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Apoptosis in Medical News

Cathepsin B increases apoptosis in fulminant hepatic failure

The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulmi...

Sigma-Aldrich Licenses From NeuroSurvival Technologies a Leading Marker for Molecular Imaging of Apoptosis in Vivo

The marker, Apo-TRACE(TM), offers a breakthrough in advancing apoptosis-related research in a range of fields in biology and medicine ST. LOUIS, Feb. 26 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) and NeuroSurvival Technologies Ltd. (NST) announced today that they have si...

FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis

BALTIMORE, March 26 /PRNewswire/ -- FASgen Diagnostics, LLC is pleased to report that results of studies using the Company's FAS-detect(TM) IHC and FAS- detect(TM) ELISA research tests were the subject of an address to Society of Gynecologic Oncologists annual meeting last week in Tampa, Flori...

A Combination Of Drugs Used For Anti-Angiogenesis And Apoptosis More Effective

Imantanib is a drug which prevents the growth of new blood vessels, thereby inhibiting the growth of tumour(anti-angiogenesis). //It has been discovered that using Imantanib (Glivec [1]) and a drug that induces cell death (apoptosis) works better. It was found that the combination was more effectiv...

Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway

The Mycotoxin citrinin (CTN) is a secondary metabolite produced by several fungal species that belong mainly to the genus Penicillium and Monascus. It is widely considered as a hazard contaminant of foods// and feeds, including corn, wheat, rice, barley and nuts, and is known to be cytotoxic and ge...

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

...own, TREANDA may act in two distinct ways to kill cancer cells. Preclinical studies suggest that TREANDA may lead to cell death by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptoti...
Apoptosis in Medical Technology

Oncolytics Biotech(R) Inc. Announces Publication of Research on Synergistic Activity of Reovirus and Chemotherapy in NSCLC

...tentiated by taxanes and other chemotherapeutic agents, and that the reovirus-taxane combination most effectively achieves synergy through accelerated apoptosis triggered by prolonged mitotic arrest. About Oncolytics Biotech Inc. Oncolytics is a Calgary-based biotechnology company focused on the deve...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...in a new class of selective, irreversible proteasome inhibitors. Carfilzomib produces specific and sustained inhibition of the proteasome, leading to apoptosis in cancer cells with minimal off-target effects. In Phase 1 and Phase 2 clinical trials, carfilzomib has demonstrated single-agent activity in hemato...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...ion with established therapeutics (Abstract 8571) and that TRU-016-mediated apoptosis in CLL cells occurs via a distinct mechanism of apoptosis compared with many other therapeutic agents utilized for the treatment of C...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

...in a new class of selective, irreversible proteasome inhibitors. Carfilzomib produces specific and sustained inhibition of the proteasome, leading to apoptosis in cancer cells with minimal off-target effects. In Phase 1 and Phase 2 clinical trials, carfilzomib has demonstrated single-agent activity in hemato...

Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506

...ys, including VEGFR and TIE2. BAY 73-4506 has also been shown in preclinical studies to prevent the proliferation of tumor cell lines while promoting apoptosis (cell death) by directly targeting several oncogenic TK receptors. The clinical significance of these studies is not known and warrant further invest...

Senesco Announces H1N1 Influenza Survival Test Results in Mice

...further underscore Factor 5A's ability to mitigate apoptosis caused by inflammation, in this case from the H1N1...ogy is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain diseases inflamma...
Apoptosis in Medical Products

VersaFluor Cuvette Fluorometer

Features:...ble filters Is the only instrument needed to detect and quantitate DNA from PCR amplification, restriction digests, and plasmid preps, to quantitate apoptosis activity, and to assay the reporter enzymes beta-glucuronidase (GUS) and beta-galactosidase Quantitates DNA at concentrations as low as 10 ng/ml usi...
Company:Bio-Rad Laboratories

Epi-K

Features:... layer. Presence of an applanation front plate prevents cutting into the stroma. Implication of potential better wound healing: less apoptosis (more stable result). possibly less pain. Expected more rapid visual recovery. ...
Company:Moria S.A.
Apoptosis in Biological News

Study by NTU professors provides important insight into apoptosis or programmed cell death

A study by Nanyang Technological University (NTU)'s Assistant Professor Li Hoi Yeung, Assistant Professor Koh Cheng Gee and their team have made an important contribution to the understanding of the process that cells go through when they die. This process known as 'apoptosis' or programmed cell d...

Novel structure proteins could play a role in apoptosis

Isoforms from Novel Structure Proteins (NSP), a new family of genes discovered by researchers in the Sbarro Institute for Cancer Research and Molecular Medicine in Temple University's College of Science and Technology, could be involved in apoptosis or programmed cell death. NSPs were discove...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine. Though mult...

Protein that promotes cancer cell growth identified

...r of cell death proteins are missing from human tumors, allowing cancer cells to ignore the cues that keep their growth in check. Cells that can evade apoptosis have a clear growth advantage. Because Caspase-8 is involved in programmed cell death, it would seem that reducing Caspase-8 in cancer cells would pro...

How mitochondria get their membranes bent

...rage of molecules. Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment. When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diameter and the shape of the inner...

Cancer: The cost of being smarter than chimps?

...estes, liver, kidneys and heart. They found distinct differences in the way apoptosis or programmed cell death operates, suggesting that humans do not "self-destroy" cells as effectively as chimpanzees do. apoptosis is one of the primary mechanisms by which our bodies destroy cancer cells. ...
Apoptosis in Biological Technology

Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar

Tracy Worzella and Brad Larson Promega Corporation, Madison, WI, USA Application Note 138 Rev. 07/2006 Correlated measurement of an apoptosis marker (or caspase activity) ...

Caspase-3 Activation - An Indicator of Apoptosis in Image-Based Assays

Introduction The understanding of the cellular signaling processes leading to programmed cell death (apoptosis) is of utmost importance in the study of autoimmune diseases such as rheumatoid arthritis or Parkinsons and Alzheimers disease. Here, errors in the signal...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

Key words: In Cell Analyzer • apoptosis • multiplexing • cell based assays Apoptosis represents a gene-directed, morphologically and biochemically distinct form of programmed cell death. Inappropriate control of apoptosis is associated...

RT-PCR Primers for the Study of Apoptosis

Investigating programmed cell death Wei-ping Yang Danny Hoang Douglas McKenzie Peter Pingerelli Stratagene The apoptotic response is a complex biological process that requires the regulation of a variety of genes that interact with and respond to intracellular and extr...

Senesco Technologies Enters Into Agreements For Additional $700,000 In Financing

...o determine if the technology is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain inflammatory and ischemic diseases. Senesc...

Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing

...o determine if the technology is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain inflammatory and ischemic diseases. Senesc...

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Apoptosis in Biological Products

MitoLight® Mitochondrial Apoptosis Detection Kit from Upstate

Description: ...
Company:Upstate

SelectFX Alexa Fluor 488 Cytochrome c Apoptosis Detection Kit - for fixed cells from Molecular Probes (Invitrogen)

Description: The SelectFX Alexa Fluor 488 Cytochrome c Apoptosis Detection Kit provides all the reagents you need to detect cytochrome c in fixed cells. The kit employs an anti-cytochrome c primary antibody and an Alexa Fluor 488 dye-labeled secondary antibody. Alexa Fluor 488 dye exhibits bright green fluores...
Company:Molecular Probes (Invitrogen)

FlowTACS Flow Cytometry Apoptosis Detection Kit from R&D Systems

Description: The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
Company:R&D Systems

Vybrant Apoptosis Assay Kit #4 from Molecular Probes (Invitrogen)

Description: The Vybrant Apoptosis Assay Kit #4 detects apoptosis on the basis of changes that occur in the permeability of cell membranes. This kit contains ready-to-use solutions of both YO-PRO-1 and propidium iodide nucleic acid stains. YO-PRO-1 stain selectively passes through the plasma membranes of apop...
Company:Molecular Probes (Invitrogen)

Vybrant Apoptosis Assay Kit #7 - Hoechst 33342/YO-PRO-1/propidium iodide - 200 assays from Molecular Probes (Invitrogen)

Description: See product name for description....
Company:Molecular Probes (Invitrogen)

TUNEL Apoptosis Detection Kit from Upstate

Description: TUNEL Apoptosis Detection Kit...
Company:Upstate

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Apoptosis in Biological Definition

Apoptosis

In biology , apoptosis (from the Greek words apo = from and ptosis = falling, pronounced ap-a-tow'-sis [1] ) is one of the main types of programmed cell death (PCD). As such, it is a process of deliberate suicide by an unwanted cell in a multicellular organism . In contrast t...

Antigen

...ass I histocompatibility molecules . If cytotoxic CD8 + T cells recognize them, they begin to secrete different toxins that cause the lysis or apoptosis of the infected cell. In order to keep the cytotoxic cells from killing cells just for presenting normal proteins, they run through a test cycle (neg...

Cancer

... with poor prognosis , since those tumor cells are less likely to go into apoptosis (programmed cell death) when damaged by therapy. There are more mutations ...sarcoma , lymphoma or leukemia , have distinct properties: evading apoptosis unlimited growth potential (immortalitization) self-sufficiency of ...

Cytotoxic T cell

...expand and eventually lyse . T C also release granzyme , a serine protease , that can enter target cells via the perforin-formed pore and induce apoptosis (cell death). Most T C cells have present on the cell surface the protein CD8 , which is attracted to portions of the Class I MHC molecule. This a...

Developmental biology

..., which could lead to the specific cloning of organs for medical purposes. Another biologically important process that occurs during development is apoptosis - cell "suicide". For this reason, many develpmental models are used to delucidate the physiology and molecular basis of this cellular process. ...

Homeostasis

...e pituitary gland , which in turn is directed by the hypothalamus . See also Acclimatization Biological rhythm Metabolism apoptosis Aging Balance Self-organization Cybernetics ...
Apoptosis in Biological Dictionary

Apoptosis

Apoptosis is the process of programmed cell death (PCD) that may occur in multicellular organisms. Programmed cell death involves a series of biochemical events leading to a characteristic cell morphology and death; in more... Outlines the mechanisms of cell suicide. apoptosis ...

Thyroid gland

.... The Iodine Source is your source for detoxified iodine. ... 9) Iodine and the Thyroid Gland . 10) Iodine Functions in the Body. 11) Iodine and apoptosis ... What is your thyroid gland ? ... The thyroid gland is located in the middle of the lower neck, below the larynx ... "masses" in their ...

Schwann cells

...strated their ... tigate the changes in the Schwann cells found in Golgi tendon ... apoptotic death of these Schwann cells and that this apoptosis ... The Schwann cells are also present, and they closely cover every branch of the neuron. ... This work suggests that signal comes from the ...

Retrotransposon

...e ... The Ty5 retrotransposon is used as a genetic model to study the architecture and ... Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells ... Jr, Boeke JD: Human L1 retrotransposon encodes a conserved endonuclease required ... inferred from 33 non-LTR retrotr...

Proteome

...a biomarkers for Alzheimer's disease" ... Proteome Resources provides enzymes, nucleases and protein expression services to ubiquitin and apoptosis research scientists in academic, government, ... Proteome Software would like to hear what you have to say about Proteomics, and ... To get the ...

Proteasome

...toplasm and nucleus of all eukaryotic cells that is the site The scientific resource for elucidating the Ubiquitin / Proteasome Pathway. ... apoptosis meets proteasome , an invaluable therapeutic target of anticancer drugs. ... Ubiquitin and Proteasome Proteasome , signalosome, & TPPII ...
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