Antibody

JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab

A novel anticancer agent, consisting of a monoclonal antibody linked to a chemotherapy drug, showed substantial antitumor activity in ovarian cancer cell lines and in mice, according to a study published online July 29 in the Journal of the National Cancer Institute . The agent, known as an im...

Bcl6 gene sculpts helper T cell to boost antibody production

HOUSTON - Expression of a single gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases and development of B cell lymphoma, scientists at The University of Texas M. D. Anderson Cancer Center r...

Caltech chemists say antibody surrogates are just a 'click' away

Chemists at the California Institute of Technology (Caltech) and the Scripps Research Institute have developed an innovative technique to create cheap but highly stable chemicals that have the potential to take the place of the antibodies used in many standard medical diagnostic tests. James R...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

Merrimack Pharmaceuticals' second of five oncology pipeline candidates, MM-111, a bispecific antibody, has entered clinical development. Preclinical studies have demonstrated that the bispecific approach shows antitumor activity in a wide range of tumor types. The current Phase 1/2 study will eva...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

BETHESDA, Md., June 18 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced the initiation of the first clinical trial for the anti-granulo...

Morphotek(R), Inc. Announces FDA Acceptance of Investigational New Drug Application for MORAb-004, a Monoclonal Antibody for the Treatment of Solid Tumors

Antibody Targets Endosialin, a Protein Widely Expressed on Tumors and Tumor Blood Vessel Cells EXTON, Pa., June 9 /PRNewswire/ -- Morphotek(R), Inc., a subsidiary of Eisai Corporation of North America, announced that the U.S. Food and Drug Administration (FDA) cleared its investigational new ...

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Antibody in Medical Technology

TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009

SAN DIEGO, May 26 /PRNewswire/ -- TRACON Pharmaceuticals, a biotechnology company that develops targeted therapies for oncology and related diseases, announced today that Phase 1 clinical results from studies of TRC105 and TRC102 in patients with advanced cancer will be presented at the American S...

Myelin Removal Beads: Premium Efficiency for Neural Cell Separations and Antibody Stainings

BERGISCH GLADBACH, Germany, May 20 /PRNewswire/ -- Miltenyi Biotec announces the worldwide and exclusive release of Myelin Removal Beads. Myelin is a specialized membrane which ensheathes and insulates axons in the peripheral and central nervous system. During preparation of single-cell suspen...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

Top-line data indicate statistically significant improvement in ACR20 responses over placebo PRINCETON, N.J., May 14 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX ) today announced that the MDX-1100 Phase 2 proof-of-concept trial in patients with active rheumatoid arthritis (RA) rec...

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

BOTHELL, Wash. and BRISBANE, Australia, May 8 /PRNewswire/ -- Implicit Bioscience Ltd and CMC ICOS Biologics today announced the execution of a manufacturing contract to support the next stage of development and commercialization of IC14, a clinical-stage monoclonal antibody for acute lung injury ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

Pivotal Trial Expected to Initiate in 2010 for Blinatumomab NEW YORK, April 24 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today held an R&am...

Data Presented at AACR Annual Meeting Show Anti-Tumor Activity of Peregrine's Fully Human Anti-PS Antibody in Prostate Cancer Model

-Preclinical Results Further Validate Significant Anti-Tumor Potential of Fully Human Anti-PS Antibodies and Expand the Company's PS-Targeting Platform- -Treatment with Mouse Equivalent to the Human Antibody Inhibited Tumor Growth in a Prostate Cancer Model by More than 90%- DE...

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Antibody in Medical Products

XSera Rapid HIV-1/2 Antibody Controls

Description: Xsera Rapid HIV-1/2 Antibody Controls are unassayed positive and negative quality control materials used for monitoring the performance of qualitative rapid HIV-1 and HIV-2 test kits....
Company:RNA Medical

Trichinella Antibody by ELISA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Treponema pallidum Antibody by TP-PA (MHA-TP)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Treponema pallidum Antibody (FTA-ABS), Serum, IgG by IFA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Toxocara Antibody IgG by ELISA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Thyroid Stimulating Hormone Receptor Antibody (TRAb)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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Antibody in Medical Dictionary

Antibody

Find the Primary antibodies , secondary antibodies and sera you ... Antibody Alphabetical Index ... CONGRATULATIONS to our Antibody Photo Contest Winners, ... SENP3 Antibody (N-term) Apoptosis, SENP3 Antibody (N-term) Cell Function, SENP3 ... Western blot analysis of SENP3 N-term pol...

Titer

...example, positive readings in the first 8... antibody titer is a laboratory test that measures the pre... helpful in determining medical treatment. ... antibody titer . Definition: A test that measure the ... L...s of antibodies in the blood (also known as the antibody titer ) are measured to determine: ... Tite...

Tissue

... tissue and diagnose breast cancer within hours instead of weeks. The same instrument can be used ... IMGENEX offers a large selection of antibody reagents to factors that are involved in the cascade of number of key factors including oncogenes and tumor suppressor ... Multiple organ nor...

Sprue

...sease, also called celiac sprue , is an inherited disease ... several antibody blood tests are useful in diagnosing celiac sprue disease. ... ..... Dermatitis, herp... Digestive ... health care provider will order these antibody test if celiac sprue is suspected. ... Health Library > Health ...

Smooth muscle

..... Smooth muscle . ... Smooth muscle proliferation and differentiation. Mechanism of atherosclerosis ... Anti- smooth muscle -actin antibody (clone 1A4) was ... Smooth Muscle ... Smooth muscle has no striations and is composed of small spindle-shaped cells ... understand the me...

Rheumatoid factor

...most relevant in rheumatoid arthritis. It is an antibody against the Fc portion of IgG, which is itself an...a blood test that measures the amount of the RF antibody in the blood. ... High levels of rheumatoid fa... (RF) blood test measures the amount of the RF antibody present in most people ... A high level of rheum...

Antibody in Biological News

First human gets new antibody aimed at hepatitis C virus

Boston, Mass. Building upon a series of successful preclinical studies, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed ...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

This release is available in Chinese . Researchers in Israel and Kenya have shown that the contribution of variable degrees of immune suppression, either due to existing chronic infections such as parasitemi...

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

Hamburg, Germany and Copenhagen, Denmark, May 12th, 2009 / b3c newswire / – Richter-Helm BioLogics GmbH & Co. KG announces today a technological breakthrough in the field of purification of antibody fragments from an E. coli expression system. Richter-Helm BioLogics has finalized ...

Novel antibody prevents infection by hepatitis C virus

Boston, Mass. Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

WHITEHOUSE STATION N.J., PRINCETON, N.J. and JAMAICA PLAIN, Mass., April 21, 2009 Merck & Co., Inc., (through an affiliate), Medarex, Inc. (NASDAQ: MEDX) and Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that they have signed an...

UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology

Bioinformatics researchers at the University of California, San Diego and Genentech have developed a new, quicker way to sequence monoclonal antibodies a process that is many times faster than the sequencing technology typically used by academic and industry researchers today. The breakthroug...

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Antibody in Biological Technology

Micromet Receives European Orphan Drug Designation for Treatment of Acute Lymphoblastic Leukemia with BiTE Antibody Blinatumomab

BETHESDA, Md., Aug. 3 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced that it has received Orphan Drug Designation from the Europ...

OMT announces a breakthrough in the development of a novel human antibody platform

Palo Alto, CA: July 23, 2009 Open Monoclonal Technology, Inc. (OMT), in collaboration with Sangamo BioSciences, Inc. (NASDAQ, SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), The Medical College of Wisconsin, and INSERM, today announced the creation of the first targeted knockout rats as detaile...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

ROCKVILLE, Md. , July 13 /PRNewswire/ -- MacroGenics, Inc. today announced the initiation of the PARADIGM trial, a Phase 2 clinical study evaluating MGAWN1, a humanized monoclonal antibody, for the treatment of individuals with suspected central nervous system infection due to West Nile Viru...

Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110

DENVER , April 22 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, yesterday presented data at the annual meeting of the American Association for Canc...

AACR 100th Annual Meeting Highlights Superior Ability of InNexus' DXL-Modified Anti-CD20 Antibody to Attach and Kill NHL With Safety Comparable to Approved Antibody Therapies in Preclinical Studies

-- Key Data are New Releases for the Company Building on Milestones with Recent FDA Meetings and Technology Discoveries -- DENVER, April 20 /PRNewswire-FirstCall/ -- DXL625 monoclonal antibodies appear to be superior to commercial-stage antibodies in their ability to attach and deplete NHL ...

Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth

BETHESDA, Md., April 8 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced the publication of data in the peer-reviewed Journal of Immunot...

Antibody in Biological Products

ChemiArray Mouse Lysate Cytokine Antibody Array III, 62 cytokines per membrane from CHEMICON

Description: Request Info...
Company:CHEMICON

ChemiArray Mouse Lysate Atherosclerosis Antibody Array I, 20 cytokines per membrane from CHEMICON

Description: Request Info...
Company:CHEMICON

Human Atherosclerosis Antibody Array I Kit, ChemiArray, 20 cytokines per membrane from CHEMICON

Description: ChemiArray Human Cytokine Antibody Array VII, 60 cytokines per membrane...
Company:CHEMICON

ReBlot™ Plus Strong Antibody Stripping Solution, 10x from Upstate

Description: Applications: Western blotting ...
Company:Upstate

Human Antibody Array I Kit, RayBio L Series 507: RayBio Label-based from Raybiotech, Inc.

Description: RayBio L Series 507: RayBio Label-based Antibody Array I (2 membranes) Class: Antibody Array Products Product Group: Antibody Array...
Company:Raybiotech, Inc.

Human Atherosclerosis Antibody Array 1.1 (4) Kit, RayBio from Raybiotech, Inc.

Description: RayBio Human Atherosclerosis Antibody Array 1.1 (4) with Accessory, detects 40 inflammatory factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Company:Raybiotech, Inc.

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Antibody in Biological Definition

Antibody

An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses . Each antibody recognizes a specific antigen unique to its target. Contents showTocToggle("show","hide") 1 Definition 2 Structure of the antibody...

Monoclonal antibody

Monoclonal antibodies ( mAb ) are antibodies that are identical because they were produced by one type of immune cell , all clones of a single parent cell. Given any substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they can then serve to de...

Affinity chromatography

...ity chromatography can be used in a number of applications, including nucleic acid purification, protein purification from cell free extracts and antibody purification from blood serum . Possibly the most common use of affinity chromatography is for the purification of recombinant proteins. Essential...

B cell

...ology or Medicine for demonstrating how B cells create the enormous diversity of antibodies from only a few genes. See also T lymphocyte antibody ...

Biotechnology

...overed the laws of inheritance 1919 Karl Ereky , a Hungarian engineer, first used the word biotechnology 1975 Method for producing monoclonal antibody developed by Kohler and Milstein 1980 Modern biotech is characterized by recombinant DNA technology . The prokaryote model, E. coli , is us...

Immune system

...ajor histocompatibility complex / class I MHC /class II MHC monoclonal antibody / polyclonal antibody ...

Antibody in Biological Dictionary

Antibody

Antibodies are gamma globulin proteins that are found in blood or other bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses. They are... (Click to enlarge) antibody When bacteria enter a flesh wound, a...

Polyclonal Antibody

Polyclonal antibodies (or antisera) are antibodies that are derived from different B cell lines. They are a mixture of immunoglobulin molecules secreted against a specific antigen, each recognizing a different epitope. Polyclonal antibodies This article deals exclusively with the produ...

Monoclonal Antibody

Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are identical because they are produced by one type of immune cell that are all clones of a single parent cell. Given almost any substance, it is possible... Monoclonal antibody therapy is the use of monoclonal an...

Z-DNA

... (chemical compound), ...variants of DNA are known. In A-DNA, which forms under conditions of high salt concentration ... Buy quality rabbit ZBP1 antibody (interacts with human), anti-ZBP1, ZBP1 ( Z-DNA binding protein 1) antibody, rabbit polyclonal antibody, ZBP1 ( Z-DNA binding protein ... B-...

Western blotting

...> Western Blot ... 2% non-fat dry milk in Blotting Buffer as a starting point to ... For Western blots , incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, ... Phototope®-HRP Western Blot Detection System: (#7071 anti-rabbit) or (#7072 anti ... Western Blotting with Mono...

Western blot

...s to determine the molecular weight of a protein ... Immunochemistry Protocols: Western blot Antibody. Step 1 ... Contact us • Ubiquitination antibody • Western Blot Antibodies • Acetylation ... ...