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Altered in Medical News

Reversing effects of altered enzyme may fight brain tumor growth

An international team of scientists from the Moores Cancer Center at the University of California, San Diego, the University of North Carolina and several institutions in China have explained how a gene alteration can lead to the development of a type of brain cancer, and they have identified a co...

As a Result of the FDA Investigation Into TNF-Alpha Inhibitors, 30 Percent of Surveyed Rheumatologists Have Altered Their Prescription Patterns for Juvenile Idiopathic Arthritis

Twenty Percent of Surveyed MCO Pharmacy Directors Say They Will Alter Reimbursement of TNF-alpha Inhibitors for Juvenile Idiopathic Arthritis and Pediatric Crohn's Disease, According to a New Report from Decision Resources WALTHAM, Mass., March 26 /PRNewswire/ -- Decision Resources, one of th...

Effectiveness of Progesterone in Reducing Preterm Births May Be Altered by Genetic Predisposition

March of Dimes Awards Abstract at SMFM Meeting. SAN DIEGO, Jan. 30 /PRNewswire-USNewswire/ -- New research that may explain why taking progesterone to prevent preterm birth is only effective for some women was unveiled today at the 29th Annual Society...

Premature babies have altered sensory responses in later life

Premature infants who need intensive care or surgery are less sensitive to thermal (hot and cold) sensations later in life, according to research conducted at UCL (University College London). The study, published in the journal Pain , suggests that pain and injury related to major medical interve...

Undiagnosed OSA patients have altered cardiovascular responses during exercise recovery

WESTCHESTER, Ill. A study published in the January 1 issue of the journal SLEEP finds that people with untreated obstructive sleep apnea (OSA) have altered cardiovascular responses during recovery from maximal exercise. These results suggest an imbalance in the autonomic control of heart rate du...

Penguins Altered Diet When Humans Began Hunting Whales and Seals

Adlie penguins living in Antarctica switched from eating fish to krill (shrimp-like marine invertebrate animals) around the time that humans began hunting seals and whales, ancient eggshell fragments reveal. According to Steven Emslie of the University of North Carolina in Wilmington, and...

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Altered in Medical Technology

Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)

...mited to one part of the body, or may be generalised to involve the whole body. Patients may also experience abnormal sensations, altered behaviour or altered consciousness. Epilepsy is a disorder with many possible causes. Often the cause of epilepsy is unknown. However, anything that disturbs the normal pa...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

...eviously identified in other neurodevelopmental disorders, including autism, schizophrenia and Tourette syndrome. The CNVs found in ADHD families also altered genes important in psychological and neurological functions such as learning, behavior, synaptic transmission and nervous system development. "We...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

...ith Zyprexa. If signs and symptoms appear, immediate discontinuation is recommended. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia). Additional ...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...ipation (IBS-C) IBS-C is a chronic functional gastrointestinal disorder characterized by abdominal pain, discomfort, and bloating associated with altered bowel habits. There are currently few available therapies to treat this disorder. Nine million U.S. patients have been diagnosed with IBS-C, and as ma...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

...mphetamine, the active medication. Other pharmacokinetic parameters (maximum plasma concentration and area under curve) of active medication were not altered for either VYVANSE or ADDERALL XR when coadministered with Prilosec OTC. This study, which is the first to evaluate the pharmacokinetics of VYVANSE a...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

...has been reported with the use of antipsychotic medications, including RISPERDAL(R) CONSTA(R). Clinical manifestations include muscle rigidity, fever, altered mental status and evidence of autonomic instability (see full Prescribing Information). Management should include immediate discontinuation of antipsy...
Altered in Medical Products

IMA ACB Test COBAS Mira Plus, 100T

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations

IMA ACB Test INTEGRA 700/800

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations

IMA ACB Test Beckman LX 20

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations

IMA ACB Test Controls

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations

IMA ACB Test Hitachi 911

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations

IMA ACB Test 917/MODULAR P

Description:...ischemic tissue in the heart. During ischemia, the N-terminus of albumin is altered through a series of chemical reactions that cause free radical damage to albumin. This altered albumin is produced continually during ischemia. IMA concentrations in bloo...
Company:Inverness Medical Innovations
Altered in Medical Definition

Autoinoculation

... Autoinoculation is the process in which cells are removed from a person's body, medically altered , then reinserted into the same person again. [1] It is also the process of spreading infections from an infection already found in the body. For...

Autoimmune regulator

... References ^ OMIM. [1] ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by t...

Somatic dysfunction

... In osteopathic medicine , somatic dysfunction is the impaired or altered function of the musculo-skeletal system treated by osteopathic manipulative medicine (OMM) . Contents 1 Diagnosis 2 Signi...
Altered in Medical Dictionary

Tissue

...s. ... saving resection of soft tissue sarcoma arising in the limb. ... Lipidomics is the new frontier in biomolecular structural studies. ... altered levels of phospholipids in tissue are associated with Farber disease, ... Community Tissue Services ethically provides procurement, processing...

Tay-Sachs disease

...y - Sachs disease , Canavan disease , and related lysosomal storage diseases. In late-onset Tay - Sachs disease (LOTS), the hex A gene is altered so that it ... A baby with Tay - Sachs disease appears healthy at birth. ... Tay - Sachs disease is a progressive neurological genetic d...

Seizure

...en by the authors of this ... Seizure is a common presentation in the emergency care setting, and new-onset ... The seizure threshold can be altered by fatigue, malnutrition, lack of sleep or ... This is actually a simple partial seizure . ... After the seizure , there is drowsiness or co...

Rapid heartbeat

...ater than 100 beats per minute) are called tachycardias. ... Neuroleptic Malignant Syndrome or NMS is a potentially fatal ... rapid heartbeat . altered mental state. tremor. dark urine. profuse sweating. rapid breathing ... Tachycardia — Comprehensive overview covers symptoms, diagnosis and ...

Paralysis

.... Learn about facial nerve problems and Bell's palsy symptoms such as facial muscle paralysis , weakness, twitching of the face, dry mouth, altered taste. Causes and ... Information about paralysis in the free online English dictionary and ... akinesia, akinesis - motionlessness attributable...

Numbness and tingling

... Numbness and tingling are decreased or abnormal sensations caused by altered sensory nerve function. ... all ages experience episodes of numbness a... Numbness and tingling are decreased or abnormal sensations caused by altered ... This same combination of numbness and tingling can occur in any r...
Altered in Biological News

Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition

SAN DIEGO, CA, JAN. 30, 2009 New research that may explain why taking progesterone to prevent preterm birth is only effective for some women was unveiled today at the 29th Annual Society for Maternal-Fetal Medicine (SMFM) meeting The Pregnancy Meeting. The drug, 17 alpha-hydroxyprogesterone c...

Scientists unlock possible aging secret in genetically altered fruit fly

PROVIDENCE, R.I. [Brown University] Brown University researchers have identified a cellular mechanism that could someday help fight the aging process. The finding by Stephen Helfand and Nicola Neretti and others adds another piece to the puzzle that Helfand, a professor of biology, molecular b...

Researchers reveal structure of protein altered in autism

As a result of mapping the structure of the protein complex implicated in autism spectrum disorders, a research team led by scientists at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences has discovered how particular genetic mutations affect this...

Salmonella survives better in stomach due to altered DNA

Since 1995 there has been a considerable increase in the number of infections with a specific type of Salmonella bacteria transmitted via food. This type, Salmonella serovar Typhimurium DT104, is resistant to at least five different antibiotics. Dutch researcher Armand Hermans found new genetic inf...

Genetically altered mice no longer like cocaine

Researchers found that they could eliminate the rewarding effect of cocaine on mice by genetically manipulating a key target of the drug in the animal's brain. While the researchers aren't suggesting that these genetic modifications be made in humans, the work brings to light the key protein that...

Researchers offer proof-of-concept for Altered Nuclear Transfer

Scientists at Whitehead Institute for Biomedical Research have successfully demonstrated that a theoretical--and controversial--technique for generating embryonic stem cells is indeed possible, at least in mice. The theory, called altered nuclear transfer (ANT), proposes that researchers first ...
Altered in Biological Technology

Teva Pharmaceutical's Altered Peptide Ligand Copaxone Boasts the Greatest Patient Share Among First- and Second-Line Therapies for the Treatment of Multiple Sclerosis

Lack of Flulike Side-Effects Drives Physician Prescribing of Copaxone over an Interferon-Beta Therapy, According to a New Report from Decision Resources WALTHAM, Mass., March 11 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory f...

Plastics that convert light to electricity could have a big impact

...how much of the electric current actually gets to the wires leading out of the cell. The number of bubbles and channels and their configuration can be altered by how much heat is applied and for how long. The exact structure of the bubbles and channels is critical to the solar cell's performance, but the...

Charging ahead: University of Houston team revealing secrets of electricity-producing materials

...l activity caused by flexoelectricity also affects a material's resiliency. They tested their theory that the elasticity of a material would be quite altered by flexoelectricity-caused electrical activity by poking the material with a sophisticated needle. "We basically predicted that when you poke it, ...

Solace Pharmaceuticals Appoints Professor David Julius, Renowned Pain Physiologist, to Scientific Advisory Board

...gnificant discoveries in the molecular basis of somatosensation - the process whereby we experience touch and temperature - and how somatosensation is altered in response to tissue or nerve injury. Professor Julius discovered that capsaicin, the main pungent ingredient in chili peppers, activates an excitato...

OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial

... - Criteria for a maximum tolerated dose were not met at the highest dose evaluated as monotherapy (1000 mg). - No evidence of altered cardiac activity was observed. - Majority of adverse events were mild and mainly occurred during the loading doses. Adverse events cons...

Regular light bulbs made super-efficient with ultra-fast laser

...ent," says Chunlei Guo, associate professor of optics at the University of Rochester. "We fired the laser beam right through the glass of the bulb and altered a small area on the filament. When we lit the bulb, we could actually see this one patch was clearly brighter than the rest of the filament, but there...
Altered in Biological Products

Bacterial Strain BMH 71-18 mutS, Glycerol Stock (noncompetent) from Promega

Description:... efficiencies and making them helpful in such systems as the GeneEditor and altered Sites II Mutagenesis Systems. Both ES1301 and BMH 71-18 mutS are recA+, the...ntaining highly repetitive sequences may be unstable. ES1301 is used in the altered Sites II System and is Tets, which allows for cycling between antibiotic re...
Company:Promega

Bacterial Strain ES1301 mutS, Glycerol Stock (noncompetent) from Promega

Description:... efficiencies and making them helpful in such systems as the GeneEditor and altered Sites II Mutagenesis Systems. Both ES1301 and BMH 71-18 mutS are recA+, the...ntaining highly repetitive sequences may be unstable. ES1301 is used in the altered Sites II System and is Tets, which allows for cycling between antibiotic re...
Company:Promega

Mouse Anti-Porcine Pyruvate Dehydrogenase (PDH), complex Immunocapture Kit Monoclonal Antibody, Protein G-Agarose Conjugated, Clone 15D3G9C11 from MitoScience LLC

Description:...rometry. Uses for this PDH immunocapture kit include but are not limited to examining alterations in assembly of the complex in genetic PDH deficiency altered PDH functioning in late-onset diabetes (NIDMM) and the response of the enzyme complex to diet, exercise and sepsis....
Company:MitoScience LLC

MitoLight Mitochondrial Apoptosis Detection Kit from CHEMICON

Description:...lthy cells, the dye accumulates and aggregates in the mitochondria, giving off a bright red fluorescence (l em = 585-590 nm). In apoptotic cells with altered mitochondrial membrane potential, the dye in its monomeric form stays in the cytoplasm, fluorescing green (l em = 527-530 nm), providing a ready discr...
Company:CHEMICON

Metabolic Profiler from Bruker Daltonics

Description:... evaluation and statistical analysis for applications like: Assessment of the metabolic profile of a living organism to distinguish between normal and altered states Discovery and identification of potential biomarkers Study mechanism of drug induced toxicity and/or efficacy at pre-clinical or clinic...
Company:Bruker Daltonics

Nutrient Mixture F-12 Ham, Coon's Modification (Ham's F-12 Coon's) from Sigma-Aldrich

Description:...ed by viral fusion. The modification consists of doubling the amino acids and pyruvate, and including ascorbic acid. The salt concentrations have been altered as well. This formula contains 0.863 mg zinc sulfate per liter, which may render it unsuitable for culturing mouse L-cells....
Company:Sigma-Aldrich
Altered in Biological Definition

Apoptosis

...ated in this disease, are derived from nucleosomes. As nucleosomes are mainly generated during programmed cell death, excess of apoptotic material and altered clearance may induce autoreactive immune responses. On the other side of the spectrum, failure to die, as exemplified in MRL/1pr mice and human lympho...

Biotechnology

...ine. Modern biotechnology is often associated with the use of genetically altered microorganisms such as E. coli or yeast for the production of substances ...o transgenic animals or transgenic plants , such as Bt corn. Genetically altered Mammalian cells, such as Chinese Hamster ovarian cells, are also widely us...

Cancer

... insensitivity to anti-growth factors increased cell division rate altered ability to differentiate no ability for contact inhibition abilit...nescence ), then it ceases to divide. Tumor cells keep dividing forever. altered morphology . Building of cellular clusters ( foci ). Loss of contact...

Diabetes mellitus

...ydration . Another common presenting symptom is altered vision. Prolonged high blood glucose causes change...maul breathing (a rapid, deep breathing), and any altered state of consciousness or arousal (hostility and m...onfusion and lethargy). The most dangerous form of altered consciousness is the so-called "diabetic coma" whi...

Diffusion

...portion of the membranes. Ions Diffusion of ions depends on the concentration gradient, and the membrane potential. The net flux of ions can be altered by opening or closing ion channels. Diffusion in chemical engineering Diffusion is the movement of matter due to the movement of the individu...

Molecular biology

...e chain reaction is an extremely versatile technique for copying DNA. In brief, PCR allows a single DNA sequence to be copied (millions of times), or altered in predetermined ways. For example, PCR can be used to introduce restriction enzyme sites, or to mutate (change) particular bases of DNA. PCR can also...
Altered in Biological Dictionary

Zona pellucida

...a . ... In mice and humans, this matrix is known as the zona pellucida ... The mammalian zona pellucida is an extracellular matrix that ... altered mice lacking a zona pellucida due to loss of ZP3, 2-cell ... The Zona Pellucida . Pick-up of the Oocyte Cumulus Complex by the Oviduct ... Z...

Ventral root

...· Sympathetic trunk ... With the other three proteins, most of the detectable change occurred in the ventral root only. ... total RNA synthesis altered after ventral root transection? ... Ventral - Definition of Ventral at Dictionary.com a free online ... Ventral fin. Ventral epigastric...

Variation

...d true north, ... Variation (music), formal technique where material is altered during repetition ... In music, variation is a formal technique where material is altered during repetition: reiteration with changes. The changes may involve harmon...

Transgenic mouse

... A genetically modified organism (GMO) or genetically engineered organism (GEO) is an organism whose genetic material has been altered using genetic engineering techniques. These techniques, generally known as recombinant DNA... Explanations about transgenic mouse and the h...

Transgenic animals

... A genetically modified organism (GMO) or genetically engineered organism (GEO) is an organism whose genetic material has been altered using genetic engineering techniques. These techniques, generally known as recombinant DNA... Transgenic animals , i.e., engineered to carry...

Transgenic

... engineered organism (GEO) is an organism whose genetic material has been altered using genetic engineering techniques. These techniques, generally known a... Organism, any microorganism, plant, or animal that has been genetically altered to contain a gene from another organism, usually from a... Transgenic...
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