Anticancer

Now we know what blocks the effects of a newly developed anticancer therapy

A new approach being developed to treat individuals with cancer that is resistant to standard therapy is the use of adenovirus-based therapies. Although promising clinical results have been obtained in some settings, in many cases the therapies have had little impact. One reason for this lack of e...

Bionovo to Present Recent Findings of BN108, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium

EMERYVILLE, Calif., Dec. 12 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) will present findings on the mechanism of action of its anti-cancer agent BN108 at the 31st Annual San Antonio Breast Cancer Symposium being held at the Henry B. Gonzalez Convention Center, San Antonio TX, Decemb...

Harnessing miRNA natural gene repressors for anticancer therapy

Michel Sadelain and colleagues, at Memorial Sloan-Kettering Cancer Center, New York, have developed a new approach to modulate the expression of genes for therapeutic purposes, and used this to mediate effective anticancer therapy in mice. Small, noncoding RNA molecules known as miRNAs are powe...

InNexus Biotechnology Announces Third Antibody and Expands Pipeline of Anticancer Compounds

BRITISH COLUMBIA, Canada, Aug. 6 /PRNewswire-FirstCall/ -- InNexus Biotechnology Inc., (TSX VENTURE: IXS.V; OTC Bulletin Board: IXSBF) ( http://www.ixsbio.com ), a drug development company commercializing the next generation of monoclonal antibodies based on its Dynamic Cross Linking (DXL(TM))...

Data Published in Anticancer Research Show ChemoFx(R) Assay Results Correlate With Outcomes in Breast Cancer

Ability to Perform Testing on Biopsy-sized Specimens Allows for Greater Clinical Utility in all Breast Cancer Settings PITTSBURGH, July 1 /PRNewswire/ -- Precision Therapeutics Inc. announced today that results from the ChemoFx(R) Assay, a cell-based test that examines the response...

Cytopia To Present Data on FMS Program With Anticancer Potential

MELBOURNE, Australia, June 18 /PRNewswire/ -- Cytopia Limited (ASX: CYT) will present details of its FMS drug discovery and development program at the Protein Kinase Targets conference, a leading conference for breakthrough scientific data on new kinase inhibitory drugs. This conference will b...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

New Medicine's Oncology KnowledgeBASE (nm/OK) tracks the development and use of patient and tumor assessment methodologies that represent one of the most unique opportunities in the oncology field LAGUNA NIGUEL, Calif., June 11 /PRNewswire/ -- Drug development in oncology is at the ...

Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean

This release is available in Spanish . A group of scientists from the Department of Organic Chemistry and the Biotechnology Institute of the University of Granada have found out that the plant Dittirichia viscose, known as elecampe, can be used to obtain inhibitors of neurogenic vas...

St. Jude gene study reveals basis of anticancer drug resistance in childhood leukemia

The first analysis of the genetic determinants of resistance to the anti-cancer drug methotrexate in childhood acute lymphoblastic leukemia (ALL) could offer a pathway to predicting such resistance and treatments to overcome it, according to a St. Jude Childrens Research Hospital study. Besides...

'Nanomachine' Releases Anticancer Drugs Inside Cells

In response to light, its pores let loose chemicals targeting disease FRIDAY, April 4 (HealthDay News) -- A nanomachine that can kill cancer cells has been developed by researchers at the University of California, Los Angeles. The "nanoimpeller" collects and stores anti-cancer drug...

Anticancer in Medical Technology

Celator Pharmaceuticals Receives Orphan Drug Designation for Anticancer Agent CPX-351

CPX-351 awarded orphan designation for the treatment of Acute Myeloid Leukemia PRINCETON, N.J., Sept. 4 /PRNewswire/ -- Celator Pharmaceuticals today announced that the U.S. Food & Drug Administration (FDA) has granted orphan drug designation to CPX-351 (Cytarab...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

- Zometa when added to hormone therapy, following surgery, significantly reduced the risk of cancer returning or death by 36% beyond clinical benefits achieved with hormone therapy alone(1) - Findings may allow clinicians to improve standard of care for premenopausal women diagn...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

HAYWARD, Calif., April 16 /PRNewswire-FirstCall/ -- Kosan Biosciences Incorporated (Nasdaq: KOSN ) presented preclinical data on its proprietary nuclear export inhibitors (NEI) showing potent in vitro and in vivo activity as well as tolerability in leukemia xenograft models, and further eluci...

BioNumerik Commences Global Phase III Ovarian Cancer Trial on Novel Anticancer Drug Candidate Known as Karenitecin(R)

SAN ANTONIO, Feb. 7 /PRNewswire/ -- BioNumerik Pharmaceuticals, Inc. today announced treatment of the first patient in a global Phase III clinical trial of BioNumerik's anticancer drug candidate known as Karenitecin(R) in advanced ovarian cancer patients. BioNumerik is developing Karenitecin (...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...igator. The study announced today is being fully funded by an external grant provided by a private organization. KRX-0401 is a novel, oral, anticancer agent that modulates Akt and several other important signal transduction pathways. Keryx is currently in the process of finalizing late-stage protocol...

Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM)

...idin is a formulation of MCC, a sterile mycobacterial cell wall-DNA complex composition that has a dual mode of action: immune stimulation and direct anticancer activity. Urocidin is formulated for the treatment of bladder cancer, where it is administered by trans-urethral catheter directly into the bladder,...

USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic

...ved from the National Cancer Institute. The NCI RAID program is a peer-reviewed competitive award program designed to assist translation of novel anticancer therapeutics to the clinic. The goal of the program is to show proof of principle that a new molecule is a viable candidate for expanded clinical eva...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...ess in treating ALL, it produces side effects that include second cancers, stunted growth, hormone imbalances and cognitive deficits. Optimized use of anticancer drugs, especially those instilled directly into the spinal fluid, have enabled clinicians to reduce radiation use, and only patients at highest risk f...

Alfacell Provides Shareholder Update

...Onconase strongly enhances effect of many types of anticancer drugs. The enhancement of the anticancer effectiveness by Onconase was shown to involve pre...nse mechanism which generally are triggered by the anticancer drugs and provide resistance to treatment. This pr...

Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells

... of ovarian cancer and non-small cell lung cancer. Other clinical-stage products in the Endocyte pipeline include: EC0225, a combination of two potent anticancer drugs; BMS493, a potent drug being developed in partnership with Bristol-Myers Squibb; EC17, a targeted immunotherapy agent; and EC0489, a targeted ca...

Anticancer in Biological News

Better beer: College team creating anticancer brew

College students often spend their free time thinking about beer, but a group of Rice University students are taking it to the next level. They're using genetic engineering to create beer that contains resveratrol, a chemical in wine that's been shown to reduce cancer and heart disease in lab anim...

Certain anticancer agents could be harmful to patients with heart disease

A set of promising new anticancer agents could have unforeseen risks in individuals with heart disease, suggests research at Washington University School of Medicine in St. Louis. The anticancer drugs which go by the strange name of hedgehog antagonists interfere with a biochemical process that ...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. However, it also kills healthy tissue. Many scientists are creating alternative drugs or cisplatin analogs in attempts to find treatments without side effects. One approac...

New drug shows promise as powerful anticancer agent

Research published in the March issue of the journal Cancer Cell describes a small molecule inhibitor of polo-like kinase1 (Plk1) that could lead to a new avenue for targeted cancer therapy. The compound, ON01910, is a potent inhibitor of human tumors in a mouse model system and has low toxicity. T...

Publication sets guidelines across cancer therapies: Ensuring the best in patient management

...pact patient care by providing access to critical imaging procedures to ensure that patients get the right treatment early on in their cancer." Most anticancer drugs are effective only in subgroups of patients, and many of the various techniques developed to monitor tumor response to these drugs have proven t...

New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity

...l cellular transactions of DNA, and the finding that many antimicrobial and anticancer therapeutics target the DNA topoisomerases, few articles have been written ...as targets of therapeutic agents, including antibiotics (such as Cipro) and anticancer drugs. Each of the ten chapters includes key references for those looking ...

American Chemical Society Weekly PressPac -- April 8, 2009

...aten in small amounts. There is no known antidote. Quantitation of ricin also has medical applications, since ricin immunoconjugates have been used as anticancer agents. Although earlier researchers have developed tests capable of identifying ricin by protein recognition methods, existing tests are generally sl...

Einstein researchers devise a fast and sensitive way to detect ricin

...retrospect, like many scientific advances, it's such a simple idea that I'm surprised it wasn't thought of earlier." Ricin has also been used as an anticancer agent by linking it to antibodies that home to tumors and deliver the ricin 'warhead' to kill cancer cells. Einstein scientists indicate that detecti...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... for predicting treatment response too unreliable for the information to be used in a standard way in the clinic. These standard systems, in which anticancer drugs were tested in human cancer-cell lines, do not factor in the effects of a real tumor's environment on its growth. At the same time, placing thes...

New high-throughput screening technique makes probing puzzling proteins possible

...eductase enzyme. Enzymes from this class are gaining attention as potential anticancer drug targets because they are concentrated in aggressive cancer cells that ...the enzymes' roles in cancer, the potential of the inhibitors identified as anticancer drugs, and the enzymes' broader roles. The success of both experiments ...

Anticancer in Biological Technology

Clavis Pharma Raises NOK 129 Million (USD 20 Million) in a Private Placement to Fund Further Development of its Pipeline of Novel Anticancer Drug Candidates

OSLO, Norway, June 26 /PRNewswire-FirstCall/ -- Clavis Pharma ASA (OSE: CLAVIS) today announced that the Company has raised NOK 129 million (equivalent to USD 20 million) in gross proceeds through a private placement of 10,750,000 new shares, each with a par value of NOK 1.00 at a price of NOK...

AEterna Zentaris To Present Data on Anticancer Compounds AEZS-112 and AEZS-126 at AACR Annual Meeting

QUEBEC CITY, April 15 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; Nasdaq: AEZS ), a global biopharmaceutical company focused on endocrine therapy and oncology, today announced that it will present two posters on its PI3K inhibitor compound, AEZS-126, as well as a poster on its oral...

Senetek PLC Acquires Rights to Additional Anticancer RNAi Technology

NAPA, Calif., Dec. 15 /PRNewswire-FirstCall/ -- Senetek PLC (OTC Bulletin Board: SNKTY), a Life Sciences company engaged in the development of technologies that target the science of healthy aging, today announced an agreement with the Institute of Bioorganic Chemistry of the Polish Academy of Sci...

Bionovo to Present Recent Findings of BN107, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium

EMERYVILLE, Calif., Dec. 12 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) will present findings on the mechanism of action of its anti-cancer agent BN107 at the 31st Annual San Antonio Breast Cancer Symposium being held at the Henry B. Gonzalez Convention Center, San Antonio TX, Decemb...

Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040

- Scientific Presentation at the 99th Annual Meeting of the American Association for Cancer Research (AACR) - TORONTO, April 16 /PRNewswire-FirstCall/ - Lorus Therapeutics Inc. ("Lorus") (TSX: LOR; AMEX: LRP), a biopharmaceutical company specializing in the research, developme...

Bionovo to Present Recent Findings of BN107 and BN108, Its Anticancer Agents, at the American Association of Cancer Research

EMERYVILLE, Calif., April 15 /PRNewswire-FirstCall/ -- Bionovo Inc. (Nasdaq: BNVI ) will present findings on the mechanism of action of two of its anti-cancer agents BN107 and BN108 at the American Association of Cancer Research (AACR) being held at the San Diego Convention Center in San Dieg...

Sunesis Reports Financial Results for the Second Quarter 2009

...09, compared to $8.2 million and $18.7 million for the same periods in 2008. About Voreloxin Voreloxin is a first-in-class anticancer quinolone derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and ...

MuGard Data From UK Study Shows Prevention of Oral Mucositis in Head and Neck Cancer Patients

...." MuGard is a novel, ready-to-use mucoadhesive oral wound rinse for the management of oral mucositis , a debilitating side effect of many anticancer treatments. Up to 40% of all patients receiving chemotherapy and/or radiotherapy develop moderate to severe mucositis, and almost all patients receivi...

Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models

...at, since LB-1.2 has a biochemical action similar to an older drug used for anticancer treatment for many years in China, we are cautiously optimistic that LB-1.2...may be a general method for improving the effectiveness of several standard anticancer drugs not only against tumors of the brain and neural tissue but also again...

Access Pharmaceuticals Announces Granting of Two US Patents for MuGard(TM)

...or the management of oral mucositis , a debilitating side effect of many anticancer treatments (for more information, please see http://www.slideshare.net/a...se for the management of oral mucositis, a debilitating side effect of many anticancer treatments. Up to 40% of all patients receiving chemotherapy and/or radioth...

Anticancer in Biological Definition

Growth curve

...e sensitive to the toxic effects that conventional anticancer drugs have on the cancer cells . Many conventional anticancer drugs (for example, 5-Fluoro Uracil ) interfere wi...ng cells and more cell death upon exposure to such anticancer drugs. In the example shown in Figure 2, a tum...

Tubulin

...been found to localize at centrioles and may play a role in forming the mitotic spindle during mitosis. Pharmacology Tubulins are targets for anticancer drugs like taxol . The anti- gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decr...

Anticancer in Biological Dictionary

Proteasome

... The scientific resource for elucidating the Ubiquitin / Proteasome Pathway. ... Apoptosis meets proteasome , an invaluable therapeutic target of anticancer drugs. ... Ubiquitin and Proteasome Proteasome , signalosome, & TPPII ('Zomes') subunit data and nomenclature ' ... Subunit-Subunit Inter...

Intercalation

...his study was to investigate whether hydrotalcite is able to intercalate diclofenac, a nonsteroidal anti-inflammatory drug, and release it in a ... anticancer Anthracycline - DNA complex by intercalation ... As a result of intercalation with daunomycin4, the GC and CG base pairs 'buckle' by ca. ... ...