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Allogeneic in Medical News

Stemedica Discovers Significant Breakthrough in the Use of Stem Cells and Stem Cell Factors for the Treatment of Retinal Degeneration

...he manufacturing and development of clinical grade allogeneic adult stem cell technology, has discovered a signi...e manufacturing and development of clinical grade allogeneic adult stem cell technology, has discovered a signi...une privilege amplifies the significant promise of allogeneic donor stem cells in the treatment of retinal degen...

St. Jude Scientist Named Pew Scholar

...el genomic abnormalities in leukemogenesis; and the genetics of disease susceptibility and disease phenotype, most notably the genetic determinants of allogeneic hematopoietic stem cell transplant outcome. "Being named a Pew Scholar is a tremendous honor and will provide very important support at this stag...

Study IDs benefit of donor SCT for adults with acute myeloid leukemia

... (which uses a patient's own blood stem cells); or allogeneic SCT (in which compatible donor cells are transplan...lly recommended. For AML with "poor-risk" changes, allogeneic SCT is usually recommended. For AML with "intermed...with poor-risk AML benefited significantly from an allogeneic transplant performed in first remission, while tho...

Donor Stem-Cell Transplant Best For Acute Myeloid Leukemia

...e compatible donor stem cells in what is called an allogeneic transplant, Koreth said. "The question has bee...ed at the relapse-free survival and the benefit of allogeneic stem-cell transplantation vs. nonallogeneic stem-c... with poor- and intermediate-risk AML who received allogeneic stem cell transplants -- the donor stem cells -- i...

5 Spanish centers join a study for a new leukemia and lymphoma treatment technique

...pacity for transplantation in adolescents and adults. It is estimated that more than 11,000 patients in the European Union are in need of an allogeneic (from a source outside of the patient's body) hematopoietic (blood) stem cell transplantation. This is an unofficial figure calculated based on the me...

Stemedica Announces the Appointment of Carl Bullen as Director of Manufacturing

...y requirements is a significant advantage as we prepare to supply our adult allogeneic stem cell lines to preclinical and clinical research centers around the wor...h California's Food & Drug Board and evolve toward the manufacturing of allogeneic clinical grade product for external clients as well as for our own clinical...

DOR BioPharma Announces Potential $30 Million North American Partnership Agreement with Sigma-Tau Pharmaceuticals for orBec(R) in the Treatment of Graft-versus-Host Disease

...ide clinically meaningful outcomes when compared with the current standard of care, including a lowered exposure to systemic corticosteroids following allogeneic transplantation. Currently, there are no approved products to treat GI GVHD. The first trial was a 60-patient Phase 2 single-center clinical trial con...

ViroPharma Reports Results of Phase 3 Clinical Trial for Maribavir in Bone Marrow Transplant Patients

...nnounced that its Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its pr...olled, multicenter pivotal Phase 3 study in 681 patients who have undergone allogeneic stem cell transplantation. Following transplantation and transplant engraft...

CORD:USE Cord Blood Bank Receives Prestigious Accreditation from the Foundation for the Accreditation of Cellular Therapy

...of CORD:USE Cord Blood Bank. "Obtaining FACT Accreditation for cord blood collection, processing, testing, banking, selection and release of unrelated allogeneic cord blood units validates the high quality procedures which CORD:USE and our world-class team utilize. This accreditation gives additional assurance ...

A new light on tumor immunotherapy for gastric cancer

...acter of typical mature DCs. However, immature DCs cultured with cytokines for 5 d did not have typical DCs phenotypic markers and could not stimulate allogeneic T cells. Ex vivo primed T cells with SGC-7901 tumor cell lysate-pulsed (TP) DCs were able to induce effective CTL activity against SGC-7901 tumor cell...
Allogeneic in Medical Technology

HEALTHPOINT-Sponsored Venous Leg Ulcer Clinical Trial Enrolls First Subject for Second Phase II Study

... support the patient's own skin cells' healing ability. HP802-247 utilizes allogeneic cells, which are living human cells derived from an individual donor that a...ion and a cell preparation containing a mixture of growth arrested, living, allogeneic epidermal keratinocytes and dermal fibroblasts. Based on in vitro studies...

DOR BioPharma Receives EMEA Agreement on the Design of its Confirmatory Phase 3 Clinical Trial of orBec(R) in GI GVHD

...ide clinically meaningful outcomes when compared with the current standard of care, including a lowered exposure to systemic corticosteroids following allogeneic transplantation. Currently, there are no approved products to treat GI GVHD. The first trial was a 60-patient Phase 2 single-center clinical trial con...

Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery

...nagement. Continuous and noninvasive SpHb(TM) monitoring has the potential to greatly improve clinical decision-making and reduce patient exposure to allogeneic transfusion, reduce complications, and preserve a precious resource and costs." Masimo continuous and noninvasive hemoglobin monitoring (SpHb) te...

Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting

...and infections resulting in death. Leukine also has been approved in the U.S. for use in four additional indications: myeloid reconstitution following allogeneic and autologous bone marrow transplantation (BMT), peripheral blood stem cell (PBSC) mobilization and subsequent myeloid reconstitution in patients und...

Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers

... sequentially on the wound bed at the time of treatment: a fibrinogen solution and a cell preparation containing a mixture of growth arrested, living, allogeneic epidermal keratinocytes and dermal fibroblasts. Based on in vitro studies, HP802-247 is expected to release various growth and angiogenic factor...

TissueGene Announces Regulatory Allowance to Initiate Phase IIa Study of TG-C in South Korea for Osteoarthritis of the Knee

...e IIa clinical trial of TissueGene-C (TG-C) in patients with severe osteoarthritis of the knee. TG-C has been developed for the localized delivery of allogeneic human cells expressing TGF-beta1 in order to induce the regeneration of cartilage. In Asia, TissueGene has licensed intellectual property rights ...

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

...by their origin - autologous (from the patient) or allogeneic (from a donor). Effect of Stem Cell Sour...e outcomes of adults over the age of 65 undergoing allogeneic stem cell transplantation for the treatment of acu... should not be a limiting factor for proceeding to allogeneic stem cell transplantation in these patients. ...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

...py for a hematologic malignancy (313 patients), chemotherapy for a solid tumor (seven patients), autologous stem cell transplant (429 patients), or an allogeneic stem cell transplant (523 patients). Patients were prophylactically transfused on days when platelet counts were less than or equal to 10,000 microlit...

Bayer Announces Upcoming Presentations of Campath(R) and Leukine(R) Data at the 50th Annual Meeting of the American Society of Hematology

...nd infections resulting in death. Leukine also has been approved in the U.S. for use in four additional indications: myeloid reconstitution following allogeneic and autologous bone marrow transplantation (BMT), peripheral blood stem cell (PBSC) mobilization and subsequent myeloid reconstitution in patients und...

Kiadis Pharma Announces Positive Clinical Results for ATIR(TM) in Mismatched Bone Marrow Transplantations

...tarting recruitment early 2009. In this study the efficacy of ATIR(TM) will be investigated in patients diagnosed with AML, ALL or MDS eligible for an allogeneic bone marrow transplantation but for whom no matching donor is available. "Bone marrow transplantations are often the only treatment option lef...
Allogeneic in Medical Dictionary

Graft Versus Host Disease

... Graft - versus - host disease (GVHD) is a common complication of allogeneic bone marrow transplantation in which functional immune cells in the t...vention ... Graft - versus - host disease is a frequent complication of allogeneic BMTs. ... This is the infamous Graft versus Host Disease , GVHD....

Bone marrow transplant

... with cancer or other diseases which affect the bone marrow . It replaces bone marrow that is either not working properly or has been ... allogeneic bone marrow transplant . " Allo" means "other. ... Bone marrow transplantation (BMT) is a special therapy for patients with cancer .....
Allogeneic in Biological News

Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf

...isease, of which studies are rare and not well-funded. Current disease management includes prenatal diagnosis, transfusion therapy, iron chelation and allogeneic bone marrow transplantation (BMT). The hallmark of the disease is ineffective erythropoiesis (IE), which leads to erythroid marrow expansion to as muc...

UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells

...ting the cells back into the same person. This treatment eliminates the complications of graft-versus-host disease or host rejection that can occur in allogeneic transplants (therapy where the cell donor is different from the recipient). In the current study, 630 immunodeficient mice received mesenchymal ste...

Cell Therapy for Cardiovascular Diseases

...EPAIR-AMI) of bone-marrow- or blood-derived progenitor cells for acute myocardial infarction will be reviewed by Dr. Andreas M. Zeiher Intravenous allogeneic mesenchymal stem cells for acute myocardial infarction will be presented by Dr. Joshua M. Hare MAGIC 5: combined approach using granulocyte colony...

Top scientists meet for global conference on stem cell therapy for cardiovascular diseases

... bone-marrow- or blood-derived progenitor cells for acute myocardial infarction will be reviewed by Dr. Andreas M. Zeiher Intravenous allogeneic mesenchymal stem cells for acute myocardial infarction will be presented by Dr. Joshua M. Hare MAGIC 5: combined approach using granu...

Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases

...EPAIR-AMI) of bone-marrow- or blood-derived progenitor cells for acute myocardial infarction will be reviewed by Dr. Andreas M. Zeiher Intravenous allogeneic mesenchymal stem cells for acute myocardial infarction will be presented by Dr. Joshua M. Hare MAGIC 5: combined approach using granulocyte colony...

Investigating the measles virus as a tool to kill multiple myeloma

...eloma study will be adults with relapsed or refractory (that is, having had more than one type of treatment fail them) myeloma. They must not have had allogeneic (from another person) stem cell transplants and must either have had a prior measles infection or been vaccinated against it. In the 1970s, meas...

Long-term cancer risk follows stem cell transplant recipients

...f the American Cancer Society, the study reveals that within 10 years of an allogeneic HSCT, the relative risk of a second, solid cancer is almost twice that of t...for patients who received stem cells from a female donor. Myeloablative, allogeneic HSCT is an effective standard therapy for specific life-threatening disease...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...ls into the monkeys. In vivo, these cells have been shown to proliferate, differentiate and reverse hyperglycemia in immunodeficient diabetic mice and allogeneic out-bred pigs. However, humans and Old World primates have naturally occurring antibodies that are directed against antigens that can cause hypera...
Allogeneic in Biological Technology

MaxCyte Introduces the GT(TM) Flow Transfection System for Application with Autologous and Allogeneic Stem Cell Therapies

Technology enhances biological activity (regenerative potential) of stem cells and accelerates development of proprietary enhanced therapeutics GAITHERSBURG, Md., Feb. 17 /PRNewswire-USNewswire/ -- MaxCyte announces today the introduction of its GT(TM) Flow Transfection System at the 4th Annu...

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

...ost disease (cGVHD) in patients who have undergone allogeneic hematopoietic cell transplantation. The US ...sus-Host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation. GVHD is an inf... immunocompromised cancer patients after receiving allogeneic stem cell or bone marrow transplants. Similar to ...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

... gastrointestinal Graft-versus-Host disease (GI GVHD) patients who received allogeneic hematopoietic cell transplants (HCT). Non-infectious inflammation of the l...eclomethasone Dipropionate on Early Non-Infectious Pulmonary Outcomes after allogeneic Hematopoietic Cell Transplantation: Results from Two Randomized Trials," is...

PharmaNet Development Group Clinical Research Experts to Present at Global Professional Meetings in June

... will make a presentation on "Delivering Strategic Solutions to Manufacturing and Product Characterization Challenges with allogeneic Therapies." AAPS National Biotechnology Conference Seattle, Washington, Booth 305 Taylor Technology's Rober...

Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma

... capacity for transplantation in adolescents and adults. It is estimated that more than 11,000 patients in the European Union are in need of an allogeneic (from a source outside of the patient's body) hematopoietic (blood) stem cell transplantation. This is an unofficial figure calculated based on the me...

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...f (R) (tacrolimus) Prograf(R) (tacrolimus capsules and injection) is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver, kidney, or heart transplants. It is recommended that Prograf be used concomitantly with adrenal corticosteroids. Because of the risk of anaphy...

Renowned Stem Cell Researcher Files Study Results With Stemedica

...n-union bone injuries using autologous stem cells, allogeneic stem cells and comparative traditional treatment t...n-union bone injuries using autologous stem cells, allogeneic stem cells and comparative traditional treatment t... This was followed by the clinical application of allogeneic stem cells seven years later in 1997. Through eac...

CIRM Completes Briefing Visit to Stemedica Cell Technologies

...sit to Stemedica's manufacturing facility. "I was impressed with the progress that Stemedica has made on the licensing process for clinical grade allogeneic stem cell manufacturing and am excited about expanding our research relationship with the Stemedica team. Having a manufacturing resource like this in...

Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS

...t bone marrow transplant report," commented Dale Ando, M.D., Sangamo's vice president of therapeutic development and chief medical officer. "However, allogeneic bone marrow transplantation (bone marrow taken from a different person) is not widely applicable as a therapeutic approach for HIV as it is a risky pr...

Stem Cell Transplantation Program at Hackensack University Medical Center: First in Nation to Receive Joint Commission Certification for Quality and First in New Jersey to be Named a Blue Distinction(R) Center for Specialty Care.

...New Jersey that is approved by the National Marrow Donor Program to perform all types of transplants: autologous (using the patient's own stem cells), allogeneic (using a donor's stem cells), and umbilical cord (using stem cells collected from umbilical cords). Many of the advances in stem cell transplantation ...
Allogeneic in Biological Definition

Stem cell

... cryoprotectant, and injected through a vein of the patient. This kind of treatment, where the stem cells are collected from another donor, is called allogeneic treatment. When the cells are collected from the same patient on whom they will be used, it is called autologous and when collected from identical ...
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