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Alterations in Medical News

Gene alterations associated with response to anthracycline therapy for breast cancer

Alterations in the topoisomerase II alpha ( TOP2A ) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regimens, according to a study in the April 28 online issue of the Journal of the National Cancer Institute. The incre...

Ape Humans? Alterations in Proteins Affects Genes.

Did you know that the genetic code of chimpanzees is so much alike the code of humans, almost a 98% similarity, and perhaps that explains why they ‘ape’ us. And yet, // there are glaring differences, despite the 98% similarity, that make us humans. According to scientists, it was not a different se...

Continual Fear Linked to Genetic Alterations in the Brain

A bully seems to have an unabating negative influence on the victim. Scientists have observed this unnerving effect of big mice on small ones, // and the findings have revealed that stress can cause certain genetic changes in the brain. This finding can go a long way in supporting the research into...

Age-Dependent Alterations Not Specific For Alzheimers Disease

Alzheimers disease (AD) has lately been suggested to be a systemic disorder, not confined only to the brain. An increasing volume of evidence indicates that AD is also associated with peripheral vascular changes //that might be important markers in tests of given pathophysiological hypotheses. ...

Carnegie Mellon develops innovative method to detect genetic causes of complex diseases

...h as diabetes, asthma and cancer, which are characterized by multiple clinical and molecular traits. Rather than searching one at a time for genetic alterations that cause a particular symptom or trait, as in most conventional approaches, the Carnegie Mellon scientists use a statistical method that enables th...

Knowing What to Look for Can Aid in Proper Diagnosis & Treatment of Mild Traumatic Brain Injuries

...ch, taste, smell, vision, hearing), vertigo, nausea, and impairments in fine motor speed and coordination Cognitive: confusion, disorientation, alterations in judgment, and increased distractibility Social: changes in abilities to engage in hobbies and leisure activities, isolation, and increased al...
Alterations in Medical Technology

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

ROCKVILLE, Md. and NEW YORK, Jan. 27 /PRNewswire-USNewswire/ -- Researchers from the J. Craig Venter Institute (JCVI) and the Ludwig Institute for Cancer Research (LICR) have uncovered new genomic alterations that lead to gene fusions in a breast cancer cell line by using 454 Life Sciences sequenc...

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...nical, and regulatory expertise to find and exploit a specific cancer's 'context of vulnerability.' Specifically, SM defines the molecular and genetic alterations (context) that cause cancer cells to be particularly sensitive (vulnerable) to a drug or combination of drugs--the "context of vulnerability." ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

...t, but had not been previously associated with ADHD. "Because the gene alterations we found are involved in the development of the nervous system, they may ev...atry . Unlike changes to single DNA bases, called SNPs or "snips," the alterations examined in the current study are broader changes in structure. Called copy...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

...lyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment should undergo fasting blood glucose testing. Undesirable alterations in lipids have been observed with Zyprexa use. Clinical monitoring, including baseline and follow-up lipid evaluations in patients using Zyprexa, is a...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...e11 . Accessed May 2009. Carvajal RD, et al. A phase II study of Imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT. Abstract # 9001. American Society of Clinical Oncology 2009 Annual Meeting, Orlando, FL. Hainsworth J et al. Phase II trial of bevaci...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... in the blood. Additional pharmacokinetic studies have demonstrated that the conversion of VYVANSE to active medication is unlikely to be affected by alterations in GI transit times and does not rely on gastric pH. ADDERALL XR has a drug delivery system which utilizes immediate release and pH dependent release...
Alterations in Medical Products

Vasopressin (AVP) RIA Test

Description:...terior pituitary for storage and eventual release. AVP secretion is regulated by changes in blood osmolality and also by baroreceptors that respond to alterations in blood volume or arterial pressure. Non-osmotic stimuli include pain, stress, sleep and exercise [1]. The primary function of AVP is the regulation ...
Company:Diagnostic Systems Laboratories, Inc.
Alterations in Medical Dictionary

Serum calcium

... Health Encyclopedia ... Serum calcium is a laboratory test to measure the amount of calcium in ... The primary endocrinopathies producing alterations in serum calcium ... thyroid gland) are responsible for maintaining the serum ionized calcium ... Serum calcium - Overview, Serum c...

Pseudoxanthoma Elasticum

...and cardiovascular system. elastoma n. An inherited disorder of connective tissue characterized by slightly ... Extracutaneous ultrastructural alterations in pseudoxanthoma elasticum " ... pseudoxanthoma elasticum ... Pseudoxanthoma elasticum stiffens the fibers that enable tissue ... is...

Pellagra

...ease caused by lack of niacin (vitamin B3). It can be caused by decreased intake of niacin, tryptophan, or perhaps leucine. It may also result from alterations in protein metabolism in... More about Pellagra : Causes and symptoms Diagnosis Treatment Prognosis Prevention Resources Pellagra Definitio...

Pancreatic carcinoma

...er of the pancreas. Pancreatic cancer Cancer ... What is Pancreatic Carcinoma ? Alternative names. Causes. Symptoms & Signs. Exams ... alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma " ... The molecular genetics of pancreatic ductal carcinoma " ... ...

EEG

...ition, risks, results of this diagnostic test. ... et al. Electroencephalography ( EEG ) in the diagnosis of ... ... the exact location of EEG alterations was also made much ... EEG brain topography is not performed in all cases requiring a recording of the brain activity. ... Neurodiagnostic tests...

Collagen Disease

...nent of the connective tissue. collagen disease ( ′käləjən di′zēz ) ( medicine ) Any of various clinical syndromes characterized by widespread alterations of connective tissue, We are talking about a disease where there is not enough collagen ! ... 1. Willis, S., et al., Haemorrhoids - A Collagen...
Alterations in Biological News

Chemical compound present in detergents produce bacteria alterations in agricultural soils

This release is also availabe in Spanish. Detergents are a pollutant agent which can be found frequently in agricultural soils. There are numerous channels for the passing of chemical components to the soils. Two primary ways are the use of distilled water (both of domestic and industrial...

Symposium to discuss geoengineering to fight climate change at the ESA Annual Meeting

...pproach, the riskier it is for the environment," says session organizer Robert Jackson , director of Duke University's Center on Global Change. Global alterations of Earth's natural cycles have too many uncertainties to be viable with our current level of understanding, he says. One global-scale geoengineerin...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...raise the possibility that the development of AML may require fewer genetic alterations than other cancers and that a very limited number of biological processes m...art genome-wide regions of DNA gain or loss, which are known as copy number alterations (CNAs). To identify point mutations, the researchers also performed DNA re-...

US-Mexico border wall could threaten wildlife species

...connectivity" of wildlife, biologists say, and the animals' potential isolation is a threat to populations of some species. However, technology and alterations to the design could dramatically improve the potential for animals to move more freely between the two countries, the scientists added. Results of ...

'Normal' cells far from cancer give nanosignals of trouble

...from a malignant or premalignant tumor undergo molecular and other kinds of abnormal changes. The most striking findings were that these nanoscale alterations occurred at some distance from the tumor and, importantly, could be identified by assessing more easily accessible tissue, such as the cheek for lung ...

Mouse model provides clues to human language development

... In the brains of the mice the researchers found alterations which may be closely linked to speech and language...chimpanzee lineages diverged, only minimal genetic alterations have occurred, even with reference to the mouse: T... our colleagues in Leipzig that specifically these alterations in the brain were the evolutionary step that gave ...
Alterations in Biological Technology

Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies

Modern technologies developed in recent years have prompted new and exciting approaches to support biomedical research. The ability to study the entire human genome using limited sources of genomic material to detect genetic disordersmade possible through Sigma-Aldrich Biotechnolo...

UCR scientists manipulate ripples in graphene, enabling strain-based graphene electronics

...omic force microscope. They found that almost all the graphene membranes underwent dramatic morphological changes when heated, displaying significant alterations in the ripple geometry, a buckling of the graphene membrane, or both. Their experimental system, which involved a stage inside a scanning electron...

Study Published in Child and Adolescent Psychiatry and Mental Health Demonstrated Once-Daily Vyvanse(R) (lisdexamfetamine dimesylate) CII Provided Significant Improvement of ADHD Symptoms for Children at 13 Hours After Administration

...gically active d -amphetamine. The conversion of Vyvanse to d -amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in GI transit times. Additional information about Vyvanse and Full Prescribing Information, including Medication Guide, are available at w...

Study Showed VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Significant Efficacy at 14 Hours After Administration in Adults with ADHD in an Adult Simulated Workplace Environment

...gically active d -amphetamine. The conversion of VYVANSE to d -amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in GI transit times. Additional information about VYVANSE and Full Prescribing Information, including the Medication Guide, are available at w...

Scientists identify gene vital to early embryonic cells forming a normal heart and skull

...al heart development is the most common human birth defect, affecting about 1 percent of newborns. The researcher team also wants to explore the exact alterations in neural crest cell migration, expansion and differentiation that contribute to birth defects of other organ systems. ...

FDA Approves Labeling Change for VYVANSE(R) (lisdexamfetamine dimesylate) CII to Include Supplementary Clinical Data Supporting Efficacy at 13 Hours Postdose in Children Aged 6 to 12 with ADHD

...gically active d -amphetamine. The conversion of VYVANSE to d -amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in GI transit times. Additional information about VYVANSE and Full Prescribing Information, including Medication Guide, are available at www.v...
Alterations in Biological Products

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description:...c approaches or antibody detection of these modifications. Potential uses for the Complex V immunocapture kit include but are not limited to examining alterations of Complex V subunits in inherited mitochondrial diseases, Alzheimers disease, angiogenesis, hypertension and aging....
Company:MitoScience LLC

Mouse Anti-Porcine Pyruvate Dehydrogenase (PDH), complex Immunocapture Kit Monoclonal Antibody, Protein G-Agarose Conjugated, Clone 15D3G9C11 from MitoScience LLC

Description:...on state, which can then be analyzed in more detail by mass spectrometry. Uses for this PDH immunocapture kit include but are not limited to examining alterations in assembly of the complex in genetic PDH deficiency altered PDH functioning in late-onset diabetes (NIDMM) and the response of the enzyme complex to ...
Company:MitoScience LLC
Alterations in Biological Definition

Albinism

...e usual amounts of a pigment called melanin . There are many genes which are now scientifically proven to be associated with albinism (or better: alterations of the genes). All alterations, however, lead to an alteration of the melanin (pigment/coloring) production in the body. Melanin helps protect the sk...

Magnetic resonance imaging

...s as well as detecting the amount of bound water in geological structures. It is primarily used to demonstrate pathological or other physiological alterations of living tissues and is a commonly used form of medical imaging . MRI has also found many niche applications outside of the medical and biological f...

Reverse genetics

... deletion of a gene by gene knockout (as can be done in some organisms, such as yeast and mice ) -- and only afterwards look for the effect of such alterations in the whole organism. The discovery of gene silencing using double stranded RNA, also known as RNA interference (RNAi), and the development of gene...
Alterations in Biological Dictionary

Synapton

...heimer's disease (AD), nicotine patches improved attentional ... extended-release physostigmine salicylate ( Synapton ) to be effective for the ... alterations in behavior, mood or mental status can be very confusing to ... and galantamine (Reminyl) and physostigmine SR ( Synapton ) are in development. ... ...

Structural biology

...with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because... Welcome to SBB, the Structural Biology Br...

Seminiferous tubules

...les in the Online Dictionary. Meaning of Seminiferous tubules . ... Seminiferous tubules . Seminific. Seminification. seminin ... Structural alterations in the seminiferous tubules of rats treated with ... Seminiferous tubules cross sections were randomly chosen in three non-serial ... Locat...

Secondary palate

...dary palate ' ... Medical Dictionary - ' Secondary Palate ' How to search: 1. ... secondary palate . Type: Term. Definitions: ... Epithelial alterations of Secondary Palate Formation. Marcos Alan Vieira BITTENCOURT ... Development of the secondary palate is a complex and critical event and its ...

Punctuated equilibrium

...ldredge's model for one kind of evolutionary change. punctuated equilibrium n. The theory that speciation occurs in spurts of major genetic alterations that punctuate long periods of little Looks at how PE provides paleontologists with an explanation for the patterns which they find in the fossi...

Polymorphisms

...rphisms , analysis of function in genes, cytochrome P450, Environmental Genome Project, enzymes ... Single nucleotide polymorphisms are minor alterations in the genetic code, but they can result in very important downstream effects on protein function and expression. Fact sheet about SNPs, the SN...
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