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Aminotransferase in Medical News

AlphaRx Reports Positive Preclinical Data on GAI-122 Against Liver Disease

...ical results on GAI-122 injectable nano-emulsion in multiple models of acute hepatitis, an inflammatory liver disease. GAI-122 significantly reduced aminotransferase (ALT), an enzyme released into the blood that indicates damage to the liver, following IP administration in three different preclinical models of acut...

Varicella zoster infection causes severe autoimmune hepatitis

...09/L, platelets 512 109/L, erythrocyte sedimentation rate 39 mm/h, alanine aminotransferase (ALT) 1066 U/L, aspartate aminotransferase (AST) 755 U/L, alkaline phosphatase (ALP) 185 U/L, total bilirubin 425 _...

A potential drug for ischemia/reperfusion related liver injury

...ratrol group: rats pretreated with resveratrol (10 μmol/L, iv). Serum liver enzymes and histological changes were studied. They found that Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while supero...

Ortho Biotech Announces NDA Submission for Trabectedin for the Treatment of Relapsed Ovarian Cancer

...er damage or other clinical consequences. These included increased alanine aminotransferase (55% versus 9%) and increased aspartate aminotransferase (40% versus 10%); and Fatigue (46% versus 36%). ...

Antipodean Pharmaceuticals Announces Results of Phase 2 Study of Lead Compound MitoQ(R)

...h the Hepatitis C virus (HCV) were enrolled to study the effects of MitoQ on elevated liver enzymes. Researchers measured patients' baseline levels of aminotransferase (ALT), an enzyme released into the blood that indicates damage to the liver. The double-blind trial randomized patients to one of three treatment grou...

Dads' Early-Onset Obesity Linked to Liver Disease in Kids

.... The researchers found that people whose fathers were clinically obese at an early age were more likely to have increased liver enzyme (serum alanine aminotransferase -- ALT) levels, an indicator of liver disease. When the researchers conducted a secondary analysis that didn't include obese offspring, they still ...

Elevated liver enzymes associated with higher future mortality

.../hepatology ). Liver enzymes include aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and high concentrations in the blood tend t...cade, the authors report. The relation between the aminotransferase results at the outset and the subsequent risk of d...

Geisinger and Celera to collaborate on liver disease test

...rican College of Gastroenterology estimates that NAFLD affects 2 to 5 percent of Americans and 10 to 20 percent of those who are obese. Elevated serum aminotransferase levels and evidence of insulin resistance are suggestive of early stages of the disease with ultrasound and liver biopsy used in the diagnosis of the ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... reported rarely at all dosages (see ADVERSE REACTIONS). In AFCAPS/TexCAPS, the number of participants with consecutive elevations of either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) (> 3 times the upper limit of normal), over a median of 5.1 years of follow- up, was not significantly diffe...

Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

... ART with one or two drugs were excluded from the analysis, as were those with signs and symptoms of acute hepatitis. LEE was defined as alanine aminotransferase (ALT) levels (>5 x the baseline level or >3.5 x baseline when the baseline was >40 IU/l). Changes of ALT from time of enrolment in the study were anal...
Aminotransferase in Medical Technology

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

...ral dose of cysteamine and will measure possible reduction of blood alanine aminotransferase ("ALT") and aspartate aminotransferase ("AST") levels as a biomarker of cysteamine's efficacy for potentially trea...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

...4 weeks after completion of therapy. Patients not achieving undetectable HCV RNA did not show significant reductions in viral load or alanine aminotransferase (ALT) levels. Patients responding to nitazoxanide treatment had lower viral loads at baseline. Adverse events were typically mild to moderat...

FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment

...the Phase II study and its extension, with the most common adverse events being nasopharyngitis, headache, fatigue and influenza. Increases in alanine aminotransferase (liver enzymes) were observed in 16% of patients. Dermatological screening of patients was implemented in the extension after a small number of cases ...

Conatus Pharmaceuticals Reports Positive Results of CTS-1027 in Multiple Preclinical Studies of Liver Disease

...-1027 significantly reduced liver damage following oral administration in four different preclinical models of liver injury. CTS-1027 markedly reduced aminotransferase (ALT) activity and improved survival and liver histology in the TNFalpha/Gln model. CTS-1027 was equally effective dosed at the same time as the insul...

The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor

... of increases in liver enzyme concentrations with dabigatran etexilate is low during the entire extended treatment period. Results showed that alanine aminotransferase (ALT) elevation greater than three times the upper limit of normal occurred in 5.3% enoxaparin group, as compared to 3.0% in the 150mg group and 3.0% ...

Data to be presented at AAN Meeting -Study results of drug candidate for MS

...720 treatment was associated with initial dose-dependent decreases in heart rate and expiratory air flow. Clinically asymptomatic increases in alanine aminotransferase (liver enzyme) and an increase in blood pressure were also observed. No unexpected adverse events emerged in patients treated for up to 24 months comp...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

...erated. All infusions were unproblematic and there were no signs of cytokine release or complement activation. Two patients had rises in serum alanine aminotransferase (ALT) following the last dose (i.e. after a total dose of 24mg/kg) which were transient and the patients recovered fully. Two cases of grade 3 thrombo...

Prothrombin Time Comes in Small (CLIA-Waived) Packages

...ve state, antiphospholipid syndrome, hyperhomocystinemia, among others. Prothrombin levels are also monitored along with other tests (such as aspirate aminotransferase and alanine aminotransferase) to help evaluate liver function. Given the broad applicability of this test, it is helpful to many clinicians that sever...
Aminotransferase in Medical Products

Aspartate Aminotransferase (AST) (GOT) IFCC WITH P5P

Description: The AST method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma...
Company:Randox Laboratories Ltd.

Aspartate Aminotransferase (AST) (GOT)

Description: For the quantitative in vitro determination of Aspartate Aminotransferase (AST) in serum and plasma....
Company:Randox Laboratories Ltd.

Alanine Aminotransferase (ALT) GPT

Description: The ALT method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of alanine aminotransferase activity in serum or plasma....
Company:Randox Laboratories Ltd.

Alanine Aminotransferase (ALT) Liquid

Description: For the quantitative in vitro determination of alanine aminotransferase in serum or plasma....
Company:Randox Laboratories Ltd.

Alanine Aminotransferase (ALT)

Description: For the quantitative in vitro determination of Alanine Aminotransferase (ALT) in serum and plasma....
Company:Randox Laboratories Ltd.

AST (SGOT) Reagent Set (UV-Kinetic Method)

Description:... AST (SGOT) reagent is used for the quantitative determination of aspartate aminotransferase (AST) in human serum....
Company:Teco Diagnostics

AST/SGOT Liquid Reagent (Kinetic Method)

Description:... For the quantitative determination of aspartate aminotransferase (AST) in human serum. The reagents are used in routine examination and monitoring of therapy and relapses....
Company:Teco Diagnostics

AST (GOT) + Starter Reagent

Description:... Intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma. Reaction: Kinetic. Wavelength: 340 nm. Linearity: 268 U/L at 30C. Two vials, dry powder reagents....
Company:Hemagen Diagnostics, Inc.

AST (GOT) Liquidplus Reagent

Description:... Intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma. Reaction: Kinetic. Wavelength: 340 nm. Linearity: 440 U/L at 30C. Liquid buffer and dry powder reagent....
Company:Hemagen Diagnostics, Inc.

AST GOT Reagent

Description:... Intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma. Reaction: Kinetic. Wavelength: 340 nm. Linearity: 440 U/L at 30C. Single vial, dry powder reagent....
Company:Hemagen Diagnostics, Inc.

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Aminotransferase in Medical Dictionary

AST

...) also called serum glutamic oxaloacetic transaminase (SGOT) or aspartate aminotransferase (ASAT/AAT) (EC 2.6.1.1) is similar to alanine transaminase (ALT) in that it..... The story of AST 's genesis is a classic tale of a ... An aspartate aminotransferase ( AST ) test measures the amount of this enzyme in the blood. ... AST f...

ALT

.... It is also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT). The alt .* hierarchy is a major class of newsgroups in Usenet,... responding ... designed Control- Alt -Escape to trigger ... An alanine aminotransferase ( ALT ) test measures the amount of this enzyme in the ... ALT formerly...
Aminotransferase in Biological News

A place in the sun

...the enzyme indeed uses tryptophan to catalyze the first reaction in a three-step auxin-synthesis pathway and the new enzyme became known as tryptophan aminotransferase of Arabidopsis, or TAA1 for short. Despite the importance of auxin for plant growth and development, the details of how auxin is synthesized conti...

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

...d the gene encoding the enzyme L,L-diaminopimelate aminotransferase from the plant Arabdiopsis thaliana. The results o...rs could find an inhibitor for L,L-diaminopimelate aminotransferase they would have a new antibiotic that would target...red. Moreover, an inhibitor to L,L-diaminopimelate aminotransferase would be very specific for Chlamydia since this en...
Aminotransferase in Biological Products

Rabbit Anti-ABAT Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... Homo sapiens 4-aminobutyrate aminotransferase Antigen: Recombinant Protein...
Company:Proteintech Group, Inc.
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