Androgen

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

AUGUSTA, Ga. A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say. Levels of the protein, βarrestin2, are lower in some prostate cancer cells t...

Pharmacopeia Acquires Selective Androgen Receptor Modulator ('SARM') Program from Bristol-Myers Squibb

PRINCETON, N.J., Oct. 15 /PRNewswire-FirstCall/ -- Pharmacopeia (Nasdaq: PCOP ), an innovator in the discovery and development of novel small molecule therapeutics, today announced that it has licensed from Bristol-Myers Squibb (NYSE: BMY ) a selective androgen receptor modulator (SARM) prog...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

...luate the safety of BP-GMAX-CD1 and AP1903 in a minimum of 24 patients with androgen independent prostate cancer (also known as castrate resistant prostate canc... autologous vaccine, is in clinical development for patients with advanced, androgen independent prostate cancer. BP-GMAX-CD1 and follow-on product candidates h...

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

...ents. FIRMAGON is not indicated in women or pediatric patients. Long-term androgen deprivation therapy prolongs the QT interval. Physicians should consider whether the benefits of androgen deprivation therapy outweigh the potential risks in patients with congenita...

Scientists discover key event in prostate cancer progression

... 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules located in the nucleus of cel...show that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate a group of ... "Some late-phase prostate cancer does not require androgen hormones for tumor growth, but it does require...

Acupuncture, Exercise May Ease Polycystic Ovarian Syndrome

...earing age who suffer from a common endocrine disease called polycystic ovarian syndrome (PCOS). Women with the condition have elevated levels of androgen hormones -- including testosterone -- and often develop ovarian cysts, irregular menstrual cycles and infertility. A key feature of the disease is an ...

Androgen in Medical Technology

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

...se 1-2 trial evaluating MDV3100, a next-generation androgen receptor antagonist, in castration-resistant prost...n contrast to those achieved with first-generation androgen receptor antagonists." In vitro data recently... mechanism of action is unlike that of the leading androgen receptor antagonist, bicalutamide. Specifically, M...

Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update

...ues to grow despite current standard of care hormonal (anti-androgen) therapies. CRPC is more invasive and more likely to spread to other organs than androgen dependent prostate cancers. Patients with CRPC have few treatment options and a poor prognosis. About Picoplatin Picoplatin is designe...

Poniard Pharmaceuticals to Present New Data from Phase 2 Clinical Trials of Picoplatin in Multiple Tumor Types at the 45th Annual Meeting of the American Society of Clinical Oncology

...ues to grow despite current standard of care hormonal (anti-androgen) therapies. CRPC is more invasive and more likely to spread to other organs than androgen dependent prostate cancers. Patients with CRPC have few treatment options and a poor prognosis. About Colorectal Cancer CRC is the third m...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

...nzyme that converts testosterone to DHT, D-3263 is not an inhibitor of this enzyme suggesting that the two agents may act by different means to affect androgen metabolism and prostate hyperplasia. "BPH is a condition that affects a significant number of men, and based on the preclinical data announced to...

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

... investigate the use of degarelix for intermittent androgen deprivation therapy (IADT) in patients with advanc...rapies. The study will compare IADT to continuous androgen deprivation therapy (ADT) for 14 months with eithe...as measured by PSA suppression. "Intermittent androgen deprivation therapy is a commonly employed treatme...

Data Presented at AACR Annual Meeting Show Anti-Tumor Activity of Peregrine's Fully Human Anti-PS Antibody in Prostate Cancer Model

...S reported that similar to bavituximab, the human antibody PGN635 targets and binds specifically to the tumor vascular endothelium(1). Treatment with androgen deprivation therapy or docetaxel substantially increased the percentage of tumor blood vessels with PGN635 binding. The researchers also reporte...

Androgen in Medical Products

Androstanediol Glucuronide RIA Test

Description:...urement of serum 3alpha-diol G levels may be useful in the clinical evaluation and management of hirsutism and other conditions with excessive adrenal androgen production. References 1. Rittmaster RS. Endocrin Rev 14:121-132, 1993. 2. Dorfman RI & Shipley RA. Androgens. John Wiley and Sons, ...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:...urement of serum 3alpha-diol G levels may be useful in the clinical evaluation and management of hirsutism and other conditions with excessive adrenal androgen production. References 1. Rittmaster RS. Endocrin Rev 14:121-132, 1993. 2. Dorfman RI & Shipley RA. Androgens. John Wiley and Sons, ...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione EIA Test

Description:...ificant extra-adrenal conversion of androstenedione to testosterone occurs [1,2,3]. Measurement of serum androstenedione provides a useful marker of androgen biosynthesis. Elevated androstenedione levels have been demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels ar...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione RIA Test

Description:...ificant extra-adrenal conversion of androstenedione to testosterone occurs [1,2,3]. Measurement of serum androstenedione provides a useful marker of androgen biosynthesis. Elevated androstenedione levels have been demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels ar...
Company:Diagnostic Systems Laboratories, Inc.

ACTH RIA Test

Description:...are directly inhibited by glucocorticoids [1,2]. ACTH stimulates adrenal steroidogenesis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. Decreased ACTH secretion can occur in a variety of pituitary and hypothalamic disorders and in certain systemic infections. Elevated plasma...
Company:Diagnostic Systems Laboratories, Inc.

DHEA RIA Test

Description:... children and in adult women, DHEA is an important androgen as circulating DHEA levels may be several-fold hig...rement of serum DHEA is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in hypo...ment of DHEA levels may aid in the localization of androgen source in virilizing conditions. Dorfman RI, S...
Company:Diagnostic Systems Laboratories, Inc.

Androgen in Medical Definition

Pathology

...uberty - Precocious puberty Other Autoimmune polyendocrine syndrome - Carcinoid syndrome - Laron syndrome - Psychogenic dwarfism - androgen insensitivity syndrome - Progeria v • d • e Nutritional pathology ( E40-68 ) Malnutrition Kwashior...

Androgen in Medical Dictionary

Androgen

Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen ... The androgen receptor (AR), also known as NR3C4, is a type of ...

Testosterone

... Testosterone is a steroid hormone from the androgen group. In mammals, testosterone is primarily se...ase testosterone level ... Testosterone is an androgen found in both men and women. ... The connecti... testing has come of age as increased testing for androgen ... Testosterone is the principal ...

Testicular feminization

... androgen insensitivity syndrome (AIS), also referred to as androgen resistance syndrome, is a set of disorders of s...nt caused by mutations of the gene encoding the androgen receptor. The nature of the resulting... Onli...

Testes

... androgen insensitivity syndrome (AIS), also referred to as androgen resistance syndrome, is a set of disorders of s...nt caused by mutations of the gene encoding the androgen receptor. The nature of the resulting... Huma...

Sebaceous glands

... glossary with medical definitions ... Definition of Sebaceous gland . Sebaceous gland : A normal gland of the skin which empties an ... androgen production stimulates sebaceous glands and cause them to enlarge. People who develop hormonal acne have over stimulated sebaceous glands . .....

Reifenstein syndrome

... androgen insensitivity syndrome (AIS), also referred to as androgen resistance syndrome , is a set of disorders of...nt caused by mutations of the gene encoding the androgen receptor. The nature of the resulting... Rei...

Androgen in Biological News

Study reveals a reprogrammed role for the androgen receptor

BOSTONThe androgen receptor a protein ignition switch for prostate cancer cell growth and division is a master of adaptability. When drug therapy deprives the receptor of androgen hormones, thereby halting cell proliferation, the receptor manages to find an alternate growth route. A new study by...

3-D research model tackles prostate cancer spread

...prostate removal surgery should have low levels of androgen and the cancer cells should be suppressed. However...e fact that the cancer cells are very sensitive to androgen and even low levels of androgen in the body could promote the growth of these canc...

New drug shows promise in treating drug-resistant prostate cancer

...ovel compounds, MDV3100 and RD162, which block the androgen receptor (AR) in CRPC cells, and report results fr...0 was "designed as a very strong antagonist of the androgen receptor to stop the growth of any prostate cancer...n cancer cells begin to increase production of the androgen receptor, Sawyers said. When the level of...

New medications show promise in treating drug-resistant prostate cancer

...n cancer cells begin to increase production of the androgen receptor, said Sawyers. When the level of androgen receptors on the cells' surface reaches a certain ...ny scientists have questioned whether blocking the androgen receptor is a wise course of action. But Sawyers a...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

... only been on the market a few years and are targeted to inhibit aromatase specifically. But because the structure was not known, nor the mechanism of androgen to estrogen conversion, the AIs currently in use have been developed using trial and error methods resulting in greater vulnerability to contraindicat...

Why the 'perfect' body isn't always perfect

...cludes testosterone, increase waist-to-hip ratios in women by increasing visceral fat, which is carried around the waist. But on the upside, increased androgen levels are also associated with increased strength, stamina, and competitiveness. Cortisol, a hormone that helps the body deal with stressful situatio...

Androgen in Biological Technology

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... novel cancer drug candidates from Santaris Pharma and Enzon has announced the targets for four of these compounds: Her3, beta catenin, PIK3CA and the androgen receptor. Pipeline Summary In H1 2009 Santaris Pharma continued the progress for both the drug discovery programs and the drug developme...

Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Casodex(R) Tablets

...US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for generic Casodex(R) tablets. Bicalutamide tablets are an androgen receptor inhibitor indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 m...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

...apy (IMRT) II-43 Benefits of IMRT II-44 Drawbacks of IMRT II-44 androgen Deprivation Therapy (ADT) II-44 High Dose Radiation (HDR) Monotherapy I...ll Therapeutics Reveals Phase 2 Clinical Trial Results of XYOTAX(TM) in androgen Independent Prostate Cancer Patients II-56 Sanofi-Aventis' Taxotere(R) ...

Dendreon Announces Data Presentations and Webcast at AUA Annual Meeting

...April 28, 2009, 2:20 p.m. CDT - "A randomized, double-blind, placebo-controlled, multi-center, phase III trial of sipuleucel-T in men with metastatic, androgen independent prostatic adenocarcinoma (AIPC)." AUA Late-Breaking Science Forum to be held from 1:00 p.m. to 2:30 p.m. CDT. Room W375 at McCormick Pla...

Medivation Announces Upcoming Scientific Presentations at Medical Conferences

... April 30, at 11:30 a.m. Pacific Time (Poster Session VIII) About MDV3100 MDV3100 is a novel small-molecule androgen receptor antagonist drug candidate in development for the treatment of castration-resistant (also known as hormone-refractory) prostate cancer (CRPC)....

Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

...ng Phase 1-2 clinical trial of the Company's novel androgen receptor antagonist MDV3100 in castration-resistan... and a poor prognosis. Overexpression of the androgen receptor is believed to contribute to the progress...rostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits...

Androgen in Biological Products

PolarScreen Androgen Receptor Competitor Assay Kit, Red from Molecular Probes (Invitrogen)

Description: The PolarScreen Androgen Receptor (AR) Competitor Assay Kits provide a sensitive and efficient method for studying and screening potential AR ligands using fluorescence polarization (FP). The kits contain rat AR ligand binding domain protein tagged with His and GST [AR-LBD (His-GST)], and a novel, ...
Company:Molecular Probes (Invitrogen)

Androgen in Biological Definition

X chromosome

...s category is vitamin D resistant rickets . The following genetic disorders are associated with the X chromosome: Alport syndrome androgen insensitivity syndrome Charcot-Marie-Tooth disease Coffin-Lowry syndrome Fabry disease fragile X syndrome hemophilia inc...

Androgen in Biological Dictionary

Receptor

... may attach. A molecule which binds to a receptor is called a... The androgen receptor (AR), also known as NR3C4, is a type of nuclear receptor which...ither of the androgenic hormones testosterone or dihydrotestosterone. The androgen receptor is most closely... Receptor Hardware Plug-in Player. UniWir...

Gene amplification

...multiple drug ... News release issued by the National Human Genome Research Institute in June 1995 on the discovery that the amplification of the androgen receptor (AR) gene may ... Easy-to-use, talking glossary of genetic terms, produced by the National Human Genome Research Institute. ... Biolog...

Cell growth

...Mastocytosis The outermost circle represents the various cell types in C. elegans in which ... genes that promote cancer cell growth in the androgen independent state. ... One cannot watch cells crawling, dividing, segregating their chromosomes, or rearranging their surface without feeling c...

Androgens

... androgen is the generic term for any natural or synthetic c...Information about Androgens , male sex hormone androgen ... Bioidentical Androgens Used to Enhance Perf...omen may cause hyperandrogenic symptoms while low androgen levels may cause low libido during and after peri...