ligand generally decreases the survival rate of cancer cells via differentiation, apoptotic induction, and changes in genes or proteins associated with entrance into the G1/S phase. There have been some reports suggesting that stomach cancer ...

Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate

...nesco's SNS-01 consists of three components: an eIF5A plasmid, an siRNA against eIF5A and polyethyleneiminie (PEI). The eIF5A plasmid upregulates the apoptotic pathways within cancer cells. The siRNA downregulates proinflammatory cytokines, NF-kB and ICAM, which are proliferation factors for multiple myeloma...

Maslinic acid provides a natural defense against colon cancer

...ment with maslinic acid, a triterpenoid compound isolated from olive-skin pomace, results in a significant inhibition of cell proliferation and causes apoptotic death in colon-cancer cells. Maslinic acid is a novel natural compound and it is able to induce apoptosis or programmed death in human HT29 colon-canc...
Apoptotic in Medical Technology

Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines

SOMERSET, N.J., July 21 /PRNewswire-FirstCall/ -- Alfacell Corporation (Nasdaq: ACEL ) today announced that a paper published in Molecular Cancer Therapeutics (2008; 7(7):1871-9) reports that a combination of ONCONASE (ranpirnase) and the thiazolidinedione antidiabetic drug rosiglitazone show...

Light Sciences Oncology Completes Patient Enrollment in Phase 3 Clinical Trial of Litx as a Treatment for Hepatocellular Carcinoma

... system to attack untreated tumors. Since 2007, data from a number of published animal and human studies has demonstrated that the production of large apoptotic masses in tumors with light-activated drug therapies, including Litx, yields tumor-specific clones of CD8+ T-cells that infiltrate distant, untreated ...

Human Genome Sciences Completes Enrollment in Randomized Phase 2 Trial of HGS-ETR1 in Non-Small Cell Lung Cancer

... Pharm., Ph.D., Vice President, Clinical Research - Oncology, HGS. "HGS-ETR1 is the most advanced of any product in development that targets the TRAIL apoptotic pathway. The NSCLC study is one of three ongoing HGS trials designed to evaluate combinations of HGS-ETR1 with chemotherapeutic agents for the treatme...

Aegera Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156

...ncer cells acquire multiple mutations that disable their normal response to apoptotic triggers. AEG35156, a second generation antisense which targets XIAP, is designed to lower the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death a...

Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss

...th its persistence in the cochlear hair cells for at least 15 days. In preclinical animal studies, AHLi-11 appears to protect cochlear hair cells from apoptotic cell death induced by the chemotherapeutic agents, cisplatin and carboplatin, and by acoustic trauma. Daniel Zurr, CEO of Quark Pharmaceuticals, said...

Scottish Scientists Test ‘Secret Weapon’ Against Tumours

...gunn-Jones in the press office on 020 7061 8311, or, out of hours, the duty press officer on 07050 264 059. Notes to Editors: *A novel p53-derived apoptotic peptide de-represses p73 to cause tumor regression in vivo. Helen S. Bell et al, 2007. Journal of Clinical Investigation. This research was funded b...

Studies Show Mild Hyperthermia Enhances Antitumor Effects of Alfacell's Onconase

... these experiments, apoptosis was manifested by classical changes in cell morphology and the activation of caspase-3, both considered hallmarks of the apoptotic mode of cell death. "This is very encouraging data that support our work in investigating multiple therapeutic options for the ONCONASE franchise," ...

Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual Meeting of the American Association of Cancer Research (AACR)

...d on Sunday, April 15 from 1 to 5 p.m. Poster #26 (section 7) entitled "Triapine(R) binds with iron and causes S- phase arrest and activation of the apoptotic pathway in advanced cancer patients" will be presented on Monday, April 16 from 8 a.m. to 12 p.m. Vion Pharmaceuticals, Inc. is committed to extendi...

Sunesis Presents Data Supporting SNS-032's Potential Anticancer Activity in Multiple Myeloma at the American Association for Cancer Research Meeting

...osing SOUTH SAN FRANCISCO, April 16, 2007 /PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. presented non-clinical data demonstrating SNS-032's apoptotic activity in a multiple myeloma model. These data were presented today in a poster session during the Annual Meeting of the American Association for Ca...

Gemin X Biotechnologies Announces Publication in Blood of Positive Preclinical Data of Lead Compound in Mantle Cell Lymphoma

...tion of Mcl-1 by GX15-070, in contrast, overcame this resistance. This positive preclinical activity of GX15-070 led to an increased activation of the apoptotic pathway, while showing no significant cytotoxic effect in normal cells from healthy donors when used both alone and in combination with bortezomib. ...
Apoptotic in Medical Dictionary

Phagocyte

...unction. ... Partial correction of the phagocyte defect in patients with X-linked chronic ... The role of phosphatidylserine in recognition of apoptotic cells by phagocytes . ... in detecting the activity of phagocyte NADPH oxidase and other oxidases. ... ... root sheath; P, postnatal day; PGK, ...
Apoptotic in Biological News

Cancer: The cost of being smarter than chimps?

... absolutely, according to McDonald. However, his lab has recently obtained additional direct experimental evidence consistent with the hypothesis that apoptotic function is more efficient in chimps than in humans. ...

Scattered light rapidly detects tumor response to chemotherapy

..., researchers can analyze the light scattered by these bodies to detect the apoptotic changes in real time. "The new technology allowed us to detect the tell-...re the paper's first authors. "If we had a way to detect early on in the apoptotic process whether or not a drug was working, patients would not have to wait ...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

...ssociated with use of grape seed extract that led to cell death, or apoptosis. They found that the extract activates JNK, a protein that regulates the apoptotic pathway. While grape seed extract has shown activity in a number of laboratory cancer cell lines, including skin, breast, colon, lung, stomach and ...

Genes that control cell death fingered in age-related hearing loss

... genes, employing a newer technique known as a PCR array to measure activity. Through that test the scientists identified eight genes, all part of the apoptotic process, whose activity differed between the two groups. Apoptosis itself is certainly nothing new. Such programmed cell death happens constantly ...

A step forward in virology

... a new one. Other viruses, such as herpes, adeno and H1 viruses use macropinocytosis. However the vaccinia virus is the first one identified that uses apoptotic mimicry as an entry strategy. Knowledge of the virus strategies and the signal proteins involved in the ingestion of a virus by a cell is crucial t...

Fruit flies show how salmonella escapes immune defenses

... suppressed the same immune signaling pathways and apoptotic reaction as in the drosophila model. A mutant form...biochemical crossroad required for both immune and apoptotic pathways," says Neish. "The AvrA protein is able t...to suppress both the inflammatory response and the apoptotic immune response at the same time. We suspect that...

2 genes are important key to regulating immune response

...ages express the IL-10 cytokine in the presence of apoptotic cells. IL-10 suppresses the activity of immune ...macrophage -- was important for the recognition of apoptotic cells by macrophages. In this work, the researcher...6 also helped to trigger IL-10 production whenever apoptotic cells were around. The team then asked a deeper...

Dominant cholesterol-metabolism ideas challenged by new research

...poptosis), PS is also expressed on the surface of apoptotic cells to signal macrophages to come and clean up the dead cells. Both the macrophages and apoptotic cells must express PS on their surfaces for this ...fect on the movement of PS to the cell surface in apoptotic cells," says Schlegel. "We conclude that the ABC...

JCI table of contents: Aug. 9, 2007

...sidered to occur mostly through a process known as apoptotic cell death, a new study appearing online on August...ailure is a pleiotropic disease that involves both apoptotic and necrotic cardiomyocyte death. TITLE: Ca2+- ...rticle.php?id=31060 CARDIOLOGY: Extent of apoptotic cell death affects risk factor for heart failure ...

Protein found to control tumor growth in certain breast cancers

...researchers to take a fresh look at the Nod1 protein." In the study, researchers looked at a number of biological processes where Nod1-dependent apoptotic (programmed cell death) pathways were a critical component, including the regulation of tumor cell growth where the failure of malignant cells to unde...
Apoptotic in Biological Technology

Cynvec to Present at The 2009 New York Venture Summit

...developing novel cancer therapies that harness the apoptotic ability of the sindbis viral vector, today announc...veloping proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology...and radiation. CYN 101 is a replication defective, apoptotic RNA vector that has shown tumor eradication and hi...

Cynvec to Present at the 11th Annual Shanghai International Forum on Biotechnology and Pharmaceutical Industry

...developing novel cancer therapies that harness the apoptotic ability of the sindbis viral vector, today announc...veloping proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology...and radiation. CYN 101 is a replication defective, apoptotic RNA vector that has shown tumor eradication and hi...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...ur development pipeline to demonstrate broad anti-cancer activity in pre-clinical models, including synergy with other agents, by targeting a specific apoptotic pathway," said Mel Sorensen, MD, CEO of Ascenta Therapeutics. "On the basis of these encouraging data, we plan to submit an Investigational New Drug ...

Cynvec to Present at New York Biotechnology Association 18th Annual Meeting

...developing novel cancer therapies that harness the apoptotic ability of the sindbis viral vector, today announc...veloping proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology...and radiation. CYN 101 is a replication defective, apoptotic RNA vector that has shown tumor eradication and hi...

Cynvec to Present at the BIO National Venture Conference

...developing novel cancer therapies that harness the apoptotic ability of the sindbis viral vector, today announc...veloping proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology...and radiation. CYN 101 is a replication defective, apoptotic RNA vector that has shown tumor eradication and hi...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...s: it selectively attacks existing tumor blood vessels leading to hemorrhagic tumor necrosis without affecting normal vasculature, and it has a direct apoptotic effect on tumor cells. In preclinical models of cancer, including lung, breast, sarcoma, colon and prostate, NPI-2358 demonstrated potent and selecti...

Oncolytics Biotech(R) Inc. Collaborators Present Reovirus Research at Replicating Oncolytic Virus Meeting

...ycin and reovirus is only seen when rapamycin is administered after reovirus, and that simultaneous administration of rapamycin and reovirus decreases apoptotic cell death and viral replication. However, unlike the in vitro observations, the combination of rapamycin and reovirus is synergistic in vivo. Further...

Improved Cryopreservation Outcomes in Potential $100B Tissue Engineering Market Enabled by BioLife Solutions CryoStor(TM)

... with other published data describing post-thaw survival overestimates, and suggest that the decrease in cell viability might be related to sequential apoptotic and necrotic processes not evident immediately subsequent to thawing. This supports very early BioLife research and discoveries of the phenomena of p...

Cynvec LLC(SM) to Present at the Cowen and Company 29th Annual Health Care Conference

...ology company focused on developing novel cancer therapies that harness the apoptotic ability of the sindbis viral vector, today announced that Frank Stonebanks,...technology company, is developing proprietary cancer therapies based on the apoptotic sindbis oncolytic viral vector, a novel technology that targets overexpress...

Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer

...ncer cells acquire multiple mutations that disable their normal response to apoptotic triggers. AEG35156, a second generation antisense which targets XIAP, is designed to lower the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death a...
Apoptotic in Biological Products

Magnetic Separator (Re-usable) from BioVision

Description:... Reusble. Uses in conjunction with the apoptotic Cell Isolation Kit....
Company:BioVision

Apoptotic DNA Laddering Kit - Tissue Supplement from R&D Systems

Description:... TACS apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
Company:R&D Systems

Vybrant Apoptosis Assay Kit #4 from Molecular Probes (Invitrogen)

Description:...ns ready-to-use solutions of both YO-PRO-1 and propidium iodide nucleic acid stains. YO-PRO-1 stain selectively passes through the plasma membranes of apoptotic cells and labels them with moderate green fluorescence. Necrotic cells are stained red-fluorescent with propidium iodide....
Company:Molecular Probes (Invitrogen)

Caspase Inhibitor Ac-DEVD-CHO, Unconjugated from Promega

Description:...bit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in extracts of apoptotic THP-1 cells....
Company:Promega

ProteoJuice Protein Transfection Reagent from Novagen

Description:... Introduction of a protein into cells permits studies of protein-protein interactions, protein turnover, cell signaling pathways, apoptotic pathways, and transcription factor-mediated gene regulation. The most rapid method for studying the effects of a specific protein in a mammalian cell ...
Company:Novagen

Flow Cytometry Kit for Apoptosis from Sigma-Aldrich

Description:...A laddering". The fragmentation creates a large number of 3'-hydroxyl sites at the DNA breaks. This property is used in the APO-BRDU kit to identify apoptotic cells by labeling the 3'-hydroxyl sites with bromodeoxyuridine triphosphate (Br-dUTP). Br-dUTP is enzymatically attached to the 3-hydroxyl sites of d...
Company:Sigma-Aldrich

Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.

Description:... signaling pathways involved in apoptosis and cell death. Splice variants have been reported that affect both the activation and inhibition of defined apoptotic pathways. With Apoptosis and Cell Death SpliceArrays you can perform a classical expression profiling and at the same time detect the different alter...
Company:ExonHit Therapeutics Inc.

Mito Casp from BACHEM

Description:...hondrial membrane potential is visualized by a cell-permeable cationic red fluorescent dye which is accumulated by the mitochondria of healthy but not apoptotic cells. The kit can be used in conjunction with other antibodies or stains. Application: Fluorescence via flow cytometry, microwell plate reader, and m...
Company:BACHEM

Apoptotic Cell Isolation Kit from MBL International

Description:...ides a simple and efficient means for isolation of apoptotic cells from normal c lture using annexin V magnetic...otein with high affinity for phosphatidylseri The apoptotic Cell Isolation Kit provides a simple and efficient means for isolation of apoptotic cells or removal of dead cells from cell culture o...
Company:MBL International

ApoDIRECT DNA Fragmentation Assay Kit from MBL International

Description:...d negative control cells for convenient detection of DNA fragmentation in cultured cells and tissue sections. The assay offers an one-step labeling of apoptotic cells. Internucleosomal DNA fragmentation is a hallmark of apoptosis in mammalian cells. MBLs ApoDIRECT In Situ DNA Fragmentation Assay Kit provides...
Company:MBL International
Apoptotic in Biological Definition

Apoptosis

...rate. As will be explained further on, the way the apoptotic process is executed facilitates the safe disposal ...s importance as a biological phenomenon, defective apoptotic processes have been implicated in a very wide vari...evelopment 1.5 Immune cell regulation 2 apoptotic process 2.1 Morphology 2.2 Biochemical s...

Immune system

...ing T-cell receptors to probe the surface of other cells. If they recognize an infected cell, they release granzymes to signal that cell to become apoptotic ("commit suicide"), thus killing that cell and any viruses it is in the process of creating. Helper T cells (T H cells) activate infected ...
Apoptotic in Biological Dictionary

Sequential Epitope

... cascade. ... They further demonstrate that the epitope MOG92–106 has the specific ... The JNK and p38 pathways function to modulate cell-cycle, apoptotic and ... Purification: Purified from rabbit serum by sequential epitope -specific chromatography. ... ... LM7 pectic homogalacturonan epitope ...

Schwann cells

...cing group, Schwann cells (labeled with Hoechst) demonstrated their ... tigate the changes in the Schwann cells found in Golgi tendon ... apoptotic death of these Schwann cells and that this apoptosis ... The Schwann cells are also present, and they closely cover every branch of the n...

Cristae

... & Encyclopedia Articles Quickly. ... ... relating to ' cristae ' ... of cytochrome c stored in intramitochondrial cristae . ... OPA1 Controls apoptotic Cristae Remodeling Independently from ... Information about cristae in the free online English dictionary and encyclopedia. ... Plural cristae...

Caspase

...mine if a caspase inhibitor is reversible or ... ROLE OF CASPASE -3 IN ... Caspase activation is a cellular event associated with the onset of apoptotic death. Detection of caspase activity provides a useful assay for analyzing one of the ... FLICA Caspase Detection Kits ... FLICA APOPTOSIS CAS...

Apoptosis

...: What is Apoptosis ? ... Apoptosis is the term used to describe the generally normal death of the cell in ... Learn about apoptosis and the apoptotic cascade. Find protocols and methods for ... Apoptosis is the term given when programmed cell death (PCD) occurs in ... ...
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