Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO
ORLANDO, Fla. and CARLSBAD, Calif., June 1 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today that Isis' collaborators presented new clinical data on drugs in Isis' partnered oncology franchise at this year's American Society of Clinical Oncology (ASCO) Annual M...Isis' Partners Present Clinical Data on Antisense Drugs at the American Society of Clinical Oncology
CHICAGO and CARLSBAD, Calif., June 2 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today that two of the Company's partnered oncology drugs were highlighted during the American Society of Clinical Oncology (ASCO) meeting. Data from both drugs highlighted posit...Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
- Excaliard closes $15.5 million Series A financing from Alta Partners, ProQuest Investments and RiverVest Venture Partners CARLSBAD, Calif. and ENCINITAS, Calif., Nov. 27 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) and Excaliard Pharmaceuticals, Inc. announc...Isis Pharmaceuticals to Present at Canaccord Adams' 29th Annual Global Growth Conference
...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...iseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...Webcast Alert: Isis Pharmaceuticals' Second Quarter 2009 Financial Results Conference Call
...ts partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are ...evere neurodegenerative diseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnyl...Small Molecule Might Play Big Part in Lung Cancer
...va). To test their hypothesis that miR-21 and EGFR may make attractive targets for therapy, the researchers tested two experimental compounds: an antisense molecule designed to bind to the RNA and essentially turn it off; and a compound called AG1478, which targets the cell's EGFR and tyrosine kinase path...Isis Pharmaceuticals to Present at Jefferies' 3rd Annual Healthcare Conference
...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...iseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...Isis Pharmaceuticals to Present at Needham's 8th Annual Life Sciences Conference
...maceuticals, Inc. (Nasdaq: ISIS ), the leader in antisense therapeutics, today announced that management will... has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug ...metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of ...Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
...ighting the versatility and broad applicability of antisense drugs to inhibit targets that could offer new aven... and the momentum to realize the full potential of antisense as a drug discovery technology," concluded Ms. Par... Isis' partnered pipeline continues to mature as antisense drugs that Isis' satellite companies are developin...Isis and Collaborators Present New Research at the ATVB Annual Conference
... two late-stage research programs, one on a direct antisense inhibitor of apoC-III, which may provide a promisi...ew drug to lower triglycerides, and a second on an antisense inhibitor to Factor XI, which has the potential to...ase. Isis and collaborators also presented data on antisense inhibitors against 11 beta-HSD1 and apoF, potentia...Another LNA-based RNA Inhibitor Enters Clinical Trials
...42, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and enhances antiproliferative effect of Gefitinib in tu...ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis
...RLSBAD, Calif., Sept. 22 /PRNewswire-FirstCall/ -- antisense Therapeutics Ltd. (ASX: ANP) and Isis Pharmaceutic...rate, for the first time, that a second-generation antisense drug designed to specifically inhibit the producti...ients." Mark Diamond, Chief Executive Officer of antisense Therapeutics, said, "We are delighted to have our ...Isis Initiates Clinical Trial of CRP Drug
...t has initiated a Phase 1 study of ISIS 353512, an antisense drug that inhibits the production of C-reactive pr...ed." ISIS 353512 Targets CRP ISIS 353512 is an antisense drug that targets CRP. For many years, CRP has bee... has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug d...Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen
...omersen, a novel lipid-lowering drug that utilizes antisense technology. The companies also announced that th...o. 7,407,943. The patent broadly covers the use of antisense compounds targeting the apoB messenger RNA except ...f both single-stranded and double-stranded (siRNA) antisense drugs complementary to any site of the mRNA of hum...Making sense of antisense microRNAs
Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. The studies from Drs. Alexander Stark and Manolis Kellis (MIT) and colleagues, and from Dr. Eric Lai (MSKCC) and colleagues, both reveal that anti...Gold nanoparticles could improve antisense cancer drugs
In the fight against cancer, antisense drugs, which prevent genes from producing harmful proteins such as those that cause cancer, have the promise to be more effective than conventional drugs, but the pace of development of these new drugs has been slow. Using gold nanoparticles combined with DN...ISU researchers find possible treatment for spinal muscular atrophy
...normal protein because of the presence of a specific intronic sequence in the gene or DNA. To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence. When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effec...Newly discovered gene plays vital role in cancer
...rates that Wrap53 gives rise to a molecule, called antisense RNA, the presence of which is necessary for the pr... The study is also one of the first to show how antisense RNA regulates genes in the human body. It is alrea...oducts usually proteins on gene expression. With antisense regulation, control is effected instead through th...A new gene silencing platform -- silence is golden
.... Gene silencing molecules also have potential prophylactic and therapeutic applications based upon ongoing clinical trials using RNAi and traditional antisense approaches. For some genes that cause disease, these other approaches may not be effective enough and U1 Adaptors may provide a novel solution.' ...UD researchers discover novel 'gene toggles' in world's top food crop
...otides long, these novel molecules, called natural antisense microRNAs (nat-miRNAs), target the genes sitting d...ecules are a special type of microRNA that have an antisense configuration relative to their targets. It's an e...g the unique new group of molecules called natural antisense microRNAs. When a gene is ready to produce a ...Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
...nd copy of the gene to include the missing piece. Dr. Krainer and his team sought to change the splicing by introducing synthetic molecules, called antisense oligonucleotides or ASOs, that precisely match various sections of the RNA. They reasoned that if these molecules stuck to the right part of the RNA, ...Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription
...genic regions, genes have more stable sense RNA/DNA duplexes than potential antisense RNA/DNA duplexes. "The difference between stability of sense and antisense mRNA/DNA is a property that can aid gene discovery," explains Stoynov. ...Researchers discover that sheep need retroviruses for reproduction
...us retrovirus might have a role in development of the human placenta. The team blocked expression of the envelope of the enJSRVs using morpholino antisense oligonucleotides, which inhibit translation of specific messenger RNA. When production of the envelope protein was blocked in the early placenta, the...Scientists discover role for dueling RNAs
...lementary to that of the messenger, or sense, RNA. antisense RNA has been detected for a number of genes, but i...overed that in the case of a gene called IME4, the antisense RNA blocks the sense RNA. In other words, the gene...ase where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on t...Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug
ISIS-SGLT2Rx - Isis' first kidney-targeted antisense drug for type 2 diabetes enters clinical development CARLSBAD, Calif., Feb. 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today it has initiated a Phase 1 study of ISIS-SGLT2Rx, an antisense drug that in...OncoGenex Reports Second Quarter 2009 Financial Results
...e phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...OncoGenex Pharmaceuticals Completes $9.5 Million Registered Direct Offering
...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...OncoGenex Pharmaceuticals to Raise $9.5 Million Through Sale of Common Stock
...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...OncoGenex Pharmaceuticals Added to Russell Indexes
...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...OncoGenex Pharmaceuticals Files Shelf Registration Statement
...e Phase 1 clinical trial; and CSP-9222 and OGX-225 are currently in pre-clinical development. OGX-011, OGX-427 and OGX-225 utilize second-generation antisense technology, licensed from Isis Pharmaceuticals (NASDAQ: ISIS ), to effectively target and inhibit production of specific proteins in tumor cells. On...Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion
Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...Silencer Pre-designed siRNA, standard purity from Ambion
Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...Custom siRNA, PAGE purified from Ambion
Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your c...Silencer Pre-designed siRNA, HPLC purified from Ambion
Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your convenien...Custom siRNA, PAGE purified, annealed from Ambion
Description:...gene silencing research. Custom siRNAs can be readily ordered online by providing either the 19-21 base target sequence, or by providing the sense and antisense siRNA sequences. (Also check out Ambion's Silencer Validated and Silencer Pre-designed siRNAs, which are already designed for you.) For your c...Antisense oligonucleotides from Thermo Scientific
Description:... to prevent enzymatic degradation and chain elongation.Lit: J.F.R. Ortigao, H. Rosch, H. Selter, A. Frohlich, A. Lorenz, M. Montenarh, and H. Seliger, antisense Res. & Dev., 1992, 2, 129-146 2-O-Methyl-RNA Oligos from 10 to 105 bases, purified by HPLC and MS-checked.The methyl residue at the 2-OH of the ribo...