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Aneuploidy in Medical News

New DNA Test Is Basis for Groundbreaking IVF Refund Plan, Easing Financial Burden for Patients

... (referred to as "aneuploidy") will result in either a non-viable embryo, a miscarriage or, if implanted and carried to term, a birth defect. Because aneuploidy is the most common cause of IVF failure, identifying viable embryos for transfer to the uterus can significantly boost birthrates for IVF. "We ca...

MUHC in the spotlight at the 14th World Congress on In Vitro Fertilization

...nosis of adenomyosis Preimplantation genetic diagnosis: - Asangla Ao - Monday 17.09.2007 at 10:00am Preimplantation genetic diagnosis for aneuploidy screening; an overview of current practices Surgery : - Srinivasan Krishnamurthy - Tuesday 18.09.2007 at 10:30am Young women and myomectomy...

Researchers Identify New Drug Targets for Cancer

... characteristic of cancer cells called aneuploidy. aneuploidy – the occurrence of one or more extra or missing c...variable number of chromosomes to discover if such aneuploidy made the mice more tumor-prone. “We found th...d other genetic errors to mice with a high rate of aneuploidy – tumor development was slowed. The UCSD research...

Amniocentesis Safer for Pregnant Women

...titutions involved in the First and Second Trimester Evaluation of Risk for aneuploidy trial (FASTER trial) have just reported in the November issue of the journa...rate after midtrimester amniocentesis using patients who were recruited for aneuploidy screening. A total of 35,003 unselected patients were enrolled between 10 3...

Vasectomy Reversal to Lead to Birth Defects

... of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men. This rais...l. If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by va...vasectomy reversal operations and will compare the aneuploidy rate of these and of the sperm we will collect eac...

Protein Complex prevents cancer

...ch is found to protect cell from transforming into aneuploidy state, which has an abnormal number of chromosomes...dy state in the cell and prevents the formation of aneuploidy state. Prof. Deursen has published the resul...or cancer treatment as most of the cancers involve aneuploidy cells which plays a role in most cancers by making...
Aneuploidy in Medical Technology

Newly Published Article Details How PGS Techniques Directly Effect Successful Pregnancy Outcomes

...ty of embryos created in vitro are chromosomally abnormal. When done correctly, PGS screens the most important chromosomes in terms of preimplantation aneuploidy (22, 16, 21 and 15), improving implantation rates. Dr. Santiago Munne, of Reprogenetics, LLC. in Livingston, NJ, who has performed close to 15 th...

Lenetix Launches Screening Study of New Down Syndrome Test

...ear the risks of amniocentesis," said Steve Brown, M.D., Lenetix Medical Director. "Our test offers the promise of a comprehensive assessment of fetal aneuploidy in the first trimester using a maternal blood sample. It's a higher-quality test that will protect the mother and fetus." "I'm personally honor...

Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer

... and his research team found that PSMA-expressing cells spent less time dividing. They found that PSMA interferes with the function of APC and induces aneuploidy in cancer cells. "When PSMA is present, cells hurried to complete their division prior to having all their chromosomes properly segregated," said Dr. ...

Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos

...ce miscarriage risk, and decrease the risk of some major congenital anomalies such as Down syndrome. This procedure, known as "Accurate 23 chromosome aneuploidy screening in human blastomeres using single nucleotide polymorphisms (SNP)," provides fertility specialists for the first time with a rapid and accura...

American Fertility Association Calls for Expanded Research to Advance New Technology to Screen Embryos for Genetic Abnormalities

... medicine in a decade. We must work to bring this new technology to patients as quickly as possible." The procedure, known as "Accurate 23 chromosome aneuploidy screening in human blastomeres using single nucleotide polymorphisms (SNP)," makes it possible for the first time to fully evaluate the genetic make u...
Aneuploidy in Medical Products

Vysis UroVysion Bladder Cancer Kit

Description:... The UroVysion Bladder Cancer Kit (UroVysion Kit) is designed to detect aneuploidy for chromosomes 3, 7, 17, and loss of the 9p21 locus via fluorescence in situ hybridization (FISH) in urine specimens from persons with hematuria susp...
Company:Abbott Diagnostics
Aneuploidy in Biological News

New research finds possible genetic link to cause of pregnancy loss and disorders

... bad copy of the gene with a normal male. When the female carried the bad copy, there were fewer births. Further research revealed this is because aneuploidy was generated in the egg and passed on to the single-cell zygote that forms when a sperm fertilizes an egg. And this led to the loss of the embryo. ...

New test can detect both genetic and chromosomal abnormalities in embryos

...ibrosis, but that it was also capable of detecting aneuploidy (an abnormal number of any of the 23 pairs of chro...sing chromosomes, it also detects the existence of aneuploidy at the same time. "The range of applications is...s for virtually any genetic disease and screen for aneuploidy of all 23 pairs of chromosomes simultaneously. Thi...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

...tsushita, University of Puget Sound Mentor: Andreas Madlung A role for aneuploidy as a means for hybrid speciation in the genus Arabidopsis I am incredibly...t biology began last summer when I started studying the possible effects of aneuploidy on the evolution of an Arabidopsis allopolyploid, and was able to find some...

Rong Li Lab offers insight into adaptive ability of cells

...on the architecture of molecular networks present in the cell; and in extending our research into mammalian cell systems to directly study the role of aneuploidy in the evolution of cancer." ...

New blood test for Down syndrome

...an techniques used in previous efforts to diagnose aneuploidy by analyzing fetal DNA. aneuploidy occurs when there are either too many or too few c... 35 and older, where the age-related risk of fetal aneuploidy outweighs the risk of miscarriage. As a result, mo...

Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle

... a lower pregnancy rate from the time of their first attempt, and this rate remains consistent thereafter. It is possible that the incidence of embryo aneuploidy in this age group is the over-riding factor affecting pregnancy outcome in this age group. "For the group aged 36-39, the pregnancy rate was 25% at...

'Signature' of chromosome instability predicts cancer outcomes

...n as aneuploidy, in which chunks of DNA are either missing or duplicated. The technique developed by Szallasi's team indirectly measures the degree of aneuploidy -- and thus the degree of chromosomal instability -- by looking for abnormal expression levels of genes at the different chromosomal locations. N...

Chromosomal abnormalities in sperm higher after vasectomy reversal

... He found that they had high rates of chromosomal aneuploidy (where an abnormal number of specific chromosomes ... of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men", said Pro.... If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by va...

MIT sheds light on how tumor cells form

...al number of chromosomes, but scientists have been puzzled by evidence that aneuploidy can result even when these proteins appear to be normal. What MIT resea...subtle errors in them. (These subtle errors are believed to be the cause of aneuploidy and the rapid growth of tumors.) Before cells divide, individual chromos...

Common viruses may cause cancer

... longer have the proper genetic makeup and frequently die. But researchers now know that tumor cells are often aneuploid--and very much alive. Whether aneuploidy is a cause or a consequence of a cancerous cellular state is the crux of a current debate. In a recent study, Dr. Yuri Lazebnik and his colleagues ...
Aneuploidy in Biological Technology

Telik Reports Preclinical Results at AACR Annual Meeting

...sis during mitosis. Over-expression of Aurora kinases has been demonstrated in both solid tumors and leukemia and is considered to be associated with aneuploidy and carcinogenesis. Inhibition of Aurora kinase activity induces growth arrest and apoptosis in cells and leads to tumor-growth inhibition in xenogra...

China Medical Technologies Receives SFDA Approval for Its Bladder Cancer FISH Probe

...iagnostic test kit that uses DNA probes for early detection and monitoring the course of bladder cancer. It is designed to detect and identify whether aneuploidy for chromosomes 3, 7, 17 and loss of the p16 locus are present in the human bladder cells. A number of hospitals in China have applied the Probe for d...

Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced

...lly something." Dr Christophe Blockeel. University Medical Center Utrecht, The Netherlands. Research title: Assessment of oocyte quality by embryo aneuploidy rates and cumulus cell gene expression: effect of late follicular phase hCG administration. Dr Esther Baart, principal applicant of the second winni...

Empire Genomics and Reprogenetics Join Forces to Improve Preimplantation Genetic Diagnosis (PGD)

...ct other microdeletion occurrences." The abstract, entitled "Comprehensive aneuploidy Screening in Single Cells Using Microarray Comparative Genomic Hybridizatio... the field since 1990. Reprogenetics was the first to develop PGD tests for aneuploidy and translocations. The company's program director, Santiago Munne, the res...

Protein Depletion for Plasma and Serum Proteomic Analysis

...69.
  • Wang TH, Chang YL, Peng HH, Wang ST, Lu HW, Teng SH, Chang SD, Wang HS: Rapid detection of fetal aneuploidy using proteomics approaches on amniotic fluid supernatant. Prenatal Diagnosis 2005, 25 :559-566.
  • Aneuploidy in Biological Definition

    Chromosome

    ...versions , although it may lead to a higher chance of having a child with an chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, aneuploidy , may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. The gain or...

    Ploidy

    ... 3 Haplodiploidy 4 Haploidisation 5 aneuploidy 6 Polyploidy Haploid Haploid (m...ers to produce Kaguya the fatherless mouse. aneuploidy aneuploidy is when a cell contains an abnormal or non-intege...

    Ploidy

    ... 3 Haplodiploidy 4 Haploidisation 5 aneuploidy 6 Polyploidy Haploid Haploid (m...ers to produce Kaguya the fatherless mouse. aneuploidy aneuploidy is when a cell contains an abnormal or non-intege...
    Aneuploidy in Biological Dictionary

    Aneuploidy

    Aneuploidy is an abnormal number of chromosomes. An extra or missing chromosome is a common cause of genetic disorder (birth defect). Cancer cells also have abnormal numbers of chromosomes. Aneuploidy occurs during cell... aneuploidy n. The state or condition of being aneuploid. ... Ge...

    Oocytes

    ...togenetic survey of mature human oocytes has been and remains a subject of ... genetic investigation of human oocytes in the understanding of aneuploidy ... Immature oocytes from superovulated cycles can undergo the final stages of ... MI oocytes have already undergone the process of germinal ...

    Euploidy

    ...y. Development of Aneuploids. Phenotypic Effects of Aneuploidy. Genetics of aneuploidy ... Euploidy . Euploidy in Animals ... Euploidy in plants ... Aneup...y. Development of Aneuploids. Phenotypic Effects of Aneuploidy. Genetics of aneuploidy ... Euploidy and Plant Speciation ... Euploidy . Euploidy . Variatio...

    Centrosome

    ...h with its pair of centrioles, move to ... from tubulin monomers in the cytoplasm and grow out from each centrosome . ... ... high degrees of aneuploidy (and centrosome amplification) are also hallmarks of ... In most normal cells, centrosome duplication is regulated by a "block" that ... Inf...

    Aneuploid

    ...romosome content may be part of the constitutional ... Aneuploid neurons are functionally active and integrated into brain circuitry" ... aneuploidy n. The state or condition of being aneuploid . ... Aneuploid neurons are functionally active and integrated into brain circuitry" ... aneuploid...
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