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Anaplastic in Medical News

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

...opment in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. A Phase I dosimetry trial in GBM patients in the U.S. has completed patient enrollment and a Ph...

Delivering Chemo Directly Into Brain Tumors Shows Promise

...amage to the brain. The patients had two types of tumors: 10 had a glioblastoma multiforme (GBM), an invasive and fast-growing tumor, while six had anaplastic glioma. "Topotecan by convection-enhanced delivery has significant anti-tumor effects at doses that are not harmful to normal brain tissue," Bruce ...

Avastin effective at delaying brain tumor progression in recurrent disease

...ients conducted by a researcher at the Seattle Cancer Care Alliance. The patients all had a recurrent malignant glioma known as alkylator-refractory anaplastic oligodendroglioma (AO), for which there is no existing standard therapy. Oligodendrogliomas begin in brain cells called oligodendrocytes, which provid...

'Sharing Miracles' Television Program to Feature Boston Red Sox Star Pitcher Jon Lester

... only nine games with the Sox, he was diagnosed with cancer - specifically, anaplastic large cell lymphoma, a type of non-Hodgkin's lymphoma. In this month's...r Institute, more than 66,000 new cases of non-Hodgkin's lymphoma (of which anaplastic large cell lymphoma is one) were diagnosed in 2008. Today, America's pharma...

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

...tly as monotherapy, and for patients with malignant gliomas, such as GBM or anaplastic astrocytoma (AA), showing recurrence or progression after standard therapy..... TEMODAR is indicated for the treatment of adult patients with refractory anaplastic astrocytoma, i.e., patients who have experienced disease progression on a d...

2 gene mutations linked to most common brain cancers -- and longer survival

...of Medicine. Further analysis of their data showed that glioblastoma and anaplastic astrocytoma patients carrying the mutations survived longer than those who ...H1 or IDH2 was 31 months versus 15 months for those lacking the mutations. anaplastic astrocytoma patients carrying the mutations were found to have a median sur...

Red Sox Pitcher Jon Lester Wins 2008 Hutch Award(R)

...aid. "I'm humbled to know that legends such as Mickey Mantle, Sandy Koufax and Lou Brock have won this award in the past." Lester was diagnosed with anaplastic large-cell lymphoma in August 2006. Referred to the Seattle Cancer Care Alliance, the treatment arm of Fred Hutchinson Cancer Research Center, he unde...

Silicone Breast Implants Might Raise Risk of Rare Lymphoma

...use other health problems. Researchers have identified previous cases of non-Hodgkin lymphoma in women with breast implants, and most of these were anaplastic large T-cell lymphoma (ALCL). Normally, ALCL is exceedingly rare, representing 3 percent or less of all non-Hodgkin lymphoma in adults, and there ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...ase; adenosine monophosphate (AMP); alpha5beta1 integrin; alphanubeta3 integrin; alphanubeta5 integrin; alpha-fetoprotein (AFP) receptor (RECAF); Akt; anaplastic lymphoma kinase (ALK); androgen receptor (Ar); angiopoietin-1; angiopoietin-2; APEX; ATP synthase [alpha] subunit; axl; Bap31; Bcl-xL; Bcl-2; bcr-abl/...

Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment

...ty and University Hospitals, looked at the records of 1753 patients who were treated for glioblastoma multiforme (GBM) and of 205 patients treated for anaplastic astrocytoma (AA) between 1991 and 1999. GBMs are the most common malignant brain tumors in adults. AAs are less common, but are treated similarly to...
Anaplastic in Medical Technology

2007 ASCO Annual Meeting: Clinical Results on Phase IIb-study with AP 12009 in Anaplastic Astrocytoma selected for Poster Discussion

REGENSBURG, Germany, May 10th, 2007 - Antisense Pharma, a German biopharmaceutical company specialized in targeted therapies for malignant tumors, today announced, that data from the Phase IIb-study with AP 12009 in high-grade glioma will be presented at the 43rd Annual Meeting of the American Soc...

Antisense Pharma: Promising Phase IIb Results of Targeted Therapy with AP 12009 in Recurrent Anaplastic Astrocytoma

CHICAGO and REGENSBURG - June 21, 2007 - “In anaplastic astrocytoma, AP 12009 as a monotherapy is actually clearly superior to temozolomide,” Prof. Albert Wong, M.D., Stanford University, California, U.S.A. commented on the international Phase IIb study with the TGF-beta 2-inhibitor AP...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

...glioblastoma multiforme (GBM) concomitantly with radiotherapy and subsequently as monotherapy, and for patients with malignant gliomas, such as GBM or anaplastic astrocytoma (AA), showing recurrence or progression after standard therapy. The CHMP recommendation serves as the basis for a European Commission app...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

...lleagues first discovered that a region of chromosome 2 was associated with the disease. Further sequencing of that region identified mutations in the anaplastic lymphoma kinase (ALK) gene in eight families with familial neuroblastoma. "This finding means that it is possible to offer simple, non-invasive scre...

Clinical Proof of Concept for TGF-beta 2-Inhibitor AP 12009 in Phase Iib EMEA provides Guidance on Phase III Design and Approval Requirements

...pcoming Phase III study in recurrent or refractory anaplastic astrocytoma patients. Furthermore, 14-month progre...ment over chemotherapy. In recurrent or refractory anaplastic astrocytoma, 83.3% of the patients treated with 10...tes for 10 μM AP 12009 in recurrent or refractory anaplastic astrocytoma, with up to 42% at 14 months. At the s...

Data To Be Presented at ASCO Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

...lopment in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. Cotara is in a Phase I dosimetry trial in GBM patients in the U.S. and a Phase II safety and eff...

Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting

...ent of Adults with Newly Accepted for (polifeprosan 20 Diagnosed Glioblastoma publication with carmustine Multiforme or anaplastic only. implant) Astrocytoma with Surgery, Gliadel Wafers and Limited Field Radia...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

...ular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas related to lymphoproliferative disorders following bone marrow or stem cell t...

Long-Term Data from a Landmark Phase III Trial Show Survival Benefit at Three- and Four-Years in Patients with Glioblastoma multiforme

...ytopenia in 14 percent of patients treated with temozolomide. In refractory anaplastic astrocytoma, Grade 3/4 neutropenia occurred in 14 percent and Grade 3/4 thr... for the treatment of malignant glioma, such as glioblastoma multiforme and anaplastic astrocytoma (AA), showing recurrence or progression after standard therapy....

Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India

... academic brain cancer centers. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. About Peregrine Pharmaceuticals Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company...
Anaplastic in Medical Dictionary

Thyroid cancer

...early stages of thyroid cancer , no symptoms are present. ... Information on thyroid cancer , including papillary, medullary, follicular and anaplastic thyroid cancer . ... has shown that thyroid cancer patients face a ... Incidence of thyroid cancer has been increasing in recent years,...

Rhabdomyosarcoma

...es are absent ... rhabdomyosarcoma ( ¦rabdō′mīōsär′kōmə ) ( medicine ) A malignant tumor of skeletal muscle in the extremities composed of anaplastic muscle Describes the fast-growing, highly malignant tumor which accounts for over half of the soft tissue sarcomas in children. Detailed i...

Leiomyosarcoma

...h and intestines, the walls of all blood vessels, and the... leiomyosarcoma ( ′līō′mīōsär′kōmə ) ( medicine ) A malignant tumor composed of anaplastic smooth muscle ... Since leiomyosarcoma can occur in any location, the ... Leiomyosarcoma can spread (metastasize) to other areas of the body...

Gliomas

...oastrocytomas, contain cells from different types of glia. ... Low-grade gliomas comprise a class of slow growing, less aggressive tumors of ... anaplastic astrocytoma or grade III astrocytoma (see high-grade gliomas ) ... Gliomas that occur at the brainstem, which connects the brain to the spinal ...

Cutaneous

...on Resources Cutaneous T-Cell The Cutaneous Lymphoma Foundation is an idependent, non-profit patient advocacy ... Download Primary Cutaneous anaplastic Large Cell Lymphoma Fast Facts ... Cutaneous and subcutaneous masses account for a large percentage of chief ... Most dogs present with a sing...

Cell

...itute conducts and supports research, hosts the National Stem Cell Bank (NSCB) and provides training for scientists and educational outreach ... anaplastic Large Cell Lymphomas (ALCL) ... In both types the characteristic cell has large, often lobated, open nuclei, ... markers are called "null- cell " ...

Anaplastic thyroid cancer

... anaplastic thyroid cancer (ATC) is a form of thyroid can...ce to cancer treatments. Information about anaplastic thyroid cancer , a rare but deadly form of thyroid cancer . ... anaplastic thyroid cancer typically is diagnosed due to ...
Anaplastic in Biological News

A new radiation therapy treatment developed for head and neck cancer patients

...oblastoma (a highly malignant brain tumour) and another clinical trial that assesses safety and efficacy of BNCT in the treatment of glioblastomas and anaplastic astrocytomas (a type of brain tumour) that have recurred after conventional radiation therapy. Our plan is to investigate BNCT in the treatment of c...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...e. The majority ?339 ?were high-grade glioblastomas; 117 were mid-grade, or anaplastic astrocytoma; and 154 cases were low-grade. The scientists found that re...term antihistamine use was associated with an increased risk for developing anaplastic astrocytomas and low-grade brain tumors. "To our knowledge, this report ...
Anaplastic in Biological Technology

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

...opment in this deadly disease. Cotara has been granted orphan drug status and fast track designation for the treatment of glioblastoma multiforme and anaplastic astrocytoma by the U.S. Food and Drug Administration. A Phase I dosimetry trial in GBM patients in the U.S. is in the final stages of patient enrollm...

OncoGenex receives completed Special Protocol Assessment for primary registration study of lead drug candidate OGX-011

...ncreased clusterin production is observed in many human cancers, including prostate, non-small cell lung, breast, ovarian, bladder, renal, pancreatic, anaplastic large cell lymphoma and colon cancers and melanoma. Increased clusterin production is linked to faster rates of cancer progression, treatment resistan...

OncoGenex reports lead drug candidate OGX-011 achieved primary endpoint in Phase 2 Trial with second-line chemotherapy for prostate cancer

...ncreased clusterin production is observed in many human cancers, including prostate, non-small cell lung, breast, ovarian, bladder, renal, pancreatic, anaplastic large cell lymphoma and colon cancers and melanoma. Increased clusterin production is linked to faster rates of cancer progression, treatment resistan...

ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB

...blastoma multiforme (GBM), the level of expression is even higher. A study involving 29 adults with newly diagnosed high-grade gliomas, including both anaplastic astrocytomas (AA) and GBM, who were treated with surgery, external beam radiotherapy and nimotuzumab showed that the treatment was well tolerated, the...
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