Specific antagonism lowers blood pressure

High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension. Exactly why NSAIDs cause hypertension is not clear because they inh...

ChemoCentryx to Present at The 9th World Congress on Inflammation in Tokyo, Japan

...in Tokyo, Japan. Dr. Schall's lecture titled, "Treating Inflammation by Inhibition of Chemokine Receptors: Practical Requirements and Efficacy of CCR9 antagonism in Inflammatory Bowel Disease" will be given on Thursday, July 9, 2009 at 9:00 am local time. "It is a privilege to have been invited to speak at...

Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211, a Novel Product Candidate for the Treatment of Respiratory Diseases

..., Vice President, Clinical Development. "While a great deal of clinical work remains on this program, we are particularly excited since we believe DP2 antagonism would be a novel therapeutic approach to various respiratory diseases." Bob Baltera, Chief Executive Officer, added, "Once again the Amira team d...

Presented Data Confirm That RAPAFLO(TM) (silodosin) Provides Rapid, Highly Effective, Symptom Relief for Benign Prostatic Hyperplasia (BPH) Patients

...ntagonist. RAPAFLO (TM) maximizes target organ activity by binding with high affinity to the alpha (1A) receptors concentrated in the prostate. The antagonism of these receptors cause the smooth muscles in these tissues to relax and results in improved urine flow and a reduction in BPH symptoms. The binding...

Do antidepressants enhance immune function?

...provide evidence that natural killer cell function in HIV infection may be enhanced by selective serotonin reuptake inhibition and also by substance P antagonism in both depressed and non-depressed individuals. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University ...

Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients

.... Vicriviroc is a next-generation extracellular inhibitor of HIV infection designed to block entry of infectious virions into uninfected CD4 cells via antagonism of the CCR5 co-receptor. Researchers reported the data in a late-breaker oral presentation at the 15th Conference on Retroviruses and Opportunistic ...

Psychiatrists: Least religious but most interested in patients' religion

...s or spiritual 'awareness' in our training programs." "The division between psychiatry and religion may be narrowing," Curlin said. "The historical antagonism appears to be waning." ...

Nurturing Our Nurses for Healthcare Par Excellence

... the nurses' health, exposing them to injuries. Violence in the workplace is another worrying area, where nurses are at the receiving end of antagonism from patients or their families. Nurses need to feel safe and secure to operate in their environment, and healthcare policies must cater to this need....

Heart Failure Medication Provides Some Symptom Relief

...erm clinical outcomes." Marvin A. Konstam, M.D., of Tufts - New England Medical Center, Boston, and colleagues with the Efficacy of Vasopressin antagonism in Heart Failure: Outcome Study With Tolvaptan (EVEREST) trial, examined the long-term clinical outcomes of the heart failure medication tolvaptan. Th...

Heart disease: Men Are From Mars, Women From Venus

... It has been known for a long time that mutual antagonism between husband and wife can lead to increased risk of heart disease//. It has now been possible to pinpoint the exact reason. Expression of hostility...

Antagonism in Medical Technology

Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 5, 2007 - Elixir Pharmaceuticals, Inc., announced today new preclinical data confirming ghrelin antagonism as a potential method for regulating metabolism, decreasing body weight and managing blood glucose. The data were presented in poster sessions during END...

RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days

...or antagonist. RAPAFLO(TM) maximizes target organ activity by binding with high affinity to the alpha (1A) receptors concentrated in the prostate. The antagonism of these receptors cause the smooth muscles in these tissues to relax and results in improved urine flow and a reduction in BPH symptoms. The binding ...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...d to as ITI-722) whose actions are predominantly mediated by 5HT2A receptor antagonism is being developed for the treatment of SMI. "The results that we have...e reduction of psychotic symptoms without incurring high levels of dopamine antagonism that cause motor disturbances and other deleterious side effects. In addit...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

...al. Resistance Artery Mechanics, Structure, and Extracellular Components in Spontaneously Hypertensive Rats: Effects of Angiotensin Receptor antagonism and Converting Enzyme Inhibition. Circulation 1999;100;2267-75 4. Schiffrin EL, Park JB, Intengan HD, Touyz RM. Correction of arterial str...

Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat

...h we had evidence from the phase III studies conducted with rimonabant that antagonism of the endocannabinoid system could induce a reduction in waist circumferen...the liver, results of ADAGIO-LIPIDS are consistent with the hypothesis that antagonism of the these peripheral CB1 receptors could slow lipogenesis in both adipos...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007

...TI-007 is an orally available compound which combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of...e reduction of psychotic symptoms without incurring high levels of dopamine antagonism that cause motor disturbances and other deleterious side effects. In additi...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722

...TI-007 is an orally available compound which combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of...e reduction of psychotic symptoms without incurring high levels of dopamine antagonism that cause motor disturbances and other deleterious side effects. In additi...

Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache

...rotonergic 5-HT2A receptors. While drugs that antagonize the D2 receptor are efficacious in treating migraine, it was proposed that the 5HT2A receptor antagonism might yield an improved adverse effect profile over drugs blocking primarily the D2 receptor. This dual mechanism of pharmacological action provided t...

Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders

... cognitive deficits seen in patients with schizophrenia. About ITI-007 ITI-007 is an orally available compound that combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors. As a dopamine receptor phosphoprotein modulator (DPPM)...

Intra-Cellular Therapies Presents Preclinical Data From Schizophrenia and Sleep Maintenance Programs

...ic drugs and relative to its potency at 5HT2A receptors. About ITI-007 ITI-007 is an orally available compound that combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors. As a dopamine receptor protein phosphorylation modulat...

Antagonism in Biological News

Study reveals conflict between doctors, midwives over homebirth

... CORVALLIS, Ore. Two Oregon State University researchers have uncovered a pattern of distrust and sometimes outright antagonism among physicians at hospitals and midwives who are transporting their home-birth clients to the hospital because of complications. Oregon State U...

Human hormone blocker found to help prevent obesity and diabetes: study

...esity. The Study A new study examined whether prolonged GIP receptor antagonism using daily injections of (Pro3) GIP was able to reverse well established d...lated metabolic abnormalities. The new study is entitled, "GIP Receptor antagonism Reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances...

The surprising story of Charles Darwin and his homeopathic doctor

...at the thought of having to publish such a statement about these results. An endorsement of homeopathy by Darwin at that time might have led to great antagonism against his new theories about life and evolution. Many famous people benefited from Dr. Gullys care, including Charles Dickens (novelist and writ...

JCI table of contents: Aug. 16, 2007

...-2595; E-mail: sawyersc@mskcc.org . View the PDF of this article at: https://www.the-jci.org/article.php?id=30890 EDITOR'S PICK: Specific antagonism lowers blood pressure High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of ...

Antagonism in Biological Technology

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... to optimize the level of dopamine receptor modulation holds promise for the reduction of psychotic symptoms without incurring high levels of dopamine antagonism that cause motor disturbances and other deleterious side effects. In addition, the wide separation of affinity at 5HT2A and D2 receptors may allow fo...

Attraction at the atomic level

...th a hero and heroine who initially repel each other, only to find them thrown together in uncomfortable circumstances and ultimately rejoice as their antagonism switches to ardor. Odd as it seems, this tried-and-true romantic formula may also describe the scintillating secret behind the science of supercond...

Oncothyreon announces data from multiple small molecule programs to be presented at American Association of Cancer Research Annual Meeting

... Abstract # 2566, Session: Novel Mechanisms of Drug Action Presentation: Monday, April 14, 2008, 2:55 p.m. to 3:10 p.m. P.T. - HIF-1alpha antagonism by PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice Abstract # 1440...

Oncothyreon's PX-478 is effective in preclinical model of human lung cancer

...val. PX-478 was effective in models of both non-small cell lung cancer and small cell lung cancer that express HIF-1 alpha. "These data suggest that antagonism of HIF-1 alpha with PX-478 significantly inhibits the growth and spread of lung cancers expressing HI-1 alpha and will prove valuable in planning clin...

Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs

... of a new class of designed small molecules that directly, or in combination with other anti-cancer treatments, cause the death of tumor cells through antagonism of IAP function. Preclinical studies clearly demonstrate that AEG40826 potently stimulates apoptosis of human tumor cells in vitro and in vivo. Consis...

Arpida Presents Preclinical Data on AR-2474 at ICAAC

...ould be selected using different methodologies. F1-2098: The data showed that AR-2474 is bactericidal, exhibits a post antibiotic effect and shows no antagonism with other antibiotics tested. About Arpida Ltd. Arpida (SWX: ARPN) is a biopharmaceutical company with research facilities near Basel, Switzerland ...

Nektar Presents Positive Results from Phase 1 Clinical Trial of NKTR-118 (oral PEG-naloxol) at American College of Clinical Pharmacology Meeting

... using the lactulose hydrogen gastrointestinal motility test. Pupillometry, a measurement of the diameter of the pupil of the eye, was used to monitor antagonism of morphine-induced pupil constriction, a central nervous system (CNS) effect. Escalating single oral doses of NKTR-118 up to 1,000 mg were studied. A...

High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system

...in the literature 2 of isoproterenol stimulation of the beta-2-adrenergic receptor with an EC 50 of 110 nM and propranolol antagonism with an IC50 = 0.55 nM. Table 3. Measured EC 50 and IC 50 Values for Beta-2-Adrenergic ...