Measuring medicine: How new technologies could help doctors predict patient outcomes
...g well even if the tumor grows.
Presence of amphiregulin
autocrine-loop predicts sensitivity of EGFR wild t... cell carcinoma (HNSCC) cell lines. This so-called amphiregulin
autocrine loop appears to predict response to the targeted therapies gefitinib and cetuximab.
expression could, in fact, be a suitable biomarker...
A New Strategy to Control Breast Cancer
...e) acts like a “molecular scissors” that releases a pair of ligands, called amphiregulin
and TGF-alpha, from the cell surface. These ligands activate EGFR.
EG...short interfering RNAs (siRNAs) that silence the TACE gene, the shedding of amphiregulin
and TGF-alpha ligands could effectively be blocked.
This also resulte...
Tobacco smoke increases the levels of Cox 2.
...h factor receptor (EGFR). EGFR is a protein related to the growth of various forms of cancer. Oral mucosal cells exposed to tobacco smoke produce more amphiregulin
and TGF-a. Both of these chemicals are responsible for triggering EGFR functions.
The researchers from Weill Medical College of Cornell Universit...
...ersal of the transformed phenotype . ... Thus, thymosin ß4 is a determinant of AdoMetDC-induced transformed phenotype and invasiveness. ... amphiregulin
Contributes to the Transformed Phenotype of Human Hepatocellular Carcinoma Cells ... autocrine loop that contributes to the transformed phenoty...