Breast cancer risk amplified by additional genes in combo with BRCA mutation
PHILADELPHIA - Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published this month in the American Journal of Human Genetics. Researchers at the University of Pennsylvania School of Medicine join an i...Gen-Probe Reports Financial Results for Second Quarter 2009
...ted from revenue associated with Tepnel's transplant diagnostics and genetic testing products, and continued growth of the APTIMA Combo 2(R) assay, an amplified nucleic acid test (NAT) for simultaneously detecting Chlamydia trachomatis and Neisseria gonorrhoeae . Sales of our market-leading assay increased...Gene Connections Key to Brain Tumor Growth
...ectivity with the other genes. The hub gene is the EGFR (epidermal growth factor receptor) oncogene on chromosome 7, according to the study. It is amplified in about 45 percent of glioblastoma cases, Bredel said. Oncogenes are genes that drive cancer growth. The amplification seems to happen in paralle...Study pinpoints novel cancer gene and biomarker
...mosome to see what genes reside there. Using a method called genomic qPCR that can pick out specific sequences of DNA, they found four genes in the amplified region, two of which, GOLPH3 and SUB1, were expressed at high levels, due to the increase in gene copy. To determine whether both, or either, of thes...Music Can Make the Heart Beat Faster
...n our studies, volunteers selected music that made them feel good or feel bad," Miller said. "Our belief is that cardiovascular reactions to music are amplified by emotional responses. Our results were not inconsistent with these findings." The Italian study results were called "fascinating" by Barry A. Fra...Why Do African-Americans Fare Worse With Cancer? Access and Economics Are Only Part of the Story
...ily Comprehensive Cancer Center. The urgency of addressing the reasons for racial disparities in outcomes - both sociological and biological - is amplified by another recent study in the Journal of Clinical Oncology . It predicts the cancer incidence among minorities will nearly double in the coming dec...Scientists Discover Why Teeth Form in a Single Row
...s, but no additional teeth. Thus, without Osr2, enough BMP4 was expressed for the first molar teeth to grow, but without Msx1, the BMP4 signal was not amplified to the point where it could kick off the next tooth in the row. With these results, Jiang argues that BMP4 cooperates with other factors to create a t...Rubicon Provides Genome Amplification for the Cancer Genome Atlas Project
...amplify clinical DNA samples to the constant concentration and quality necessary for reproducible and accurate analysis using microarrays and PCR. The amplified DNA libraries will be deposited into the International Genomics Consortium Biospecimen Research Core as a renewable resource to be shared among intern...St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing
... A new study shows how sounds are amplified in the inner ear, a finding that could explain how hearing loss can result from genetic mutation or overdose of drugs MEMPHIS, Tenn., May 7 /PRNew...Neisseria gonorrhoeae by Amplified Detection (APTIMA)
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...Mycobacterium tuberculosis Amplified Direct Detection
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...Mycobacterium tuberculosis Amplified Detection , CSF
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...Chlamydia trachomatis by Amplified Detection (APTIMA)
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...Chlamydia trachomatis & Neisseria gonorrhoeae by Amplified Detection (APTIMA), ThinPrep
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...Chlamydia trachomatis&Neisseria gonorrhoeae by Amplified Detection (APTIMA)
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...US-Mexico border wall could threaten wildlife species
...taste for mutton." The scientists say the wall along the U.S.-Mexican border is not the only issue for wildlife. Human activity, vehicular traffic, amplified noise and artificial lighting associated with the barrier can all affect how animals behave. "There is a political reality and a biological reality...Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...lly engineered human insulin, the first therapeutic derived from gene cloning. In 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culmina...Random picks better than complicated process in gene identification
...typically the most numerous. By adding specific enzymes, many of the overabundant genes are decreased in number, while the few that reunite slowly are amplified until the genes are equal in number, making it easier to sort through them. DeWoody and Hale believe normalization is not necessary given the vast ...Scientists discover why teeth form in a single row
...s, but no additional teeth. Thus, without Osr2, enough BMP4 was expressed for the first molar teeth to grow, but without Msx1, the BMP4 signal was not amplified to the point where it could kick off the next tooth in the row. With these results, Jiang argues that BMP4 cooperates with other factors to create a t...NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
...tly, two properties necessary for metastasis. MiRNA 182 also belongs to a cluster located in a genomic region, chromosome 7q, that is frequently amplified in melanoma and contains two other oncogenes; BRAF and C-MET. The study found a correlation between genomic amplification and miRNA over expression, t...JCI online early table of contents: Jan. 19, 2009
...signaling pathways, and many therapies aimed at disrupting these signaling pathways are under development. In this study, the FAK gene was found to be amplified in a substantial number of the human breast cancer samples analyzed. Consistent with this having a role in tumor development, mice lacking the Fak gen...Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...lly engineered human insulin, the first therapeutic derived from gene cloning. In 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culmina...BRAHMS, Cezanne and Lumiphore Announce Partnership for Diagnostic Tests
...ness Development. BRAHMS' KRYPTOR analysis systems can currently perform various analyses in random-access operations using TRACE (Time Resolved amplified Cryptate Emission) technology, based on Forster resonance energy transfer (FRET). - FRET uses two fluorophores as a donor and an acceptor. The energy...Innovative Biosensors and ProGenTech Partner to Develop a Rapid Diagnostics System
.... Cross-linking of the antibodies by even minute amounts of the specific pathogen leads to elevation of intracellular calcium and light emission. The amplified light output can then be detected using a luminometer. ProGenTech has been developing workflow automation solutions for the life science & di...Helping Young Women Succeed in Today's Unpredictable World
...ent of young Americans are in debt(1)," notes Francis. "Struggling to pay off loans and credit cards is overwhelming for anyone, but the situation is amplified when it's a young woman trying to make ends meet in a tight economy on an entry-level salary. WhatWillYourPlanBe.com supports women in their quest fo...TRIMMER-Direct cDNA Normalization Kit from Evrogen JSC
Description:... does not include physical separation steps. Normalization using the TRIMMER-DIRECT kit significantly increases the efficiency of random sequencing of amplified cDNA....TempliPhi 100 Amplification Kit from GE Healthcare, formerly Amersham Biosciences
Description:...pare circular DNA templates for cycle sequencing in 4-6 h.Generate microgram quantities of template DNA from picogram amounts of starting material.Use amplified DNA directly for cycle sequencing without purification.Amplify DNA from bacterial or M13 liquid cultures, colonies, plaques, or purified circular (pla...TempliPhi 500 Amplification Kit from GE Healthcare, formerly Amersham Biosciences
Description:...pare circular DNA templates for cycle sequencing in 4-6 h.Generate microgram quantities of template DNA from picogram amounts of starting material.Use amplified DNA directly for cycle sequencing without purification.Amplify DNA from bacterial or M13 liquid cultures, colonies, plaques, or purified circular (pla...Zero Blunt TOPO PCR Cloning Kit with One Shot TOP10 Chemically Competent E. coli from Invitrogen
Description:...o Blunt TOPO PCR Cloning Kit offers the fastest and easiest method for high-efficiency (greater than or equal to95%) cloning of blunt-end PCR products amplified with proofreading thermostable polymerases. The kit includes the linearized and topoisom...Restriction fragment length polymorphism
...an individual specimen is first extracted and purified. Purified DNA may be amplified by Polymerase Chain Reaction (PCR). The DNA is then chopped into restric...also used to determine the relationships among species . See also amplified fragment length polymorphism Genetics Retrotransposon ...