Novo Nordisk Insulin Analogs Have Proven Safety Profiles
PRINCETON, N.J., June 28 /PRNewswire/ -- On Friday June 26, Diabetologia, the journal of the European Association for the Study of Diabetes (EASD) published online data from four studies relating to a possible link between a long-acting insulin analog, insulin glargine, and cancer(1). As a basis f...
Prostate Cancer Preventable By Vitamin D Analogs
The most common cancer of men is prostate cancer. New research studies point towards its being preventable .
Calcitriol, an active metabolite of vitamin D and other vitamin D analogs, may help prevent prostate cancer, according to a study presented Nov. 1,// at the American Association for Ca...
New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report
... Immunomodulators in Pipeline by Company, and Development Stage II-11
Adjuvant Therapies to Compete with Mainline Therapies II-12
and Fibrosis/Inflammation Inhibitors in
Pipeline by Company II-12
Vaccine Development Remains at Low Scale II-12
HCV Vaccines in Pipeline ...
Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development
...ad development candidate from two series of purine analogs
for the treatment of chronic hepatitis C virus (HC...elopment in the future."
Purine nucleos(t)ide analogs
have many of the benefits of pyrimidine nucleos(t)...ntivirals targeting HCV. In addition, these purine analogs
are also active against the S282T resistant varian...
Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
...ert J. Fram, Timothy B. Lowinger
This study showed that XMT-1107 has enhanced anti-angiogenic and anti-tumor activity compared to small molecule analogs
delivered without the benefit of Fleximer. XMT-1107 inhibited human MetAP2 in vitro, was highly active in human umbilical vein endothelial cell (HUV...
ImQuest Presentations at Keystone Symposium Focus on Advancements in Their Therapeutic and Microbicide Development Programs
...Buckheit, Jr., Ph.D. (Executive Vice President and Chief Scientific Officer) presented the results of studies which demonstrate the ability of various analogs
of IQP-0410 to more effectively suppress the replication of viruses which are resistant to the action of other NNRTIs used in the clinic. ImQuest, in ...
University of Washington scientists one step closer to stopping bone loss during spaceflight
...itative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bedrest Analog." The study is expected to move to the NASA Flight analogs
Facility at the University of Texas Medical Branch in Galveston in June 2009. Cavanagh will collaborate with fellow scientists at NASA until the anti...
Gut instinct: Salmonella bacteria's molecular tactics to cause illness
...niverse may be good news for those hoping to target this system through vaccine development or other therapeutic intervention. Discovering competitive analogs
of ppGpp, for instance, could provide an alternate approach, curtailing SlyA's function.
Shi is optimistic that a firmer grasp of such regulatory m...
Substance in Red Grapes and Wine Key to Alzheimer's Disease
...ed a new potential molecular target – AMPK – to lower Abeta levels in Alzheimer’s. It also opens the door to considering more potent analogs
of resveratrol. Feinstein scientists are now screening libraries of substances to see whether there are any compounds that could mimic the effects fou...
Pharsight to Present on Its Vision for Modeling and Simulation Software at PAGE Annual Meeting
...igm simplifies implementation of software products with complex graphical displays and user interface requirements. -- June 19: Nonparametric analogs
to POSTHOC Estimates for Exploratory Data Analysis. Dr. Leary will present a nonparametric model evaluation method to complement commonly used...
Analogs in Medical Technology
EntreMed Receives New Patent for 2-Methoxyestradiol Analogs
Patent Covers Compositions and Methods
ROCKVILLE, Md., June 11 /PRNewswire-FirstCall/ -- EntreMed, Inc.
(Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing
therapeutics for the treatment of cancer and inflammatory diseases, today
announced the issuance of U.S....
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
...THrP (parathyroid hormone-related protein) and its analogs
are critical peptides for promoting new bone forma... they act through the same receptor, PTHrP and its analogs
play a distinct biological role from the PTH (para...et cells in bone and kidney, whereas PTHrP and its analogs
regulate cell proliferation and differentiation in...
Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C
...g with good efficacy that can be administered once daily at a low milligram dose. Given these characteristics and the potential benefits of nucleotide analogs
over other classes of HCV direct acting antivirals, we continue to believe that PSI-7851 could become a key component of any future combination treatm...
Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis
...sinus, and in contact lens solutions.
Developed by NovaBay to mimic the body's defense against infection, Aganocides(R) are proprietary synthetic analogs
of the same molecules used by white blood cells to destroy harmful microbes in the body, such as viruses and bacteria. Because of their natural mecha...
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
...apeutic strategies for fighting cancer, including novel targeted agents, monoclonal antibodies, deacetylase (DAC) inhibitors, multiligand somatostatin analogs
and novel cytotoxics.
Sandostatin LAR important safety information
Sandostatin LAR is a long-acting, injectable depot formulation of octreoti...
NovaBay(R) Pharmaceuticals Enters into Agreement to Broaden Intellectual Property Estate and Expand Clinical Opportunities for Its Aganocide(R) Compounds
...rs on the use of N-chlorotaurine (NCT), a natural antimicrobial produced by the body's white blood cells. NovaBay's Aganocide compounds are synthetic analogs
of NCT that maintain or enhance the biological activity of the natural compound while adding pharmaceutically acceptable stability. Professors Gottar...
Oramed Pharmaceuticals Launches GLP1-Analog Program, Based on its Proprietary Drug Delivery Platform
...n cited in causing regeneration of pancreatic insulin
secreting cells, and in tissue protective properties including protection
of the heart. GLP1 and analogs
are associated with gradual weight loss,
which is very desirable in diabetes patients.
"The launch of pre-clinical trials of ORMD 0901 and expansion...
Sanofi Aventis: People With Type 2 Diabetes Treated With LANTUS(R) and APIDRA(R) Achieved Greater Reductions in A1C Than Those Treated With Pre-mixed Insulin
...zation") patients treated with LANTUS(R)
and APIDRA(R) achieved an adjusted mean A1C of 6.93% versus 7.52% for
patients treated with pre-mixed insulin analogs
p=0.009) and A1C reduction was 2.3% versus 1.7%). Hypoglycemia was recorded
in charts for 36% versus 42% (difference= -6%, p=0.37...
New Drug Application for Inhaled Treprostinil Submitted to the U.S. Food and Drug Administration
... background therapy
only groups. Safety findings were typically those associated with the
well-known vasodilatory side effects of prostacyclin and its analogs
headache, nausea, dizziness, flushing) and those commonly associated with
the inhalation route of administration (e.g., cough and throat irrita...
Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C
... active drug in the liver. We anticipate completing the required
animal toxicity studies and filing an IND in the first quarter of 2009."
have shown the ability to deliver higher levels of
the active triphosphate form of the drug into infected cells. PSI-7851 has
demonstrated in vitro an...
Analogs in Medical Dictionary
...n resistance syndrome, written by the ... A patient information handout on insulin lispro is provided on page 289. ... Short-acting insulin analogs
are designed to overcome the limitations of regular ... types (remember, everyone has a unique response to insulin , so the times ... (NovoLog), ...
Analogs in Biological News
DOE funds bio-inspired solar fuel center at Arizona State
...ates and oils.
Following the natural design principles of photosynthesis, scientists in the new ASU center will investigate how to make artificial analogs
of these catalysts and light harvesting units, and how to put them together to build a complete system that uses sunlight to oxidize water (producing ...
AGU journal highlights -- March 12, 2009
...le boundary and is distinguished by large seismic velocity jumps. Using forms of a synthetic, solid compound containing calcium, iridium and oxygen as analogs
for perovskite and postperovskite, Walte et al. conduct laboratory experiments to simulate the perovskite transitions under high temperatures and pres...
Queen's chemist sheds light on health benefits of garlic
...they do not have the same medicinal properties. Dr. Pratt and his colleagues believe that this is due to a slower rate of decomposition of the allicin analogs
in the onions, leaks and shallots, which leads to a lower level of sulfenic acid available to react as antioxidants with radicals.
January-February GSA Bulletin media highlights
...hanisms control minibasin bathymetry, which, in turn, controls sediment-fill patterns. Furthermore, salt-withdrawal minibasins are in many ways simple analogs
for crustal basins, so minibasin subsidence can provide insight into problems in crustal dynamics.
Tracking the burial and tectonic history o...
Snails and humans use same genes to tell right from left
...eated snails died, some lost the asymmetric expression of Pitx and, most strikingly, developed a straight shell, Patel said.
Grande has since found analogs
of nodal in the genome of the marine worm Capitella, which was sequenced by JGI, suggesting that nodal is active throughout the Lophotrochozoa.
Surface tension drives segregation within cell mixtures
...cell interactions drive shape and structure formation at a very deep level," Hutson says.
Currently, these interactions are often modeled using analogs
from fluid mechanics including viscosity and surface tension. "What we have shown is a fascinating new role for surface tension in the process of cell...
NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use
$1.1 million (3 years)
Near-Term Development of Reagents and Enzymes for Genome Sequencing
This laboratory will apply innovative nucleic acid analogs
and enzymes that accept them to stepwise diminish the cost of whole genome sequencing. These technologies, supported by bioinformatic workbenches, ena...
Vitamin D: New way to treat heart failure?
...min D's effects. There's also increasing interest in using vitamin D or its analogs
to treat autoimmune disorders.
In more than a dozen types of tissues an... they are to see improvement in their symptoms, Simpson says.
Vitamin D analogs
already are on the market for some conditions. One present drawback of thes...
Stopping unwanted cell death: Implications for drug discovery
...de small and specific structural changes to necrostatin-1, to see if loss of the RIP1 kinase inhibition resulted in the inability of the necrostatin-1 analogs
to prevent necrosis. Similar experiments were conducted for necrostatin-3 and necrostatin-5 with similar results, which was surprising as the structur...
March GEOLOGY and GSA TODAY media highlights
Neogene extension and basin deepening in the West Antarctic rift inferred from comparisons with the East African rift and other analogs
Wesley LeMasurier, Institute of Arctic and Alpine Research, University of Colorado at Boulder, 1560 30th St., 450 UCB, Boulder, Colorado 80309-045...
Analogs in Biological Technology
New Report Just Published: World Prostate Cancer Therapeutics Market Report
Medical Hormone Therapy II-32
Dose of LHRH Agonists for Advance Prosta...-48
Anti-Androgen and LHRH analogs
Drive the French Market III-48
Current and Fut...arket Analysis III-57
- The Market Driver III-57
Current and Future ...
Hollis-Eden Pharmaceuticals Announces Appointment of Dr. James M. Frincke President and CEO
...en Pharmaceuticals, Inc.
Hollis-Eden Pharmaceuticals, Inc. is developing a new series of small molecule compounds that are metabolites or synthetic analogs
of endogenous hormones derived by the adrenal glands from the body's most abundant circulating adrenal steroid. The Company's clinical drug developmen...
Pulmo BioTech Inc. Announces Paper to be Presented at Symposium
...tors and Kinin 2009 to be held in Quebec, Canada from June 26th to 29th.
The paper, which is titled "Development of Radiolabeled Adrenomedullin analogs
Designed for Molecular Imaging of the Pulmonary Circulation", will be part of the session "From a Peptide to a Drug: Rational Drug Design".
PolyOrg, Inc. Acquires a License to Manufacture and Distribute PNA Monomers Worldwide
...m ; Tel : (978)
466-7978. Additional information is also available at
PNAs are oligonucleotide analogs
in which the sugar-phosphate backbone of
DNA is substituted by amino-ethyl-glycine backbone. Invented in 1991 by
scientists at the University of Cope...
Amylin Pharmaceuticals Highlights 2009 Value Creation Opportunities
... program designed to show comparative superiority
Continue growing SYMLIN revenue
Complete obesity clinical trials with amylin/leptin analogs
and finalize obesity development and funding strategy
Improve operating results and make significant progress toward achieving positive opera...
Video: Allergan Announces U.S. Food and Drug Administration (FDA) Approval of Latisse(TM) -- First and Only Treatment Approved by the FDA for Hypotrichosis of Eyelashes
...ear. As the exclusive U.S. and foreign patent owner, Allergan obtains the rights to the use of bimatoprost and other prostaglandins and prostaglandin analogs
as a treatment to stimulate eyelash growth.
LATISSE (TM) Clinical Development Program
In the pivotal Phase III study, 278 healthy adult p...
BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition
... Effects (Poster # 2583 )
Sunday, December 7, 2008, 6:00 p.m. - 8:00 p.m. Pacific Time; Hall A
In-Vitro Efficacy of the Deoxyguanoside analogs
Forodesine (BCX-1777) and ARA-G in Pediatric Acute Lymphoblastic Leukemia Cells (Poster # 1925)
Sunday, December 7, 2008, 6:00 p.m. - 8:00 p.m. P...
Best Practice Database Supports Bio-Pharma Product Launch
...search alerts, invitations to participate
in topical new studies and ongoing advisory services to address research
A series of six case study analogs
recently published to the database
review various aspects of product launch, providing unique perspectives for
understanding the strategies and tactic...
Halozyme Therapeutics Reports 2008 First Quarter Financial Results
...blood glucose control compared to the best insulin
products available today indicated for diabetes. The existing global market
for insulin and insulin analogs
is estimated at $10 billion. A faster
acting insulin may allow physicians and patients tighter glycemic control
that more closely mimics natural physi...
NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the Annual Meeting of the American Association for Cancer Research (AACR); Scientific Advisory Board Chairman Tyler Jacks Named President-elect
...cicol and exhibit higher affinity to Hsp90 than radicicol.
NXD30001 and its analogs
efficiently inhibit cell proliferation and deplete
multiple Hsp90 client pr...than 2 days, consistent with the
pharmacokinetic tumor data.
"A number of analogs
with activity similar to or better than NXD30001
have been synthesized and ...
Analogs in Biological Definition
... Artificial life , also known as alife or a-life , is the study of life through the use of human-made analogs
of living systems. Computer scientist Christopher Langton coined the term in the late 1980s when he held the first "International Conference on ...
...he pH of the solution to reduce reactions at the injection site, and so on. Some recent insulins are not even precisely insulin, but so called insulin analogs
. The insulin molecule in an insulin analog is slightly modified so that they are
absorbed rapidly enough to mimic real beta cell insulin (Lilly'...
Analogs in Biological Dictionary
...s of ticks. ... Lyme disease spirochetes are generally restricted to the ... These spirochetes differ genetically from their American and Asian analogs
while ... Exposure risk for relapsing fever–like spirochetes is similar to that of certain ... spirochete's natural history. Specifically, we w...
...rneal (SIRC) epithelial cell ... Nucleoside analogs
were among the first compounds shown to be effecti...potCost.com - New and used books like Nucleoside analogs
Cancer Therapy Basic and Clinical Oncology 2nd edi...hCare... Steps in Phosphorylation: Nucleoside analogs
(zidovudine, didanosine, zalcitabine, stavudine, a...
... structure . ... Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure . ... synthetic Holliday junction analogs
and related branched DNA structures by ... ... mediated Holliday junction resolution: structure -specific recognition, ... T4 endonuclease V...
...to: navigation, search ... Retrieved from "http://en.wikipedia.org /wiki/Talk: Concatemer " ... In cells expressing the concatemer , amphetamine analogs
promoted GABA efflux and ... The concatemer was tagged on its amino terminus with CFP, which afforded the ... Next message: Concatemer Chain ...