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Anion in Medical News

Winalite International Healthy Love Moon Sanitary Pads Takes World by Storm

...lite International's flagship product is Love Moon anion sanitary Pads, which, besides providing the obviou...y developed Love Moon sanitary Pads, which contain anion chips. Activated by friction of wearing the pads t...ional has scientific documentation of the positive anion results from several non-U.S. Countries. As st...

New study shows how spikes in nitrite can have

... , researchers at Boston University School of Medicine have demonstrated for the first time that short elevations in circulating levels of this simple anion are sufficient to have a lasting impact on the heart by modulating its oxidation status and its protein machinery. Nitrite, an oxidation product...

JCI online early table of contents: Feb. 16, 2009

...t provide an effective way to modulate CFTR function. TITLE: Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice AUTHOR CONTACT: Ursula Seidler Hannover Medical School, Hannover, Germany. Phone: 49-0-511-532-9427; Fax: 49-0-511-532-8428; E...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin. The clinical relevance of hOAT-3 in sitagliptin transport has n...

Can rectal vitamin E induce remission in patients with mild to moderate ulcerative colitis?

...ivities which protects membrane lipids from peroxidation by scavenging not only chain carrying peroxyl radicals but also singlet oxygen and superoxide anion radicals. This is especially interesting in case of UC, considering the pivotal role of oxygen free radicals in the genesis of mucosal damage. Given t...

Lutein and Zeaxanthin Improve Sports Vision for Athletes

... reach an elite level of performance," says company president Will Horan. He explains that this is accomplished by up-regulating the voltage dependent anion channel, a small pore-forming protein on the outer membrane of cellular mitochondria. This will improve synaptic plasticity, the ability of the synaps...

Quick and Inexpensive DNA Testing

...taching to ionically charged gold nanoparticles. Because ions have electric charges, having gained or lost electrons, they attract their opposites. An anion with a negative electric charge will attract positive charges, a cation with a positive charge will attract negative charges. Single-stranded DNA adso...

New Study Suggests Perchlorate Effects on Thyroid Function of U.S. Women

... Early last year, a National Academy of Sciences (NAS) panel concluded its review of research on the health effects of perchlorate, an inorganic anion and component of rocket// fuel known to inhibit the thyroid’s ability to absorb iodine from the bloodstream, by recommending a new reference dose. The...

Elusive Step In DNA Mutation Uncovered By Researchers

...quires more energy than seems to be available because, formally, it requires that a water molecule (H2O) split apart into a proton (H+) and a hydroxyl anion (OH-). This large energy requirement has puzzled scientists for a long time. Now the research team, led by Landman and Gary Schuster, provost-designat...
Anion in Medical Technology

Genetic Engineering & Biotechnology News Reports on the Growing Role of Ion-Channel Studies in Global Biotech R&D

... a lab focused on elucidating the molecular mechanisms underlying the function of the CLC chloride channels, the largest molecular family of mammalian anion channels. Dr. Maduke's interest in the CLC family is that half of the members are chloride channels, while the other half are chloride-proton antiport...

Prolexys Pharmaceuticals Initiates Phase 1 Study

...pplication of the company's proprietary chemiproteomics discovery platform identified the mitochondrial outer membrane protein VDAC (Voltage Dependent anion Channel) as a potential target of erastin (Nature 447: 864-868, 2007), and PRLX 93936. PRLX 93936 was tested against a series of normal and tumor cel...

Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action

...f erastin. The results, to be published in the June 14, 2007 issue of the journal Nature reveal that erastin binds to mitochondrial voltage- dependent anion channels (VDACs) -- a novel target for anti-cancer drugs. Knock-down of VDAC2 and VDAC3 gene expression causes resistance to erastin, implicating the ...

Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics

...al disease, and extends survival. TRO19622 binds directly to two components of the mitochondrial permeability transition pore: the voltage-dependent anion channel (VDAC) and the translocator protein (or peripheral benzodiazepine receptor), suggesting a potential mechanism for its neuroprotective activity...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

... Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin. The clinical relevance of hOAT-3 in sitagliptin transport has...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

... Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin. The clinical relevance of hOAT-3 in sitagliptin transport has...
Anion in Medical Dictionary

Surfactant

...factant Physiology ... ... and the Mechanism of Chromate Sorption to Surfactant -Modified Clinoptilolite ... subsequent sorption of the chromate anion to surfactant -modified zeolite (SMZ) ... ... that ties augmented surfactant production by ... monary surfactant , a developmentally regulated...

Metabolic acidosis

...propriately alkaline urine, ... In primary dRTA, metabolic acidosis of varying severity is usually accompanied ... Appreciate the use of the anion gap in the differential diagnosis of metabolic acidosis ... Alveolar ventilation during metabolic acidosis is governed by the ... Metab...

Cyanide

... which consists of a carbon atom triple-bonded to a nitrogen atom. Inorganic cyanides are hydrogen cyanide salts in which cyanide is generally the anion CN-. Organic compounds that have a -C≡N... Cyanide poisoning occurs when a living organism is exposed to cyanide . The cyanide ion, if used a...

Chloride

... The chloride ion is formed when the element chlorine picks up one electron to form an anion Cl−. The salts of hydrochloric acid HCl contain chloride ions and can also be called chlorides. Polyvinyl chloride , ) commonly abbreviated P...

Aspartic acid

... Aspartic acid is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CO2H. The carboxylate anion of aspartic acid is known as aspartate. The L-isomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of protein...

Alcoholic ketoacidosis

... ... Alcoholic ketoacidosis causes nausea, vomiting, and abdominal pain. ... Alcoholic ketoacidosis is characterized by hyperketonemia and anion gap ... Alcoholic ketoacidosis causes nausea, vomiting, and abdominal pain. ... Alcoholic ketoacidosis is caused by excessive alcohol use....
Anion in Biological News

Wastewater produces electricity and desalinates water

...gative ions. When the bacteria in the cell consume the wastewater it releases charged ions -- protons -- into the water. These protons cannot pass the anion membrane, so negative ions move from the salty water into the wastewater chamber. At the other electrode protons are consumed, so positively charged i...

Breakthrough in plant research

...activity have been discovered earlier. However, an anion channel, which is of central importance in the reg...oup from the University of Helsinki identified the anion channel using a mutation of Arabidopsis thaliana c...l measurements that the gene identified encodes an anion channel involved in the regulation of stomatal act...

Gene that controls ozone resistance of plants could lead to drought-resistant crops

... the function of what they called a slow or S-type anion channel. Anions are negatively charged ions and these particular anion channels are located within specialized cells call...pores. The gene was therefore named SLAC1 for slow anion channel 1. Guard cells close stomatal pores in ...

Kilogram quantities at last!

...le to an organism. Carbon dioxide and water are produced in this process. This reaction mechanism is named after one of the intermediate products, the anion of citric acid. In nature, isocitric acid is always found with its isomer, citric acid. The difference between these two compounds is merely that t...

Biophysical Society announces winners of 2008 Student Travel Awards

...ractions. Ronak N. Shah, Drexel University, Heme-Protein Interactions in Horse Heart Ferricytochrome c Induced By Changes of Ionic Strength and anion Binding to Protein Surface Charges. Leila Shokri, Northeastern University, The Reaction of Glyoxal with Single DNA Molecules: Structural Eviden...

Rapid, Low-Cost DNA Testing

...taching to ionically charged gold nanoparticles. Because ions have electric charges, having gained or lost electrons, they attract their opposites. An anion with a negative electric charge will attract positive charges, a cation with a positive charge will attract negative charges. Single-stranded DNA adso...

Water management in cells

...n addition to water channels and ion channels, organic particles play an important role. If the salt balance is disrupted, so-called 'volume-regulated anion channels' are first of all activated. These ensure that chloride ions leave the cell. Further research revealed that the efflux of organics only start...
Anion in Biological Technology

Luminol-enhanced Assay for Superoxide Anion (O2 face="Symbol" )

Non-cytotoxic chemiluminescent enhancer for increased sensitivity Luminol-enhanced Assay for Superoxide Anion (O 2 ) Danny Q. Hoang Stratagene Lorraine C. Pfefferkorn Dartmouth School of Medicine, Dept. of Microbiology, Hanover, NH Stra...

Stevens researchers provide new information about mass spectrometry

...ic cleavage to eliminate an *H and form a distonic anion radical, which eventually loses CO to produce a pe...gen in the CO molecule that is eliminated from the anion of meta-hydroxybenzaldehyde originates from either...imination of a H(2) molecule was observed from the anion derived from 2,4-dihydroxybenzaldehyde, wrote Atty...

Calcium Flux Assays using the LabChip 3000

...ould be used. Typically, 6 x 10 6 cells are loaded with 6 mL of physiological buffer containing 1 μM Fluo-4 and 1 μM Fura Red. In addition, anion transport inhibitors such as probenecid should be used for cell lines such as CHO-m1 that rapidly export Ca 2+ indicators. After loading of dye, the ...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

...h buffer: this buffer contains a final concentration of 1X HBSS and 20 mM HEPES diluted in sterile d.H 2 O. Important: To prevent dye extrusion by the anion exchange protein, the wash buffer is supplemented with 2.5 mM probenecid. Step 2 Prepare a fresh stock of 250 mM probenecid. Diss...

High Sensitivity, Wide Dynamic Range, Horseradish Peroxidase (HRP) ELISA Using the LMax Microplate Luminometer (MaxLine Application Note #41)

...minol/peroxide substrate solution is added to the wells to produce light. The reaction involves the oxidation of luminol to an excited 3aminophthalate anion (not shown) which decays to the product shown and releases light (Figure 1). Over a wide dynamic range, the amount of light produced is a function of ...

Speciation of Arsenic by LC-ICP-MS

...ProStar 230 Tertiary Solvent Delivery Module, a Rheodyne injector with a 50 μL sample loop, and a Hamilton PRP-X100 (4.1 mm x 250 mm, 10 μm) anion exchange column. The Varian ICP-MS was used for all arsenic measurements. ICP-MS setup was fully controlled by Varians ICP-MS Expert softwar...

The Bio-Rad Silver Stain, Rev E

... (1985) 21. Gemski MJ et al., Single step purification of monoclonal antibody from murine ascites and tissue culture fluids by anion exchange high performance liquid chromatography, Biotechniques, 3, 378-384 (1985) 22. Goldman D and Merril CR, Silver staining of...

Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer

... and transformed into DH5a cells. Plasmid DNA was isolated using anion exchange chromatography. A λZap (Stratagene) cDNA clone for...transformed into DH5α cells. Plasmid DNA was isolated using anion exchange chromatography. Quantitation of the DNA was a...

Separation Reproducibility With the BioLogic Chromatography Systems

...ected onto a column. The test mixture was purified in consecutive anion exchange runs using an UNO Q1 column or an Econo-Pac High Q ...on the BioLogic DuoFlow QuadTec system as a queue of alternating anion exchange and equilibration runs (160 runs total). As shown in Fi...

A Simple and Rapid Technique to Purify High-Quality Midiprep DNA

...s with endotoxin removal); the standard anion exchange method takes a minimum of 3 ho...Cl density gradient centrifugation, and anion exchange methods were sequenced at Sequ...CsCl density gradient centrifugation, and four for anion exchange. ...
Anion in Biological Products

Big CHAP, Deoxy from Calbiochem

Description:...holamide White solid. HYGROSCOPIC. A non-ionic detergent analog of CHAPS and CHAPSO. Has reduced electrostatic interactions that do not interfere in anion exchange chromatography on DEAE-cellulose. Aggregation number: 8-16. Purity: ≥95% by HPLC. Soluble in H 2 O. Aggregation number 8 - 16, CMC 1.1 -...
Company:Calbiochem

Anion Exchange ProteinChip Arrays from Ciphergen

Description:...ic acid. Binding occurs at high pH with low salt and binding decreases as pH decreases and salt concentration increases. ProteinChip SAX2: is a strong anion exchange array with a higher-capacity quartenary ammonium surface to bind anionic proteins....
Company:Ciphergen

Macro-Prep High Q Support, 500 ml from Bio-Rad

Description:...orous beads enhance access to ionic sites, and the hydrophilic matrix reduces nonspecific binding. Macro-Prep High Q support is a high-capacity strong anion exchanger with very high flow rates and resolution. It has Cl- as the counterion; nominal particle size of 50 micrometers. Supplied as 500 ml....
Company:Bio-Rad

Mouse Anti-Human Porin 31HL Monoclonal Antibody, Unconjugated, Clone 89-173/016 from Calbiochem

Description:... Anti-VDAC (Voltage-Dependent anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
Company:Calbiochem

Dithio-bis(2-nitrobenzoic acid) BioChemica from AppliChem GmbH

Description:.... The free thiol group of thiocholine reacts with DTNB included in the assay mixture, producing the yellow 4-nitrothiolate. The release of this yellow anion is followed at 412 nm. The assay may be performed at 30C in 0.1 M sodium phosphate buffer with 10 mM DTNB and 12.5 mM acetylthiocholine iodide (1). St...
Company:AppliChem GmbH

Ubiquitin Fraction I Extract from GeneTex

Description:... those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80876 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. GTX80876 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). GTX80876 is ideal for demonstrating if ...
Company:GeneTex

IRS Extract from GeneTex

Description:...teins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80877 is the protein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80877 contains ubiquitin activating enzyme (E1), most ubiquitin conjugati...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:...de those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. EP-500 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating if FI...
Company:ABR-Affinity BioReagents

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:...teins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80878 is the protein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugati...
Company:GeneTex
Anion in Biological Definition

Oxidative phosphorylation

...tive oxygen species Several highly reactive, transient oxygen derivatives can be formed during this process: Hydrogen peroxide Superoxide anion Hydroxyl radical ...
Anion in Biological Dictionary

Phosphate ion

...a solution having a lithium ion ... In inorganic chemistry, a phosphate is a salt of phosphoric acid. ... The phosphate ion is a polyatomic anion with the empirical formula P O 43 and a ... In inorganic chemistry, a phosphate is a salt of phosphoric acid. ... The phosphate ion carries a...

Malpighian tubule

...gaster Malpighian tubule provides a unique opportunity to ... Fluid secretion by the Malpighian tubule of Drosophila melanogaster is ... of anion and cation transport in Malpighian tubules of Drosophila melanogaster. ... Definition of malpighian tubule from the Merriam-Webster Online ...

Hydroxyl radical

...ydroxyl radical and the singly-charged hydroxyl anion is called hydroxide.... Hydroxyl in chemistry...al form is a hydroxyl radical and the hydroxyl anion is called a hydroxide. When the oxygen atom is...ration of Hydroxyl Radical and Sulfur Trioxide anion Radical from Oxidation of Sodium Sulfite, Nickel...

Disulfide bridge

...-C. The terminology... In chemistry, a disulfide usually refers to the structural unit composed of a linked pair of sulfur atoms. The disulfide anion is S22−. The term disulfide can also refer to a chemical compound that contains a disulfide ... A disulfide bond (SS-bond), also called a d...
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