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Alleles in Medical News

Researchers estimate risk of transmission of Huntington's disease to offspring among male carriers

...ping HD. While several studies suggest that male carriers of high normal alleles have a low probability of transmitting an expanded HD allele in the penetra...th rate, frequency of no family history of HD, and frequency of high normal alleles in the general population. "The estimated probability that a male high norm...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...ssue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide wit...reby preventing simultaneous recombination on both alleles and thus reducing the chance of translocations. ...and researchers propose that homologous pairing of alleles undergoing recombination has a number of functions...

Genetic marker may predict early onset of prostate cancer

...notyped 631 men enrolled in the Prostate Cancer Risk Assessment Program at Fox Chase. Overall, while there were differences in the distribution of the alleles by race, the risk allele did not have a major contribution to disease in 400 African American men or in 231 Caucasian men with a family history of pro...

ASHG hosts fourth annual DNA Day essay contest, supports genetics education efforts

...rieties. Modes of inheritance like co-dominance, incomplete dominance, and epistasis involve intricate interactions between the expression of multiple alleles and/or genes that often result in the existence of three or more varieties of traits, such as human blood markers and flower color." Molina concluded ...

Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening

...w the widespread and thoughtful experience with [cystic fibrosis] mutation testing and screening continues to reveal new insights about the mutational alleles of the CFTR gene and further refinements in how best to detect them and assure appropriate quality control while doing so," said Wayne W. Grody, M.D.,...

Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction

...one of the major receptors in the brain that mediate the actions of the neurotransmitter dopamine, is associated with tobacco dependence, and that two alleles of a variant within this gene are differentially expressed. "In the current study, we demonstrated that such differential expression of DRD1 is regula...
Alleles in Medical Technology

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

...at most closely genetically matched the patient were selected for transfusion. All non-cultured cord blood stem cells were matched for four out of six alleles for each patient. For the cultured cord blood cells, two patients received a five-out-of-six allele match and four patients received a four-out-of-six...

The Past, Present and Future of HLA Typing

...ci. Each locus is highly polymorphic; for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. A clear understanding of the differences betwee...mentary to the range of HLA polymorphisms, it is possible to detect the HLA alleles directly by PCR. In fact, this technique was used in the first commerciall...
Alleles in Medical Products

DPB1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible w...
Company:Dynal Biotech, LLC

DQB1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible w...
Company:Dynal Biotech, LLC

DQA1 SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible w...
Company:Dynal Biotech, LLC

DRB96 SSP UniTray

Description:...h resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compat...
Company:Dynal Biotech, LLC

B Locus High Res SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible w...
Company:Dynal Biotech, LLC

Cw High Res SSP UniTray®

Description:... high resolution results, no need for initial low resolution typing Allele level typing with a single tray Unique reaction pattern for most common alleles Can resolve ambiguities seen with other typing techniques Same procedure and thermal cycling conditions as all SSP UniTray products Compatible w...
Company:Dynal Biotech, LLC
Alleles in Medical Dictionary

Rh factor

... type and Rh factor , which ... The Rh factor genetic information is also inherited from our parents, but it is ... There are 2 different alleles for the Rh factor known as Rh + and Rh ... The Rh factor in your blood type can cause harm to your baby. ... If you have questions ab...

Blood typing

...explanation of Rh ... PROTEINS & BLOOD TYPES ... The ABO blood type classification system uses the presence or absence of these ... of alleles produce blood types in the following ... Lifeshare Blood Centers ... Those with type AB blood are known as "universal recipients. ... Do...
Alleles in Biological News

Measuring intellectual disability

...ectrum disorders, but also developmental delay, behavioral difficulties, anxiety, ADHD, and mood. Involvement among carriers of smaller (premutation) alleles can also involve developmental delays and/or autism spectrum disorders." In future studies, Dr. Hagerman and colleagues plan to explore "further large...

Penn researchers discover genetic risk factor for testicular cancer

... required in conjunction with KITLG for disease development. This remains to be determined." Only a small proportion of men who carry the high-risk alleles will develop the disease. The key now, the researchers say, is to find out what modifies the genetic risks and pushes one individual toward cancer whi...

Immune genes adapt to parasites

...and fungi than by that of worms. SNPs in some of these genes are known risk alleles for inflammatory bowel diseases, such as Crohn's and celiac disease. These "risky" alleles were probably maintained during evolution because they promote the kind of ...

A genome may reduce your carbon footprint

...o soil, temperature, and moisture conditions. It is still largely undomesticated and thus large gains might be realized through fixation of beneficial alleles in breeding populations. There are likely to be a few genes with large effects that will dramatically impact yields once incorporated into breeding pr...

Cystic fibrosis testing -- next steps

...w the widespread and thoughtful experience with [cystic fibrosis] mutation testing and screening continues to reveal new insights about the mutational alleles of the CFTR gene and further refinements in how best to detect them and assure appropriate quality control while doing so." ...

Researchers take first look at the genetic dynamics of inbreeding depression

...e are called alleles. If the maternal and paternal alleles differ, one of them usually dominates, conferring ...er, silenced allele is called "recessive." Some alleles are detrimental to health. Most of these are reces...two copies of them one from each parent. When the alleles differ, one (the dominant allele) often masks the ...
Alleles in Biological Technology

ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles

OXFORD, England, September 24 /PRNewswire/ -- ProImmune Ltd., a leading provider of quality research reagents for monitoring the immune system and services for antigen discovery, has announced the launch of its new MHC-peptide binding assay for Class II HLA alleles, adding to the series of dis...

Separation of HLA-DRB Alleles by Denaturing Gradient Gel Electrophoresis using the DCode System

L. A. Knapp, 1, 2 E. Lehmann, 2 L. Hennes, 3 M. E. Eberle, 2 and D. I. Watkins 2, 3 1 Department of Biological Anthropology, University of Cambridge,U.K. 2 Wisconsin Regional Primate Research Center, University of Wisconsin, ...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

... and reliable tool in analyzing DNA variations, especially where the mutant alleles are at a very low concentration within the sample (less than 1% of the tota.... Cold-PCR protocols preferentially amplify heteroduplexes such that mutant alleles become enriched compared to normal alleles. The range of enrichment demons...

New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor

...targeting IGF1 signaling. To test their reasoning they conducted a second experiment by crossing mice carrying the prostate-specific IGF-1R knockout alleles with transgenic mice that develop spontaneous prostate cancer when p53 and select other genes are compromised. The results were as predicted: Prostate...

Honey bee invaders exploit the genetic resources of their predecessors

...ly from throughout the Africanized honey bee genome showed that most of the alleles were common to African honey bees. But of the alleles common to European bees, those found in functional parts of the genome (in ...

Healthcare slow to adopt genetic advances

...t are being addressed now, that are emerging as being important areas of personalized medicine, are those associated with a few allele interactions or alleles of importance," he said, "which help detect those interactions, those biochemical interactions, that are probably leading to the disease, but for whic...
Alleles in Biological Definition

Allele

...for that gene. An organism which has two different alleles of the gene is said to be heterozygous . Often on...ce (sometimes called blending inheritance ) when alleles blend their traits in the phenotype . An example...ossing flowers with codominant "blue" and "purple" alleles for petal color, the resulting offspring would hav...

Allele frequency

...ry an allele that has a frequency of 20%. However, alleles distribute randomly only in the absence of select...nberg equilibrium . The frequencies of all the alleles of a given gene often are graphed together as an ... to changes in the distribution and frequencies of alleles -- in other words, to evolution . Besides selecti...

Barr body

...yonic development, this results in different regions of the adult body having different chromosomes inactivated. This can be significant if different alleles of a gene are present on the different chromosomes; in some regions of the body one allele will be active, and in other regions the other will. This ...

Evolution

...more specifically as a change in the frequency of alleles in a population from one generation to the next. ...urvival of traits While mutation can create new alleles , other factors influence the frequency of existin... between successive generations may result in some alleles disappearing from the population. Two separate pop...

Ewens's sampling formula

...gene at a particular locus then the probability that there are a 1 alleles represented once in the sample, and a 2 alleles represented twice, and so on, is for some positive number θ...

Gene

...opulation. Variants of a single gene are known as alleles , and differences in alleles may give rise to differences in traits, for exampl... allele is called the wild type allele, and rare alleles are called mutants . Normally, RNA is an int...
Alleles in Biological Dictionary

Alleles

An allele, (US)) is one of a series of different forms of a gene. The word is a short from of allelomorph ('other form'), which was used in the early days of genetics to describe variant forms of a gene detected as different phenotypes. Alleles are now understood to be... In classi...

Multiple alleles

Allele . From Wikipedia, the free encyclopedia (Redirected from Multiple ... In other words, alleles are members of a gene that produce different traits in a ... Multiple Alleles | Macmillan Genetics. Multiple Alleles summary with 2 pages of encyclopedia entries, research inf...

VNTR

...en show variations in length between... VNTR alleles are hypervariable regions of human DNA that dif...e for any one VNTR locus, a number of different alleles may exist, each with ... If the fragments of DNA containing the VNTR alleles are to be separated on the ... VNTR . The ful...

True-breeding

...ine.org dictionary. ... With plants, true breeding occurs when plants produce only ... True - breeding individuals are homozygous, alternate alleles are identical, ... The recessive trait's phenotype only appears in true - breeding (homozygous) individuals ... That is only true if mom i...

Single locus probe

...e , the radioactivity on the ... DNA Forensics Problem Set 2. Problem 5: alleles in a single - locus probe ... individual with a specific single - locu...UC cases (patients ... When a genetic locus is polymorphic, there are alleles for that gene. ... Single Locus Probe : A DNA probe that detects a ...

Sex chromosome

...aracteristics in an organism. Most sexual organisms have two sexes. In many cases, sex determination is genetic: males and females have different alleles or even different... The XY sex -determination system is the sex -determination system found in humans, most other mammals, some insects (Drosop...
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