Counterfeit antimalarial drug discovered in Ghana

Rockville, Md., July 22, 2009 Quantities of a prescription medication used throughout the world for treating malaria have been identified as lacking any active ingredient and presumably counterfeit. These are being removed from the market in Ghana, where they were discovered recently and confirme...

WRAIR investigators pioneering work on an exciting new class of antimalarial compounds

March 26, 2008 Silver Spring, MD: Artemisinins in Malaria Therapy, written by WRAIR researchers Dr. Qugui Li, Dr. Wilbur K. Milhous, and Dr. (COL) Peter J. Weina (Division of Experimental Therapeutics at the WRAIR, Silver Spring, MD) provides a fascinating overview of the historical use and recent...

New Insights into Antimalarial Drug Resistance

Researchers at Georgetown University Medical Center say they are moving closer to understanding why the most lethal form of human malaria has become resistant to drug treatment in the past three decades. They have been able to artificially construct, and then express in yeast, a protozoan gene tha...

Antihistamine Could also be used as a Potential Antimalarial Drug

Researchers have found that astemizole, which is used for treating allergy can also be used as a potential drug for treating malaria//. According to a study conducted by researchers from the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins University School of Medicine. Th...

Eliminating polio requires global, coordinated effort -- Health Affairs article highlights risks, rewards of eradication

...new international approach to providing affordable antimalarial drugs; an examination of the extent to which peopl...," they conclude. A New Approach To Delivering antimalarial Treatments The global fight against malaria fa...oping countries. Growing resistance to traditional antimalarial drugs has made treatment more difficult, and newer...

MiP Consortium awarded €11 million by EDCTP

...arded 3.6 million to undertake research to optimise the use of a particular antimalarial drug, sulphadoxine-pyrimethamine or SP, given to prevent malaria in pregnan...m and long-term use of SP for IPTp. Among the current available alternative antimalarial drugs, MQ offers the most comparable advantages to SP". The Prince Leopol...

Today on Capitol Hill: The Malaria Forum

... traditionally ignored by market-driven mechanisms for drug development. Since its founding in 2003, DNDi has already developed and made available two antimalarial medicines while reaching out in partnership to those in the remotest areas in Africa as well as the largest pharmaceutical companies in the world. ...

Discovery of variations in resistance to sulfadoxine across Africa

...ggests that the effectiveness of sulfadoxine as an antimalarial drug may vary across Africa. The findings have...ggests that the effectiveness of sulfadoxine as an antimalarial drug may vary across the continent. They also sugg...uggest that the effectiveness of sulfadoxine as an antimalarial drug may vary across Africa. They also point to th...

LSTM and MiP Consortium awarded further $4.5 million

...Partnership (EDCTP) to undertake research aimed at optimising the use of an antimalarial drug given to prevent malaria in pregnancy in Africa. Malaria in pregna...th, hence pregnant women showing no malaria symptoms are encouraged to take antimalarial drugs to prevent infection. Intermittent preventive treatment (IPTp) has p...

Novel bioreactor enhances interleukin-12 production in genetically-modified tobacco plants

... The system is being tested on several other plant cultures, including Artemisia annua, which naturally produces very small quantities of an effective antimalarial molecule known as artemisinin. "With our colleagues in Arkansas, we are making good progress on developing the technology and understanding the biolog...

Antimalarial in Medical Technology

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

...g the therapeutic mechanism of action for a commonly used treatment for SLE and RA. For many years, SLE and RA patients have been treated with certain antimalarial drugs as a treatment for SLE, such as hydroxychloroquine (HCQ), which was serendipitously discovered to be a moderately effective therapy for the dise...

Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice with Transplant of Purified Donor Blood Stem Cells

...depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks. About Cellerant Cellerant Therapeutic...

Antimalarial in Medical Products

Paramax-3 Rapid Test for Malaria (Pan/Pv/Pf)

Description:...specific pLDH, for the specific detection of P. falciparum and P.vivax malaria, differentiation of other malarial species and for the follow up of antimalarial therapy....
Company:Zephyr Biomedical Systems

Parascreen® Rapid Test for Malaria (Pan/Pf)

Description:...pan specific pLDH, for differentiation of P. falciparum and other malarial species viz P.vivax , P.ovale & P. malariae and for the follow up of antimalarial therapy, in whole blood samples....
Company:Zephyr Biomedical Systems

PALUTOP+4

Features:...fection, differentiation of other malarial species and for the follow up of antimalarial therapy In PALUTOP+4® the detection system for P. falciparum malari...arasities, the pan band may also be used to monitor the course of effective antimalarial therapy ...
Company:ALL.DIAG

Antimalarial in Medical Dictionary

Drug Resistance

...nce ... Drug resistance can be considered as a natural response ... antimalarial drug resistance is a major ... The WHO publication, Drug resistance in malaria, describes the state of ... antimalarial drug resistance protocol ... drug resistance ( ¦drəg ri′zistəns...

Antimalarial in Biological News

LSTM and UoL secure £1.4m ($2m) to develop new 'magic bullet' antimalarial drug

The Liverpool School of Tropical Medicine (LSTM) and the University of Liverpool (UoL) have secured a 1.4 million project grant to begin the development of new drugs to combat malaria. The project, funded by the Wellcome Trust, aims to develop new antimalarial drug candidates which work by targ...

Geisinger research: Antimalarial drug prevents diabetes in arthritis patients

DANVILLE, PA - The use of an antimalarial medication may prevent the onset of diabetes in patients with rheumatoid arthritis, new Geisinger research shows. Researchers examined the records of 2,093 Geisinger patients who received treatment for rheumatoid arthritis from 2000 to 2008. The study ...

Researchers describe 'implausible' chemistry that produces herbicidal compound

...lready widely used in agriculture and medicine. This class of compounds includes the herbicide glyphosate, the osteoporosis treatment alendronate, the antimalarial drug fosmidomycin and the antibiotics fosfomycin, dehydrophos and plumbemycin. Whether man-made or naturally produced, phosphonates and phosphina...

Milestone achieved toward production of malaria treatment using synthetic biology and fermentation

...ificant milestone toward the production of amorphadiene, a precursor of the antimalarial agent artemisinin. The article, "High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli " appears in PLoS ONE , an open-ac...

Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants

... The system is being tested on several other plant cultures, including Artemisia annua, which naturally produces very small quantities of an effective antimalarial molecule known as artemisinin. "With our colleagues in Arkansas, we are making good progress on developing the technology and understanding the biolog...

New papers offer insights into process of malarial drug resistance

...nd in areas along the Thailand/Cambodian border multiple drug-resistant strains of the disease are becoming commonplace. With the previously mainstay antimalarial drug chloroquine nearly ineffective due to drug resistance and traditional public health approaches such as mosquito netting offering uneven results, ...

ASU researchers receive NIH awards for studies of malaria and emergent disease

... types of P. falciparum populations are most prone to the emergence of drug resistance or to the reemergence of drug sensitivity. Investigating how antimalarial drug use selects for resistance is a matter of great interest in evolutionary biology and public health, Escalante says. "This work will provide g...

Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics

... bioreactors for the production of the therapeutic protein, murine interleukin-12 (m-IL-12) in transgenic tobacco roots, and the sesquiterpene lactone antimalarial drug, artemisinin, in shoot cultures. "Biofuels: Fuels Controversy" Alex DiIorio, PhD, Director, Bioprocess Center, and Chris McPhee, MS...

New way to make malaria medicine also first step in finding new antibiotics

...lliam Metcalf and his collaborators have developed a way to mass-produce an antimalarial compound, potentially making the treatment of malaria less expensive. ...wing the genes and understanding the pathway that bacteria use to make this antimalarial means the genes can be manipulated to make the compound even more effective...

Best way to treat malaria: Avoid using same drug for everyone, scientists say

... malaria, fewer unsuccessful drug treatments, and a very significant delay in the onset of drug resistance in the parasites. As parasite resistance to antimalarial drugs is the key factor that can make drugs obsolete and useless, delaying and slowing down the evolution of drug-resistance is often viewed as a publ...

Antimalarial in Biological Technology

Chimerix Joins International Network of Organizations to Cure Malaria

...tate the delivery of new, effective and affordable antimalarial drugs. The MMV will screen Chimerix' chemical libr... greater emphasis on the urgent need to fill MMV's antimalarial R&D portfolio with promising, wholly new compo...over, develop and deliver effective and affordable antimalarial drugs through public-private partnerships. MMV is ...

Malaria: New Treatment is Upcoming

...-based active ingredient which does not stay long in the body with a second antimalarial which stays longer in the body. This combination treatment is to be taken o...anization created to discover, develop and deliver effective and affordable antimalarial drugs through public-private partnerships, supported primarily by the Bill ...

Antimalarial in Biological Definition

Malaria

...sumed daily. It seems inevitable that resistance to these drugs will also occur. "Malarone" is also a recommended prophylactic. In addition to the antimalarial drugs, the use of mosquito repellents such as DEET , and mosquito nets and screens can reduce the chance of malaria, as well as the discomfort of in...