New drug shows promise as powerful anticancer agent
Research published in the March issue of the journal Cancer Cell describes a small molecule inhibitor of polo-like kinase1 (Plk1) that could lead to a new avenue for targeted cancer therapy. The compound, ON01910, is a potent inhibitor of human tumors in a mouse model system and has low toxicity. The results of this study have led to clinical evaluation of this compound in phase I clinical trials...Light activated anticancer drug targeted to DNA using cisplatin like sub-units
One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approach to analog development is light activated drugs, or photodynamic therapy (PDT). Now a Virginia Tech...Anticancer Properties of Vitamin D Could Be Separated From Other Functions
Researchers at Georgetown University’s Lombardi Comprehensive Cancer Center have managed to separate the anti-cancer properties of Vitamin D from its other functions like bone development. //It is generally accepted that Vitamin D helps protect against colorectal cancer, but high dosage intended to take advantage of its anticancer properties might lead to calcium toxicity. “We found tha...Anticancer Properties of Vitamin D Revealed
At the right dose, vitamin D is important for bone development and may help protect against the development of several cancers, particularly// colorectal cancer.To be effective against cancer large quantities of the Vitamin are needed and this can be dangerous and toxis. Now, research done at Georgetown University’s Lombardi Comprehensive Cancer Center indicates that it may be possible to separ...GSK’s New Anticancer Drug A Huge Success In Drug trail
Tykerb, the new experimental breast cancer treatment drug has proved so well in the drug trails, that based on its success alone the drug might be made //available to patients in the late stages of the disease even before it is approved by the regulators. It is speculated that Europe's largest drug maker is all set to dominate the world's biggest cancer conference in Atlanta today wit...Anticancer Effects of Curcumin Revealed
Curry powder is a mixture predominantly composed of turmeric root extract and other spices such as coriander and fenugreek. // Curcumin, a turmeric root extract, has been shown to possess activity in the treatment and prevention of cancer, multiple sclerosis, and Alzheimer's disease. The molecular mechanism for its anticancer effect is largely unknown, although it is thought to inhibi...Boiling Makes Broccoli to Loses Its Anticancer Properties
Brassica vegetables such as broccoli, Brussel sprouts, cauliflower and green cabbage are known to contain substances that reduces the risk of cancer . But, researchers have now warned that boiling these veggies makes them to lose its anticancer properties. Brassica vegetables have a high concentration of substances known as glucosinolates which are metabolized to cancer preventive s...Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
HAYWARD, Calif., April 18, 2007 /PRNewswire-FirstCall/ -- KosanBiosciences Incorporated today presented preclinical data on itsproprietary nuclear export inhibitors (NEI) showing induction ofpotent, fast-acting and long-lasting anticancer activity with ahigh degree of tolerability in multiple human tumor xenograftcancer models. Kosan's NEIs are potent, specific inhibitors of CRM1,...