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Antigenic in Medical News

URI awarded $13 million grant to develop vaccines for emerging infectious diseases

...nes, immunome-derived vaccines have the potential to be safer and more effective since they focus the protective immune response on the most essential antigenic elements of the pathogenic bacteria or virus, while eliminating potentially cross-reactive and deleterious or simply inert components, reducing the po...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or a...l surface with synthetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be m...

Universal Capital Management Reports Vystar(TM) Corporation Receives FDA Clearance for Envy(TM) Natural Rubber Latex Condom Made with Vytex(TM) NRL

...rograms/dm2, virtually undetectable levels, of the antigenic proteins that can cause an allergic response, whil...m will carry labeling that will reflect the lowest antigenic protein content currently available in a natural r...ubber latex condom with this level of reduction in antigenic proteins to the U.S. market. The Envy condom made...

InDevR's FluChip detects and distinguishes swine-origin H1N1 from human influenza viruses

...matrix proteins. Current qRT-PCR subtyping assays target a more highly mutable gene that codes for a protein, hemagglutinin (HA), which is subject to antigenic drift. "As has happened in the past, if the HA gene changes in a critical region, qRT-PCR will fail and the researcher won't know why until the gene ...

Thomson Reuters Web of Science(R) Provides Insights Into More than a Century of Influenza Research for Today's Health Professionals

...d: 155 Davenport, FM; Hennessy, AV; Francis, T. Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus. JOURNAL OF EXPERIMENTAL MEDICINE 98 (6): 641-656. (1953) Times Cited: 237 Horsfall, FL. ...

Beating a Global Killer: HIV/AIDS

...ntaneous binding with gp41 when prepared for gel electrophoresis, and subsequent fusion inhibition of HIV with CD4+ cells and increased gp41 and gp120 antigenic activity. Virus-specific CD8 cells were stimulated. Flow cytometric analysis revealed apoptosis in CD4+ cells and stimulation of virus-specific CD8 ...
Antigenic in Medical Technology

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...ology is a novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or autoimmune diseases and allergies, are potential therapeutic or preventive s...

Novavax Reports Positive Preclinical Results for a Novel, Broadly Cross-Protective H5N1 Pandemic Influenza Virus-like Particle (VLP) Vaccine Candidate

...al without the use of an adjuvant. "It is extremely important to identify a pre-pandemic vaccine candidate which is able to protect against different antigenic variants of H5N1 virus that are circulating broadly," said Dr. Honglin Chen. H5N1 avian influenza viruses emerged in humans in Hong Kong in 1997 ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

...I to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or a...rface with synthetic peptides. The L.E.A.P.S.(TM) constructs containing the antigenic disease epitope linked to a T-cell binding ligand (TCBL) can be manufacture...

MabVax Therapeutics Closes Two Licensing Agreements With Sloan-Kettering Institute for Cancer Research

...ast 25 years have developed monovalent cancer vaccines against ten distinct antigenic targets on various types of cancer cells. These vaccines target gangliosides and other carbohydrate antigens that are the most extensively expressed antigenic targets on the cell surface of certain cancers. Vaccines, or passively admi...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

...virus is an enveloped negative-strand RNA virus, with eight genome segments that code for 10 proteins. Influenza strains are subtyped according to the antigenic and genetic nature of their surface glycoproteins: hemagglutinin (HA or H) and neuraminidase (NA or N). Fifteen H and nine N subtypes have been identi...
Antigenic in Medical Products

Cyto-Chex Storage and Transport Solution

Description:... Cyto-Chex is a storage and transport solution formulated to preserve the white blood cells in samples without reducing the activity of antigenic sites. Samples treated with Cyto-Chex can be stored for up to seven days prior to analysis by flow cytometry. Cyto-Chex offers 1-year closed-vial stab...
Company:Streck

C6 B. burgdorferi (Lyme) ELISA Kit

Description:...equence of the surface protein VlsE. This peptide has been shown to represent the immunodominant portion of VlsE, containing substantially all of the antigenic reactivity of the whole protein. Recent studies have shown that the C6 peptide is a sensitive and specific marker for antibody to B. burgdorferi sens...
Company:Immunetics, Inc.

Human Myoglobin Enzyme Immunoassay

Description:...n the principle of a solid phase enzyme-linked immunosorbent assay. The assay system utilizes a unique monoclonal antibody directed against a distinct antigenic determinant on the myoglobin molecule. Mouse monoclonal anti-myoglobin antibody is used for solid phase immobilization (on the microtiter wells). A go...
Company:Diagnostic Automation, Inc.

Iso-Insulin ELISA

Description:...solid phase two-site enzyme immunoassay. It is based on the direct sandwich technique in which two monoclonal antibodies are directed against separate antigenic determinants on the insulin molecule. During incubation insulin in the sample react with peroxidase-conjugated anti-insulin antibodies and anti-insuli...
Company:IDS Ltd

Insulin Jumbo EIA Diabetes and Obesity Markers 008-10-1113-99

Description:... technique in which two monoclonal antibodies are directed against separate antigenic determinants on the human insulin molecule. During incubation, insulin in ... technique in which two monoclonal antibodies are directed against separate antigenic determinants on the human insulin molecule. During incubation, insulin in ...
Company:ALPCO Diagnostics

C-Peptide EIA Diabetes and Obesity Markers 008-10-1136-01

Description:...olid phase two-site enzyme immunoassay. It is based on the direct sandwich technique in which two monoclonal antibodies are directed against separate antigenic determinants on the C-peptide molecule. During incubation, C-peptide in the sample reacts with peroxidase-conjugated anti-C-peptide antibodies and an...
Company:ALPCO Diagnostics
Antigenic in Medical Dictionary

West Nile Virus

... West Nile virus (or WNV) is a virus of the family Flaviviridae. Part of the Japanese encephalitis (JE) antigenic complex of viruses, it is found in both tropical and temperate regions. It mainly infects birds, but is known to... Offers general overview, local...

Vaccination

... Vaccination is the administration of antigenic material (the vaccine) to produce immunity to a disease. Vaccines can prevent or ameliorate the effects of infection by a pathogen. Vaccination ...

Rh factor

...incompatibility is still the leading cause ... Rh factor n. Any of several substances on the surface of red blood cells that induce a strong antigenic response in individuals lacking the substance The Rh factor is a type of protein on the surface of red blood cells. ... Problems can arise...

Inoculation

... is the placement of something to where it will grow or reproduce, and is most commonly used in respect of the introduction of a serum, vaccine, or antigenic substance into the body of a human or animal, especially... Inoculation Theory was developed by social psychologist William J. McGuire in 1961 t...

Cholera

...nd prevention. Learn about the bacterial infection, symptoms, causes, risks, and treatment. Offers clinical description, treatment, history, antigenic variation, and more. From the Todar's Online Textbook of Bacteriology. Provides information on the diarrheal illness cholera that spreads throug...

Antigen

...est based) and carries a ... Multiple Sclerosis Encyclopaedia - antigen ... Each TCR binds to a sub-section of an antigen called an epitope or antigenic determinant. ... ...
Antigenic in Biological News

7th annual [BC]2 Basel Computational Biology Conference 'Molecular Evolution' June 18-19, 2009

...s including man. Derek Smith, Professor of Infectious Disease Informatics, Department of Zoology, University of Cambridge, UK, will present on "The antigenic evolution of influenza viruses". He will describe the study of influenza virus evolution, required for influenza vaccine strain selection. Derek is on...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

...e stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each year, causing mild to severe illness. Worldwide, ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...e stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each year, causing mild to severe illness. Worldwide, m...

American Society for Microbiology honors Eric Skaar

...nce in research in microbiology and infectious diseases. While a graduate student at Northwestern, Dr. Skaar focused on the molecular mechanisms of antigenic variation in the Gram-negative pathogen Neisseria gonorrhoeae. His research described novel systems used by N. gonorrhoeae to combat the oxidative str...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

...n". First, he noticed that small aggregates formed by an antigen fused to a polyQ tail resembled the droplets that conventional adjuvants formed with antigenic peptides exposed on their surface. Dr. Shneider hypothesized that these polyQ containing aggregates were easily taken up by antigen-presenting cells,...

Tracking influenza's every movement

...enetic makeup of each virus. The team used this information to create an antigenic map which visually shows the relationships between all the different viruse...d with the Santa Fe Institute, to develop the methods and software to build antigenic maps. This work is highly multidisciplinary, with epidemiologists, compu...
Antigenic in Biological Technology

Oncothyreon announces presentation of long-term Stimuvax data at World Conference on Lung Cancer

...and destroy cancer cells expressing MUC1. Merck KGaA currently is conducting a global Phase 3 trial of Stimuvax known as START (Stimulating Targeted antigenic Responses To NSCLC). START is a randomized, double-blind, placebo-controlled study that will evaluate patients with documented unresectable stage III ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or a...l surface with synthetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be m...

Oncothyreon announces initiation of Phase 3 trial of Stimuvax in breast cancer

...s expressing MUC1. In addition to STRIDE, Merck KGaA currently is conducting a global Phase 3 trial of Stimuvax known as START (Stimulating Targeted antigenic Responses To NSCLC). START is a randomized, double-blind, placebo-controlled study that will evaluate patients with documented unresectable stage III ...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...ing a global Phase 3 trial of Stimuvax known as START (Stimulating Targeted antigenic Responses To NSCLC). START is a randomized, double-blind, placebo-controlle...ing a global Phase 3 trial of Stimuvax known as START (Stimulating Targeted antigenic Responses To NSCLC). START is a randomized, double-blind, placebo-controlle...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...I to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or a...l surface with synthetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be m...

ImmunoVaccine Technologies Partners with FIT Biotech to advance a therapeutic HIV vaccine

...f the virus to mutate rapidly. FIT Biotech has addressed this challenge by designing a synthetic DNA plasmid, known as GTU(R) MultiHIV that covers the antigenic variability within HIV strains. GTU(R) MultiHIV and is comprised of the multi-epitope/multivalent HIV antigens. As FIT Biotech's lead vaccine candidat...
Antigenic in Biological Products

Concentrated Epitope Retrieval Buffer-Reduced pH from Bethyl Laboratories

Description:... Bethyl Laboratories Epitope Retrieval Buffer-Reduced pH will unmask antigenic sites from formaldehyde fixation and allow for subsequent immunostaining. Shelf-Life: 1 year from date of receipt...
Company:Bethyl Laboratories

Western-Re-Probe Reagent from Calbiochem

Description:...ciate and remove antibodies from membrane-bound proteins without destroying antigenic binding capacity. Recommended for stripping chemiluminescent or radioisotop...nd remove antibodies from the membrane bound protein without destroying the antigenic binding affinity....
Company:Calbiochem

IHC SELECT® APR KIT SINGLE SPECIES-RAT 150 TESTS from CHEMICON

Description:...n-biotin-antibody complex. The alkaline phosphatase activity on the chromogenic substrate results in the deposit of red insoluble precipitate at those antigenic sites containing the specific epitopes recognized by the primary antibody. Tissues processed in a variety of fixatives including neutral buffered form...
Company:CHEMICON

IHC SELECT® DAB KIT SINGLE SPECIES-RAT 150 TESTS from CHEMICON

Description:...tavidin-biotin-antibody complex. The HRP activity on the chromogenic substrate results in the deposit of brown to black insoluble precipitate at those antigenic sites containing the specific epitopes recognized by the primary antibody. Tissues processed in a variety of fixatives including neutral buffered form...
Company:CHEMICON
Antigenic in Biological Definition

Antigenic shift

... antigenic shift is the process by which two different strai...ew influenza strain, it may be highly dangerous. antigenic shift is contrasted with antigenic drift which is the natural mutation over time of...

Avian influenza

...H5, H7 and H9 are known to be capable of crossing the species barrier from birds to humans. It is feared that if the avian influenza virus undergoes antigenic shift with a human influenza virus, the new subtype created could be both highly contagious and highly lethal in humans. Such a subtype could cause a...

Vaccine

... A vaccine is an antigenic preparation used to produce active immunity to a disease, in order to prevent or ameliorate the effects of infection by any natural or 'wild' str...
Antigenic in Biological Dictionary

Vaccine

...l amount of an agent that resembles a microorganism. The agent stimulates the body's immune system to... Vaccination is the administration of antigenic material (the vaccine ) to produce immunity to a disease. Vaccines can prevent or ameliorate the effects of infection by a pathogen. Vaccination is g...

Peptide-binding groove

...unusual at both terminal ends, with a potentially ... The floor of the peptide - binding groove contains an unusual β bulge, not seen in ... an antigenic peptide engineered to replace the groove binding region of Ii ... ... of the peptide looping up and out of the peptide binding groove ...

Epitope

... An epitope , also known as antigenic determinant, is the part of a macromolecule that is recognized by the immun...y View other revisions Administration ... An epitope (also known as an antigenic determinant) is a biological structure or ... The use of epitope tagging ...

Effector cell

...ector cells expressing the degranulation associated ... and ability to estimate cytotoxic effector cell frequency, the GrB ELISPOT assay ... antigenic stimulation down-regulates CCR7 on effector T cells . ... Moreover, P14.CCR7 effector cells localized almost exclusively in the splenic ... ...

Antigenic variation

... antigenic variation is the process by which an infectious...to evade a host immune response. This change in antigenic profile may occur as the pathogen passes throug...r organisms that target long-lived... The term antigenic variation refers to the mechanism in which an i...

Antigenic shift

... antigenic shift is the process by which at least two differ... antigens of the two original strains. The term antigenic ... antigenic shift ( ′antə¦jenik ′ shift ) ( virology ) A...
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