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Antisense in Medical News

Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

ORLANDO, Fla. and CARLSBAD, Calif., June 1 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today that Isis' collaborators presented new clinical data on drugs in Isis' partnered oncology franchise at this year's American Society of Clinical Oncology (ASCO) Annual M...

Isis' Partners Present Clinical Data on Antisense Drugs at the American Society of Clinical Oncology

CHICAGO and CARLSBAD, Calif., June 2 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today that two of the Company's partnered oncology drugs were highlighted during the American Society of Clinical Oncology (ASCO) meeting. Data from both drugs highlighted posit...

Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases

- Excaliard closes $15.5 million Series A financing from Alta Partners, ProQuest Investments and RiverVest Venture Partners CARLSBAD, Calif. and ENCINITAS, Calif., Nov. 27 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) and Excaliard Pharmaceuticals, Inc. announc...

Isis Pharmaceuticals to Present at Canaccord Adams' 29th Annual Global Growth Conference

...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...iseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Quark Pharmaceuticals to Participate in IBC's Oligonucleotide Therapeutics: From Concept to Implementation Conference

...ompson will moderate is titled, "RNA Therapeutics - Are We Leveraging on the Promise?" It will cover the current state of development of siRNA, miRNA, antisense and aptamar therapeutics and examine how companies are capitalizing on the promise of the field. Panelists will include Paul Burke, Ph.D., Executive D...

Webcast Alert: Isis Pharmaceuticals' Second Quarter 2009 Financial Results Conference Call

...ts partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are ...evere neurodegenerative diseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnyl...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

... Neurodyn, Inc., Charlottetown, Prince Edward Island, Canada Validation of LRRK2 as a drug target for treatment of Parkinson's disease using antisense technology Alejandro Lloret, PhD, Isis Pharmaceuticals, Inc., Carlsbad, California Optimizing lead series of small molecule inhibitors...

Small Molecule Might Play Big Part in Lung Cancer

...va). To test their hypothesis that miR-21 and EGFR may make attractive targets for therapy, the researchers tested two experimental compounds: an antisense molecule designed to bind to the RNA and essentially turn it off; and a compound called AG1478, which targets the cell's EGFR and tyrosine kinase path...

Isis Pharmaceuticals to Present at Jefferies' 3rd Annual Healthcare Conference

...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...iseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...

Isis Pharmaceuticals to Present at Needham's 8th Annual Life Sciences Conference

...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...
Antisense in Medical Technology

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

NEW ORLEANS and CARLSBAD, Calif., June 9 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today that Isis' antisense drugs were highlighted with eight presentations (including three oral talks and two late-breaking posters) during the American Diabetes Association's...

Anti-TGF-Beta Antisense AP 12009 Shows Very Good Safety and Tolerability in Systemic Treatment of Pancreatic Carcinoma, Malignant Melanoma and Colorectal Carcinoma

CHICAGO and REGENSBURG, Germany, June 2 /PRNewswire/ -- The TGF-beta 2 inhibitor AP 12009, developed by Antisense Pharma, reveals very good safety and tolerability in the systemic treatment of pancreatic carcinoma, malignant melanoma and colorectal carcinoma. AP 12009, administered intravenous...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...ighting the versatility and broad applicability of antisense drugs to inhibit targets that could offer new aven... and the momentum to realize the full potential of antisense as a drug discovery technology," concluded Ms. Par... Isis' partnered pipeline continues to mature as antisense drugs that Isis' satellite companies are developin...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... two late-stage research programs, one on a direct antisense inhibitor of apoC-III, which may provide a promisi...ew drug to lower triglycerides, and a second on an antisense inhibitor to Factor XI, which has the potential to...ase. Isis and collaborators also presented data on antisense inhibitors against 11 beta-HSD1 and apoF, potentia...

Another LNA-based RNA Inhibitor Enters Clinical Trials

...42, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and enhances antiproliferative effect of Gefitinib in tu...

Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer

...ll line is transplanted into livers of mice, in order to evaluate the efficacy of systemic microRNA-based treatment in these mice. Chemically modified antisense oligos (ASOs) were delivered systemically, targeting the over-expressed microRNA. Using this animal model, the scientists have shown that the targeted...

Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study

... "The progress our partners are making with antisense drugs discovered using Isis' antisense technology demonstrates the value of our technolog... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

...RLSBAD, Calif., Sept. 22 /PRNewswire-FirstCall/ -- antisense Therapeutics Ltd. (ASX: ANP) and Isis Pharmaceutic...rate, for the first time, that a second-generation antisense drug designed to specifically inhibit the producti...ients." Mark Diamond, Chief Executive Officer of antisense Therapeutics, said, "We are delighted to have our ...

Isis Initiates Clinical Trial of CRP Drug

...t has initiated a Phase 1 study of ISIS 353512, an antisense drug that inhibits the production of C-reactive pr...ed." ISIS 353512 Targets CRP ISIS 353512 is an antisense drug that targets CRP. For many years, CRP has bee... has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug d...

Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen

...omersen, a novel lipid-lowering drug that utilizes antisense technology. The companies also announced that th...o. 7,407,943. The patent broadly covers the use of antisense compounds targeting the apoB messenger RNA except ...f both single-stranded and double-stranded (siRNA) antisense drugs complementary to any site of the mRNA of hum...
Antisense in Biological News

Making sense of antisense microRNAs

Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. The studies from Drs. Alexander Stark and Manolis Kellis (MIT) and colleagues, and from Dr. Eric Lai (MSKCC) and colleagues, both reveal that anti...

Gold nanoparticles could improve antisense cancer drugs

In the fight against cancer, antisense drugs, which prevent genes from producing harmful proteins such as those that cause cancer, have the promise to be more effective than conventional drugs, but the pace of development of these new drugs has been slow. Using gold nanoparticles combined with DN...

ISU researchers find possible treatment for spinal muscular atrophy

...normal protein because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effec...

Newly discovered gene plays vital role in cancer

...rates that Wrap53 gives rise to a molecule, called antisense RNA, the presence of which is necessary for the pr... The study is also one of the first to show how antisense RNA regulates genes in the human body. It is alrea...oducts usually proteins on gene expression. With antisense regulation, control is effected instead through th...

A new gene silencing platform -- silence is golden

.... Gene silencing molecules also have potential prophylactic and therapeutic applications based upon ongoing clinical trials using RNAi and traditional antisense approaches. For some genes that cause disease, these other approaches may not be effective enough and U1 Adaptors may provide a novel solution.' ...

UD researchers discover novel 'gene toggles' in world's top food crop

...otides long, these novel molecules, called natural antisense microRNAs (nat-miRNAs), target the genes sitting d...ecules are a special type of microRNA that have an antisense configuration relative to their targets. It's an e...g the unique new group of molecules called natural antisense microRNAs. When a gene is ready to produce a ...

Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy

...nd copy of the gene to include the missing piece. Dr. Krainer and his team sought to change the splicing by introducing synthetic molecules, called antisense oligonucleotides or ASOs, that precisely match various sections of the RNA. They reasoned that if these molecules stuck to the right part of the RNA, ...

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

...genic regions, genes have more stable sense RNA/DNA duplexes than potential antisense RNA/DNA duplexes. "The difference between stability of sense and antisense mRNA/DNA is a property that can aid gene discovery," explains Stoynov. ...

Researchers discover that sheep need retroviruses for reproduction

...us retrovirus might have a role in development of the human placenta. The team blocked expression of the envelope of the enJSRVs using morpholino antisense oligonucleotides, which inhibit translation of specific messenger RNA. When production of the envelope protein was blocked in the early placenta, the...

Scientists discover role for dueling RNAs

...lementary to that of the messenger, or sense, RNA. antisense RNA has been detected for a number of genes, but i...overed that in the case of a gene called IME4, the antisense RNA blocks the sense RNA. In other words, the gene...ase where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on t...
Antisense in Biological Technology

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

ISIS-SGLT2Rx - Isis' first kidney-targeted antisense drug for type 2 diabetes enters clinical development CARLSBAD, Calif., Feb. 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today it has initiated a Phase 1 study of ISIS-SGLT2Rx, an antisense drug that in...

Isis Pharmaceuticals and Thomas, McNerney & Partners Announce That the Newly Formed Altair Therapeutics Will Develop Antisense Drugs for Respiratory Conditions

- Isis will own 18 percent of Altair and will receive milestones and royalties on antisense drugs developed by Altair - Altair to conduct clinical development of ISIS 369645 for asthma CARLSBAD, Calif. and SAN FRANCISCO, Oct. 16 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, In...

Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases

- Includes license of two antisense drugs in development targeting glucagon receptor and glucocorticoid receptor - Includes research collaboration to identify antisense drugs to inhibit additional targets to treat metabolic diseases - Conference call webcast Thursd...

OncoGenex Reports Second Quarter 2009 Financial Results

...e phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals Completes $9.5 Million Registered Direct Offering

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals to Raise $9.5 Million Through Sale of Common Stock

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals Added to Russell Indexes

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals Files Shelf Registration Statement

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals Completes Amendment to Phase 3 Special Protocol Assessment for Confirming Survival Benefit in Patients Receiving OGX-011 with First-Line Docetaxel for Metastatic Prostate Cancer

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...

OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer

...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...
Antisense in Biological Products

Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion

Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...
Company:Ambion

Silencer Pre-designed siRNA, standard purity from Ambion

Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...
Company:Ambion

Custom siRNA, PAGE purified from Ambion

Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your c...
Company:Ambion

Silencer Pre-designed siRNA, HPLC purified from Ambion

Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...
Company:Ambion

Custom siRNA, PAGE purified, annealed from Ambion

Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your c...
Company:Ambion

Antisense oligonucleotides from Thermo Scientific

Description:... to prevent enzymatic degradation and chain elongation.Lit: J.F.R. Ortigao, H. Rosch, H. Selter, A. Frohlich, A. Lorenz, M. Montenarh, and H. Seliger, antisense Res. & Dev., 1992, 2, 129-146 2-O-Methyl-RNA Oligos from 10 to 105 bases, purified by HPLC and MS-checked.The methyl residue at the 2-OH of the ribo...
Company:Thermo Scientific
Antisense in Biological Definition

DNA

...Chemical nomenclature (5' and 3') 7.2 Sense and antisense 7.3 An exception: viruses 7.4 As viewed by t... strand is said to be descending. Sense and antisense As a result of their antiparallel arrangement an...d or translatable, and they call its complement " antisense ". It follows then, somewhat paradoxically, that t...

Exon

... so that targeted exons are excluded from mature mRNA transcripts by blocking the access of splice-directing proteins to pre-mRNA using Morpholino antisense oligos. This has become a standard technique in developmental biology . See also Peptide External links and references Walter Gi...

Gene therapy

... supplement a defective mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success. antisense therapy is not strictly a form of gene therapy, but is often lumped together with them. Contents showTocToggle("show","hide") 1 Backg...

Reverse genetics

...ce relies on systems within the cell for efficacy (e.g. the dicer proteins, the RISC complex) a simple alternative for gene knockdown is Morpholino antisense oligos. While RNAi acts by directing cellular systems to degrade target messenger RNA (mRNA), Morpholinos bind and block access to the target mRNA ...
Antisense in Biological Dictionary

Antisense

Antisense molecules interact with complementary strands of nucleic acids, ... Enzyme-dependent antisense includes forms dependent on RNase H activity to ... Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene ...

SnRNP

... of each snRNP particle prevents pre-mRNA splicing but arrests ... ... early 5′ splice site/tri- snRNP interaction requires ATP, occurs in ... antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides ... Surprisingly, instead of U1A we have identified a novel U1 s...

SiRNA

...olecules – microRNA (miRNA) and small interfering RNA ( siRNA ) – are central... At some point the siRNA duplex unwinds, and it appears that the antisense strand ... siRNA technology is now extensively recognized as a powerful tool for the ... Describes the design of small interfering RNA ( siRNA...

Sense strand

...ics, the sense strand is complementary to the antisense strand or nonsense strand . The sense strand...) ... each fragment then separate — releasing the antisense strand . ... There is no need to invoke mysti... " sense " because it results in a gene ... the antisense strand so that it can bind to the complementary...

RNA Splicing

...tores genetic information in a ... RNA splicing is not ... diseases are caused by mutations that affect RNA splicing . ... RNA Splicing antisense technology studied at Cold Spring Harbor Laboratory effectively corrected an mRNA splicing defect found in spinal muscular atrophy patients. Wit...

Ribozyme

... The name of hammerhead ribozyme is given by the similarity between its secondary ... As well as other ribozymes, the hammerhead ribozyme is an antisense RNA. ... Ribozyme summary with 6 pages of encyclopedia entries, essays, summaries, research information, and more. ... A ribozyme (from ribon...

Pre-mRNA

... enhanced or inhibited by the presence of short ... an unclassified pre - mRNA sequence by computing the posterior probability that each ... antisense RNA inhibits splicing of pre - mRNA in vitro. S H Munroe ... and a closed complex in which pre - mRNA is sequestered at an early stage of splic...

Oligodeoxyribonucleotide

...ynthesis of oligodeoxyribonucleotide –oligo spermine conjugates ... An antisense oligonucleotide phosphorothioate, previously shown to inhibit HIV-1 vira...ly infected H9 cells, was fluorescently labeled to ... ... modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic ... oligodeox...

Non-coding strand

...known ... anticoding strand definition. AKA: antisense strand , non - coding strand , template st...-> non - coding a) there are 15 bases ... antisense strand . Definition(s) The non - coding strand in double-stranded DNA. The antisense strand serves as the template for mRNA synthe...

Complementary RNA

...e of the strands of ... When mRNA forms a duplex with a complementary antisense RNA sequence, translation is blocked. ... into an antisense RNA complementary to the mRNA for ... Ribonucleic acid ( RNA ) is a...
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